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The map label for this gene is nhaA [H]

Identifier: 93005622

GI number: 93005622

Start: 933079

End: 934134

Strand: Direct

Name: nhaA [H]

Synonym: Pcryo_0792

Alternate gene names: 93005622

Gene position: 933079-934134 (Clockwise)

Preceding gene: 93005621

Following gene: 93005623

Centisome position: 30.49

GC content: 44.32

Gene sequence:

>1056_bases
ATGCCCAACTGGCCGCCAGACCCTAACAAACGTCCTGATAATTCGGCAAATCAGCCAGCACCGATGCAGCAGTCAAACCA
GCCGAGCGGGCAAGAATGGCGACTGATTGAAAATACTTTATTAGCAAGCGTGGTCGAGCAACGCCGTGCCCGTCGTTGGA
GTATTTTCTTTAAGCTACTGACCTTTGGCTATATTTTATTGATATTTTTGACGATTGGTCGTAGCTGTAGTACTGAAGCA
CCCACTGGTCTTGATGGTATAGATACCAGTAAGCCGCATTTGGCAGTGGTTGAGCTTCAAGGAACTATTAGCAGTGGTGA
TGTCGCTAATGCTTATGATGTCAATGATGCGCTCACACGCGCCTTTAAAAACAGTAACTCAAAGGCAGTGGCGCTCGATA
TCAACTCACCGGGTGGTTCGCCTGTACAGTCAGATGAAATCTGGCAGACTATGATGGATTTGCGTAAAGAATATCCAGAT
AAAAAGCTTTATGCAGTGATTGGCGATATGGGTGCTTCTGGCGCGTATTATATCGCATCAGCGGCTGATGAGATTTATGT
CAACCCATCAAGCCTAGTCGGTTCGATCGGCGTCATTATGCCAAGCTATAATGTAAAAGGCTTGATGGACAAGGTCGGCG
TAGAAGATCTCACCATTACAGCAGGTGAATATAAAGATATCTTGAGCCTGTCACGTCCCCTAACGGATTATGAAGAAAAG
CATGTTGAAAAAGTGCTAGACAATACTCATAAGCATTTTATCAATGCCGTAAAAGAAGGTCGTGGCGATCGTCTAAAAAA
TCCTGAACAAAATAAGCTGTTTTCGGGATTGTTTTGGACAGGTGAGCAATCTATCGAGTTTGGCTTGGCGGATAAAAAAG
GCAGTATTTCAAGTTTAGAGAAGCAGCTTAAATTAAATAACGTGGTTAATTATACGCCAAGTGATCCGTTCCAATTATTT
ATGGATCGCTTCGCCGTTAAATTGGGCGCAGGTGTGGGTTCAAGCATCAATCTTGATCTCTTGCCACAAGAAGAAGGCAA
CGCGCAGATGCGTTAA

Upstream 100 bases:

>100_bases
TCATACAGAAAACTTAAACAGTAAGAATCTCGAATTTTCTGTCGTAAGTTTATATAATCTGTCTTTTATCGTTTTACATT
GTTTCTACTTAGGAAGTTAT

Downstream 100 bases:

>100_bases
TAGACTTTAATTTTTAGCGTTACCGTGTATGATTGTTAAGGCTGAGCGTATGATTACGCTCAGCCTTATTTATGTGTCGC
TATCTAGCATTTAAAACCAT

Product: signal peptide peptidase SppA, 36K type

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MPNWPPDPNKRPDNSANQPAPMQQSNQPSGQEWRLIENTLLASVVEQRRARRWSIFFKLLTFGYILLIFLTIGRSCSTEA
PTGLDGIDTSKPHLAVVELQGTISSGDVANAYDVNDALTRAFKNSNSKAVALDINSPGGSPVQSDEIWQTMMDLRKEYPD
KKLYAVIGDMGASGAYYIASAADEIYVNPSSLVGSIGVIMPSYNVKGLMDKVGVEDLTITAGEYKDILSLSRPLTDYEEK
HVEKVLDNTHKHFINAVKEGRGDRLKNPEQNKLFSGLFWTGEQSIEFGLADKKGSISSLEKQLKLNNVVNYTPSDPFQLF
MDRFAVKLGAGVGSSINLDLLPQEEGNAQMR

