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The map label for this gene is degP [H]

Identifier: 92113752

GI number: 92113752

Start: 1849516

End: 1850952

Strand: Direct

Name: degP [H]

Synonym: Csal_1628

Alternate gene names: 92113752

Gene position: 1849516-1850952 (Clockwise)

Preceding gene: 92113751

Following gene: 92113753

Centisome position: 50.03

GC content: 65.69

Gene sequence:

>1437_bases
ATGAAATATATCGCCCGTCATACCACGCTCTGGTGTCTTGCCCTGCTGACGCTTTTCACCGCTCAGCTCGCTCAGGCACG
CGACCTGCCGGACTTCACCCAGCTGGTGAAGGATGCCGCCCCCGGGGTCGTCAACATCTCCACCACCAGTACCGTCGAAT
CCCGGGGCATGGCCGGATCGCCGTTCGGCAGTCAGGACGTGCCCGACATCTTCCGGCACTTCTTCGGCGATCAGATGCCG
CCGATGATACCCGGGGCGCCGGGCTACGGCGGCAGTGAAGAGCGCCACTCCCTCGGCTCCGGTTTCGTCATCAGCCGCGA
CGGCTACATCATGACCAACGCCCACGTGGTCGACGGTGCCGACGAGATCGTGGTGCGCCTCAACGACCGTCGCGAGCTCG
AGGCCACGCTCGTGGGGGCCGACAAGAAAACCGACGTCGCCGTGCTCAAGGTCGATGCCGACGACTTGCCGGTACTCGAG
ATGGGAGACTCCGACGCTCTGGAAGTCGGTGAATGGGTCGCCGCCATCGGCTCGCCCTTCGGCTTCGATCATTCGGTGAC
CTCGGGCATCGTCAGCGCCATCGACCGTACGCTGCCCAGCGACGCCTATGTGCCGTTCATCCAGACCGACGTGGCGATCA
ACCCCGGCAATTCCGGCGGTCCGCTGTTCAACCTCGATGGCGAGGTCGTGGGTATCAACTCGCAGATCTATACCCGCAGT
GGCGGCTTCATGGGGGTGTCCTTCGCCATTCCCATCAACGTGGCGATGGATATCGCCGATCAGTTGAAGGACTCCGGGCA
TGTCAATCGCGGCTGGCTCGGCGTGGTGATTCAGCCGGTATCCCGTGACCTGGCGGAATCCTTCGGGCTCGACGGTCCGC
GCGGCGCGCTGATTTCCGATGTCACCGACGACAGCCCGGCAAGCCGTGCGGGACTCGAGGCGGGCGACGTGGTGCTGTCC
GTCAACGACGATCGCGTCGAGGATTCCAGCTCGTTGCCGCGTCTGGTGGGGCGTGTCGCGCCGGGCGAGGACATCACGCT
GACGGTGATGCGCGATGGCGAACGCCGCGATCTCGACGTGACCGTGGGCAGCTGGCCCGACGAGGGCAAGGCCGTGACGG
GGACGTCGAAGAAGGACGACAGCCAGGTGCGGCTCGGCATCGCCATCAGCGATCTGGATGAACCGATGCGCCGGCAACTG
GACGTCGACAGCGGCGTGCTGGTGCGCCAGGTCGACCCGCGTGGTGCGGCCGCCGCCGCCGGCCTGTCACGCGGCGATGT
CATCGTCAGCTTCAACGGCCAGGACATCGAGGATACCGATGCCCTGATGGAGGCGGTGAAGGACGCGCCCACCGATCGTG
CCGTGCCCGTGCGCATCGTGCGCGACGGCCAATCGTTGTTCGTGGCGCTGCGCCTGGAGACCGAAAAGCAGGAGTGA

Upstream 100 bases:

>100_bases
TGTCGCGGTCGGCCATGGTAGGTCGGCGAGACCCGCCGGCCATTGTCAATGCGACTCCTCGTTTGGTTAACGAGTCCACG
CTTTGTATCAGGAGTCTTTG

Downstream 100 bases:

>100_bases
CGCCCGCGGCAATGCTCACCACCTGAGGACGAGGCCCCGCCGAAGCGGGGCCTCGTCGTGTCCGGCAACGCGTCGATCGC
ACGCGCTTGCTGTCCATGTC

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKYIARHTTLWCLALLTLFTAQLAQARDLPDFTQLVKDAAPGVVNISTTSTVESRGMAGSPFGSQDVPDIFRHFFGDQMP
PMIPGAPGYGGSEERHSLGSGFVISRDGYIMTNAHVVDGADEIVVRLNDRRELEATLVGADKKTDVAVLKVDADDLPVLE
MGDSDALEVGEWVAAIGSPFGFDHSVTSGIVSAIDRTLPSDAYVPFIQTDVAINPGNSGGPLFNLDGEVVGINSQIYTRS
GGFMGVSFAIPINVAMDIADQLKDSGHVNRGWLGVVIQPVSRDLAESFGLDGPRGALISDVTDDSPASRAGLEAGDVVLS
VNDDRVEDSSSLPRLVGRVAPGEDITLTVMRDGERRDLDVTVGSWPDEGKAVTGTSKKDDSQVRLGIAISDLDEPMRRQL
DVDSGVLVRQVDPRGAAAAAGLSRGDVIVSFNGQDIEDTDALMEAVKDAPTDRAVPVRIVRDGQSLFVALRLETEKQE

Sequences:

>Translated_478_residues
MKYIARHTTLWCLALLTLFTAQLAQARDLPDFTQLVKDAAPGVVNISTTSTVESRGMAGSPFGSQDVPDIFRHFFGDQMP
PMIPGAPGYGGSEERHSLGSGFVISRDGYIMTNAHVVDGADEIVVRLNDRRELEATLVGADKKTDVAVLKVDADDLPVLE
MGDSDALEVGEWVAAIGSPFGFDHSVTSGIVSAIDRTLPSDAYVPFIQTDVAINPGNSGGPLFNLDGEVVGINSQIYTRS
GGFMGVSFAIPINVAMDIADQLKDSGHVNRGWLGVVIQPVSRDLAESFGLDGPRGALISDVTDDSPASRAGLEAGDVVLS
VNDDRVEDSSSLPRLVGRVAPGEDITLTVMRDGERRDLDVTVGSWPDEGKAVTGTSKKDDSQVRLGIAISDLDEPMRRQL
DVDSGVLVRQVDPRGAAAAAGLSRGDVIVSFNGQDIEDTDALMEAVKDAPTDRAVPVRIVRDGQSLFVALRLETEKQE
>Mature_478_residues
MKYIARHTTLWCLALLTLFTAQLAQARDLPDFTQLVKDAAPGVVNISTTSTVESRGMAGSPFGSQDVPDIFRHFFGDQMP
PMIPGAPGYGGSEERHSLGSGFVISRDGYIMTNAHVVDGADEIVVRLNDRRELEATLVGADKKTDVAVLKVDADDLPVLE
MGDSDALEVGEWVAAIGSPFGFDHSVTSGIVSAIDRTLPSDAYVPFIQTDVAINPGNSGGPLFNLDGEVVGINSQIYTRS
GGFMGVSFAIPINVAMDIADQLKDSGHVNRGWLGVVIQPVSRDLAESFGLDGPRGALISDVTDDSPASRAGLEAGDVVLS
VNDDRVEDSSSLPRLVGRVAPGEDITLTVMRDGERRDLDVTVGSWPDEGKAVTGTSKKDDSQVRLGIAISDLDEPMRRQL
DVDSGVLVRQVDPRGAAAAAGLSRGDVIVSFNGQDIEDTDALMEAVKDAPTDRAVPVRIVRDGQSLFVALRLETEKQE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=336, Percent_Identity=34.8214285714286, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI22129776, Length=255, Percent_Identity=38.0392156862745, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI24308541, Length=248, Percent_Identity=36.2903225806452, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI7019477, Length=266, Percent_Identity=38.3458646616541, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1786356, Length=456, Percent_Identity=34.4298245614035, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI1789629, Length=454, Percent_Identity=34.5814977973568, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789630, Length=278, Percent_Identity=37.7697841726619, Blast_Score=180, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24646839, Length=264, Percent_Identity=34.469696969697, Blast_Score=151, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50869; Mature: 50869

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYIARHTTLWCLALLTLFTAQLAQARDLPDFTQLVKDAAPGVVNISTTSTVESRGMAGS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCHHHCCCCCC
PFGSQDVPDIFRHFFGDQMPPMIPGAPGYGGSEERHSLGSGFVISRDGYIMTNAHVVDGA
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCEEEECCEEECCC
DEIVVRLNDRRELEATLVGADKKTDVAVLKVDADDLPVLEMGDSDALEVGEWVAAIGSPF
CEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHCCCC
GFDHSVTSGIVSAIDRTLPSDAYVPFIQTDVAINPGNSGGPLFNLDGEVVGINSQIYTRS
CCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCEEECCCCEEEECCEEEEEC
GGFMGVSFAIPINVAMDIADQLKDSGHVNRGWLGVVIQPVSRDLAESFGLDGPRGALISD
CCEEEEEEEEEEHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHCCCCCCCCEEEC
VTDDSPASRAGLEAGDVVLSVNDDRVEDSSSLPRLVGRVAPGEDITLTVMRDGERRDLDV
CCCCCCCHHCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEE
TVGSWPDEGKAVTGTSKKDDSQVRLGIAISDLDEPMRRQLDVDSGVLVRQVDPRGAAAAA
EECCCCCCCCEEECCCCCCCCEEEEEEEEHHCCHHHHHHCCCCCCEEEEEECCCCCHHHC
GLSRGDVIVSFNGQDIEDTDALMEAVKDAPTDRAVPVRIVRDGQSLFVALRLETEKQE
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEEEECCCCC
>Mature Secondary Structure
MKYIARHTTLWCLALLTLFTAQLAQARDLPDFTQLVKDAAPGVVNISTTSTVESRGMAGS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCHHHCCCCCC
PFGSQDVPDIFRHFFGDQMPPMIPGAPGYGGSEERHSLGSGFVISRDGYIMTNAHVVDGA
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCEEEECCEEECCC
DEIVVRLNDRRELEATLVGADKKTDVAVLKVDADDLPVLEMGDSDALEVGEWVAAIGSPF
CEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHCCCC
GFDHSVTSGIVSAIDRTLPSDAYVPFIQTDVAINPGNSGGPLFNLDGEVVGINSQIYTRS
CCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCEEECCCCEEEECCEEEEEC
GGFMGVSFAIPINVAMDIADQLKDSGHVNRGWLGVVIQPVSRDLAESFGLDGPRGALISD
CCEEEEEEEEEEHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHCCCCCCCCEEEC
VTDDSPASRAGLEAGDVVLSVNDDRVEDSSSLPRLVGRVAPGEDITLTVMRDGERRDLDV
CCCCCCCHHCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEE
TVGSWPDEGKAVTGTSKKDDSQVRLGIAISDLDEPMRRQLDVDSGVLVRQVDPRGAAAAA
EECCCCCCCCEEECCCCCCCCEEEEEEEEHHCCHHHHHHCCCCCCEEEEEECCCCCHHHC
GLSRGDVIVSFNGQDIEDTDALMEAVKDAPTDRAVPVRIVRDGQSLFVALRLETEKQE
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]