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The map label for this gene is mucA [H]

Identifier: 92113751

GI number: 92113751

Start: 1848409

End: 1849200

Strand: Direct

Name: mucA [H]

Synonym: Csal_1627

Alternate gene names: 92113751

Gene position: 1848409-1849200 (Clockwise)

Preceding gene: 92113750

Following gene: 92113752

Centisome position: 50.0

GC content: 68.69

Gene sequence:

>792_bases
ATGAATCAGAACGTGCGAGAGTCTTTTTCCGCGCTGATGGATAACGAAGGCGATGACCTGGAAATACGGCGTGCCTTGAA
GGCGCTGCAGGGCTCGCCCGAGGAAGCCGATACATGGCGGCGTTACCATCTGGCGCGCAGCATGATGCAGCGCGATCGCG
ATGTGGATGTCACGACCGATCTCTCCGCCGGCATCATGGCGCGGCTGGCCGACGAGCCCGCGCCGCAGGAAGCGCCGGCG
CCATCCACATCGCGCCGCGCCGCGCCGTTTTCCTTCGCCGGTAGTGCCGCCGTCGCGGCGGCGGTATCCCTGATGGTCAT
CACCGGCGTTCAGGTCTACAACGCCAACGCTCCGGGCGATGGCGAAGGCGCGGAGTTCGCCAGCAGCGACGCGGTCCCGG
GCCAGGGCGGCGCCGATGCGCAGCGCGCCTCGCTGACCAGCGCTCCCTCGGGCGGCGCCATGGTGACGCCGGCCGGCATG
GGGGGCGACGCCTCGGGGTTCCTGGCCTCTTCGGCAGGCAGCGGGCCGGTCTTTCCGAGCCTGGCACCGTCAGCGCCGGG
CGGCCTCATGGAGGCGGGCATGGACTCGCCGCTGTTCGCCGATCCCGATCACCAGTCCCAGCGCAGCGGCTATCAGTTCC
AGCGTAGCGACTACGAGCAGGTGCTCATGTTGCAGGCGTATCTGAATCAGCATGCCGACCAGTTCGCTGGCGATGGCGCG
GGCGATGCGTGGATGTCCAGCCACAGCGTGTCGGGTGGCCCGGAAGCGTCCGAGAGGGCGAGCCAGCGCTGA

Upstream 100 bases:

>100_bases
TTTCAGAACCGGTTTCAGGAGCTGTGTTGCCACATGCGAGCTGCTACGCAGCGCCCAATGGACGATGGGCATTCGTCTTG
TCGAATGTGAGGGTGTAGGT

Downstream 100 bases:

>100_bases
TGCGCCGGACGGCAAGGACACACGAATGACCCATGGGGCGCGCCGCGGATTGCCGGGTGCGCCCTTTTATCGTTCGGGCC
GGGGCGTGCGTGTCATGGAG

Product: negative regulator of sigma E activity-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MNQNVRESFSALMDNEGDDLEIRRALKALQGSPEEADTWRRYHLARSMMQRDRDVDVTTDLSAGIMARLADEPAPQEAPA
PSTSRRAAPFSFAGSAAVAAAVSLMVITGVQVYNANAPGDGEGAEFASSDAVPGQGGADAQRASLTSAPSGGAMVTPAGM
GGDASGFLASSAGSGPVFPSLAPSAPGGLMEAGMDSPLFADPDHQSQRSGYQFQRSDYEQVLMLQAYLNQHADQFAGDGA
GDAWMSSHSVSGGPEASERASQR

Sequences:

>Translated_263_residues
MNQNVRESFSALMDNEGDDLEIRRALKALQGSPEEADTWRRYHLARSMMQRDRDVDVTTDLSAGIMARLADEPAPQEAPA
PSTSRRAAPFSFAGSAAVAAAVSLMVITGVQVYNANAPGDGEGAEFASSDAVPGQGGADAQRASLTSAPSGGAMVTPAGM
GGDASGFLASSAGSGPVFPSLAPSAPGGLMEAGMDSPLFADPDHQSQRSGYQFQRSDYEQVLMLQAYLNQHADQFAGDGA
GDAWMSSHSVSGGPEASERASQR
>Mature_263_residues
MNQNVRESFSALMDNEGDDLEIRRALKALQGSPEEADTWRRYHLARSMMQRDRDVDVTTDLSAGIMARLADEPAPQEAPA
PSTSRRAAPFSFAGSAAVAAAVSLMVITGVQVYNANAPGDGEGAEFASSDAVPGQGGADAQRASLTSAPSGGAMVTPAGM
GGDASGFLASSAGSGPVFPSLAPSAPGGLMEAGMDSPLFADPDHQSQRSGYQFQRSDYEQVLMLQAYLNQHADQFAGDGA
GDAWMSSHSVSGGPEASERASQR

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucA causes a switch from the non- mucoid to mucoid state resulting in constitutive expression of alginate

COG id: COG3073

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseA family [H]

Homologues:

Organism=Escherichia coli, GI1788925, Length=124, Percent_Identity=37.0967741935484, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005573
- InterPro:   IPR005572 [H]

Pfam domain/function: PF03873 RseA_C; PF03872 RseA_N [H]

EC number: NA

Molecular weight: Translated: 27218; Mature: 27218

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNVRESFSALMDNEGDDLEIRRALKALQGSPEEADTWRRYHLARSMMQRDRDVDVTTD
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
LSAGIMARLADEPAPQEAPAPSTSRRAAPFSFAGSAAVAAAVSLMVITGVQVYNANAPGD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCC
GEGAEFASSDAVPGQGGADAQRASLTSAPSGGAMVTPAGMGGDASGFLASSAGSGPVFPS
CCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCCCCCCCEECCCCCCCCCCC
LAPSAPGGLMEAGMDSPLFADPDHQSQRSGYQFQRSDYEQVLMLQAYLNQHADQFAGDGA
CCCCCCCHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GDAWMSSHSVSGGPEASERASQR
CCHHHCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MNQNVRESFSALMDNEGDDLEIRRALKALQGSPEEADTWRRYHLARSMMQRDRDVDVTTD
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
LSAGIMARLADEPAPQEAPAPSTSRRAAPFSFAGSAAVAAAVSLMVITGVQVYNANAPGD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCC
GEGAEFASSDAVPGQGGADAQRASLTSAPSGGAMVTPAGMGGDASGFLASSAGSGPVFPS
CCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCCCCCCCEECCCCCCCCCCC
LAPSAPGGLMEAGMDSPLFADPDHQSQRSGYQFQRSDYEQVLMLQAYLNQHADQFAGDGA
CCCCCCCHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GDAWMSSHSVSGGPEASERASQR
CCHHHCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 10984043 [H]