Sequences:

>Translated_351_residues
MPNWPPDPNKRPDNSANQPAPMQQSNQPSGQEWRLIENTLLASVVEQRRARRWSIFFKLLTFGYILLIFLTIGRSCSTEA
PTGLDGIDTSKPHLAVVELQGTISSGDVANAYDVNDALTRAFKNSNSKAVALDINSPGGSPVQSDEIWQTMMDLRKEYPD
KKLYAVIGDMGASGAYYIASAADEIYVNPSSLVGSIGVIMPSYNVKGLMDKVGVEDLTITAGEYKDILSLSRPLTDYEEK
HVEKVLDNTHKHFINAVKEGRGDRLKNPEQNKLFSGLFWTGEQSIEFGLADKKGSISSLEKQLKLNNVVNYTPSDPFQLF
MDRFAVKLGAGVGSSINLDLLPQEEGNAQMR
>Mature_350_residues
PNWPPDPNKRPDNSANQPAPMQQSNQPSGQEWRLIENTLLASVVEQRRARRWSIFFKLLTFGYILLIFLTIGRSCSTEAP
TGLDGIDTSKPHLAVVELQGTISSGDVANAYDVNDALTRAFKNSNSKAVALDINSPGGSPVQSDEIWQTMMDLRKEYPDK
KLYAVIGDMGASGAYYIASAADEIYVNPSSLVGSIGVIMPSYNVKGLMDKVGVEDLTITAGEYKDILSLSRPLTDYEEKH
VEKVLDNTHKHFINAVKEGRGDRLKNPEQNKLFSGLFWTGEQSIEFGLADKKGSISSLEKQLKLNNVVNYTPSDPFQLFM
DRFAVKLGAGVGSSINLDLLPQEEGNAQMR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=168, Percent_Identity=32.7380952380952, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787527, Length=209, Percent_Identity=31.5789473684211, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 38707; Mature: 38576

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNWPPDPNKRPDNSANQPAPMQQSNQPSGQEWRLIENTLLASVVEQRRARRWSIFFKLL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFGYILLIFLTIGRSCSTEAPTGLDGIDTSKPHLAVVELQGTISSGDVANAYDVNDALTR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHH
AFKNSNSKAVALDINSPGGSPVQSDEIWQTMMDLRKEYPDKKLYAVIGDMGASGAYYIAS
HHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEE
AADEIYVNPSSLVGSIGVIMPSYNVKGLMDKVGVEDLTITAGEYKDILSLSRPLTDYEEK
CCCEEEECHHHHHHHHHHEECCCCHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCHHHHH
HVEKVLDNTHKHFINAVKEGRGDRLKNPEQNKLFSGLFWTGEQSIEFGLADKKGSISSLE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEECCCCCEEECCCCCCCCHHHHH
KQLKLNNVVNYTPSDPFQLFMDRFAVKLGAGVGSSINLDLLPQEEGNAQMR
HHHHHHCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
PNWPPDPNKRPDNSANQPAPMQQSNQPSGQEWRLIENTLLASVVEQRRARRWSIFFKLL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFGYILLIFLTIGRSCSTEAPTGLDGIDTSKPHLAVVELQGTISSGDVANAYDVNDALTR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHH
AFKNSNSKAVALDINSPGGSPVQSDEIWQTMMDLRKEYPDKKLYAVIGDMGASGAYYIAS
HHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEE
AADEIYVNPSSLVGSIGVIMPSYNVKGLMDKVGVEDLTITAGEYKDILSLSRPLTDYEEK
CCCEEEECHHHHHHHHHHEECCCCHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCHHHHH
HVEKVLDNTHKHFINAVKEGRGDRLKNPEQNKLFSGLFWTGEQSIEFGLADKKGSISSLE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEECCCCCEEECCCCCCCCHHHHH
KQLKLNNVVNYTPSDPFQLFMDRFAVKLGAGVGSSINLDLLPQEEGNAQMR
HHHHHHCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA