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The map label for this gene is mdtA [H]

Identifier: 99080829

GI number: 99080829

Start: 1058675

End: 1059922

Strand: Reverse

Name: mdtA [H]

Synonym: TM1040_0988

Alternate gene names: 99080829

Gene position: 1059922-1058675 (Counterclockwise)

Preceding gene: 99080835

Following gene: 99080828

Centisome position: 33.11

GC content: 64.34

Gene sequence:

>1248_bases
ATGCGCATCATCCCTCTTCTGACCGCTGCGGTCGTGACCGCTGGCCTCTATGCTGTGGTCATGGAGCGCGACAGCCTGTT
GGCCTTCGCCCGCGGCGAGGACGCCCCGTCTGCTGACGCCACTGACGCGCAGGCTGAACCGGGCGACGCATCGACCGATG
TGGCGCAATCTGGTCCAAAGGTCGCAGTTGTTGCCGTGCACTCCACGGCGCGCGCCATCGACAATGCGGTGGTTCTGCGT
GGGCAGACCCGGGCCATTCGGCAGGTGAATGTGCTGGCAGAGACCTCCTCGACCGTGATCTCTGAGCCGCTGCGCAAGGG
GGCCTCTGTGAAGAAGGGCGATGTTCTCTGTGAACTCGATCCGGGCACGCGACCTGCCTCCCTATTGGAGGCGCGCGCCC
GCCTCGCGGAGGCCCGTGCCAATATCCCCGCAGCCGAGGCCCGCCTTGAAGAGGCAAAAGCCGTACTCGAAGAAGCGCGC
ATCAACCTCACGGCGGCAGAGAAGCTTTCGGAAGGCGGATTTGCCTCCGAGACACGCCTCGCCTCAGCCCGCGCCGCCGA
GCGCACCGCGCAAGCGGCCATCGCGACAGCCGAGGGCGGGCTCACCTCTTCGCATGCGAGCATCGAGTCCGCCTCTGCCG
CAGTGGATGCCGCCGAGCAGGAGATCGAACGCATCGTGATCCACGCGCCCTTTGATGGGATCCTCGAGTCCGACACCGCA
GAGCTCGGAAGCCTGTTGCAGGCTGGAACCCTCTGCGCGACGGTGATCCAGCTCGATACAATCAAGCTGGTTGGCTATGT
GCCGGAGACCTCGATCGACCGTGTCGAAATGGGTGCCGCTGCAGGCGCACGGCTGGCAACCGGCCAACAAGTGACGGGCA
CCGTGTCCTTCATCAGCCGCTCTGCCGATGAAACAACCCGCACCTTCGAGGTTGAGATCACGGTCGCCAACCCGGACCTC
AAAATCCGCGACGGTCAGACCGCAGAGATCGTGATTGCCGCCGAAGGCACCAAGGCGCATCGTTTGCCGCAATCGGCGCT
GACCCTCAACAACGAAGGCCAGCTTGGTGTGCGCGTGGTGCGCGACGACATGACCGCGGGCTTTGTGCCCGTCACCTTGC
TGCGCGACGAAGCCAGCGGTGTCTGGCTCGATGGGCTACCAGAGGAAGCAAATGTCATCACCGTGGGACAGGACTTTGTC
ACCGAAGGCGTCGCCCTTGCCCCCACCTATCAGGAGATGAGTGAATGA

Upstream 100 bases:

>100_bases
CCTTATTACCTTCGCTGAATGTGACCTGCTTCACAGTGTGACGCCTTGGAACACGGTAGACATCACAGAAAAGTGTCCAA
TTTCGGAGTCGAATTTTAGA

Downstream 100 bases:

>100_bases
TCGGTCTTGTTAACTGGGCCGCAGATCGGGCGAGGATGGTCCTCGCCTTCATCGCGATCTCGCTGCTGGTCGGCGGATTT
GCCTATGTGAGCCTGCCCAA

Product: secretion protein HlyD

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MRIIPLLTAAVVTAGLYAVVMERDSLLAFARGEDAPSADATDAQAEPGDASTDVAQSGPKVAVVAVHSTARAIDNAVVLR
GQTRAIRQVNVLAETSSTVISEPLRKGASVKKGDVLCELDPGTRPASLLEARARLAEARANIPAAEARLEEAKAVLEEAR
INLTAAEKLSEGGFASETRLASARAAERTAQAAIATAEGGLTSSHASIESASAAVDAAEQEIERIVIHAPFDGILESDTA
ELGSLLQAGTLCATVIQLDTIKLVGYVPETSIDRVEMGAAAGARLATGQQVTGTVSFISRSADETTRTFEVEITVANPDL
KIRDGQTAEIVIAAEGTKAHRLPQSALTLNNEGQLGVRVVRDDMTAGFVPVTLLRDEASGVWLDGLPEEANVITVGQDFV
TEGVALAPTYQEMSE

Sequences:

>Translated_415_residues
MRIIPLLTAAVVTAGLYAVVMERDSLLAFARGEDAPSADATDAQAEPGDASTDVAQSGPKVAVVAVHSTARAIDNAVVLR
GQTRAIRQVNVLAETSSTVISEPLRKGASVKKGDVLCELDPGTRPASLLEARARLAEARANIPAAEARLEEAKAVLEEAR
INLTAAEKLSEGGFASETRLASARAAERTAQAAIATAEGGLTSSHASIESASAAVDAAEQEIERIVIHAPFDGILESDTA
ELGSLLQAGTLCATVIQLDTIKLVGYVPETSIDRVEMGAAAGARLATGQQVTGTVSFISRSADETTRTFEVEITVANPDL
KIRDGQTAEIVIAAEGTKAHRLPQSALTLNNEGQLGVRVVRDDMTAGFVPVTLLRDEASGVWLDGLPEEANVITVGQDFV
TEGVALAPTYQEMSE
>Mature_415_residues
MRIIPLLTAAVVTAGLYAVVMERDSLLAFARGEDAPSADATDAQAEPGDASTDVAQSGPKVAVVAVHSTARAIDNAVVLR
GQTRAIRQVNVLAETSSTVISEPLRKGASVKKGDVLCELDPGTRPASLLEARARLAEARANIPAAEARLEEAKAVLEEAR
INLTAAEKLSEGGFASETRLASARAAERTAQAAIATAEGGLTSSHASIESASAAVDAAEQEIERIVIHAPFDGILESDTA
ELGSLLQAGTLCATVIQLDTIKLVGYVPETSIDRVEMGAAAGARLATGQQVTGTVSFISRSADETTRTFEVEITVANPDL
KIRDGQTAEIVIAAEGTKAHRLPQSALTLNNEGQLGVRVVRDDMTAGFVPVTLLRDEASGVWLDGLPEEANVITVGQDFV
TEGVALAPTYQEMSE

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=360, Percent_Identity=25, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43240; Mature: 43240

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIPLLTAAVVTAGLYAVVMERDSLLAFARGEDAPSADATDAQAEPGDASTDVAQSGPK
CEEHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCC
VAVVAVHSTARAIDNAVVLRGQTRAIRQVNVLAETSSTVISEPLRKGASVKKGDVLCELD
EEEEEECHHHHHHCCEEEEECCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEEEEEC
PGTRPASLLEARARLAEARANIPAAEARLEEAKAVLEEARINLTAAEKLSEGGFASETRL
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHH
ASARAAERTAQAAIATAEGGLTSSHASIESASAAVDAAEQEIERIVIHAPFDGILESDTA
HHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCHHCCCHH
ELGSLLQAGTLCATVIQLDTIKLVGYVPETSIDRVEMGAAAGARLATGQQVTGTVSFISR
HHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHHCCCCCCEECCCCCCEEHHHHHHC
SADETTRTFEVEITVANPDLKIRDGQTAEIVIAAEGTKAHRLPQSALTLNNEGQLGVRVV
CCCCCCEEEEEEEEEECCCEEEECCCCEEEEEEECCCHHHCCCHHHEEECCCCCEEEEEE
RDDMTAGFVPVTLLRDEASGVWLDGLPEEANVITVGQDFVTEGVALAPTYQEMSE
ECCCCCCCEEEEEEEECCCCEEECCCCCCCCEEEECHHHHHCCEEECCCHHHHCC
>Mature Secondary Structure
MRIIPLLTAAVVTAGLYAVVMERDSLLAFARGEDAPSADATDAQAEPGDASTDVAQSGPK
CEEHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCCC
VAVVAVHSTARAIDNAVVLRGQTRAIRQVNVLAETSSTVISEPLRKGASVKKGDVLCELD
EEEEEECHHHHHHCCEEEEECCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEEEEEC
PGTRPASLLEARARLAEARANIPAAEARLEEAKAVLEEARINLTAAEKLSEGGFASETRL
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHH
ASARAAERTAQAAIATAEGGLTSSHASIESASAAVDAAEQEIERIVIHAPFDGILESDTA
HHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCHHCCCHH
ELGSLLQAGTLCATVIQLDTIKLVGYVPETSIDRVEMGAAAGARLATGQQVTGTVSFISR
HHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHHCCCCCCEECCCCCCEEHHHHHHC
SADETTRTFEVEITVANPDLKIRDGQTAEIVIAAEGTKAHRLPQSALTLNNEGQLGVRVV
CCCCCCEEEEEEEEEECCCEEEECCCCEEEEEEECCCHHHCCCHHHEEECCCCCEEEEEE
RDDMTAGFVPVTLLRDEASGVWLDGLPEEANVITVGQDFVTEGVALAPTYQEMSE
ECCCCCCCEEEEEEEECCCCEEECCCCCCCCEEEECHHHHHCCEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA