Click here to switch to the map view.

The map label for this gene is hisA1

Identifier: 99080894

GI number: 99080894

Start: 1131760

End: 1132503

Strand: Direct

Name: hisA1

Synonym: TM1040_1053

Alternate gene names: 99080894

Gene position: 1131760-1132503 (Clockwise)

Preceding gene: 99080893

Following gene: 99080895

Centisome position: 35.36

GC content: 60.35

Gene sequence:

>744_bases
ATGATGATTTATCCCACGATGGAACTTTTGGACGGGCGGTGTGTGACGCTGGACAAAGGCAATCTGGATGCGCCGATGAT
CTGGCATGTGGACCCGGTTGAAACCGCCAAGGGCTTTGCCGAGGCGGGCGCCGAGTGGATGCATCTGACCGATTTCAATG
CGCTTCAGGGCGACAGCAGCAATCAGGACCTTGTGGAGGAGCTCATTCGCACGGCGGGTCTGCCCATCCAGCTCGGCGGC
GGCATCCGCTCGCGCGAGCAGGCCGAGTTCTGGATCGAAAAAGGCGTGGGGCGCGTGGTGATCGGCACCATGGCGGCTTA
TGATCCTGCTGCGGTGGCTGAGCTGGCCAAATACTATCCCGATCAGGTGGTCCTCGCGGTGGATGTGTGGCAGGGGCAGG
TGATGACCGAAGGCTGGCGTAAATCCGGGGCCTGGACCCCCGAGGCTTTTGTCAAAGCCTTTGGCAACGCCCCATTTGCG
GGCATTCTGGTGACCGACATCGATAGTGACATGAGCGATCTGGACGCCCAGCTTGGCTTGATCTCAGGCCTTGCGGAGCA
GGCGCATTCTCCGGTGATCGCAAGCGGCGTGGTGCGCAGCAAGGACGATATTTCGAGGCTGAAATATCTGCCCAATATTT
CTGGCGCTCTGGTGGGCCGGGCACTCTTCAACAAAACCATCACCCTCGAAGAGGCGATGGAGACGGCGCAGCCCAACCCC
GAACCCGTGGCAGAGTTCCTCTGA

Upstream 100 bases:

>100_bases
CCCGCTTGTGTTAACCATTCACCTGCCGGCAGCGGGTCGAATTTTGCTGACTTCGTGCTACACTGATAATCATTATGAAA
TTGATCGGAGAGAACAGCGC

Downstream 100 bases:

>100_bases
TCACTCGGGGGCTCTGGTCCCCACTCCGAGCGGCCCGCGTTGAACCTGTGCTGACACCGAATGCGGTCTTGGCCAATCTT
AGCGCGACGCGCCGGTTCAA

Product: histidine biosynthesis

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase 1

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MMIYPTMELLDGRCVTLDKGNLDAPMIWHVDPVETAKGFAEAGAEWMHLTDFNALQGDSSNQDLVEELIRTAGLPIQLGG
GIRSREQAEFWIEKGVGRVVIGTMAAYDPAAVAELAKYYPDQVVLAVDVWQGQVMTEGWRKSGAWTPEAFVKAFGNAPFA
GILVTDIDSDMSDLDAQLGLISGLAEQAHSPVIASGVVRSKDDISRLKYLPNISGALVGRALFNKTITLEEAMETAQPNP
EPVAEFL

Sequences:

>Translated_247_residues
MMIYPTMELLDGRCVTLDKGNLDAPMIWHVDPVETAKGFAEAGAEWMHLTDFNALQGDSSNQDLVEELIRTAGLPIQLGG
GIRSREQAEFWIEKGVGRVVIGTMAAYDPAAVAELAKYYPDQVVLAVDVWQGQVMTEGWRKSGAWTPEAFVKAFGNAPFA
GILVTDIDSDMSDLDAQLGLISGLAEQAHSPVIASGVVRSKDDISRLKYLPNISGALVGRALFNKTITLEEAMETAQPNP
EPVAEFL
>Mature_247_residues
MMIYPTMELLDGRCVTLDKGNLDAPMIWHVDPVETAKGFAEAGAEWMHLTDFNALQGDSSNQDLVEELIRTAGLPIQLGG
GIRSREQAEFWIEKGVGRVVIGTMAAYDPAAVAELAKYYPDQVVLAVDVWQGQVMTEGWRKSGAWTPEAFVKAFGNAPFA
GILVTDIDSDMSDLDAQLGLISGLAEQAHSPVIASGVVRSKDDISRLKYLPNISGALVGRALFNKTITLEEAMETAQPNP
EPVAEFL

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=246, Percent_Identity=30.8943089430894, Blast_Score=104, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS41_SILST (Q1GHT0)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613048.1
- ProteinModelPortal:   Q1GHT0
- STRING:   Q1GHT0
- GeneID:   4078111
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1053
- NMPDR:   fig|292414.1.peg.3120
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   AGAEWMH
- ProtClustDB:   CLSK751584
- BioCyc:   SSP292414:TM1040_1053-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26751; Mature: 26751

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIYPTMELLDGRCVTLDKGNLDAPMIWHVDPVETAKGFAEAGAEWMHLTDFNALQGDSS
CEECCCHHHHCCEEEEEECCCCCCCEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCCCC
NQDLVEELIRTAGLPIQLGGGIRSREQAEFWIEKGVGRVVIGTMAAYDPAAVAELAKYYP
CHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHCC
DQVVLAVDVWQGQVMTEGWRKSGAWTPEAFVKAFGNAPFAGILVTDIDSDMSDLDAQLGL
CEEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHH
ISGLAEQAHSPVIASGVVRSKDDISRLKYLPNISGALVGRALFNKTITLEEAMETAQPNP
HHHHHHHHCCCEEHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCC
EPVAEFL
CHHHHCC
>Mature Secondary Structure
MMIYPTMELLDGRCVTLDKGNLDAPMIWHVDPVETAKGFAEAGAEWMHLTDFNALQGDSS
CEECCCHHHHCCEEEEEECCCCCCCEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCCCC
NQDLVEELIRTAGLPIQLGGGIRSREQAEFWIEKGVGRVVIGTMAAYDPAAVAELAKYYP
CHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHCC
DQVVLAVDVWQGQVMTEGWRKSGAWTPEAFVKAFGNAPFAGILVTDIDSDMSDLDAQLGL
CEEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHH
ISGLAEQAHSPVIASGVVRSKDDISRLKYLPNISGALVGRALFNKTITLEEAMETAQPNP
HHHHHHHHCCCEEHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCC
EPVAEFL
CHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA