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The map label for this gene is uvrB [H]

Identifier: 92113956

GI number: 92113956

Start: 2087818

End: 2089848

Strand: Direct

Name: uvrB [H]

Synonym: Csal_1833

Alternate gene names: 92113956

Gene position: 2087818-2089848 (Clockwise)

Preceding gene: 92113955

Following gene: 92113957

Centisome position: 56.48

GC content: 60.91

Gene sequence:

>2031_bases
ATGAGCAAACCCTTTCGTATTCAGTCGCAGTATCGGCCCGCGGGTGACCAGCCAGCGGCTATCGACGGCCTGATAAAAGG
CTTCAATGCCGGGCTGGCGCATCAGACCCTGCTGGGGGTGACCGGCTCGGGAAAGACGTTCACCATGGCCAACGTGGTCG
AGCGCCTGCAGCGCCCGACCATCGTGATGGCGCCCAACAAGACGCTGGCCGCCCAGCTTTATGGCGAGTTCAAGAGTTTC
TTTCCCGACAATGCGGTGGAGTACTTCGTTTCCTATTACGATTACTACCAGCCGGAAGCCTATGTTCCCTCATCGGATAC
CTTCATCGAGAAGGACGCCTCGATCAATGACCATATCGAGCAGATGCGTCTTTCGGCCACCAAGGCACTGCTGGAGCGCC
GCGATGCCTTGATCGTGGTCTCGGTCTCGGCGATCTACGGCCTGGGCGATCCCGATCAATATCTGAAGATGCGTCTGCAC
TTCAATCGCGGCGAGTTGATCGACCAGCGCACCTTCCTGCGACGTCTCGCCGAGTTGCAGTACACGCGCAACGACATGGA
CTTTCGGCGAGGGACGTACCGGGTCCGGGGCGATGTCATCGACATCTTTCCCGCCGATGCGGAAGACGAGGCCGTCAGGG
TCGAGCTGTTCGACGACGAGATCGAGACGATCAGCCTGTTCGATCCTCTTACCGGGGAGGTGCGCGACAAGGTTCCGCGC
ATGACGATCTATCCCAAGAGTCACTACGTGACGCCTCGCGAGACGATTCTCGCCGCCGTCGAGGACATCAAGGTCGAGCT
GGCCGATCGCCTGGCCTGGATGCGCCAGCATGACAAGCTCGTCGAGGCTCAGCGGCTCGAGCAGCGCACCCTGTATGACA
TCGAGATGATGCTCGAACTCGGGTACTGCAACGGCATCGAGAACTACTCGCGCTATCTGTCGGGACGGGAGCCCGGCGAA
GCGCCGCCCACGTTCTTCGATTATCTGCCTGACGATACTCTGCTGTTCATCGACGAGTCCCACGTCAGCGTCCCGCAGGT
GGGGGGCATGTACAAGGGCGACCGTTCGCGCAAGGAAACTCTGGTCGAGTACGGCTTCCGCTTGCCTTCGGCACTGGACA
ACCGTCCGATGAAGTTCGAGGAATGGGAGCGCATTTGCCCGCAAACCGCGTTTGTGTCAGCGACACCGGGCCCTTACGAA
GCCGAGCATGCAGGGCAGGTGGTCGAGCAGGTCGTGCGGCCGACGGGGCTGGTCGATCCCGAAATCGAAGTCCGGCCGGC
ACAAACCCAGGTCGATGACCTGCTTTCCGAGATCAAGCTGCGAACCGACGTGGGCGAACGTGTCCTGGTCACGACATTGA
CCAAGCGCATGGCGGAGGATCTCACCGAGTATCTCGACGAGCACGACATTCGCGTGCGCTATCTGCACTCGGACATCGAC
ACCGTCGAGCGGATCGAAATCATACGCGATCTGCGCCTGGGCAAGTTCGATGTGCTCGTGGGGATCAACCTGCTGCGCGA
GGGGCTCGATATTCCCGAGGTCTCGTTGGTCGCGATTCTCGATGCCGACAAGGAAGGGTTCCTGCGTGCCGAGCGGTCGT
TGATCCAGACCATAGGGCGTGCGGCACGCAACGCGCATGGCAAGGCCATTCTCTACGGAGACCGTGTCACCAACTCGATG
CAGCGTGCCATCGACGAAACGGAACGGCGTCGCAACAAGCAGATCGCCTTCAACGAAGAGCACGGTATCACGCCCACGAC
GGTCACCAAGTCGGTTGCCGATATCATGGAAGGGGCCCAGACGCCCGGCAAGAAAGTCGGCCGCAAGCGTCCCGACAAGC
GGGTTGCCGAAGCGCCTGGCGACTACAGCAGCGAACAGCTCAACCAGATGGATGCAGCGGGCCTCACGCGGGAAATCGGC
AAGCTGGAGGATGCCATGCACGAGGCGGCGCAGAACCTGGAGTTCGAAGAGGCGGCACGCTTGCGCGATCAGTTGCAGTC
GTTGAAGGCCAGGCTGATCGAACTGGGGTGA

