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The map label for this gene is lysA [H]

Identifier: 93005050

GI number: 93005050

Start: 262434

End: 263765

Strand: Direct

Name: lysA [H]

Synonym: Pcryo_0219

Alternate gene names: 93005050

Gene position: 262434-263765 (Clockwise)

Preceding gene: 93005049

Following gene: 93005051

Centisome position: 8.58

GC content: 45.72

Gene sequence:

>1332_bases
ATGAGTCAGTCAGTCACGACCCAAACTGAGCAAGGCCTGTACATCAATCCTGAAGCCTTAACCGCCCATTTGCCTGAACT
ACATTATCAAAATAATACGCTACATATGGAGCAAGTCAGTATTACCGAAGTGGTTAAACACTATGGTACGCCTTGTTATG
TGTACTCAAAGCAAGCCATTTTGGATGTCTATCAAGCTTATACCGATAGCTTTGCCAGCTTAACTCACCAGATTTGCTAT
GCGGTAAAAGCAAACTCAAACCTTGCGGTACTTGGCGTATTGGCGCAAGCAGGCGCAGGGTTTGATATCGTTTCACGTGG
CGAGCTGATGCGGGTATTGGCGGCAGGGGGCGAAGCTACACGTGTGGTATTCTCAGGCGTCGGCAAAACCTATAGCGATA
TTGAATATGCGCTTAACCAAGGTATTGGTTGCTTTAATGTTGAGTCGATTAGCGAGCTGACTCTAATCAATGAAGTAGCC
GCGCAGCTTGATAAATCAGCGCCGATATCACTACGTGTCAATCCTGATGTAGATGCCAAAACCCATCCGTATATTTCAAC
AGGTCTCAAAGACAATAAATTCGGTATTGCTCACGAGGATGCGCTGGTCGTTTATCAACAAGCCGCCAAATTGTCTCATA
TCGATATCGTTGGTATTGACTGTCATATCGGCTCGCAGTTGACTGAAGTTGCGCCATTCGTTGCGGCATTGGACAAAGTG
ATTGAGCTGGTGCATAGCTTACGTAAAGCAGGTATTGAGCTGCGTCATATCGATTTGGGTGGTGGTCTGGGTGTGCGTTA
TATTGATGAGACGCCTGTGTCTATTGATGAATTTGCCAATGCGTTATTACCAAAACTTAGTGAGCTTGGCTTGACGGTAT
TCTTTGAGCCGGGTCGTAGTATCGTGGCAAATGCTGGGGTATTATTGACCAAGGTTGACGTGCTCAAACCAACTGAGCAT
AAGAATTTTGCCATTGTTGACGCGGCAATGAACGACTTAATTCGCCCTGCTTTATATCAAGCAGAAATGGCAGTAATTCC
AAACGTTTTGCCTAGTAATGGTATTAATACAGAAAGTACTGAGCCATGGGATATCGTCGGCGCTATCTGTGAAACGGGTG
ATTTCTTAGCAAAAGATCGTTTGTTGTCGCTCTCAACAGGCGATATCTTGGCGATCACGGGTGCTGGTGCTTATGGCTTT
ACTATGAGTAGCAACTATAATTCACGCCCGCGAGCTAGTGAAGTCATGGTAGCTGATGATCGCCACCAGCTGATTCGCAA
ACGCGAAACCGTTGAAGCGCTATATGCAGACGAAGTATTGTGGCAAGGTTAA

Upstream 100 bases:

>100_bases
ACTAATAAGTAATCATGAATTCTTAAAATGTAAATGCTCAAACGATTTTTGAGCAAGCCCAATACTTTATTGTTACCTTG
ATTATATTAGAGATATTTAT

Downstream 100 bases:

>100_bases
CGGCTAAGCAGCATAAAGTATCTCAAAAATCTAACCCATTATCATAATGCTAGTGGGTTTTTTTATGGCAAATTTTGATC
AAACACCTGAATAATAAGTG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSQSVTTQTEQGLYINPEALTAHLPELHYQNNTLHMEQVSITEVVKHYGTPCYVYSKQAILDVYQAYTDSFASLTHQICY
AVKANSNLAVLGVLAQAGAGFDIVSRGELMRVLAAGGEATRVVFSGVGKTYSDIEYALNQGIGCFNVESISELTLINEVA
AQLDKSAPISLRVNPDVDAKTHPYISTGLKDNKFGIAHEDALVVYQQAAKLSHIDIVGIDCHIGSQLTEVAPFVAALDKV
IELVHSLRKAGIELRHIDLGGGLGVRYIDETPVSIDEFANALLPKLSELGLTVFFEPGRSIVANAGVLLTKVDVLKPTEH
KNFAIVDAAMNDLIRPALYQAEMAVIPNVLPSNGINTESTEPWDIVGAICETGDFLAKDRLLSLSTGDILAITGAGAYGF
TMSSNYNSRPRASEVMVADDRHQLIRKRETVEALYADEVLWQG

Sequences:

