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The map label for this gene is gltP [H]

Identifier: 93006945

GI number: 93006945

Start: 2597213

End: 2598586

Strand: Direct

Name: gltP [H]

Synonym: Pcryo_2121

Alternate gene names: 93006945

Gene position: 2597213-2598586 (Clockwise)

Preceding gene: 93006944

Following gene: 93006947

Centisome position: 84.88

GC content: 44.03

Gene sequence:

>1374_bases
ATGTGGAAAAATATGGGTTTGACCGGCAAAATTATTGTTGCCATGGTGCTCGGTATTATACTGGGTCTATTTATAAACTA
CTCTGGCTTGAACACGGAAGGCAGCTTTGTTAATAATTATGTCACCAACGGTTTTCTTGCCATTGTCGGTAAGCTGTTTG
TTAACTCGCTAAAAATGCTCGTCGTGCCACTGGTCTTGATTTCACTAATCTGCGGCGTATGCGGTATCGGTGATATTCGT
CTATTAGGGCGTATTGGTACTAAAACCTTTTTCATCTATATGGTGACGACAGCACTGGCGATTGCAACTGCTATTGGGCT
TGGCGTGCTGTTTGGTATCGGCAAAGGCATGAATATAGCAACAGAGGCGGCGTTTGAAGCTGAGAAAGCGCCACCACTAC
TCGATGTATTTTCCAATATTATTCCCTCTAACCCCATCAGTGCGATGGCAAACGGCGACATGCTATCGATTATCTTCTTT
GCCGTTTTGATTGGTATTAGTATTTTGATGGTAGGAAAACCCGCTAAAGGCTTAGTTCAAAGTTTAGAGCTCATCAATGA
AGTCATCTTAAAAATGGTGACTATCATTATGAATCTTGCACCATATGGTGTCTTTGCGCTATTGACCAAAGCAATGGCAG
AGCTTGGCTTAGACCTGATTTGGTCATTACTTGGTTATGTTGCGGTACTGGTTGGTTCACTGGCATTCCATTTCTTTGTG
ACCATGATGATTGTCCTCAAGCTGTCTTCAGGCTTGTCAGTCAGAACGTTTTTGGCAAAAATGCGCGAAGTACAGATTTT
TGCTTTTAGTACTTCAAGCTCGAATGCAACGATTCCAATTACCTTGCGCACGGTCACCAAGCGCATGGGTGTTAATAACT
CAGTTGCTTCATTCACCATCCCTTTTGGCGCGACGATCAACATGGATGGTACAGCCATCATGCAAGGCACAGCGACCATT
TTTATTGCCAATATTTATGGTATTGACTTGGGTATAACTGAGTATTTGACCGTTATTTTGATGTCAGTGCTCGCCTCTGT
CGGTACGGCAGGTGTTCCGGGTGTTGGTCTAATCATGCTGTCAATGGTATTTGCCCAAGTCGGTCTACCGATTGAAGGTA
TTGGTCTTATTTTAGGGGTCGACCGTATCCTTGATATGTTACGTACAGCAGTCAATGTCGGCGGTGATGCTGCGGTGACC
GCTATCGTCGCAAAATCAGAAGGTAAAATGGATTTAGCGATTTATAACGATCCTGATGCTGGCTCAAAAGATGTCTTTGA
CGGTCATATCGATGAGAACAGCGAACGCGAATTCTCTGAAGTCTTTAGCGATGGCATTATGGGCAGCGAGTATGACGATG
TTAAGCGCGGCTAA

Upstream 100 bases:

>100_bases
TATAGACGTCACAGCAACAGTCATGACAGCAATCTTGCACTCATATTGAGCGCGCTATTGTGTCTATTGCTGTGCGTAAC
GGACACCAAGGATAGCGTTT

Downstream 100 bases:

>100_bases
TCGTGATCAGTGATTGCCTATAAATAAGTCATAAAAAAACCTCAGCCGATTGGTCTGAGGTTTTTTTATGCAGCAAGTAG
GTTTTTAGACCAAGAGTTGC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MWKNMGLTGKIIVAMVLGIILGLFINYSGLNTEGSFVNNYVTNGFLAIVGKLFVNSLKMLVVPLVLISLICGVCGIGDIR
LLGRIGTKTFFIYMVTTALAIATAIGLGVLFGIGKGMNIATEAAFEAEKAPPLLDVFSNIIPSNPISAMANGDMLSIIFF
AVLIGISILMVGKPAKGLVQSLELINEVILKMVTIIMNLAPYGVFALLTKAMAELGLDLIWSLLGYVAVLVGSLAFHFFV
TMMIVLKLSSGLSVRTFLAKMREVQIFAFSTSSSNATIPITLRTVTKRMGVNNSVASFTIPFGATINMDGTAIMQGTATI
FIANIYGIDLGITEYLTVILMSVLASVGTAGVPGVGLIMLSMVFAQVGLPIEGIGLILGVDRILDMLRTAVNVGGDAAVT
AIVAKSEGKMDLAIYNDPDAGSKDVFDGHIDENSEREFSEVFSDGIMGSEYDDVKRG

Sequences:

>Translated_457_residues
MWKNMGLTGKIIVAMVLGIILGLFINYSGLNTEGSFVNNYVTNGFLAIVGKLFVNSLKMLVVPLVLISLICGVCGIGDIR
LLGRIGTKTFFIYMVTTALAIATAIGLGVLFGIGKGMNIATEAAFEAEKAPPLLDVFSNIIPSNPISAMANGDMLSIIFF
AVLIGISILMVGKPAKGLVQSLELINEVILKMVTIIMNLAPYGVFALLTKAMAELGLDLIWSLLGYVAVLVGSLAFHFFV
TMMIVLKLSSGLSVRTFLAKMREVQIFAFSTSSSNATIPITLRTVTKRMGVNNSVASFTIPFGATINMDGTAIMQGTATI
FIANIYGIDLGITEYLTVILMSVLASVGTAGVPGVGLIMLSMVFAQVGLPIEGIGLILGVDRILDMLRTAVNVGGDAAVT
AIVAKSEGKMDLAIYNDPDAGSKDVFDGHIDENSEREFSEVFSDGIMGSEYDDVKRG
>Mature_457_residues
MWKNMGLTGKIIVAMVLGIILGLFINYSGLNTEGSFVNNYVTNGFLAIVGKLFVNSLKMLVVPLVLISLICGVCGIGDIR
LLGRIGTKTFFIYMVTTALAIATAIGLGVLFGIGKGMNIATEAAFEAEKAPPLLDVFSNIIPSNPISAMANGDMLSIIFF
AVLIGISILMVGKPAKGLVQSLELINEVILKMVTIIMNLAPYGVFALLTKAMAELGLDLIWSLLGYVAVLVGSLAFHFFV
TMMIVLKLSSGLSVRTFLAKMREVQIFAFSTSSSNATIPITLRTVTKRMGVNNSVASFTIPFGATINMDGTAIMQGTATI
FIANIYGIDLGITEYLTVILMSVLASVGTAGVPGVGLIMLSMVFAQVGLPIEGIGLILGVDRILDMLRTAVNVGGDAAVT
AIVAKSEGKMDLAIYNDPDAGSKDVFDGHIDENSEREFSEVFSDGIMGSEYDDVKRG

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=467, Percent_Identity=29.1220556745182, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI169790839, Length=443, Percent_Identity=27.9909706546275, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI66773030, Length=462, Percent_Identity=29.4372294372294, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI21314632, Length=427, Percent_Identity=29.03981264637, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI5032093, Length=372, Percent_Identity=30.9139784946237, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI4827012, Length=284, Percent_Identity=34.1549295774648, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI194239697, Length=299, Percent_Identity=30.7692307692308, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI223468564, Length=247, Percent_Identity=31.5789473684211, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI223468566, Length=256, Percent_Identity=31.25, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI262359914, Length=384, Percent_Identity=25.2604166666667, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI301601644, Length=171, Percent_Identity=33.9181286549708, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI1790514, Length=447, Percent_Identity=34.8993288590604, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1789947, Length=438, Percent_Identity=27.6255707762557, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788024, Length=404, Percent_Identity=29.2079207920792, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1789473, Length=381, Percent_Identity=25.9842519685039, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=440, Percent_Identity=30.9090909090909, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71983106, Length=440, Percent_Identity=30.9090909090909, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17537407, Length=389, Percent_Identity=33.4190231362468, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71996953, Length=446, Percent_Identity=28.9237668161435, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI193206505, Length=458, Percent_Identity=28.82096069869, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17541374, Length=392, Percent_Identity=28.0612244897959, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI193206654, Length=407, Percent_Identity=25.0614250614251, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24583025, Length=462, Percent_Identity=28.1385281385281, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI17137668, Length=462, Percent_Identity=28.1385281385281, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24583023, Length=462, Percent_Identity=28.1385281385281, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI281360481, Length=474, Percent_Identity=27.6371308016878, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281360483, Length=474, Percent_Identity=27.6371308016878, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17137666, Length=474, Percent_Identity=27.6371308016878, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 48390; Mature: 48390

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHCCCC
>Mature Secondary Structure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CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]