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The map label for this gene is ppi [H]

Identifier: 99080926

GI number: 99080926

Start: 1161321

End: 1161827

Strand: Direct

Name: ppi [H]

Synonym: TM1040_1085

Alternate gene names: 99080926

Gene position: 1161321-1161827 (Clockwise)

Preceding gene: 99080917

Following gene: 99080927

Centisome position: 36.28

GC content: 59.96

Gene sequence:

>507_bases
ATGGCCGAGATCAAGGATCCCGAAAACACCATCATCATCGAGCTGAAAGATGGCAATGTGGTCATCGAACTGCTGCCGGA
TGTGGCACCGATGCATTGCGACCGCATGAAAGAGCTCGCACGTGAAGGTCAGTATGACAACGTGGCCTTTCACCGGGTGA
TCGACGGCTTCATGGCGCAGACCGGCGACGTGCAGCACGGCGATATGGAAGATGGCTTCAACCTCGGCCGCGCCGGCACC
GGTGGCTCCGACAAGAAAGACCTGCCCGCGGAATTCTCTGGCGTGCCCCATGACCGTGGCACCCTGGGCGCGGCGCGGTC
GCAGAACCCCAACTCCGCCAACTCGCAGTTCTTTATCAACTTCAAGGACAACCACTTCCTGAACCGCCAGTACACGGTCT
ATGGCCGCGTCATCGAGGGCATGGAGCATGTGGATGCGATCACCCGTGGCGAGCCGCCAGCAAAGCCTGATCGCATGATC
TCCGTGAAGGTGGCCGCCGATGCTTAA

Upstream 100 bases:

>100_bases
GACTTCCTGCCGACGCAAGGGGATCGCTACATTGATCCCTTGGCAAGCGCGGGCATGGACTTTAGGTATTCCGGCAATAC
GAATGTGACAGGAGGGCCTC

Downstream 100 bases:

>100_bases
GCGTCTGAGCGCACTGGCCCTTTTGGCGGCGTCGCCCGCTTTTGCCACCGGTCTGGAGATCCAGGTCGAGGGCGAGGCCA
ATGGCACCATCGTGATCGAT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MAEIKDPENTIIIELKDGNVVIELLPDVAPMHCDRMKELAREGQYDNVAFHRVIDGFMAQTGDVQHGDMEDGFNLGRAGT
GGSDKKDLPAEFSGVPHDRGTLGAARSQNPNSANSQFFINFKDNHFLNRQYTVYGRVIEGMEHVDAITRGEPPAKPDRMI
SVKVAADA

Sequences:

>Translated_168_residues
MAEIKDPENTIIIELKDGNVVIELLPDVAPMHCDRMKELAREGQYDNVAFHRVIDGFMAQTGDVQHGDMEDGFNLGRAGT
GGSDKKDLPAEFSGVPHDRGTLGAARSQNPNSANSQFFINFKDNHFLNRQYTVYGRVIEGMEHVDAITRGEPPAKPDRMI
SVKVAADA
>Mature_167_residues
AEIKDPENTIIIELKDGNVVIELLPDVAPMHCDRMKELAREGQYDNVAFHRVIDGFMAQTGDVQHGDMEDGFNLGRAGTG
GSDKKDLPAEFSGVPHDRGTLGAARSQNPNSANSQFFINFKDNHFLNRQYTVYGRVIEGMEHVDAITRGEPPAKPDRMIS
VKVAADA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=141, Percent_Identity=31.2056737588652, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI24308049, Length=155, Percent_Identity=32.258064516129, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI7706339, Length=140, Percent_Identity=32.1428571428571, Blast_Score=70, Evalue=8e-13,
Organism=Escherichia coli, GI1786736, Length=138, Percent_Identity=39.1304347826087, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1789763, Length=178, Percent_Identity=31.4606741573034, Blast_Score=82, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=142, Percent_Identity=33.0985915492958, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=142, Percent_Identity=33.0985915492958, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=152, Percent_Identity=33.5526315789474, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=151, Percent_Identity=31.7880794701987, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=156, Percent_Identity=32.0512820512821, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17986117, Length=182, Percent_Identity=31.8681318681319, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24652460, Length=142, Percent_Identity=31.6901408450704, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19922912, Length=149, Percent_Identity=32.2147651006711, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18497; Mature: 18366

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIKDPENTIIIELKDGNVVIELLPDVAPMHCDRMKELAREGQYDNVAFHRVIDGFMAQ
CCCCCCCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHC
TGDVQHGDMEDGFNLGRAGTGGSDKKDLPAEFSGVPHDRGTLGAARSQNPNSANSQFFIN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEE
FKDNHFLNRQYTVYGRVIEGMEHVDAITRGEPPAKPDRMISVKVAADA
ECCCEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
AEIKDPENTIIIELKDGNVVIELLPDVAPMHCDRMKELAREGQYDNVAFHRVIDGFMAQ
CCCCCCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHC
TGDVQHGDMEDGFNLGRAGTGGSDKKDLPAEFSGVPHDRGTLGAARSQNPNSANSQFFIN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEE
FKDNHFLNRQYTVYGRVIEGMEHVDAITRGEPPAKPDRMISVKVAADA
ECCCEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA