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The map label for this gene is lyx [H]

Identifier: 99081035

GI number: 99081035

Start: 1284794

End: 1286305

Strand: Direct

Name: lyx [H]

Synonym: TM1040_1194

Alternate gene names: 99081035

Gene position: 1284794-1286305 (Clockwise)

Preceding gene: 99081034

Following gene: 99081036

Centisome position: 40.14

GC content: 62.76

Gene sequence:

>1512_bases
TTGGGTCTGGATGCGGGCAATACGGTCATCAAAGCCGTGTTGTTCGATCAAGACGGGCGGCAAGTGGCGATGCAGGCGCT
CGATGGGCAGACCGCGACCCCAGCACCGGGCCATGTGGAGCGCGACCTGGGCGAATTGTGGCAGAACGCGGGTCAGGTGA
TCCGGGGCTGCATCGAAGAGGCTGGCATCTCCGCCCGCCAGATCGCTGGCGTTGGGTGCGCGGGGCATGGCAACGGGCTC
TATGCGCTGGATAAATCTGGCGCGCCTTTGATTGGCATTCAGTCGCTTGATACCCGCGCCGCAGAGCTAGCGGAAGACCT
ATCCGAGACCCATGGCTCCGACCTGCACAAGATCTGCCTGCAGAAACCCTGGCCGTCGCAGACGCCGGTGTTGCTCGCCT
GGGTCAAGCGACATCAGCCCGAGATCTATGACCGGATCGGAACGGTGTTGCTCTGCAAGGATTTCATCACCCATCAGCTG
ACGGGTATAAAGGTGAGTGACATCTCCGATATGTCCGGCTGTGGTCTGACGCGGATGCCAGCCTGCCGTTATGATGCTGA
ATTGATGCGCCTCTACGGGCTTCAGGATGCGCTTTCGATGCTGCCCGCGCTTGTGGAACCTGCCGAGATCGCGGGTCATG
TGACCGCCGCTGCTGCCGCGCAGACCGGTCTCATCGAGGGGACGCCGGTGATTGGCGGCTACTTTGACGTGATCTCTTCG
GCGCTGGGGTCCGGTGTCTGTCGCGCGGGGGAGGCATCAATCATCGCCGGAACCTGGTCGGTCAATCAGGTCTTTTCGCC
AGAGCCGGTGTTGGACTCTTCGGTGTTCATGGCGTCCGGTTTTGCGCCGGGGCGCTTTGTGAACATCGACTCCTCGGCCA
CATCGGCGGTCAACCTCGAATGGTATGTGCGCGAACTGGTCGAGCGCGGCGCCCATGTCGATGATCCCTTTGGCCAATGC
AACAATTTGGTGGCCGAGGTAACGCCCGCGCCGGATGATCCGATCTGCCAGCCCTTTCTCTACGGGTCGGGGCAGGGCGC
TCAGTTCCGGGGCGGCTATTTTGGTCTTGCGGGCTGGCACGGCGAGGGCCACCTGCTGCGCGCGCTTTTTGAGGGCGTCG
TATTCGAGCACCGCCGCCATATCGAGGTGCTGCGCGGGGCGGGGCTCGACTTTGACACAGCGGTGCTGTCGGGGGGCGGC
TCGCGCAGCCCGCATTGGCCGCAGATCTTTGCCGATTGCCTTGATCGCAAGATCCGTGTTTCCGAGGCCAAGGAAACAGG
CGCATTGGGAGCCGCCATCGGCGTCGCGGTGGCCGTGGGGCTGGCCGAGGACTATGAGAGCGCCGTGGCGCGGATGACCC
GTACCAAGGCCGAGTTCACCCCAAACCCATTGATGAGACGGCATTACGACCAGCGCTACGCGCTCTACTCGGAGCTCAAC
GCGACTCTGCAGCCGCTTTGGGCACGATTGGGCGCCATGCAGACCGGCCAATGTGATGAGAATGGATCATAA

Upstream 100 bases:

>100_bases
AAAGCCGTGGTCAATGCCTTGATGGCCATGATCCACTCTGGCGCGGATGGTGAAGAAGCATGGGACATTTATAACCGTGG
GTGAGGAACAGACATATCTC

Downstream 100 bases:

>100_bases
GAGGAGGCCGCAATGGCCGTTTTGGTAATCGCAGAGCTGAAGACCGCTTATGAGCGGCGGGACACGCTGTTGGAGTTCGT
CCAGACCCTCGCAGCGCACA

Product: carbohydrate kinase, FGGY

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MGLDAGNTVIKAVLFDQDGRQVAMQALDGQTATPAPGHVERDLGELWQNAGQVIRGCIEEAGISARQIAGVGCAGHGNGL
YALDKSGAPLIGIQSLDTRAAELAEDLSETHGSDLHKICLQKPWPSQTPVLLAWVKRHQPEIYDRIGTVLLCKDFITHQL
TGIKVSDISDMSGCGLTRMPACRYDAELMRLYGLQDALSMLPALVEPAEIAGHVTAAAAAQTGLIEGTPVIGGYFDVISS
ALGSGVCRAGEASIIAGTWSVNQVFSPEPVLDSSVFMASGFAPGRFVNIDSSATSAVNLEWYVRELVERGAHVDDPFGQC
NNLVAEVTPAPDDPICQPFLYGSGQGAQFRGGYFGLAGWHGEGHLLRALFEGVVFEHRRHIEVLRGAGLDFDTAVLSGGG
SRSPHWPQIFADCLDRKIRVSEAKETGALGAAIGVAVAVGLAEDYESAVARMTRTKAEFTPNPLMRRHYDQRYALYSELN
ATLQPLWARLGAMQTGQCDENGS

Sequences:

>Translated_503_residues
MGLDAGNTVIKAVLFDQDGRQVAMQALDGQTATPAPGHVERDLGELWQNAGQVIRGCIEEAGISARQIAGVGCAGHGNGL
YALDKSGAPLIGIQSLDTRAAELAEDLSETHGSDLHKICLQKPWPSQTPVLLAWVKRHQPEIYDRIGTVLLCKDFITHQL
TGIKVSDISDMSGCGLTRMPACRYDAELMRLYGLQDALSMLPALVEPAEIAGHVTAAAAAQTGLIEGTPVIGGYFDVISS
ALGSGVCRAGEASIIAGTWSVNQVFSPEPVLDSSVFMASGFAPGRFVNIDSSATSAVNLEWYVRELVERGAHVDDPFGQC
NNLVAEVTPAPDDPICQPFLYGSGQGAQFRGGYFGLAGWHGEGHLLRALFEGVVFEHRRHIEVLRGAGLDFDTAVLSGGG
SRSPHWPQIFADCLDRKIRVSEAKETGALGAAIGVAVAVGLAEDYESAVARMTRTKAEFTPNPLMRRHYDQRYALYSELN
ATLQPLWARLGAMQTGQCDENGS
>Mature_502_residues
GLDAGNTVIKAVLFDQDGRQVAMQALDGQTATPAPGHVERDLGELWQNAGQVIRGCIEEAGISARQIAGVGCAGHGNGLY
ALDKSGAPLIGIQSLDTRAAELAEDLSETHGSDLHKICLQKPWPSQTPVLLAWVKRHQPEIYDRIGTVLLCKDFITHQLT
GIKVSDISDMSGCGLTRMPACRYDAELMRLYGLQDALSMLPALVEPAEIAGHVTAAAAAQTGLIEGTPVIGGYFDVISSA
LGSGVCRAGEASIIAGTWSVNQVFSPEPVLDSSVFMASGFAPGRFVNIDSSATSAVNLEWYVRELVERGAHVDDPFGQCN
NLVAEVTPAPDDPICQPFLYGSGQGAQFRGGYFGLAGWHGEGHLLRALFEGVVFEHRRHIEVLRGAGLDFDTAVLSGGGS
RSPHWPQIFADCLDRKIRVSEAKETGALGAAIGVAVAVGLAEDYESAVARMTRTKAEFTPNPLMRRHYDQRYALYSELNA
TLQPLWARLGAMQTGQCDENGS

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI164663828, Length=536, Percent_Identity=24.0671641791045, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI164663830, Length=554, Percent_Identity=23.4657039711191, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=35.140562248996, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1787789, Length=500, Percent_Identity=26.4, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789987, Length=507, Percent_Identity=27.6134122287968, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1789168, Length=478, Percent_Identity=26.3598326359833, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790361, Length=497, Percent_Identity=22.5352112676056, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17535599, Length=450, Percent_Identity=23.5555555555556, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24657106, Length=536, Percent_Identity=23.8805970149254, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24657102, Length=536, Percent_Identity=23.8805970149254, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 53699; Mature: 53568

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLDAGNTVIKAVLFDQDGRQVAMQALDGQTATPAPGHVERDLGELWQNAGQVIRGCIEE
CCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AGISARQIAGVGCAGHGNGLYALDKSGAPLIGIQSLDTRAAELAEDLSETHGSDLHKICL
HCCCHHHHCCCCCCCCCCCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
QKPWPSQTPVLLAWVKRHQPEIYDRIGTVLLCKDFITHQLTGIKVSDISDMSGCGLTRMP
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCC
ACRYDAELMRLYGLQDALSMLPALVEPAEIAGHVTAAAAAQTGLIEGTPVIGGYFDVISS
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
ALGSGVCRAGEASIIAGTWSVNQVFSPEPVLDSSVFMASGFAPGRFVNIDSSATSAVNLE
HHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCEEEEECCCCCCEEHHH
WYVRELVERGAHVDDPFGQCNNLVAEVTPAPDDPICQPFLYGSGQGAQFRGGYFGLAGWH
HHHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEEC
GEGHLLRALFEGVVFEHRRHIEVLRGAGLDFDTAVLSGGGSRSPHWPQIFADCLDRKIRV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCCEEH
SEAKETGALGAAIGVAVAVGLAEDYESAVARMTRTKAEFTPNPLMRRHYDQRYALYSELN
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ATLQPLWARLGAMQTGQCDENGS
HHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
GLDAGNTVIKAVLFDQDGRQVAMQALDGQTATPAPGHVERDLGELWQNAGQVIRGCIEE
CCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AGISARQIAGVGCAGHGNGLYALDKSGAPLIGIQSLDTRAAELAEDLSETHGSDLHKICL
HCCCHHHHCCCCCCCCCCCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
QKPWPSQTPVLLAWVKRHQPEIYDRIGTVLLCKDFITHQLTGIKVSDISDMSGCGLTRMP
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCC
ACRYDAELMRLYGLQDALSMLPALVEPAEIAGHVTAAAAAQTGLIEGTPVIGGYFDVISS
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
ALGSGVCRAGEASIIAGTWSVNQVFSPEPVLDSSVFMASGFAPGRFVNIDSSATSAVNLE
HHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCEEEEECCCCCCEEHHH
WYVRELVERGAHVDDPFGQCNNLVAEVTPAPDDPICQPFLYGSGQGAQFRGGYFGLAGWH
HHHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEEC
GEGHLLRALFEGVVFEHRRHIEVLRGAGLDFDTAVLSGGGSRSPHWPQIFADCLDRKIRV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCCEEH
SEAKETGALGAAIGVAVAVGLAEDYESAVARMTRTKAEFTPNPLMRRHYDQRYALYSELN
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ATLQPLWARLGAMQTGQCDENGS
HHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]