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The map label for this gene is dxs [H]

Identifier: 93005076

GI number: 93005076

Start: 287484

End: 289526

Strand: Direct

Name: dxs [H]

Synonym: Pcryo_0245

Alternate gene names: 93005076

Gene position: 287484-289526 (Clockwise)

Preceding gene: 93005072

Following gene: 93005077

Centisome position: 9.4

GC content: 46.79

Gene sequence:

>2043_bases
ATGCAGCAGTCACCTCATTCCCCACAGTCTCAGTCATTATCTGCGTCAGCTGTTGATTCTGCTGTACCGCTATCAAAACT
GCAACAAACGTATGCAGTGATTCCACGTGAGCGTCCGCAGACGCCATTGCTCGACAGTGTGGATAGTCCTGCTGATCTCA
AGACTTTTAGCAGTGCTGAGCTGATTACTTTAGCCGATGAGCTAAGGCTGTTTGTATTGTATTCAGCGGGTCAAAGCGGT
GGTCATTTCGGTGCCAATTTAGGCGTGATTGAATTGACTATTGCGCTACATTATTTGCTAGACACCCCACAAGATCAGAT
CGTTTGGGATGTGGGTCACCAAGCGTATGCGCACAAAGTACTGACAGGTCGCCGTGATCAGTTAGGTACTATCCGCTCTA
AAACTGGCTTAACGGCTTTTCCCGAACGTGCCGAATCTGTCTATGATACCTTTGGGGTTGGGCATTCATCAACGTCCATC
TCAGCCGGTTTAGGCATGAGCTTAGCGCTACGCTATCAAGGGCGCGCGCAGACGGTTGCCTGTATTATCGGCGATGGGGC
GATGACAGGTGGCATGGCGTTTGAAGCGATGAATGACGCGGTGCAACAAGACGCTGATTTGATGGTGATTTTGAATGACA
ATGACATGTCTATATCCTGCTCGATCGGTGGCTTTTCACGGCATTTAGCAATGCTTTGGGAGTCAGGGTATCAAGTTGAT
ATCTCTGATGCAGGCGAGCCAATATTATGTCAACGCCCTGATATGCAAGCCTTTGACCGACGTAAGCGTCATAAAGAGCA
GCGCGATGTACCGCAACTAGAAGACAATCTATTTAAGGCGATAGGCTTTACCTATTTTGGTCCTTTTGATGGTCATAATA
TTCCTGAGCTGCTACGTGTATTGTCGCTTGCCAAGCAAGTCAAAGGTCCAGTTCTGGTCCATATTTATACTACCAAAGGT
AAAGGCTTTGCGCCTGCTGAATTAGACCCAGTCGGCTATCATGCTATTAGTAGCTTACCTGCTGAAGATAACGCACCAAA
AACTGAAAAAGCAGCGATTAAACCTTCCTTAAAGTACTCGCAAGTATTTGGACAGTTTTTATGTGACAAAGCGGCACAAG
ATAAGAAGCTGCTCGCCATTACCCCAGCGATGGAAGAAGGCTCAGGGATGATTGAGTTTGCTCGTCAATTTCCAGAGCGT
TTCTTTGATGTAGCGATTGCTGAGCAACACGCTGTGACGTTGGCGGGTGGCATGGCAACACAAGGTGTAAAGCCGATTGT
GGCGATTTATTCGACGTTTTTACAGCGTGGGTACGATCAGCTGATACATGATGTTGCTTTGCAAAATCTTGATGTGATGT
TCGCCATTGATCGCGCCGGCCTAGTTGGTGAAGATGGCGCTACGCATGCAGGGGTGTTTGATTTTGCCTTTTTACGCTGC
GTGCCCAATATGCTGATTGCAGCGCCAAAAGATGAAAACGAATGCTATCATTTGCTCAATACTTGTTATGAATACCAAGG
TTGTACCGCAGTGCGCTATCCGCGCGGTGTTGGCACTGGTGCAACTATTATACAACCAGCGCAAATTTACAACATTGGTG
AGGCGGTTATAGAGTCGGTACTTGGTACAGACGATGCACCCAAGAAACTGGCATTATTGGCATTTGGTACGATGGTCGAA
ACGGCTCAGAAAGCCGCAGAAATGATTGCGAAATCCCCTTTATTAGCATCAAGCTGTCAGCTGCATGTGGTCAATATGCG
TTGGGTGAAGCCTTTAGATACTAACTTGCTTGAAACCCTAGTCGAGCAAGGTGTTACTCATATAGCGACTTTAGAAGAGC
ATATGATCATGGGCGGCGCGGGTAGTGCGGTCAATGAATACCTATTAAATGAATCGGCTGCTTTTAAAATCCATCGTCCA
ACTATCTGCAATATAGGTATCCCTGATCGGTTTGTTGCGCATGGCTCTCAAGCAGAACAGCTAGCAGATTGTGGTCTAGA
TGTGGAAGGTGTGTTCAATCAGCTCCAAAACTTATTATCTTAA

Upstream 100 bases:

>100_bases
GGATGGCATGGCTATTATTAACGCCACTTAGACTATTGCTATTGCTAGACCTTGTCTAAGGTAGCATCTGGTCAGCAGAT
TGGTAGGTATCGTACGTTTT

Downstream 100 bases:

>100_bases
CTAATGTGGCTTAAGGTTTAAAAGACGATTAATCATCTATCTGCTACATTATAAAAATAATAAATACCCATAGTCCGTAA
AAAGTTGATAAAATAGCTGT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 680; Mature: 680

Protein sequence:

>680_residues
MQQSPHSPQSQSLSASAVDSAVPLSKLQQTYAVIPRERPQTPLLDSVDSPADLKTFSSAELITLADELRLFVLYSAGQSG
GHFGANLGVIELTIALHYLLDTPQDQIVWDVGHQAYAHKVLTGRRDQLGTIRSKTGLTAFPERAESVYDTFGVGHSSTSI
SAGLGMSLALRYQGRAQTVACIIGDGAMTGGMAFEAMNDAVQQDADLMVILNDNDMSISCSIGGFSRHLAMLWESGYQVD
ISDAGEPILCQRPDMQAFDRRKRHKEQRDVPQLEDNLFKAIGFTYFGPFDGHNIPELLRVLSLAKQVKGPVLVHIYTTKG
KGFAPAELDPVGYHAISSLPAEDNAPKTEKAAIKPSLKYSQVFGQFLCDKAAQDKKLLAITPAMEEGSGMIEFARQFPER
FFDVAIAEQHAVTLAGGMATQGVKPIVAIYSTFLQRGYDQLIHDVALQNLDVMFAIDRAGLVGEDGATHAGVFDFAFLRC
VPNMLIAAPKDENECYHLLNTCYEYQGCTAVRYPRGVGTGATIIQPAQIYNIGEAVIESVLGTDDAPKKLALLAFGTMVE
TAQKAAEMIAKSPLLASSCQLHVVNMRWVKPLDTNLLETLVEQGVTHIATLEEHMIMGGAGSAVNEYLLNESAAFKIHRP
TICNIGIPDRFVAHGSQAEQLADCGLDVEGVFNQLQNLLS

Sequences:

>Translated_680_residues
MQQSPHSPQSQSLSASAVDSAVPLSKLQQTYAVIPRERPQTPLLDSVDSPADLKTFSSAELITLADELRLFVLYSAGQSG
GHFGANLGVIELTIALHYLLDTPQDQIVWDVGHQAYAHKVLTGRRDQLGTIRSKTGLTAFPERAESVYDTFGVGHSSTSI
SAGLGMSLALRYQGRAQTVACIIGDGAMTGGMAFEAMNDAVQQDADLMVILNDNDMSISCSIGGFSRHLAMLWESGYQVD
ISDAGEPILCQRPDMQAFDRRKRHKEQRDVPQLEDNLFKAIGFTYFGPFDGHNIPELLRVLSLAKQVKGPVLVHIYTTKG
KGFAPAELDPVGYHAISSLPAEDNAPKTEKAAIKPSLKYSQVFGQFLCDKAAQDKKLLAITPAMEEGSGMIEFARQFPER
FFDVAIAEQHAVTLAGGMATQGVKPIVAIYSTFLQRGYDQLIHDVALQNLDVMFAIDRAGLVGEDGATHAGVFDFAFLRC
VPNMLIAAPKDENECYHLLNTCYEYQGCTAVRYPRGVGTGATIIQPAQIYNIGEAVIESVLGTDDAPKKLALLAFGTMVE
TAQKAAEMIAKSPLLASSCQLHVVNMRWVKPLDTNLLETLVEQGVTHIATLEEHMIMGGAGSAVNEYLLNESAAFKIHRP
TICNIGIPDRFVAHGSQAEQLADCGLDVEGVFNQLQNLLS
>Mature_680_residues
MQQSPHSPQSQSLSASAVDSAVPLSKLQQTYAVIPRERPQTPLLDSVDSPADLKTFSSAELITLADELRLFVLYSAGQSG
GHFGANLGVIELTIALHYLLDTPQDQIVWDVGHQAYAHKVLTGRRDQLGTIRSKTGLTAFPERAESVYDTFGVGHSSTSI
SAGLGMSLALRYQGRAQTVACIIGDGAMTGGMAFEAMNDAVQQDADLMVILNDNDMSISCSIGGFSRHLAMLWESGYQVD
ISDAGEPILCQRPDMQAFDRRKRHKEQRDVPQLEDNLFKAIGFTYFGPFDGHNIPELLRVLSLAKQVKGPVLVHIYTTKG
KGFAPAELDPVGYHAISSLPAEDNAPKTEKAAIKPSLKYSQVFGQFLCDKAAQDKKLLAITPAMEEGSGMIEFARQFPER
FFDVAIAEQHAVTLAGGMATQGVKPIVAIYSTFLQRGYDQLIHDVALQNLDVMFAIDRAGLVGEDGATHAGVFDFAFLRC
VPNMLIAAPKDENECYHLLNTCYEYQGCTAVRYPRGVGTGATIIQPAQIYNIGEAVIESVLGTDDAPKKLALLAFGTMVE
TAQKAAEMIAKSPLLASSCQLHVVNMRWVKPLDTNLLETLVEQGVTHIATLEEHMIMGGAGSAVNEYLLNESAAFKIHRP
TICNIGIPDRFVAHGSQAEQLADCGLDVEGVFNQLQNLLS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=567, Percent_Identity=22.7513227513227, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4507521, Length=567, Percent_Identity=22.7513227513227, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI225637463, Length=505, Percent_Identity=21.980198019802, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI225637459, Length=505, Percent_Identity=21.980198019802, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI225637461, Length=235, Percent_Identity=27.2340425531915, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI133778974, Length=535, Percent_Identity=22.2429906542056, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786622, Length=648, Percent_Identity=47.9938271604938, Blast_Score=596, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24666278, Length=581, Percent_Identity=23.2358003442341, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24645119, Length=462, Percent_Identity=23.3766233766234, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45551847, Length=466, Percent_Identity=23.175965665236, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45550715, Length=466, Percent_Identity=23.175965665236, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 73734; Mature: 73734

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQSPHSPQSQSLSASAVDSAVPLSKLQQTYAVIPRERPQTPLLDSVDSPADLKTFSSAE
CCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCH
LITLADELRLFVLYSAGQSGGHFGANLGVIELTIALHYLLDTPQDQIVWDVGHQAYAHKV
HEEEHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHEEEECCHHHHHHHH
LTGRRDQLGTIRSKTGLTAFPERAESVYDTFGVGHSSTSISAGLGMSLALRYQGRAQTVA
HCCCCHHHCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCEEE
CIIGDGAMTGGMAFEAMNDAVQQDADLMVILNDNDMSISCSIGGFSRHLAMLWESGYQVD
EEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHCCCEEE
ISDAGEPILCQRPDMQAFDRRKRHKEQRDVPQLEDNLFKAIGFTYFGPFDGHNIPELLRV
ECCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCCCCCHHHHHHH
LSLAKQVKGPVLVHIYTTKGKGFAPAELDPVGYHAISSLPAEDNAPKTEKAAIKPSLKYS
HHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHCCCCCHHH
QVFGQFLCDKAAQDKKLLAITPAMEEGSGMIEFARQFPERFFDVAIAEQHAVTLAGGMAT
HHHHHHHHHHCCCCCEEEEEECCHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHH
QGVKPIVAIYSTFLQRGYDQLIHDVALQNLDVMFAIDRAGLVGEDGATHAGVFDFAFLRC
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
VPNMLIAAPKDENECYHLLNTCYEYQGCTAVRYPRGVGTGATIIQPAQIYNIGEAVIESV
HHHHHEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEECCHHHHHHHHHHHHHH
LGTDDAPKKLALLAFGTMVETAQKAAEMIAKSPLLASSCQLHVVNMRWVKPLDTNLLETL
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHHH
VEQGVTHIATLEEHMIMGGAGSAVNEYLLNESAAFKIHRPTICNIGIPDRFVAHGSQAEQ
HHCCCHHHHHHHHHHEECCCCHHHHHHHHCCCCEEEEECCEEEECCCCHHHHHCCCHHHH
LADCGLDVEGVFNQLQNLLS
HHHCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MQQSPHSPQSQSLSASAVDSAVPLSKLQQTYAVIPRERPQTPLLDSVDSPADLKTFSSAE
CCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCH
LITLADELRLFVLYSAGQSGGHFGANLGVIELTIALHYLLDTPQDQIVWDVGHQAYAHKV
HEEEHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHEEEECCHHHHHHHH
LTGRRDQLGTIRSKTGLTAFPERAESVYDTFGVGHSSTSISAGLGMSLALRYQGRAQTVA
HCCCCHHHCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCEEE
CIIGDGAMTGGMAFEAMNDAVQQDADLMVILNDNDMSISCSIGGFSRHLAMLWESGYQVD
EEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHCCCEEE
ISDAGEPILCQRPDMQAFDRRKRHKEQRDVPQLEDNLFKAIGFTYFGPFDGHNIPELLRV
ECCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCCCCCHHHHHHH
LSLAKQVKGPVLVHIYTTKGKGFAPAELDPVGYHAISSLPAEDNAPKTEKAAIKPSLKYS
HHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHCCCCCHHH
QVFGQFLCDKAAQDKKLLAITPAMEEGSGMIEFARQFPERFFDVAIAEQHAVTLAGGMAT
HHHHHHHHHHCCCCCEEEEEECCHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHH
QGVKPIVAIYSTFLQRGYDQLIHDVALQNLDVMFAIDRAGLVGEDGATHAGVFDFAFLRC
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
VPNMLIAAPKDENECYHLLNTCYEYQGCTAVRYPRGVGTGATIIQPAQIYNIGEAVIESV
HHHHHEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEECCHHHHHHHHHHHHHH
LGTDDAPKKLALLAFGTMVETAQKAAEMIAKSPLLASSCQLHVVNMRWVKPLDTNLLETL
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHHH
VEQGVTHIATLEEHMIMGGAGSAVNEYLLNESAAFKIHRPTICNIGIPDRFVAHGSQAEQ
HHCCCHHHHHHHHHHEECCCCHHHHHHHHCCCCEEEEECCEEEECCCCHHHHHCCCHHHH
LADCGLDVEGVFNQLQNLLS
HHHCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA