Click here to switch to the map view.

The map label for this gene is ccmE

Identifier: 99080965

GI number: 99080965

Start: 1209696

End: 1210139

Strand: Direct

Name: ccmE

Synonym: TM1040_1124

Alternate gene names: 99080965

Gene position: 1209696-1210139 (Clockwise)

Preceding gene: 99080964

Following gene: 99080966

Centisome position: 37.79

GC content: 58.56

Gene sequence:

>444_bases
ATGAAGTCCCTGAAGAAGCAGCGGCGTATCCAGATCATAGCGCTTGCCACCGTGGCCCTTGTTGGGTCCACGGCGCTCAT
TGGCTATGCCATGCGCGATGGCATCAACTATTTCCGCTCGCCCAGTCAGGTGATGGAGACCCCGCCCGAGCCGACAGAGA
CCTTTCGCATCGGTGGCCTTGTCGAAGAAGGCACCCTGCAACGCGGTCAGGGCGAGGCGGTGCGCTTTTCGGTGACCGAT
GGTGGCGCCAGCGTGCCGGTCACCTATGTGGGGGTTCTGCCGGATCTCTTTGAGGAAAATCAGGGCATGGTGGGGACCGG
GCGATATGTCAACGGTGTCTTTGAAGCCTCTGAAATCCTTGCAAAACATGACGAGACCTACATGCCCAAAGAGGTCGTGG
ATGCCTTGAAAGAACAAGGTGTCTACCGCGAAGGCGACAGCTGA

Upstream 100 bases:

>100_bases
AGCGGTCAGGCCTTGCAGAATGCAAACCTGATGTTAGGTGAGGACGAGACAGCCGGGCTGATGATGGCACCGCTGTTCCC
CTGAACATCAAGAGGTCCAG

Downstream 100 bases:

>100_bases
TCTTTTTGCATTCTGGTCTGATCTGATAACGCGCCCGGCGATCACCGCCCGGGCGCGTTGCGTTTGCAGCGCACGGTCCG
ACCACCGGATCGAAAGTCGC

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MKSLKKQRRIQIIALATVALVGSTALIGYAMRDGINYFRSPSQVMETPPEPTETFRIGGLVEEGTLQRGQGEAVRFSVTD
GGASVPVTYVGVLPDLFEENQGMVGTGRYVNGVFEASEILAKHDETYMPKEVVDALKEQGVYREGDS

Sequences:

>Translated_147_residues
MKSLKKQRRIQIIALATVALVGSTALIGYAMRDGINYFRSPSQVMETPPEPTETFRIGGLVEEGTLQRGQGEAVRFSVTD
GGASVPVTYVGVLPDLFEENQGMVGTGRYVNGVFEASEILAKHDETYMPKEVVDALKEQGVYREGDS
>Mature_147_residues
MKSLKKQRRIQIIALATVALVGSTALIGYAMRDGINYFRSPSQVMETPPEPTETFRIGGLVEEGTLQRGQGEAVRFSVTD
GGASVPVTYVGVLPDLFEENQGMVGTGRYVNGVFEASEILAKHDETYMPKEVVDALKEQGVYREGDS

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=143, Percent_Identity=35.6643356643357, Blast_Score=90, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_SILST (Q1GHK9)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613119.1
- ProteinModelPortal:   Q1GHK9
- SMR:   Q1GHK9
- STRING:   Q1GHK9
- GeneID:   4077245
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1124
- NMPDR:   fig|292414.1.peg.3741
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- PhylomeDB:   Q1GHK9
- ProtClustDB:   PRK13254
- BioCyc:   SSP292414:TM1040_1124-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 16016; Mature: 16016

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: BINDING 123-123

Signals:

None

Transmembrane regions:

HASH(0xe443fec)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLKKQRRIQIIALATVALVGSTALIGYAMRDGINYFRSPSQVMETPPEPTETFRIGGL
CCCCHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEECCE
VEEGTLQRGQGEAVRFSVTDGGASVPVTYVGVLPDLFEENQGMVGTGRYVNGVFEASEIL
ECCCCCCCCCCCEEEEEECCCCCCCCEEHEHHHHHHHHCCCCCEECCHHHHHHHHHHHHH
AKHDETYMPKEVVDALKEQGVYREGDS
HHCCCCCCCHHHHHHHHHCCCCCCCCH
>Mature Secondary Structure
MKSLKKQRRIQIIALATVALVGSTALIGYAMRDGINYFRSPSQVMETPPEPTETFRIGGL
CCCCHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEECCE
VEEGTLQRGQGEAVRFSVTDGGASVPVTYVGVLPDLFEENQGMVGTGRYVNGVFEASEIL
ECCCCCCCCCCCEEEEEECCCCCCCCEEHEHHHHHHHHCCCCCEECCHHHHHHHHHHHHH
AKHDETYMPKEVVDALKEQGVYREGDS
HHCCCCCCCHHHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA