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The map label for this gene is mug [H]

Identifier: 94985818

GI number: 94985818

Start: 1826457

End: 1827044

Strand: Reverse

Name: mug [H]

Synonym: Dgeo_1718

Alternate gene names: 94985818

Gene position: 1827044-1826457 (Counterclockwise)

Preceding gene: 94985819

Following gene: 94985817

Centisome position: 74.05

GC content: 70.75

Gene sequence:

>588_bases
ATGACTGAGGCGGGGTGGCCAGCGGGGGAGGACTACCTCGTCCCGGACGTGCTGCAAGAGGGCCTAACGCTGGTGCTGGT
GGGCACGGCGCCCAGCCGCATCAGCGCGCGGGCAAAGGCGTACTACGCCAACCCCGAGAACAAGTTCTGGCGGGTGCTGG
CCGAGACAGGCCTGACCCCTCGACAGCTTGCTCCCCGTGAATACCCCATCCTGCCGCAGTACGGCATCGGCCTGACGGAC
GTTGCCAAACGGCACAGCGGCGTGGACGCGGCCCTCCCCGTGGAGGCCTGGGCACCCCACGAACTGCGCGAGAAAATCCG
GCGCTACCGCCCGGCCATCGTCGCCTTTACCTCCAAGCGGGGAGCCTCGGAGACGCTGGGGGTGCCCACCGGCCGCTTGC
CCTACGGCCCGCAGGTCGGGCGACTGGAGGGGGCAGAGGTCTGGGTGCTGCCCTCCACCAGCCCTCTGGGTCACACCCAC
TTCCAGTTGGGGCCTTGGCAGGCACTCGCGGACCGGGTGCGCGCGCTGCGCCCCTCCGGGAACCGTGAGGCCAGGAGGAA
CCCGGGAGCGCCGGAGCGCGTACCCTGA

Upstream 100 bases:

>100_bases
CTCGCAGGGCTGGAATTCATGGCTGAGGACCGGCCGGGCTTCTGGGAGCGCAACGGCTACCACATGCGGGGCGATCCCTT
CAAGGAGGAGCGCTACGACG

Downstream 100 bases:

>100_bases
GGATATGGCTCTGCGCGTCCCCCGTCTGTCTTTTGCCGCCCGCACCGGCTTACGGGCGCTGCGTATGGAATGCGCCTGAT
GGGGTGGAGGACTCGGCCGC

Product: uracil-DNA glycosylase superfamily protein

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MTEAGWPAGEDYLVPDVLQEGLTLVLVGTAPSRISARAKAYYANPENKFWRVLAETGLTPRQLAPREYPILPQYGIGLTD
VAKRHSGVDAALPVEAWAPHELREKIRRYRPAIVAFTSKRGASETLGVPTGRLPYGPQVGRLEGAEVWVLPSTSPLGHTH
FQLGPWQALADRVRALRPSGNREARRNPGAPERVP

Sequences:

>Translated_195_residues
MTEAGWPAGEDYLVPDVLQEGLTLVLVGTAPSRISARAKAYYANPENKFWRVLAETGLTPRQLAPREYPILPQYGIGLTD
VAKRHSGVDAALPVEAWAPHELREKIRRYRPAIVAFTSKRGASETLGVPTGRLPYGPQVGRLEGAEVWVLPSTSPLGHTH
FQLGPWQALADRVRALRPSGNREARRNPGAPERVP
>Mature_194_residues
TEAGWPAGEDYLVPDVLQEGLTLVLVGTAPSRISARAKAYYANPENKFWRVLAETGLTPRQLAPREYPILPQYGIGLTDV
AKRHSGVDAALPVEAWAPHELREKIRRYRPAIVAFTSKRGASETLGVPTGRLPYGPQVGRLEGAEVWVLPSTSPLGHTHF
QLGPWQALADRVRALRPSGNREARRNPGAPERVP

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI59853162, Length=150, Percent_Identity=30, Blast_Score=71, Evalue=6e-13,
Organism=Escherichia coli, GI1789449, Length=154, Percent_Identity=31.1688311688312, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356805, Length=147, Percent_Identity=32.6530612244898, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015637
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.28 [H]

Molecular weight: Translated: 21412; Mature: 21280

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAGWPAGEDYLVPDVLQEGLTLVLVGTAPSRISARAKAYYANPENKFWRVLAETGLTP
CCCCCCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHHHHEEECCCCHHHHHHHHHCCCCH
RQLAPREYPILPQYGIGLTDVAKRHSGVDAALPVEAWAPHELREKIRRYRPAIVAFTSKR
HHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCC
GASETLGVPTGRLPYGPQVGRLEGAEVWVLPSTSPLGHTHFQLGPWQALADRVRALRPSG
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
NREARRNPGAPERVP
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEAGWPAGEDYLVPDVLQEGLTLVLVGTAPSRISARAKAYYANPENKFWRVLAETGLTP
CCCCCCCCCCCCCHHHHHCCCEEEEEECCCHHHHHHHHEEECCCCHHHHHHHHHCCCCH
RQLAPREYPILPQYGIGLTDVAKRHSGVDAALPVEAWAPHELREKIRRYRPAIVAFTSKR
HHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCC
GASETLGVPTGRLPYGPQVGRLEGAEVWVLPSTSPLGHTHFQLGPWQALADRVRALRPSG
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
NREARRNPGAPERVP
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA