Click here to switch to the map view.

The map label for this gene is glmS [H]

Identifier: 99080568

GI number: 99080568

Start: 783823

End: 785631

Strand: Reverse

Name: glmS [H]

Synonym: TM1040_0727

Alternate gene names: 99080568

Gene position: 785631-783823 (Counterclockwise)

Preceding gene: 99080569

Following gene: 99080567

Centisome position: 24.54

GC content: 61.36

Gene sequence:

>1809_bases
ATGTGTGGAATTATCGGAGTTCTGGGCAACCATGAAGTCTCGCCCATTTTGGTCGAAGCGCTGAAACGGCTGGAATATCG
CGGATATGACAGTGCAGGCATTGCCACGGTGAACGGCGGGCATCTGGACCGGCGCCGCGCGGTGGGCAAGCTGGTGAACC
TTTCGGATACTTTGGTGCATGATCCGCTGCCCGGCAAATCCGGCATTGGGCACACCCGCTGGGCCACCCACGGCGCGCCG
ACGGTCTCTAACGCGCATCCGCATCAGGCGGGCTGCGTCGCAGTGGTTCACAACGGGATCATCGAGAACTTCAAGGAATT
GCGCGACGAACTGGCGGCTCATGGCATCCGCTTTGTGACCGAAACCGACACAGAAACCGTGGCGCTCTTGTGCGAATTCT
ACATGCGCGACGGCACCTCTGCCGCAGAGGCGGCACGCAAGACCGTGGCACGGCTTGAAGGGGCCTTTGCGCTGGCGTTC
TTGTTTGATGGCGAAGAGGACCTTCTGATTGCCGCCCGCAAGGGATCGCCCCTGGCCGTAGGCCATGGCGAGGGCGAAAT
GTATGTCGGTTCCGACGCGATTGCGCTGGCGCCGCTGACGGATCAGATCACCTACCTCGAAGAAGGGGATTTTGTGGTCC
TGACGCGCAACAGCCATGAAATCTGGGACGCCAAGGGCAACATCGCCAACCGCGAAAAACGCCAGATCAAACTGGAGAAC
ACCCGCGTCGAAAAAGATGGCCACAAGCATTTCATGGCCAAGGAAATCGCCGAACAGCCCGTCGCCGTTGACAAGGCGCT
GAAGGCTTATCTGGACGACAGCTGCGCGATTGAGCTGCCCGAAGGGCTGGATTTCAAAAAGATCGAGCGGCTTTCGCTCG
TGGCCTGCGGCACTGCCTACTACGCGTGTCTGGTGGCGAAATACTGGCTGGAAACGATCGCTCGCCTGCCCGTTGAGGTC
GATGTGGCCTCGGAATTTCGCTACCGCGAGCCCCCCGTCGGCCCCGGCACGCTGGCGCTCTTTGTCAGCCAGTCGGGCGA
AACCGCGGACACTCTGGCAGCGCTGCGCTACATGCGAGGGAAGGCCGATGTGATCGCCGGGTTGGTGAATGTGCCCGAAA
GCTCAATCGCGCGTGAAAGCGATGTGGTGCTGCCCATCCACGCCGGCCCGGAAATCTCCGTAGCATCGACCAAAGCCTTT
ACCTGTCAGTTGACGGTGCTTTTGATGCTCGCGCTCAAGGCAGCACAGGATCGCGGACAGAAGCTGCCCGCAGGCATGCC
CGCTGACTTGCGTGCCCTGCCCGGCCTGATCCATCAGTCGCTGGCCTCTGAGGCGCAGATCGCTGCTGCCTCACGCGATC
TGGCCGGCGCACGCGACATCATTTTCCTCGGGCGCGGCGCCCTCTACCCGCTGGCTCTTGAGGGGGCGCTCAAACTCAAG
GAGCTGAGCTATATCCACGCCGAAGGTTATGCCTCGGGCGAGCTGAAACACGGGCCCATCGCGCTCATTGATGACAGCGT
GCCAGTGATTGTCATGGCACCGCGCGATGCGCTCTTTGAAAAAACCATCTCCAATATGCAGGAGGTGATGGCGCGCGGTG
GTCGGGTTATTCTTGTGACCGACGCCGAAGGCGCGCGCGAGGCCTCCGAGGGCACCGCTGAGGTCATTACCATGCCGCAG
GTACCCGACGCACTGGCCCCGATCCTCTATGCGATCCCGGCACAGCAGATCGCCTATTTCACCGCCATTGCCAAAGGCAC
CGATGTGGACCAGCCGCGCAACCTGGCCAAATCCGTGACCGTCGAATGA

Upstream 100 bases:

>100_bases
GCGATTGCGCGCGTCCAGCAGACGAACAAACCAGGCCGCGCACGCAAGCTGATGGATATGCTGCGCGCCAAGAAAGCCGC
AAAGGCCAAAGGGTAATCAC

Downstream 100 bases:

>100_bases
CGCTCGACGACGCACTGGAGGCGCTTCGTGCCGAGATTGAGCCCGGACGCGCAGAGCAGATGATAGCCTACCACAAACAG
AGCCGTGAGGTTCTGGGCGT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MCGIIGVLGNHEVSPILVEALKRLEYRGYDSAGIATVNGGHLDRRRAVGKLVNLSDTLVHDPLPGKSGIGHTRWATHGAP
TVSNAHPHQAGCVAVVHNGIIENFKELRDELAAHGIRFVTETDTETVALLCEFYMRDGTSAAEAARKTVARLEGAFALAF
LFDGEEDLLIAARKGSPLAVGHGEGEMYVGSDAIALAPLTDQITYLEEGDFVVLTRNSHEIWDAKGNIANREKRQIKLEN
TRVEKDGHKHFMAKEIAEQPVAVDKALKAYLDDSCAIELPEGLDFKKIERLSLVACGTAYYACLVAKYWLETIARLPVEV
DVASEFRYREPPVGPGTLALFVSQSGETADTLAALRYMRGKADVIAGLVNVPESSIARESDVVLPIHAGPEISVASTKAF
TCQLTVLLMLALKAAQDRGQKLPAGMPADLRALPGLIHQSLASEAQIAAASRDLAGARDIIFLGRGALYPLALEGALKLK
ELSYIHAEGYASGELKHGPIALIDDSVPVIVMAPRDALFEKTISNMQEVMARGGRVILVTDAEGAREASEGTAEVITMPQ
VPDALAPILYAIPAQQIAYFTAIAKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_602_residues
MCGIIGVLGNHEVSPILVEALKRLEYRGYDSAGIATVNGGHLDRRRAVGKLVNLSDTLVHDPLPGKSGIGHTRWATHGAP
TVSNAHPHQAGCVAVVHNGIIENFKELRDELAAHGIRFVTETDTETVALLCEFYMRDGTSAAEAARKTVARLEGAFALAF
LFDGEEDLLIAARKGSPLAVGHGEGEMYVGSDAIALAPLTDQITYLEEGDFVVLTRNSHEIWDAKGNIANREKRQIKLEN
TRVEKDGHKHFMAKEIAEQPVAVDKALKAYLDDSCAIELPEGLDFKKIERLSLVACGTAYYACLVAKYWLETIARLPVEV
DVASEFRYREPPVGPGTLALFVSQSGETADTLAALRYMRGKADVIAGLVNVPESSIARESDVVLPIHAGPEISVASTKAF
TCQLTVLLMLALKAAQDRGQKLPAGMPADLRALPGLIHQSLASEAQIAAASRDLAGARDIIFLGRGALYPLALEGALKLK
ELSYIHAEGYASGELKHGPIALIDDSVPVIVMAPRDALFEKTISNMQEVMARGGRVILVTDAEGAREASEGTAEVITMPQ
VPDALAPILYAIPAQQIAYFTAIAKGTDVDQPRNLAKSVTVE
>Mature_602_residues
MCGIIGVLGNHEVSPILVEALKRLEYRGYDSAGIATVNGGHLDRRRAVGKLVNLSDTLVHDPLPGKSGIGHTRWATHGAP
TVSNAHPHQAGCVAVVHNGIIENFKELRDELAAHGIRFVTETDTETVALLCEFYMRDGTSAAEAARKTVARLEGAFALAF
LFDGEEDLLIAARKGSPLAVGHGEGEMYVGSDAIALAPLTDQITYLEEGDFVVLTRNSHEIWDAKGNIANREKRQIKLEN
TRVEKDGHKHFMAKEIAEQPVAVDKALKAYLDDSCAIELPEGLDFKKIERLSLVACGTAYYACLVAKYWLETIARLPVEV
DVASEFRYREPPVGPGTLALFVSQSGETADTLAALRYMRGKADVIAGLVNVPESSIARESDVVLPIHAGPEISVASTKAF
TCQLTVLLMLALKAAQDRGQKLPAGMPADLRALPGLIHQSLASEAQIAAASRDLAGARDIIFLGRGALYPLALEGALKLK
ELSYIHAEGYASGELKHGPIALIDDSVPVIVMAPRDALFEKTISNMQEVMARGGRVILVTDAEGAREASEGTAEVITMPQ
VPDALAPILYAIPAQQIAYFTAIAKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=35.8600583090379, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=37.2634643377001, Blast_Score=392, Evalue=1e-109,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=47.9608482871126, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1788651, Length=221, Percent_Identity=30.316742081448, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082251, Length=311, Percent_Identity=24.4372990353698, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539970, Length=437, Percent_Identity=38.9016018306636, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17532897, Length=436, Percent_Identity=38.7614678899083, Blast_Score=284, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17532899, Length=436, Percent_Identity=38.7614678899083, Blast_Score=284, Evalue=9e-77,
Organism=Saccharomyces cerevisiae, GI6322745, Length=445, Percent_Identity=37.5280898876404, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6323731, Length=427, Percent_Identity=31.3817330210773, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323730, Length=211, Percent_Identity=34.5971563981043, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=36.098981077147, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI28573187, Length=146, Percent_Identity=33.5616438356164, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24659598, Length=242, Percent_Identity=26.4462809917355, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 64596; Mature: 64596