Upstream 100 bases:

>100_bases
CGGCTGATGACCGTCAGCGACGTGGAGATCACCACGCGGTCGGCCTGATCGACGTGGCTTTCGACTTGAAGGGTTCCCCT
ATCGACCTTATGTGAGACCC

Downstream 100 bases:

>100_bases
TCATGGATCGCTGACAGAGGCAAAGGCCCATGGCATCTCCCCATGGGCCTCTTCGTACCGATGCATGCACCCGCATGGAG
ATGGAGCAAAAATATATACC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MSKPFRIQSQYRPAGDQPAAIDGLIKGFNAGLAHQTLLGVTGSGKTFTMANVVERLQRPTIVMAPNKTLAAQLYGEFKSF
FPDNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQMRLSATKALLERRDALIVVSVSAIYGLGDPDQYLKMRLH
FNRGELIDQRTFLRRLAELQYTRNDMDFRRGTYRVRGDVIDIFPADAEDEAVRVELFDDEIETISLFDPLTGEVRDKVPR
MTIYPKSHYVTPRETILAAVEDIKVELADRLAWMRQHDKLVEAQRLEQRTLYDIEMMLELGYCNGIENYSRYLSGREPGE
APPTFFDYLPDDTLLFIDESHVSVPQVGGMYKGDRSRKETLVEYGFRLPSALDNRPMKFEEWERICPQTAFVSATPGPYE
AEHAGQVVEQVVRPTGLVDPEIEVRPAQTQVDDLLSEIKLRTDVGERVLVTTLTKRMAEDLTEYLDEHDIRVRYLHSDID
TVERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRAARNAHGKAILYGDRVTNSM
QRAIDETERRRNKQIAFNEEHGITPTTVTKSVADIMEGAQTPGKKVGRKRPDKRVAEAPGDYSSEQLNQMDAAGLTREIG
KLEDAMHEAAQNLEFEEAARLRDQLQSLKARLIELG

Sequences:

>Translated_676_residues
MSKPFRIQSQYRPAGDQPAAIDGLIKGFNAGLAHQTLLGVTGSGKTFTMANVVERLQRPTIVMAPNKTLAAQLYGEFKSF
FPDNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQMRLSATKALLERRDALIVVSVSAIYGLGDPDQYLKMRLH
FNRGELIDQRTFLRRLAELQYTRNDMDFRRGTYRVRGDVIDIFPADAEDEAVRVELFDDEIETISLFDPLTGEVRDKVPR
MTIYPKSHYVTPRETILAAVEDIKVELADRLAWMRQHDKLVEAQRLEQRTLYDIEMMLELGYCNGIENYSRYLSGREPGE
APPTFFDYLPDDTLLFIDESHVSVPQVGGMYKGDRSRKETLVEYGFRLPSALDNRPMKFEEWERICPQTAFVSATPGPYE
AEHAGQVVEQVVRPTGLVDPEIEVRPAQTQVDDLLSEIKLRTDVGERVLVTTLTKRMAEDLTEYLDEHDIRVRYLHSDID
TVERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRAARNAHGKAILYGDRVTNSM
QRAIDETERRRNKQIAFNEEHGITPTTVTKSVADIMEGAQTPGKKVGRKRPDKRVAEAPGDYSSEQLNQMDAAGLTREIG
KLEDAMHEAAQNLEFEEAARLRDQLQSLKARLIELG
>Mature_675_residues
SKPFRIQSQYRPAGDQPAAIDGLIKGFNAGLAHQTLLGVTGSGKTFTMANVVERLQRPTIVMAPNKTLAAQLYGEFKSFF
PDNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIEQMRLSATKALLERRDALIVVSVSAIYGLGDPDQYLKMRLHF
NRGELIDQRTFLRRLAELQYTRNDMDFRRGTYRVRGDVIDIFPADAEDEAVRVELFDDEIETISLFDPLTGEVRDKVPRM
TIYPKSHYVTPRETILAAVEDIKVELADRLAWMRQHDKLVEAQRLEQRTLYDIEMMLELGYCNGIENYSRYLSGREPGEA
PPTFFDYLPDDTLLFIDESHVSVPQVGGMYKGDRSRKETLVEYGFRLPSALDNRPMKFEEWERICPQTAFVSATPGPYEA
EHAGQVVEQVVRPTGLVDPEIEVRPAQTQVDDLLSEIKLRTDVGERVLVTTLTKRMAEDLTEYLDEHDIRVRYLHSDIDT
VERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRAARNAHGKAILYGDRVTNSMQ
RAIDETERRRNKQIAFNEEHGITPTTVTKSVADIMEGAQTPGKKVGRKRPDKRVAEAPGDYSSEQLNQMDAAGLTREIGK
LEDAMHEAAQNLEFEEAARLRDQLQSLKARLIELG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=678, Percent_Identity=70.6489675516224, Blast_Score=955, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=306, Percent_Identity=24.8366013071895, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76879; Mature: 76748

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPFRIQSQYRPAGDQPAAIDGLIKGFNAGLAHQTLLGVTGSGKTFTMANVVERLQRPT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHEEECCCCCEEEHHHHHHHHCCCE
IVMAPNKTLAAQLYGEFKSFFPDNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIE
EEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCHHHHHH
QMRLSATKALLERRDALIVVSVSAIYGLGDPDQYLKMRLHFNRGELIDQRTFLRRLAELQ
HHHHHHHHHHHHCCCCEEEEEEHHHHCCCCHHHHEEEEEECCCCHHHHHHHHHHHHHHHH
YTRNDMDFRRGTYRVRGDVIDIFPADAEDEAVRVELFDDEIETISLFDPLTGEVRDKVPR
HHCCCHHHHCCCEEEECCEEEEECCCCCCCEEEEEEECCCCCEEEECCCCCCHHHHCCCC
MTIYPKSHYVTPRETILAAVEDIKVELADRLAWMRQHDKLVEAQRLEQRTLYDIEMMLEL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYCNGIENYSRYLSGREPGEAPPTFFDYLPDDTLLFIDESHVSVPQVGGMYKGDRSRKET
HCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHH
LVEYGFRLPSALDNRPMKFEEWERICPQTAFVSATPGPYEAEHAGQVVEQVVRPTGLVDP
HHHHHCCCCHHHCCCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
EIEVRPAQTQVDDLLSEIKLRTDVGERVLVTTLTKRMAEDLTEYLDEHDIRVRYLHSDID
CCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH
TVERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
AARNAHGKAILYGDRVTNSMQRAIDETERRRNKQIAFNEEHGITPTTVTKSVADIMEGAQ
HHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHCCC
TPGKKVGRKRPDKRVAEAPGDYSSEQLNQMDAAGLTREIGKLEDAMHEAAQNLEFEEAAR
CCHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LRDQLQSLKARLIELG
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKPFRIQSQYRPAGDQPAAIDGLIKGFNAGLAHQTLLGVTGSGKTFTMANVVERLQRPT
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHEEECCCCCEEEHHHHHHHHCCCE
IVMAPNKTLAAQLYGEFKSFFPDNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDHIE
EEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCHHHHHH
QMRLSATKALLERRDALIVVSVSAIYGLGDPDQYLKMRLHFNRGELIDQRTFLRRLAELQ
HHHHHHHHHHHHCCCCEEEEEEHHHHCCCCHHHHEEEEEECCCCHHHHHHHHHHHHHHHH
YTRNDMDFRRGTYRVRGDVIDIFPADAEDEAVRVELFDDEIETISLFDPLTGEVRDKVPR
HHCCCHHHHCCCEEEECCEEEEECCCCCCCEEEEEEECCCCCEEEECCCCCCHHHHCCCC
MTIYPKSHYVTPRETILAAVEDIKVELADRLAWMRQHDKLVEAQRLEQRTLYDIEMMLEL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYCNGIENYSRYLSGREPGEAPPTFFDYLPDDTLLFIDESHVSVPQVGGMYKGDRSRKET
HCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHH
LVEYGFRLPSALDNRPMKFEEWERICPQTAFVSATPGPYEAEHAGQVVEQVVRPTGLVDP
HHHHHCCCCHHHCCCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
EIEVRPAQTQVDDLLSEIKLRTDVGERVLVTTLTKRMAEDLTEYLDEHDIRVRYLHSDID
CCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH
TVERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
AARNAHGKAILYGDRVTNSMQRAIDETERRRNKQIAFNEEHGITPTTVTKSVADIMEGAQ
HHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHCCC
TPGKKVGRKRPDKRVAEAPGDYSSEQLNQMDAAGLTREIGKLEDAMHEAAQNLEFEEAAR
CCHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LRDQLQSLKARLIELG
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8808952; 10984043; 8939432 [H]