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The map label for this gene is acd [H]

Identifier: 94312747

GI number: 94312747

Start: 358331

End: 359977

Strand: Direct

Name: acd [H]

Synonym: Rmet_3817

Alternate gene names: 94312747

Gene position: 358331-359977 (Clockwise)

Preceding gene: 94312743

Following gene: 94312748

Centisome position: 13.89

GC content: 65.45

Gene sequence:

>1647_bases
ATGGAATGGAGCACGCACGAGGTCACCAACGTGGTGACGGAACTGCAGGATTATAACGTCTACACCACCGATCTTCCCTT
GCAGGAGGCGGTGCGCCGCGCGGGGGCGGGCGCCCACGAAGCCGAGCTGACCGCCTACGGCGCGCGGCTTGGCAGCGCCG
AGACGATCCGCATGGCCGAGGAGGCCAACCACTTCAAGCCCGAGTTGCATACGTTCGACCGCCAGGGCCGCCGTATCGAC
CGTGTGGAGTTTCACCCGAGCTGGCACGGCGTCATGCGCATGGCGCGCGAGCAGAACCTCGTGGCACAGCCGTTCGCCGA
TCCGCGTCCCGGCGCATGGGCTGCCTATGCGGCCGGATTCTCGATGCACGGGCAGATCGAGGCGGGCTCGCAGTGCCCGA
ACTCGATGACTTTTGCGTGCATTCCAGTATTGCAACGCGAACCCGAATTGTTCGCAGCGCTCGCGCCGAAGCTCTATTCG
CGTACGTACGATGCGCGGGATATCCCGCTGGAACAGAAGGATTCGATCCTGGTCGGCATGGGCATGACGGAGAAGCAGGG
TGGCTCCGACGTGCGGGCCAACACCACGCGCGCTGAACCGCTGCGTGGCGAGGGGCGCGGCGGCGAGTATCTGATCACAG
GCCACAAGTGGTTCTTCTCGGCGCCGATGTGCGACGCGCACCTCGTGGTGGCCCGCACGGAAAGCGGCCCGGCCTGCTTC
TACGTGCCGCGCTACCGGCCCGATGGCACTAAGAACGCAGTGCAGATCCAGCGGCTGAAGGACAAGGTGGGCAATCGTTC
CAACTCCAGCAGCGAGGTGGAATTCCGTGGTGCCTGGGGGCGCATGATCGGCGAGGAAGGCCGTGGTATTCCGACCATCA
TCGAAATGGCCACTTTCACGCGCCTGAACTGCGTGATGGGCAGTACCGGCCTGATTCGCCAGTGCCTGGTCCAGGCGTTG
CACCATACCCGCCACCGTAGCGCGTTCGGCAAGACGCTGATCGACCAGCCGCTGATGCGCAACGTGCTGGCCGACATGGC
GCTCGAGTCTGAAGCGGCCACGCTGATGATGATGCGGCTGACCGAGGCCTTCGCGCTGGCCGATGAGGATCCGCTGCAGC
GTGCCTACAAGCGCATCGTCACGCCGGCGGCCAAGTTCTGGCTGGCCAAGCGCAGCGTGGAACTGTCTGGCGAGGCCATG
GAGGTCTTTGGCGGCAACGGCTATATGGATGAAGGCCCGATGGGCCGCCTGTATCGCGAAACACCGGTGATTTCGATCTG
GGAAGGATCGGGCAATGTGATGGCGCTGGACATGATCCGTGCCATCAGCCGGGAACCGCAGGCCATGCAGGCGTTGCTGG
AAGACCTGACGCCATTCTGCCGCCAGGACGCGCGTCTGAGCGATGCGGCCACGATGCTGGTCGCGGGGCTGCGGACCCAG
GGAGAGGCGACGGAATGGCTTGCGCGCCGCCATGCGCAGCTTCTGGTGCTGCTGGTGCAGGCCCGTCTGCTCGGCGAACA
TGCGCCGGCGGCGGTGACCGATGCGTTCATCGCCAGCCGGTTCGACGCGCAATGGGGCCGCGTGTTCGGCATGCTGCCGG
ATGGCGTAGCGCACGCCGCGATCCTGGATCGCGCCTGGACGCAGTAA

Upstream 100 bases:

>100_bases
CATGTCTGAGAAACCCGAACACCTTGCGGTGGACGGATTCTTATACTGGTTGTCGACAAGACCGGCTTGACTGACGAGCC
GGCGCAACGGAGACATGCCC

Downstream 100 bases:

>100_bases
GACGCCGCAAGGCCAGCGCAAGGCCAGCGCAAGGCCAGCGCAAGGCCAGCGCAAGGCCAGCACAAGGCCAGCACAAGGCC
AGCACAAGGCCAGCACAAGG

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MEWSTHEVTNVVTELQDYNVYTTDLPLQEAVRRAGAGAHEAELTAYGARLGSAETIRMAEEANHFKPELHTFDRQGRRID
RVEFHPSWHGVMRMAREQNLVAQPFADPRPGAWAAYAAGFSMHGQIEAGSQCPNSMTFACIPVLQREPELFAALAPKLYS
RTYDARDIPLEQKDSILVGMGMTEKQGGSDVRANTTRAEPLRGEGRGGEYLITGHKWFFSAPMCDAHLVVARTESGPACF
YVPRYRPDGTKNAVQIQRLKDKVGNRSNSSSEVEFRGAWGRMIGEEGRGIPTIIEMATFTRLNCVMGSTGLIRQCLVQAL
HHTRHRSAFGKTLIDQPLMRNVLADMALESEAATLMMMRLTEAFALADEDPLQRAYKRIVTPAAKFWLAKRSVELSGEAM
EVFGGNGYMDEGPMGRLYRETPVISIWEGSGNVMALDMIRAISREPQAMQALLEDLTPFCRQDARLSDAATMLVAGLRTQ
GEATEWLARRHAQLLVLLVQARLLGEHAPAAVTDAFIASRFDAQWGRVFGMLPDGVAHAAILDRAWTQ

Sequences:

>Translated_548_residues
MEWSTHEVTNVVTELQDYNVYTTDLPLQEAVRRAGAGAHEAELTAYGARLGSAETIRMAEEANHFKPELHTFDRQGRRID
RVEFHPSWHGVMRMAREQNLVAQPFADPRPGAWAAYAAGFSMHGQIEAGSQCPNSMTFACIPVLQREPELFAALAPKLYS
RTYDARDIPLEQKDSILVGMGMTEKQGGSDVRANTTRAEPLRGEGRGGEYLITGHKWFFSAPMCDAHLVVARTESGPACF
YVPRYRPDGTKNAVQIQRLKDKVGNRSNSSSEVEFRGAWGRMIGEEGRGIPTIIEMATFTRLNCVMGSTGLIRQCLVQAL
HHTRHRSAFGKTLIDQPLMRNVLADMALESEAATLMMMRLTEAFALADEDPLQRAYKRIVTPAAKFWLAKRSVELSGEAM
EVFGGNGYMDEGPMGRLYRETPVISIWEGSGNVMALDMIRAISREPQAMQALLEDLTPFCRQDARLSDAATMLVAGLRTQ
GEATEWLARRHAQLLVLLVQARLLGEHAPAAVTDAFIASRFDAQWGRVFGMLPDGVAHAAILDRAWTQ
>Mature_548_residues
MEWSTHEVTNVVTELQDYNVYTTDLPLQEAVRRAGAGAHEAELTAYGARLGSAETIRMAEEANHFKPELHTFDRQGRRID
RVEFHPSWHGVMRMAREQNLVAQPFADPRPGAWAAYAAGFSMHGQIEAGSQCPNSMTFACIPVLQREPELFAALAPKLYS
RTYDARDIPLEQKDSILVGMGMTEKQGGSDVRANTTRAEPLRGEGRGGEYLITGHKWFFSAPMCDAHLVVARTESGPACF
YVPRYRPDGTKNAVQIQRLKDKVGNRSNSSSEVEFRGAWGRMIGEEGRGIPTIIEMATFTRLNCVMGSTGLIRQCLVQAL
HHTRHRSAFGKTLIDQPLMRNVLADMALESEAATLMMMRLTEAFALADEDPLQRAYKRIVTPAAKFWLAKRSVELSGEAM
EVFGGNGYMDEGPMGRLYRETPVISIWEGSGNVMALDMIRAISREPQAMQALLEDLTPFCRQDARLSDAATMLVAGLRTQ
GEATEWLARRHAQLLVLLVQARLLGEHAPAAVTDAFIASRFDAQWGRVFGMLPDGVAHAAILDRAWTQ

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=277, Percent_Identity=24.5487364620939, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI226958414, Length=277, Percent_Identity=24.5487364620939, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI4557233, Length=277, Percent_Identity=27.0758122743682, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI4557231, Length=276, Percent_Identity=25.3623188405797, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI187960098, Length=276, Percent_Identity=25.3623188405797, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI7656849, Length=272, Percent_Identity=26.8382352941176, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4501859, Length=275, Percent_Identity=24.7272727272727, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI87082384, Length=530, Percent_Identity=44.3396226415094, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI87081958, Length=275, Percent_Identity=25.0909090909091, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=512, Percent_Identity=26.7578125, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI86563381, Length=512, Percent_Identity=26.7578125, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17538396, Length=275, Percent_Identity=26.5454545454545, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17569725, Length=274, Percent_Identity=24.8175182481752, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508101, Length=275, Percent_Identity=26.5454545454545, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506239, Length=278, Percent_Identity=25.5395683453237, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17570075, Length=273, Percent_Identity=25.2747252747253, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17505929, Length=277, Percent_Identity=27.4368231046931, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=274, Percent_Identity=24.8175182481752, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17551932, Length=267, Percent_Identity=25.4681647940075, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17533517, Length=271, Percent_Identity=24.7232472324723, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71985184, Length=274, Percent_Identity=24.0875912408759, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24660351, Length=282, Percent_Identity=28.0141843971631, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355753, Length=273, Percent_Identity=23.0769230769231, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646207, Length=288, Percent_Identity=24.6527777777778, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356377, Length=273, Percent_Identity=24.9084249084249, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363737, Length=281, Percent_Identity=22.7758007117438, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 60839; Mature: 60839

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWSTHEVTNVVTELQDYNVYTTDLPLQEAVRRAGAGAHEAELTAYGARLGSAETIRMAE
CCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHH
EANHFKPELHTFDRQGRRIDRVEFHPSWHGVMRMAREQNLVAQPFADPRPGAWAAYAAGF
HHCCCCCHHHHHHHCCCEECEEEECCCHHHHHHHHHHCCCEECCCCCCCCCCHHHHHCCC
SMHGQIEAGSQCPNSMTFACIPVLQREPELFAALAPKLYSRTYDARDIPLEQKDSILVGM
CCCCCCCCCCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
GMTEKQGGSDVRANTTRAEPLRGEGRGGEYLITGHKWFFSAPMCDAHLVVARTESGPACF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCEEEEEECCCCCEEE
YVPRYRPDGTKNAVQIQRLKDKVGNRSNSSSEVEFRGAWGRMIGEEGRGIPTIIEMATFT
EECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHCCCCCCCHHHHHHHHHH
RLNCVMGSTGLIRQCLVQALHHTRHRSAFGKTLIDQPLMRNVLADMALESEAATLMMMRL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEAFALADEDPLQRAYKRIVTPAAKFWLAKRSVELSGEAMEVFGGNGYMDEGPMGRLYRE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHC
TPVISIWEGSGNVMALDMIRAISREPQAMQALLEDLTPFCRQDARLSDAATMLVAGLRTQ
CCEEEEEECCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
GEATEWLARRHAQLLVLLVQARLLGEHAPAAVTDAFIASRFDAQWGRVFGMLPDGVAHAA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHH
ILDRAWTQ
HHHHHCCC
>Mature Secondary Structure
MEWSTHEVTNVVTELQDYNVYTTDLPLQEAVRRAGAGAHEAELTAYGARLGSAETIRMAE
CCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHH
EANHFKPELHTFDRQGRRIDRVEFHPSWHGVMRMAREQNLVAQPFADPRPGAWAAYAAGF
HHCCCCCHHHHHHHCCCEECEEEECCCHHHHHHHHHHCCCEECCCCCCCCCCHHHHHCCC
SMHGQIEAGSQCPNSMTFACIPVLQREPELFAALAPKLYSRTYDARDIPLEQKDSILVGM
CCCCCCCCCCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
GMTEKQGGSDVRANTTRAEPLRGEGRGGEYLITGHKWFFSAPMCDAHLVVARTESGPACF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCEEEEEECCCCCEEE
YVPRYRPDGTKNAVQIQRLKDKVGNRSNSSSEVEFRGAWGRMIGEEGRGIPTIIEMATFT
EECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHCCCCCCCHHHHHHHHHH
RLNCVMGSTGLIRQCLVQALHHTRHRSAFGKTLIDQPLMRNVLADMALESEAATLMMMRL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEAFALADEDPLQRAYKRIVTPAAKFWLAKRSVELSGEAMEVFGGNGYMDEGPMGRLYRE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHC
TPVISIWEGSGNVMALDMIRAISREPQAMQALLEDLTPFCRQDARLSDAATMLVAGLRTQ
CCEEEEEECCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
GEATEWLARRHAQLLVLLVQARLLGEHAPAAVTDAFIASRFDAQWGRVFGMLPDGVAHAA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHH
ILDRAWTQ
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]