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGVLGNHEVSPILVEALKRLEYRGYDSAGIATVNGGHLDRRRAVGKLVNLSDTLVH
CCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCHHHEE
DPLPGKSGIGHTRWATHGAPTVSNAHPHQAGCVAVVHNGIIENFKELRDELAAHGIRFVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
ETDTETVALLCEFYMRDGTSAAEAARKTVARLEGAFALAFLFDGEEDLLIAARKGSPLAV
ECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEE
GHGEGEMYVGSDAIALAPLTDQITYLEEGDFVVLTRNSHEIWDAKGNIANREKRQIKLEN
ECCCCCEEECCCCEEEECCCCCEEEEECCCEEEEECCCCEEECCCCCCCCCCHHEEEEEC
TRVEKDGHKHFMAKEIAEQPVAVDKALKAYLDDSCAIELPEGLDFKKIERLSLVACGTAY
CEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHH
YACLVAKYWLETIARLPVEVDVASEFRYREPPVGPGTLALFVSQSGETADTLAALRYMRG
HHHHHHHHHHHHHHHCCEEEEEHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCC
KADVIAGLVNVPESSIARESDVVLPIHAGPEISVASTKAFTCQLTVLLMLALKAAQDRGQ
CHHHHHHHHCCCCHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC
KLPAGMPADLRALPGLIHQSLASEAQIAAASRDLAGARDIIFLGRGALYPLALEGALKLK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCHHHHH
ELSYIHAEGYASGELKHGPIALIDDSVPVIVMAPRDALFEKTISNMQEVMARGGRVILVT
HHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEE
DAEGAREASEGTAEVITMPQVPDALAPILYAIPAQQIAYFTAIAKGTDVDQPRNLAKSVT
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHCC
VE
CC
>Mature Secondary Structure
MCGIIGVLGNHEVSPILVEALKRLEYRGYDSAGIATVNGGHLDRRRAVGKLVNLSDTLVH
CCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCHHHEE
DPLPGKSGIGHTRWATHGAPTVSNAHPHQAGCVAVVHNGIIENFKELRDELAAHGIRFVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
ETDTETVALLCEFYMRDGTSAAEAARKTVARLEGAFALAFLFDGEEDLLIAARKGSPLAV
ECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEE
GHGEGEMYVGSDAIALAPLTDQITYLEEGDFVVLTRNSHEIWDAKGNIANREKRQIKLEN
ECCCCCEEECCCCEEEECCCCCEEEEECCCEEEEECCCCEEECCCCCCCCCCHHEEEEEC
TRVEKDGHKHFMAKEIAEQPVAVDKALKAYLDDSCAIELPEGLDFKKIERLSLVACGTAY
CEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHH
YACLVAKYWLETIARLPVEVDVASEFRYREPPVGPGTLALFVSQSGETADTLAALRYMRG
HHHHHHHHHHHHHHHCCEEEEEHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCC
KADVIAGLVNVPESSIARESDVVLPIHAGPEISVASTKAFTCQLTVLLMLALKAAQDRGQ
CHHHHHHHHCCCCHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC
KLPAGMPADLRALPGLIHQSLASEAQIAAASRDLAGARDIIFLGRGALYPLALEGALKLK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCHHHHH
ELSYIHAEGYASGELKHGPIALIDDSVPVIVMAPRDALFEKTISNMQEVMARGGRVILVT
HHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEE
DAEGAREASEGTAEVITMPQVPDALAPILYAIPAQQIAYFTAIAKGTDVDQPRNLAKSVT
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHCC
VE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]