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The map label for this gene is pepA [H]

Identifier: 99080791

GI number: 99080791

Start: 1014475

End: 1015950

Strand: Direct

Name: pepA [H]

Synonym: TM1040_0950

Alternate gene names: 99080791

Gene position: 1014475-1015950 (Clockwise)

Preceding gene: 99080784

Following gene: 99080792

Centisome position: 31.69

GC content: 61.31

Gene sequence:

>1476_bases
ATGAGCGCGCTCACCCCGATCCGTTTTTCCGCCTTTGATCCCAAATCCCTGGCCGATGTCGAAGGTCATCTGGCTGTGGT
GGTCACGCCCGAGGGCACAATGGATCAGGCCGCCCGCAGTGCCAATCGGCTGACCAAGGGCGCGCTTGCCCGACTGATCG
CCTCCGAGGCCTTTGCCAAAGCCAAGACCGGGCAGGTGATTACGCTGGCCTGGCCGGCCGGTCTTGCGGTCGAGGCGCTG
CATGTCGTTGTCTTGCCGCGTCGCCTCACGCCGATCGAGGCCCGCAAGGCCGGGGCGAAACTTGCCGAGGCAAAAGGGCG
CAAGCCGCTGGTTGTGAAGGCGGGGAACATGGCGCGCGCCGCGGATCTGGCGCTGGGTCTCGCGCTGCGCAGCTACAGCT
TTGATGCACATAAATCCGCCGAGACCGAAAAGGCGGGCACCATCACGATCGGTCACAACAAGCCCGAAGAGATGGAGGCT
GCCTTTGCGCCGCTCCTTGCGGTGGCCGAGGGCGTGCATATGACCCGTGATCTGGTCAGCGAGCCTGCAAACATCCTCAC
CACAACCGAGTTTGCCAACCGCCTCGAAGAGATGACCGAGCTTGGTCTCGAGGTCGAAGTCCTTGAGGAAGCCGAACTCG
AAAAGCTTGGCATGCGCACGCTGCTCTGCGTGGGGCAGGGGTCTGCCAGCCCGTCCAAAGTGGTCGTGATGAAATGGAAC
GGCGCCGATGATAAAGAGGCCGCGCCTCTGGCCTTGGTCGGGAAGGGCGTGGTCTTTGACACTGGTGGCATCTCGTTGAA
ACCCGCCGCGGGCATGGAAGACATGACCATGGATATGGGCGGGGCCGGCGTTGTTGCTGGCACAATGCGCACGCTTGCGC
TGCGCAAGGCCAGAGCCAATGTGGTGGGACTTGTGGGGCTTGTTGAGAACATGCCCTCAAGCACCGCCATCCGCCCCGGT
GACGTGGTTAAATCCATGAAGGGCGATACCGTCGAGATCATCAATACCGATGCCGAAGGGCGACTGGTGCTCTGTGATGT
GCTCTGGTACGCGCAAGAGCGTTTCAAGCCCGCCGGGGTGATCGATCTGGCGACTCTGACAGGCGCAATCATCATTGGCC
TTGGCCATGAAAACGCAGGTGTCTTCTCAAATGACGATGCGCTCTGTGGAGCCTTCCTCAAAGCCGCCGACGCCGAAGGA
GAAGGGGCTTGGCGCCTACCGCTCGGTCAAGCCTATGACGATCAGTTGAAATCCAATGTGGCGGATATGAAAAACGTTGG
TGGTCGTCCGGCGGGGTCAATCACTGCGGCGCAGTTCCTCCAGCGTTTCATCAAGGAAGGCACGCCCTGGATTCATCTCG
ATATTGCAGGTGTGGCCTCGGTCAAGGCGGCAACGGACTATGCGCCCAAAGGGGCGACCGGCTGGGGGGTGATGGCACTC
AACCGTCTGGTGCAAGATCAGTTCGAGGCCGAGTAA

Upstream 100 bases:

>100_bases
TGCCGCACTGGTATTCGGGACCACCAGCCGCTACCTGTTAGGGGACGATCGCCGCGATGTCTGAACGGCGACACGAGCAG
ATCAACCACAGGAGACCCGA

Downstream 100 bases:

>100_bases
CGCGCAATGGGGGCCGCCTACTTCTACCATCTGACGCGCAAGCCCTTGCAGGAAACGCTTCCCGTGCTTCTTGACAAGGC
GCGCGGCGCGGGCTGGCGAA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MSALTPIRFSAFDPKSLADVEGHLAVVVTPEGTMDQAARSANRLTKGALARLIASEAFAKAKTGQVITLAWPAGLAVEAL
HVVVLPRRLTPIEARKAGAKLAEAKGRKPLVVKAGNMARAADLALGLALRSYSFDAHKSAETEKAGTITIGHNKPEEMEA
AFAPLLAVAEGVHMTRDLVSEPANILTTTEFANRLEEMTELGLEVEVLEEAELEKLGMRTLLCVGQGSASPSKVVVMKWN
GADDKEAAPLALVGKGVVFDTGGISLKPAAGMEDMTMDMGGAGVVAGTMRTLALRKARANVVGLVGLVENMPSSTAIRPG
DVVKSMKGDTVEIINTDAEGRLVLCDVLWYAQERFKPAGVIDLATLTGAIIIGLGHENAGVFSNDDALCGAFLKAADAEG
EGAWRLPLGQAYDDQLKSNVADMKNVGGRPAGSITAAQFLQRFIKEGTPWIHLDIAGVASVKAATDYAPKGATGWGVMAL
NRLVQDQFEAE

Sequences:

>Translated_491_residues
MSALTPIRFSAFDPKSLADVEGHLAVVVTPEGTMDQAARSANRLTKGALARLIASEAFAKAKTGQVITLAWPAGLAVEAL
HVVVLPRRLTPIEARKAGAKLAEAKGRKPLVVKAGNMARAADLALGLALRSYSFDAHKSAETEKAGTITIGHNKPEEMEA
AFAPLLAVAEGVHMTRDLVSEPANILTTTEFANRLEEMTELGLEVEVLEEAELEKLGMRTLLCVGQGSASPSKVVVMKWN
GADDKEAAPLALVGKGVVFDTGGISLKPAAGMEDMTMDMGGAGVVAGTMRTLALRKARANVVGLVGLVENMPSSTAIRPG
DVVKSMKGDTVEIINTDAEGRLVLCDVLWYAQERFKPAGVIDLATLTGAIIIGLGHENAGVFSNDDALCGAFLKAADAEG
EGAWRLPLGQAYDDQLKSNVADMKNVGGRPAGSITAAQFLQRFIKEGTPWIHLDIAGVASVKAATDYAPKGATGWGVMAL
NRLVQDQFEAE
>Mature_490_residues
SALTPIRFSAFDPKSLADVEGHLAVVVTPEGTMDQAARSANRLTKGALARLIASEAFAKAKTGQVITLAWPAGLAVEALH
VVVLPRRLTPIEARKAGAKLAEAKGRKPLVVKAGNMARAADLALGLALRSYSFDAHKSAETEKAGTITIGHNKPEEMEAA
FAPLLAVAEGVHMTRDLVSEPANILTTTEFANRLEEMTELGLEVEVLEEAELEKLGMRTLLCVGQGSASPSKVVVMKWNG
ADDKEAAPLALVGKGVVFDTGGISLKPAAGMEDMTMDMGGAGVVAGTMRTLALRKARANVVGLVGLVENMPSSTAIRPGD
VVKSMKGDTVEIINTDAEGRLVLCDVLWYAQERFKPAGVIDLATLTGAIIIGLGHENAGVFSNDDALCGAFLKAADAEGE
GAWRLPLGQAYDDQLKSNVADMKNVGGRPAGSITAAQFLQRFIKEGTPWIHLDIAGVASVKAATDYAPKGATGWGVMALN
RLVQDQFEAE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=312, Percent_Identity=39.7435897435897, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI47155554, Length=365, Percent_Identity=32.6027397260274, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1790710, Length=367, Percent_Identity=44.141689373297, Blast_Score=278, Evalue=8e-76,
Organism=Escherichia coli, GI87082123, Length=321, Percent_Identity=37.3831775700935, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=313, Percent_Identity=37.3801916932907, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=293, Percent_Identity=26.962457337884, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355725, Length=296, Percent_Identity=37.1621621621622, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24661038, Length=296, Percent_Identity=37.1621621621622, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI20129969, Length=293, Percent_Identity=33.4470989761092, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24662227, Length=291, Percent_Identity=31.9587628865979, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI161077148, Length=291, Percent_Identity=32.3024054982818, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI20130057, Length=291, Percent_Identity=32.3024054982818, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI20129963, Length=363, Percent_Identity=30.8539944903581, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21355645, Length=348, Percent_Identity=28.1609195402299, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24662223, Length=348, Percent_Identity=28.1609195402299, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19922386, Length=294, Percent_Identity=31.9727891156463, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21357381, Length=315, Percent_Identity=33.6507936507937, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI221379063, Length=315, Percent_Identity=33.6507936507937, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI221379062, Length=315, Percent_Identity=33.6507936507937, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646701, Length=132, Percent_Identity=37.1212121212121, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24646703, Length=132, Percent_Identity=37.1212121212121, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21358201, Length=132, Percent_Identity=37.1212121212121, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 51570; Mature: 51439

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALTPIRFSAFDPKSLADVEGHLAVVVTPEGTMDQAARSANRLTKGALARLIASEAFAK
CCCCCCCEECCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKTGQVITLAWPAGLAVEALHVVVLPRRLTPIEARKAGAKLAEAKGRKPLVVKAGNMARA
CCCCCEEEEECCCCHHHHHHEEEEECCCCCCHHHHHHCCHHHHHCCCCCEEEECCCCHHH
ADLALGLALRSYSFDAHKSAETEKAGTITIGHNKPEEMEAAFAPLLAVAEGVHMTRDLVS
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EPANILTTTEFANRLEEMTELGLEVEVLEEAELEKLGMRTLLCVGQGSASPSKVVVMKWN
CCHHHEEHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCEEEEEEECCCCCCCEEEEEEEC
GADDKEAAPLALVGKGVVFDTGGISLKPAAGMEDMTMDMGGAGVVAGTMRTLALRKARAN
CCCCCCCCCEEEEECCEEEECCCCEECCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHCC
VVGLVGLVENMPSSTAIRPGDVVKSMKGDTVEIINTDAEGRLVLCDVLWYAQERFKPAGV
HHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCCCE
IDLATLTGAIIIGLGHENAGVFSNDDALCGAFLKAADAEGEGAWRLPLGQAYDDQLKSNV
EEHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHH
ADMKNVGGRPAGSITAAQFLQRFIKEGTPWIHLDIAGVASVKAATDYAPKGATGWGVMAL
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCCCCHHHHHH
NRLVQDQFEAE
HHHHHHHHCCC
>Mature Secondary Structure 
SALTPIRFSAFDPKSLADVEGHLAVVVTPEGTMDQAARSANRLTKGALARLIASEAFAK
CCCCCCEECCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKTGQVITLAWPAGLAVEALHVVVLPRRLTPIEARKAGAKLAEAKGRKPLVVKAGNMARA
CCCCCEEEEECCCCHHHHHHEEEEECCCCCCHHHHHHCCHHHHHCCCCCEEEECCCCHHH
ADLALGLALRSYSFDAHKSAETEKAGTITIGHNKPEEMEAAFAPLLAVAEGVHMTRDLVS
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EPANILTTTEFANRLEEMTELGLEVEVLEEAELEKLGMRTLLCVGQGSASPSKVVVMKWN
CCHHHEEHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCEEEEEEECCCCCCCEEEEEEEC
GADDKEAAPLALVGKGVVFDTGGISLKPAAGMEDMTMDMGGAGVVAGTMRTLALRKARAN
CCCCCCCCCEEEEECCEEEECCCCEECCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHCC
VVGLVGLVENMPSSTAIRPGDVVKSMKGDTVEIINTDAEGRLVLCDVLWYAQERFKPAGV
HHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCEEEEHHHHHHHHHCCCCCE
IDLATLTGAIIIGLGHENAGVFSNDDALCGAFLKAADAEGEGAWRLPLGQAYDDQLKSNV
EEHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHH
ADMKNVGGRPAGSITAAQFLQRFIKEGTPWIHLDIAGVASVKAATDYAPKGATGWGVMAL
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCCCCHHHHHH
NRLVQDQFEAE
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA