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The map label for this gene is mro [H]

Identifier: 94972264

GI number: 94972264

Start: 226286

End: 227251

Strand: Direct

Name: mro [H]

Synonym: Dgeo_2798

Alternate gene names: 94972264

Gene position: 226286-227251 (Clockwise)

Preceding gene: 94972265

Following gene: 94972261

Centisome position: 39.41

GC content: 65.63

Gene sequence:

>966_bases
ATGACCTACGGGGGGGTGCTGGTCCGTCTCCTCACCCCCGACCGACACGGCATTCCCGGCGACATCGTTCTGGGGCATGA
CCACCCGGAGCCGTACTTCAACCGGGTCTCGTCGCCGTTTTTCGGGGCCCTGATCGGGCGCTATGCCAACCGGATCGCCG
GGGGGCGCTTCTCGCTGAATGGCCGGGTGTACCAGCTTGCACAGAATGACGGCCCCAACGCCCTGCACGGGGGCGAGCGG
GGATTTGACCAGCGGCTGTGGGCAGGGCGCGCCGTTGTGGGGGAAAACGGCCCCAGCGTGACGCTCACCTACCTCAGCCC
TGACGGGGAAGAGGGCTATCCCGGCAACCTGAGTGTTCAGGTGACCTACACCCTCACGCCGGACCACACCCTGCAGATTG
ACTCCGCGGCCACGACCGACGCGCCCACCATCCTGAACCTCGCCCAACACACCTATTGGAACCTCAGCGGCAATGCGAGC
CGGGACATCCTCGATCACGAGCTGACTGTGCGGGCCGAGACCATGACGCCGGTCGACGTGACCTTGATTCCCACAGGTGA
ACTGCGGCCGGTTGCGGGAACACCCTTCGACTTCCGCGAAGCGCGGCGCCTCGGGGAACAGATCGATGCCCCCGACGAAC
AGCTGCGCTTCGCGGGCGGCTACGATCACAATTTTGTGCTGGATGACGCGCCGGCGCTCAAAGCAGCCGCCACGCTGTAT
GACCCAGGCTCCGGACGGCAAATTGAGGTTGCCACCACCGAGCCGGGCTTACAGGTGTACTCCGGAAACTTTCTGGATGG
CCGCATCACAGGGAAGGGCGGCCAACGCTACGGCTACCGCTGGGCGGTGTGCCTCGAAACGCAGCACTTCCCCGACTCTC
CCAACCAACCGCACTTTCCCAGCGTGGTGCTCCGGCCCGGCGAGCGCTTTGCCTCCCGCACCGTCTACGCCTTCTCGACA
CGCTGA

Upstream 100 bases:

>100_bases
GAGGGGGAAGGTCCGCGAGCGGTTCTGGGGGGAAACACCAGATGGCCGCAGCATCACCCTCTATGAACTGGAGACCGCAG
GCGGCCTACGGGCCGAGATC

Downstream 100 bases:

>100_bases
GCGCAGGACCTCAACCCCACGCGGGGCCGGACCGGAACGTCGTTTTCCGCCCGGCCAGCGTGACGTGCACGAACTCCCCA
GGAATGCGGGATGTGGGATC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTYGGVLVRLLTPDRHGIPGDIVLGHDHPEPYFNRVSSPFFGALIGRYANRIAGGRFSLNGRVYQLAQNDGPNALHGGER
GFDQRLWAGRAVVGENGPSVTLTYLSPDGEEGYPGNLSVQVTYTLTPDHTLQIDSAATTDAPTILNLAQHTYWNLSGNAS
RDILDHELTVRAETMTPVDVTLIPTGELRPVAGTPFDFREARRLGEQIDAPDEQLRFAGGYDHNFVLDDAPALKAAATLY
DPGSGRQIEVATTEPGLQVYSGNFLDGRITGKGGQRYGYRWAVCLETQHFPDSPNQPHFPSVVLRPGERFASRTVYAFST
R

Sequences:

>Translated_321_residues
MTYGGVLVRLLTPDRHGIPGDIVLGHDHPEPYFNRVSSPFFGALIGRYANRIAGGRFSLNGRVYQLAQNDGPNALHGGER
GFDQRLWAGRAVVGENGPSVTLTYLSPDGEEGYPGNLSVQVTYTLTPDHTLQIDSAATTDAPTILNLAQHTYWNLSGNAS
RDILDHELTVRAETMTPVDVTLIPTGELRPVAGTPFDFREARRLGEQIDAPDEQLRFAGGYDHNFVLDDAPALKAAATLY
DPGSGRQIEVATTEPGLQVYSGNFLDGRITGKGGQRYGYRWAVCLETQHFPDSPNQPHFPSVVLRPGERFASRTVYAFST
R
>Mature_320_residues
TYGGVLVRLLTPDRHGIPGDIVLGHDHPEPYFNRVSSPFFGALIGRYANRIAGGRFSLNGRVYQLAQNDGPNALHGGERG
FDQRLWAGRAVVGENGPSVTLTYLSPDGEEGYPGNLSVQVTYTLTPDHTLQIDSAATTDAPTILNLAQHTYWNLSGNASR
DILDHELTVRAETMTPVDVTLIPTGELRPVAGTPFDFREARRLGEQIDAPDEQLRFAGGYDHNFVLDDAPALKAAATLYD
PGSGRQIEVATTEPGLQVYSGNFLDGRITGKGGQRYGYRWAVCLETQHFPDSPNQPHFPSVVLRPGERFASRTVYAFSTR

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=320, Percent_Identity=47.5, Blast_Score=277, Evalue=9e-75,
Organism=Escherichia coli, GI1786971, Length=321, Percent_Identity=40.4984423676012, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17557428, Length=322, Percent_Identity=33.8509316770186, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI115533334, Length=322, Percent_Identity=33.8509316770186, Blast_Score=184, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6319493, Length=314, Percent_Identity=30.8917197452229, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322004, Length=320, Percent_Identity=28.125, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324399, Length=320, Percent_Identity=27.8125, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24659048, Length=329, Percent_Identity=40.1215805471125, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24668282, Length=330, Percent_Identity=38.7878787878788, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24668278, Length=324, Percent_Identity=33.0246913580247, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24583720, Length=328, Percent_Identity=34.1463414634146, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24641876, Length=334, Percent_Identity=30.2395209580838, Blast_Score=155, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 35110; Mature: 34979

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYGGVLVRLLTPDRHGIPGDIVLGHDHPEPYFNRVSSPFFGALIGRYANRIAGGRFSLN
CCCCEEEEEEECCCCCCCCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHCCCEEEEC
GRVYQLAQNDGPNALHGGERGFDQRLWAGRAVVGENGPSVTLTYLSPDGEEGYPGNLSVQ
CEEEEEECCCCCCCCCCCCCCCHHHHHCCCEEECCCCCEEEEEEECCCCCCCCCCCEEEE
VTYTLTPDHTLQIDSAATTDAPTILNLAQHTYWNLSGNASRDILDHELTVRAETMTPVDV
EEEEECCCCEEEECCCCCCCCCHHHHHHHHEEEECCCCCCCCEECCEEEEEEEECCCEEE
TLIPTGELRPVAGTPFDFREARRLGEQIDAPDEQLRFAGGYDHNFVLDDAPALKAAATLY
EEEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHEEEECCCCCCEEECCCCCHHEEEEEE
DPGSGRQIEVATTEPGLQVYSGNFLDGRITGKGGQRYGYRWAVCLETQHFPDSPNQPHFP
CCCCCCEEEEEECCCCCEEEECCEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCC
SVVLRPGERFASRTVYAFSTR
EEEECCCCHHHCCEEEEEECC
>Mature Secondary Structure 
TYGGVLVRLLTPDRHGIPGDIVLGHDHPEPYFNRVSSPFFGALIGRYANRIAGGRFSLN
CCCEEEEEEECCCCCCCCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHCCCEEEEC
GRVYQLAQNDGPNALHGGERGFDQRLWAGRAVVGENGPSVTLTYLSPDGEEGYPGNLSVQ
CEEEEEECCCCCCCCCCCCCCCHHHHHCCCEEECCCCCEEEEEEECCCCCCCCCCCEEEE
VTYTLTPDHTLQIDSAATTDAPTILNLAQHTYWNLSGNASRDILDHELTVRAETMTPVDV
EEEEECCCCEEEECCCCCCCCCHHHHHHHHEEEECCCCCCCCEECCEEEEEEEECCCEEE
TLIPTGELRPVAGTPFDFREARRLGEQIDAPDEQLRFAGGYDHNFVLDDAPALKAAATLY
EEEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHEEEECCCCCCEEECCCCCHHEEEEEE
DPGSGRQIEVATTEPGLQVYSGNFLDGRITGKGGQRYGYRWAVCLETQHFPDSPNQPHFP
CCCCCCEEEEEECCCCCEEEECCEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCC
SVVLRPGERFASRTVYAFSTR
EEEECCCCHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]