>Translated_443_residues
MSQSVTTQTEQGLYINPEALTAHLPELHYQNNTLHMEQVSITEVVKHYGTPCYVYSKQAILDVYQAYTDSFASLTHQICY
AVKANSNLAVLGVLAQAGAGFDIVSRGELMRVLAAGGEATRVVFSGVGKTYSDIEYALNQGIGCFNVESISELTLINEVA
AQLDKSAPISLRVNPDVDAKTHPYISTGLKDNKFGIAHEDALVVYQQAAKLSHIDIVGIDCHIGSQLTEVAPFVAALDKV
IELVHSLRKAGIELRHIDLGGGLGVRYIDETPVSIDEFANALLPKLSELGLTVFFEPGRSIVANAGVLLTKVDVLKPTEH
KNFAIVDAAMNDLIRPALYQAEMAVIPNVLPSNGINTESTEPWDIVGAICETGDFLAKDRLLSLSTGDILAITGAGAYGF
TMSSNYNSRPRASEVMVADDRHQLIRKRETVEALYADEVLWQG
>Mature_442_residues
SQSVTTQTEQGLYINPEALTAHLPELHYQNNTLHMEQVSITEVVKHYGTPCYVYSKQAILDVYQAYTDSFASLTHQICYA
VKANSNLAVLGVLAQAGAGFDIVSRGELMRVLAAGGEATRVVFSGVGKTYSDIEYALNQGIGCFNVESISELTLINEVAA
QLDKSAPISLRVNPDVDAKTHPYISTGLKDNKFGIAHEDALVVYQQAAKLSHIDIVGIDCHIGSQLTEVAPFVAALDKVI
ELVHSLRKAGIELRHIDLGGGLGVRYIDETPVSIDEFANALLPKLSELGLTVFFEPGRSIVANAGVLLTKVDVLKPTEHK
NFAIVDAAMNDLIRPALYQAEMAVIPNVLPSNGINTESTEPWDIVGAICETGDFLAKDRLLSLSTGDILAITGAGAYGFT
MSSNYNSRPRASEVMVADDRHQLIRKRETVEALYADEVLWQG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=360, Percent_Identity=26.6666666666667, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI22538418, Length=373, Percent_Identity=26.0053619302949, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI21361583, Length=373, Percent_Identity=26.0053619302949, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI16506287, Length=360, Percent_Identity=26.9444444444444, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789203, Length=415, Percent_Identity=32.5301204819277, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1789307, Length=261, Percent_Identity=26.0536398467433, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562780, Length=356, Percent_Identity=25.8426966292135, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322664, Length=370, Percent_Identity=23.7837837837838, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586474, Length=341, Percent_Identity=28.1524926686217, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586472, Length=342, Percent_Identity=26.0233918128655, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47990; Mature: 47859

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSVTTQTEQGLYINPEALTAHLPELHYQNNTLHMEQVSITEVVKHYGTPCYVYSKQAI
CCCCCCCCCCCCEEECHHHHHHHCCCCEECCCEEEEHHHHHHHHHHHCCCCEEEECHHHH
LDVYQAYTDSFASLTHQICYAVKANSNLAVLGVLAQAGAGFDIVSRGELMRVLAAGGEAT
HHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEHHHCCCCCCEECCHHHHHHHHCCCCEE
RVVFSGVGKTYSDIEYALNQGIGCFNVESISELTLINEVAAQLDKSAPISLRVNPDVDAK
EEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
THPYISTGLKDNKFGIAHEDALVVYQQAAKLSHIDIVGIDCHIGSQLTEVAPFVAALDKV
CCCCEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHH
IELVHSLRKAGIELRHIDLGGGLGVRYIDETPVSIDEFANALLPKLSELGLTVFFEPGRS
HHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCCH
IVANAGVLLTKVDVLKPTEHKNFAIVDAAMNDLIRPALYQAEMAVIPNVLPSNGINTEST
HHHCCCEEEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
EPWDIVGAICETGDFLAKDRLLSLSTGDILAITGAGAYGFTMSSNYNSRPRASEVMVADD
CCHHHHHHHHHCCCHHHHCCEEEECCCCEEEEECCCCEEEEECCCCCCCCCCCCEEEECC
RHQLIRKRETVEALYADEVLWQG
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQSVTTQTEQGLYINPEALTAHLPELHYQNNTLHMEQVSITEVVKHYGTPCYVYSKQAI
CCCCCCCCCCCEEECHHHHHHHCCCCEECCCEEEEHHHHHHHHHHHCCCCEEEECHHHH
LDVYQAYTDSFASLTHQICYAVKANSNLAVLGVLAQAGAGFDIVSRGELMRVLAAGGEAT
HHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEHHHCCCCCCEECCHHHHHHHHCCCCEE
RVVFSGVGKTYSDIEYALNQGIGCFNVESISELTLINEVAAQLDKSAPISLRVNPDVDAK
EEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
THPYISTGLKDNKFGIAHEDALVVYQQAAKLSHIDIVGIDCHIGSQLTEVAPFVAALDKV
CCCCEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHH
IELVHSLRKAGIELRHIDLGGGLGVRYIDETPVSIDEFANALLPKLSELGLTVFFEPGRS
HHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCCH
IVANAGVLLTKVDVLKPTEHKNFAIVDAAMNDLIRPALYQAEMAVIPNVLPSNGINTEST
HHHCCCEEEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
EPWDIVGAICETGDFLAKDRLLSLSTGDILAITGAGAYGFTMSSNYNSRPRASEVMVADD
CCHHHHHHHHHCCCHHHHCCEEEECCCCEEEEECCCCEEEEECCCCCCCCCCCCEEEECC
RHQLIRKRETVEALYADEVLWQG
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]