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The map label for this gene is mutM [H]

Identifier: 93005206

GI number: 93005206

Start: 455538

End: 456461

Strand: Reverse

Name: mutM [H]

Synonym: Pcryo_0376

Alternate gene names: 93005206

Gene position: 456461-455538 (Counterclockwise)

Preceding gene: 93005207

Following gene: 93005205

Centisome position: 14.92

GC content: 41.13

Gene sequence:

>924_bases
ATGCCTGAGTTACCAGAAGTAGAAACGACAAAAACCAGTCTGACGCCTTTATTAGGACAAAAAGTCACCAACGTACAAGT
CTTTCAACCAAAGCTTCGTTGGTCGATGCCTGATAATTTATCAGATTTGATTGATTATACATTGGACAGCGTTGAGCGAC
GGGCAAAGTATTTAATCCTCAATTTTATACCGCTAGCTGATGATGGCATTTCATCTTCTGTTGAACCTAGGAATTTACAG
CCGAAACAGCTTCTGATTCATCTTGGGATGTCAGGTAGCTTGCAACAACATCATCATACTAGCGATAAGCGCAAACATGA
TCATTTGATCATGAGTTTTATCGGCGCTGACGACACTCAAACTCAGCTACATTATTATGACCCTAGACGTTTCGGCTCTA
TCTTATGGCTTGAGGATTACGGGGATAAACTACTAAACCATTTAGGACCTGAGCCACTATCAGATGATTTTACGGCAGAC
TATTTGTATTATCTTATCCAACGTAGCGAACAGTCCATCCAGACTCAAAGCAGCAAAGTGATTAAAAAGCAGCCTATCAA
ACGAGCCATCAAGTCAGTCATTATGGAGCAGCAAGCTGTGGTCGGCGTTGGTAATATTTATGCCACTGAGAGCTTATACC
TCTCAGGCATCCATCCTGCTACTCCAGCAAATAAGATATCATATGATCAAATAGTAATTTTAGTCGCCCATATCAAAACT
ATTTTACAGAAAGCTATCAAGCTAGGTGGTTCAACACTACGTGACTTTACGGTTGCTGATGGTCAAACAGGTTATTTCCA
GCAAACCTTGAATGTCTATGGTAGACAAGGTGAAACTTGTCCGCACTGTGATTCAGTTTTAGAGAATATCAAGCTCAATG
GACGTGCCAGTGTCTACTGCCCTGTTTGTCAGCCAATTAATTAG

Upstream 100 bases:

>100_bases
GTTACTTGCTAAGCTTGAACAACAGCATGGTATCTTACATGCTCGCCGCGCTGTTGCCTGATAATACCTTTAATTCTTAA
TAGAGATTTTATAAAATACT

Downstream 100 bases:

>100_bases
ATCTGGATTTCCCAATATTAATTTTTTTATTCAATATTCACTTAAATAGACCAGTTCGCCACTCTTTAACTACTTGTCAT
TAAAATAGAGCAATTAATAA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MPELPEVETTKTSLTPLLGQKVTNVQVFQPKLRWSMPDNLSDLIDYTLDSVERRAKYLILNFIPLADDGISSSVEPRNLQ
PKQLLIHLGMSGSLQQHHHTSDKRKHDHLIMSFIGADDTQTQLHYYDPRRFGSILWLEDYGDKLLNHLGPEPLSDDFTAD
YLYYLIQRSEQSIQTQSSKVIKKQPIKRAIKSVIMEQQAVVGVGNIYATESLYLSGIHPATPANKISYDQIVILVAHIKT
ILQKAIKLGGSTLRDFTVADGQTGYFQQTLNVYGRQGETCPHCDSVLENIKLNGRASVYCPVCQPIN

Sequences:

>Translated_307_residues
MPELPEVETTKTSLTPLLGQKVTNVQVFQPKLRWSMPDNLSDLIDYTLDSVERRAKYLILNFIPLADDGISSSVEPRNLQ
PKQLLIHLGMSGSLQQHHHTSDKRKHDHLIMSFIGADDTQTQLHYYDPRRFGSILWLEDYGDKLLNHLGPEPLSDDFTAD
YLYYLIQRSEQSIQTQSSKVIKKQPIKRAIKSVIMEQQAVVGVGNIYATESLYLSGIHPATPANKISYDQIVILVAHIKT
ILQKAIKLGGSTLRDFTVADGQTGYFQQTLNVYGRQGETCPHCDSVLENIKLNGRASVYCPVCQPIN
>Mature_306_residues
PELPEVETTKTSLTPLLGQKVTNVQVFQPKLRWSMPDNLSDLIDYTLDSVERRAKYLILNFIPLADDGISSSVEPRNLQP
KQLLIHLGMSGSLQQHHHTSDKRKHDHLIMSFIGADDTQTQLHYYDPRRFGSILWLEDYGDKLLNHLGPEPLSDDFTADY
LYYLIQRSEQSIQTQSSKVIKKQPIKRAIKSVIMEQQAVVGVGNIYATESLYLSGIHPATPANKISYDQIVILVAHIKTI
LQKAIKLGGSTLRDFTVADGQTGYFQQTLNVYGRQGETCPHCDSVLENIKLNGRASVYCPVCQPIN

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=308, Percent_Identity=41.5584415584416, Blast_Score=213, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 34591; Mature: 34460

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETTKTSLTPLLGQKVTNVQVFQPKLRWSMPDNLSDLIDYTLDSVERRAKYLIL
CCCCCCCCCCHHHHHHHHHCCCCCEEEECHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEE
NFIPLADDGISSSVEPRNLQPKQLLIHLGMSGSLQQHHHTSDKRKHDHLIMSFIGADDTQ
EEEECCCCCCCCCCCCCCCCHHHHHEECCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCC
TQLHYYDPRRFGSILWLEDYGDKLLNHLGPEPLSDDFTADYLYYLIQRSEQSIQTQSSKV
CEEEEECHHHHCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IKKQPIKRAIKSVIMEQQAVVGVGNIYATESLYLSGIHPATPANKISYDQIVILVAHIKT
HHHHHHHHHHHHHHHHHHHHEECCCEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ILQKAIKLGGSTLRDFTVADGQTGYFQQTLNVYGRQGETCPHCDSVLENIKLNGRASVYC
HHHHHHHHCCCHHHEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEE
PVCQPIN
CCCCCCC
>Mature Secondary Structure 
PELPEVETTKTSLTPLLGQKVTNVQVFQPKLRWSMPDNLSDLIDYTLDSVERRAKYLIL
CCCCCCCCCHHHHHHHHHCCCCCEEEECHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEE
NFIPLADDGISSSVEPRNLQPKQLLIHLGMSGSLQQHHHTSDKRKHDHLIMSFIGADDTQ
EEEECCCCCCCCCCCCCCCCHHHHHEECCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCC
TQLHYYDPRRFGSILWLEDYGDKLLNHLGPEPLSDDFTADYLYYLIQRSEQSIQTQSSKV
CEEEEECHHHHCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IKKQPIKRAIKSVIMEQQAVVGVGNIYATESLYLSGIHPATPANKISYDQIVILVAHIKT
HHHHHHHHHHHHHHHHHHHHEECCCEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ILQKAIKLGGSTLRDFTVADGQTGYFQQTLNVYGRQGETCPHCDSVLENIKLNGRASVYC
HHHHHHHHCCCHHHEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEE
PVCQPIN
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA