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The map label for this gene is mtlK [H]

Identifier: 94972329

GI number: 94972329

Start: 155720

End: 157231

Strand: Direct

Name: mtlK [H]

Synonym: Dgeo_2866

Alternate gene names: 94972329

Gene position: 155720-157231 (Clockwise)

Preceding gene: 94972330

Following gene: 94972328

Centisome position: 27.12

GC content: 68.72

Gene sequence:

>1512_bases
ATGGTCAAACTTACTCTCTCCGCCCTTCCCGCCCTGAGTCCGGCGGTGGCTGTTCCGGCCTACGATCCACGCGCACAGAT
TCCGGGCATCGTTCACTTCGGCGTGGGGGCCTTTCACCGCTCGCACCAGGCGATGTACCTCGACCGGCTGCTGAACAGCG
GGCGCGGCGCGGGCTGGGCGATCTGCGGGGTGGGGGTGCTGCCGCAGGACGCCCGCATGCGGGACGTGCTGGCCGAGCAG
GACCACCTCTACACCCTGGTCACCCGGTCCCCGGACGGGCAGGCCCAGGCGCGAGTCATCGGCGCCATCGTGGAGTTCTT
GTTTGCCCCCGACGACCCCGAGCGAGTGCTGGAGCGGCTGGCCGATCCCACCACCCGCATCGTCTCGCTCACCGTCACCG
AGGGCGGTTACAGCGTGAGCAACGCGACCGGCGAGTTCGATCCCACGCCCCCCGACATCGCGCACGACCTGACGCCGGGC
GCGGTGCCGCGCACCTTCTTCGGCTTTCTGACCGAGGGATTGCGGCGCCGCCGGGAGCGCGGCCTCCCACCCTTCACCGT
GGTGTCGTGCGACAACATGCCGGGCAACGGGGAAGTCACGCGCCGGGCACTCACCGCGTTTGCCCGCCTCCAGGACCCGG
AGCTGGGGGACTGGATTGCCCACAATGTCGCCTTTCCCAACTCGATGGTGGACCGCATCACGCCCGCCACCACCGAACAG
GACCGGCAGGACATCGCTGCGGCGTACGGCATCGAGGACGCGTGGCCGGTCGTGGCCGAGAGTTTTGCCCAGTGGGTGCT
GGAAGACCGCTTCACCCAGGGGCGGCCTGCGCTGGAGACGGTCGGGGTGCAGGTGGTCAGCGACGTGGAACCCTACGAAC
TCATGAAGCTGCGGCTGCTCAACGCCTCTCACCAGGCCCTGGCCTACCTGGGGCTGCTTGCGGGCTACCGCTTCGTGCAT
GAGGTCTGCCAGGACCCGCTCTTCGCCCGCTTTCTGTTGGACTATATGACGCAGGAGGCCACGCCGACCCTGCGGCCGGT
GCCCGGCATTGACCTCGGGGCCTACCGCCGCGAACTGATTGCTCGCTTCTCGAACCCGGCCATCCGCGACCCGCTCACCC
GTCTGACGGTGGACAGCTCAGAACGTATCCCCAAGTTCCTGCTGCCGGTCATTCGTGACCAGCTGGCGCGCGGGGGTGAG
TTGGCCCGCTGCGCCCTTGTGATCGCGTCCTGGCGGGCCTATCTCGCAACAGTGCTGGAAGAGGGCAGCGCGTCTTTCCC
CGACCAGCATGCCCAGGCCCTGGCGGAGGCGGTGCGCCGGGACGCGCAGCAGCCGGGGGCCTTTCTCGATCTGGAGGCGG
TCTTCGGGGAGCTGGGCCGCAACGCGCGCTTCCGGACGGCCTACCTCAGCGCGTGGGAAAGCCTGCGCCGCCAGGGTCCT
CTGGGGGCCATGCGGGCGCTGATGGGTGAAGAGTCCTCCCCGAGCAACGTGACTTCTCTTTCAGGAAGGTGA

Upstream 100 bases:

>100_bases
TCAGGAGAACGCCAAAGCGATCGAGGCCACTCGCCCGCGCGCCGATCTGATCGTCACGTTGATGGACTGAGTGCCGCAGG
CTTTTTGCAGGAGAACGTTC

Downstream 100 bases:

>100_bases
ATATGACCTCAACTGCTCAGATGCCCCACATCCTTGACCTCTTTCGTCTCGACGGACGCCACGCCCTGGTGACTGGCGGC
GCGCAGGGGATCGGCTTCGA

Product: mannitol dehydrogenase-like

Products: NA

Alternate protein names: M2DH; MDH [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MVKLTLSALPALSPAVAVPAYDPRAQIPGIVHFGVGAFHRSHQAMYLDRLLNSGRGAGWAICGVGVLPQDARMRDVLAEQ
DHLYTLVTRSPDGQAQARVIGAIVEFLFAPDDPERVLERLADPTTRIVSLTVTEGGYSVSNATGEFDPTPPDIAHDLTPG
AVPRTFFGFLTEGLRRRRERGLPPFTVVSCDNMPGNGEVTRRALTAFARLQDPELGDWIAHNVAFPNSMVDRITPATTEQ
DRQDIAAAYGIEDAWPVVAESFAQWVLEDRFTQGRPALETVGVQVVSDVEPYELMKLRLLNASHQALAYLGLLAGYRFVH
EVCQDPLFARFLLDYMTQEATPTLRPVPGIDLGAYRRELIARFSNPAIRDPLTRLTVDSSERIPKFLLPVIRDQLARGGE
LARCALVIASWRAYLATVLEEGSASFPDQHAQALAEAVRRDAQQPGAFLDLEAVFGELGRNARFRTAYLSAWESLRRQGP
LGAMRALMGEESSPSNVTSLSGR

Sequences:

>Translated_503_residues
MVKLTLSALPALSPAVAVPAYDPRAQIPGIVHFGVGAFHRSHQAMYLDRLLNSGRGAGWAICGVGVLPQDARMRDVLAEQ
DHLYTLVTRSPDGQAQARVIGAIVEFLFAPDDPERVLERLADPTTRIVSLTVTEGGYSVSNATGEFDPTPPDIAHDLTPG
AVPRTFFGFLTEGLRRRRERGLPPFTVVSCDNMPGNGEVTRRALTAFARLQDPELGDWIAHNVAFPNSMVDRITPATTEQ
DRQDIAAAYGIEDAWPVVAESFAQWVLEDRFTQGRPALETVGVQVVSDVEPYELMKLRLLNASHQALAYLGLLAGYRFVH
EVCQDPLFARFLLDYMTQEATPTLRPVPGIDLGAYRRELIARFSNPAIRDPLTRLTVDSSERIPKFLLPVIRDQLARGGE
LARCALVIASWRAYLATVLEEGSASFPDQHAQALAEAVRRDAQQPGAFLDLEAVFGELGRNARFRTAYLSAWESLRRQGP
LGAMRALMGEESSPSNVTSLSGR
>Mature_503_residues
MVKLTLSALPALSPAVAVPAYDPRAQIPGIVHFGVGAFHRSHQAMYLDRLLNSGRGAGWAICGVGVLPQDARMRDVLAEQ
DHLYTLVTRSPDGQAQARVIGAIVEFLFAPDDPERVLERLADPTTRIVSLTVTEGGYSVSNATGEFDPTPPDIAHDLTPG
AVPRTFFGFLTEGLRRRRERGLPPFTVVSCDNMPGNGEVTRRALTAFARLQDPELGDWIAHNVAFPNSMVDRITPATTEQ
DRQDIAAAYGIEDAWPVVAESFAQWVLEDRFTQGRPALETVGVQVVSDVEPYELMKLRLLNASHQALAYLGLLAGYRFVH
EVCQDPLFARFLLDYMTQEATPTLRPVPGIDLGAYRRELIARFSNPAIRDPLTRLTVDSSERIPKFLLPVIRDQLARGGE
LARCALVIASWRAYLATVLEEGSASFPDQHAQALAEAVRRDAQQPGAFLDLEAVFGELGRNARFRTAYLSAWESLRRQGP
LGAMRALMGEESSPSNVTSLSGR

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=479, Percent_Identity=41.1273486430063, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1790779, Length=495, Percent_Identity=40.6060606060606, Blast_Score=341, Evalue=7e-95,
Organism=Escherichia coli, GI1787823, Length=474, Percent_Identity=40.084388185654, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI48994885, Length=413, Percent_Identity=25.4237288135593, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790028, Length=213, Percent_Identity=27.2300469483568, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324401, Length=491, Percent_Identity=43.1771894093686, Blast_Score=420, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6320765, Length=491, Percent_Identity=43.1771894093686, Blast_Score=420, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.67 [H]

Molecular weight: Translated: 55207; Mature: 55207

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLTLSALPALSPAVAVPAYDPRAQIPGIVHFGVGAFHRSHQAMYLDRLLNSGRGAGWA
CEEEEEHHCCCCCCCEECCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCEE
ICGVGVLPQDARMRDVLAEQDHLYTLVTRSPDGQAQARVIGAIVEFLFAPDDPERVLERL
EEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
ADPTTRIVSLTVTEGGYSVSNATGEFDPTPPDIAHDLTPGAVPRTFFGFLTEGLRRRRER
CCCCEEEEEEEEECCCCEECCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GLPPFTVVSCDNMPGNGEVTRRALTAFARLQDPELGDWIAHNVAFPNSMVDRITPATTEQ
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHCCCCCCHH
DRQDIAAAYGIEDAWPVVAESFAQWVLEDRFTQGRPALETVGVQVVSDVEPYELMKLRLL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
NASHQALAYLGLLAGYRFVHEVCQDPLFARFLLDYMTQEATPTLRPVPGIDLGAYRRELI
CCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ARFSNPAIRDPLTRLTVDSSERIPKFLLPVIRDQLARGGELARCALVIASWRAYLATVLE
HHHCCCCHHCCHHHEECCCHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
EGSASFPDQHAQALAEAVRRDAQQPGAFLDLEAVFGELGRNARFRTAYLSAWESLRRQGP
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
LGAMRALMGEESSPSNVTSLSGR
HHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVKLTLSALPALSPAVAVPAYDPRAQIPGIVHFGVGAFHRSHQAMYLDRLLNSGRGAGWA
CEEEEEHHCCCCCCCEECCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCEE
ICGVGVLPQDARMRDVLAEQDHLYTLVTRSPDGQAQARVIGAIVEFLFAPDDPERVLERL
EEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
ADPTTRIVSLTVTEGGYSVSNATGEFDPTPPDIAHDLTPGAVPRTFFGFLTEGLRRRRER
CCCCEEEEEEEEECCCCEECCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GLPPFTVVSCDNMPGNGEVTRRALTAFARLQDPELGDWIAHNVAFPNSMVDRITPATTEQ
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHCCCCCCHH
DRQDIAAAYGIEDAWPVVAESFAQWVLEDRFTQGRPALETVGVQVVSDVEPYELMKLRLL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
NASHQALAYLGLLAGYRFVHEVCQDPLFARFLLDYMTQEATPTLRPVPGIDLGAYRRELI
CCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ARFSNPAIRDPLTRLTVDSSERIPKFLLPVIRDQLARGGELARCALVIASWRAYLATVLE
HHHCCCCHHCCHHHEECCCHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
EGSASFPDQHAQALAEAVRRDAQQPGAFLDLEAVFGELGRNARFRTAYLSAWESLRRQGP
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
LGAMRALMGEESSPSNVTSLSGR
HHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8254318 [H]