Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 103487121

GI number: 103487121

Start: 1717877

End: 1719082

Strand: Direct

Name: acdA [H]

Synonym: Sala_1636

Alternate gene names: 103487121

Gene position: 1717877-1719082 (Clockwise)

Preceding gene: 103487120

Following gene: 103487122

Centisome position: 51.35

GC content: 65.59

Gene sequence:

>1206_bases
ATGACCGACATCGAAGCCTATCGGCGCAAGGCGCGCAGCTGGCTCGAGTCCGTGGCGCCGCGCTATGGACGGGCGGCGCG
CGCGGGGTTGAGCGAAGAAGAGGATCTGGCGCTCGGGCGGGCTTATCTCAGGGAACGCCATGCGGCGGGCTATGCCGGGA
TCAACTGGCCGACTGAGTATGGCGGTCAGGGACTCGGCCATATCGAAAAGGTCGCCTTCGACACCGAAGAGATGCCGTTC
GGCATGCCGACCGCCTATTTCAGCATCTCGCTCGGCATGCCGGTCCCCGTCCTCATGCGCTTTTGCGAAGACAGGCAATG
GGTGCGCGAGCGCGTGCTCAAGGCGCTCACCGGCGAGGAAATCTGGTGCCAGCTTTTTTCGGAACCGGCGGCGGGGTCGG
ACCTCGCCGGGCTGCGCACGCGGGCCGAGCCTGACGGCAACGGCTGGAAGATCAACGGGCAGAAGGTCTGGACGAGCTGG
GCGCAATATAGTGACTATGGCGTCATCGTCGTGCGCACCGACCCGACGGTGCCCAAGCACAAGGGGCTCACATACTTCTG
GGTCGATATGAAGGCGCCGGGCGTCACCGTGCGCCCGATCAAGCTCGCGGGCGGCGACAGCCATGTCAACGAGGTGTTCT
TCGACGATGTGAAGGTCGGCGACGATCATCGCATGTCGCCGGTCGGCGGCGGCTTTGCGGTCGCGATGGCGACGCTGATG
ATCGAACGCTATGTCGCGACCGACAGCGCGGGCTTCGGTCCGCACCTCGACCTGTTCGTCGATCTGGCGAAAGAGATGAA
GCTGAACGGCCGCCCCGCGATCGAGGACGGCCGCATCCGCCAGCAGATCGCGCGCAACTATGCGATGCGGAGCGCGCTCG
ATGCCATCACCACCCGCGCGATGCGGATGATGCAGGCGGGCATGGAACCCGGCCCCGAAGGCTCGCTCAACAAGCTCGTG
TCGGTGCGTTCGCGCCAGAAGCTGTCCGAACTCGCGCTCGACCTGCAGGGCACTGCGGGTCTCGCCTTCGATGCGCACGC
CCCGGTCAAGCAGGACTGGGGCGTGAGCTGGATCAACGCGCCGACGGGTCGCATCGCGGGCGGCGCCGACGAAATGCTGC
TCAACACGATTGCCGAAAAGATCCTCGGACTTCCGCAGGATTACCGCCCCGACAAGGGCGTCCCGTTCAACCAGATTCCC
GCCTGA

Upstream 100 bases:

>100_bases
TTCACCTTCACATGCGCCGCGCGCGCAGCCTCGCGATCGAGCAGGGCAATCTTTTCTTCTGGGAGGATGTGCTCGTCGAT
CGCCTGAGGGAGCAAAGACG

Downstream 100 bases:

>100_bases
TCACAAGGATATCAGACCATGGCCGAAGCCTATATCATCGACGCCGTCCGCACCCCGCGCGGGATCGGCAAGCCCGGCAA
GGGCGCGCTGTCGCATCTCC

Product: acyl-CoA dehydrogenase-like protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTDIEAYRRKARSWLESVAPRYGRAARAGLSEEEDLALGRAYLRERHAAGYAGINWPTEYGGQGLGHIEKVAFDTEEMPF
GMPTAYFSISLGMPVPVLMRFCEDRQWVRERVLKALTGEEIWCQLFSEPAAGSDLAGLRTRAEPDGNGWKINGQKVWTSW
AQYSDYGVIVVRTDPTVPKHKGLTYFWVDMKAPGVTVRPIKLAGGDSHVNEVFFDDVKVGDDHRMSPVGGGFAVAMATLM
IERYVATDSAGFGPHLDLFVDLAKEMKLNGRPAIEDGRIRQQIARNYAMRSALDAITTRAMRMMQAGMEPGPEGSLNKLV
SVRSRQKLSELALDLQGTAGLAFDAHAPVKQDWGVSWINAPTGRIAGGADEMLLNTIAEKILGLPQDYRPDKGVPFNQIP
A

Sequences:

>Translated_401_residues
MTDIEAYRRKARSWLESVAPRYGRAARAGLSEEEDLALGRAYLRERHAAGYAGINWPTEYGGQGLGHIEKVAFDTEEMPF
GMPTAYFSISLGMPVPVLMRFCEDRQWVRERVLKALTGEEIWCQLFSEPAAGSDLAGLRTRAEPDGNGWKINGQKVWTSW
AQYSDYGVIVVRTDPTVPKHKGLTYFWVDMKAPGVTVRPIKLAGGDSHVNEVFFDDVKVGDDHRMSPVGGGFAVAMATLM
IERYVATDSAGFGPHLDLFVDLAKEMKLNGRPAIEDGRIRQQIARNYAMRSALDAITTRAMRMMQAGMEPGPEGSLNKLV
SVRSRQKLSELALDLQGTAGLAFDAHAPVKQDWGVSWINAPTGRIAGGADEMLLNTIAEKILGLPQDYRPDKGVPFNQIP
A
>Mature_400_residues
TDIEAYRRKARSWLESVAPRYGRAARAGLSEEEDLALGRAYLRERHAAGYAGINWPTEYGGQGLGHIEKVAFDTEEMPFG
MPTAYFSISLGMPVPVLMRFCEDRQWVRERVLKALTGEEIWCQLFSEPAAGSDLAGLRTRAEPDGNGWKINGQKVWTSWA
QYSDYGVIVVRTDPTVPKHKGLTYFWVDMKAPGVTVRPIKLAGGDSHVNEVFFDDVKVGDDHRMSPVGGGFAVAMATLMI
ERYVATDSAGFGPHLDLFVDLAKEMKLNGRPAIEDGRIRQQIARNYAMRSALDAITTRAMRMMQAGMEPGPEGSLNKLVS
VRSRQKLSELALDLQGTAGLAFDAHAPVKQDWGVSWINAPTGRIAGGADEMLLNTIAEKILGLPQDYRPDKGVPFNQIPA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=353, Percent_Identity=26.0623229461756, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI187960098, Length=314, Percent_Identity=28.9808917197452, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI4557231, Length=314, Percent_Identity=28.9808917197452, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI226958414, Length=222, Percent_Identity=30.6306306306306, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI226958412, Length=240, Percent_Identity=29.5833333333333, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4557233, Length=323, Percent_Identity=25.6965944272446, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4501857, Length=385, Percent_Identity=22.5974025974026, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4557235, Length=312, Percent_Identity=26.9230769230769, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI76496475, Length=312, Percent_Identity=26.9230769230769, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI7656849, Length=201, Percent_Identity=30.3482587064677, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87081958, Length=365, Percent_Identity=25.4794520547945, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786223, Length=334, Percent_Identity=23.6526946107784, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17534899, Length=273, Percent_Identity=28.2051282051282, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17506239, Length=338, Percent_Identity=26.6272189349112, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17538396, Length=204, Percent_Identity=31.3725490196078, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17569725, Length=208, Percent_Identity=28.3653846153846, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17508101, Length=338, Percent_Identity=25.1479289940828, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17505929, Length=337, Percent_Identity=27.0029673590504, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17570075, Length=329, Percent_Identity=27.355623100304, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17551932, Length=343, Percent_Identity=25.3644314868805, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32563615, Length=191, Percent_Identity=29.8429319371728, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71990804, Length=284, Percent_Identity=24.6478873239437, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356377, Length=312, Percent_Identity=27.8846153846154, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24660351, Length=228, Percent_Identity=30.7017543859649, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24646207, Length=340, Percent_Identity=25.5882352941176, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666513, Length=338, Percent_Identity=26.0355029585799, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281363737, Length=318, Percent_Identity=24.2138364779874, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355753, Length=369, Percent_Identity=25.7452574525745, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 44216; Mature: 44085

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIEAYRRKARSWLESVAPRYGRAARAGLSEEEDLALGRAYLRERHAAGYAGINWPTEY
CCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
GGQGLGHIEKVAFDTEEMPFGMPTAYFSISLGMPVPVLMRFCEDRQWVRERVLKALTGEE
CCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
IWCQLFSEPAAGSDLAGLRTRAEPDGNGWKINGQKVWTSWAQYSDYGVIVVRTDPTVPKH
HHHHHHCCCCCCCCCHHCCCCCCCCCCCEEECCHHHHHHHHHHCCCCEEEEECCCCCCCC
KGLTYFWVDMKAPGVTVRPIKLAGGDSHVNEVFFDDVKVGDDHRMSPVGGGFAVAMATLM
CCCEEEEEEECCCCEEEEEEEECCCCCHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHH
IERYVATDSAGFGPHLDLFVDLAKEMKLNGRPAIEDGRIRQQIARNYAMRSALDAITTRA
HHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MRMMQAGMEPGPEGSLNKLVSVRSRQKLSELALDLQGTAGLAFDAHAPVKQDWGVSWINA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEECC
PTGRIAGGADEMLLNTIAEKILGLPQDYRPDKGVPFNQIPA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDIEAYRRKARSWLESVAPRYGRAARAGLSEEEDLALGRAYLRERHAAGYAGINWPTEY
CCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
GGQGLGHIEKVAFDTEEMPFGMPTAYFSISLGMPVPVLMRFCEDRQWVRERVLKALTGEE
CCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
IWCQLFSEPAAGSDLAGLRTRAEPDGNGWKINGQKVWTSWAQYSDYGVIVVRTDPTVPKH
HHHHHHCCCCCCCCCHHCCCCCCCCCCCEEECCHHHHHHHHHHCCCCEEEEECCCCCCCC
KGLTYFWVDMKAPGVTVRPIKLAGGDSHVNEVFFDDVKVGDDHRMSPVGGGFAVAMATLM
CCCEEEEEEECCCCEEEEEEEECCCCCHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHH
IERYVATDSAGFGPHLDLFVDLAKEMKLNGRPAIEDGRIRQQIARNYAMRSALDAITTRA
HHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MRMMQAGMEPGPEGSLNKLVSVRSRQKLSELALDLQGTAGLAFDAHAPVKQDWGVSWINA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEECC
PTGRIAGGADEMLLNTIAEKILGLPQDYRPDKGVPFNQIPA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]