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The map label for this gene is gap [H]

Identifier: 92113692

GI number: 92113692

Start: 1786993

End: 1788447

Strand: Direct

Name: gap [H]

Synonym: Csal_1568

Alternate gene names: 92113692

Gene position: 1786993-1788447 (Clockwise)

Preceding gene: 92113689

Following gene: 92113693

Centisome position: 48.34

GC content: 63.02

Gene sequence:

>1455_bases
GTGAGTCAACAAAAGCTCGAGACCTATTTTCAGGATTGGCAAGAAAACGAAGCCCTGGCCGAGGAGATGATTCCACTGCT
GGGTCGCCTGTATCGCAAGTACAATATCGTGCCTTCGCTTTACGGTCGGTCCCTGATCAATCGCTCGGTCATTCGTATTC
TCAAGAATCACCGCTATGTCAAAAAGGTCGAGGGCACCGAGCTGTCCGTGCGCGACACCCTGCCGATGGTCAAGGCCATG
ACCGAGCTCGACCTGGGGCCCGCGCACGTCGACATCGGCAAGCTCGGCGTGGCGTTCAAGCGCTCCGGACAGGACGACGT
CAAGGCGTTCCTCGAAACGGAGCTGGCGGATATCGTCGGCCGTCATGCCGATACCGGCATGGGGGGCGAGCCCAAGGATG
TGGTGCTCTACGGCTTCGGTCGCATCGGGCGTCTGCTGGCTCGCATCATGATCGAGAAGGCCGGGGGCGGCAACCTGCTG
CGCCTGCGGGCCATCGTGGTGCGCGGGGGCGGTGACGACCTCGAGAAGCGTGCCAGCCTGCTGCGCCGCGACAGCGTGCA
CGGGCCCTTCGCCGGGACGATCCGCGTCGATCACGACAACCAGGCCATCATCGCCAACGGCAACTACATTCAGGTCATTC
ACGCCGACGCGCCCCAGGACATCGATTATACCGCGTACGGGATCGACAATGCCCTGGTGGTCGACAACACCGGCAAGTGG
CGCGACGAGGAGGGGCTGTCCCAGCACCTGGCGTCGAAGGGCGTGGCCAAGGTGCTGCTGACGGCACCGGGCAAGGGCGG
CGTCAAGAACATCGTGCATGGCATCAACCATGACGAAATCACCGACGAGGATCGCGTGATTTCCGCCGCCTCCTGCACCA
CCAACGCCATCGTGCCGGTGCTCAAGGCCGTCAACGACGAGTTCGGCATCGTGCACGGGCATGTCGAGACGGTGCATGCC
TACACCAACGATCAAAACCTGATCGACAACTACCACAAGGGCGACCGCCGCGGTCGCAGCGCCGCGCTCAACATGGTGCT
GACCGAAACCGGTGCCGCCAAGGCGGTGGCCAAGGCGCTGCCGGAGCTGTCGGGCAAGCTGTCCGGCAACGCCATCCGCG
TGCCCACGCCGGACGTGTCCATGGCGATTCTCAACCTGACGCTGGACAAGGCGGCGGACCGTCAGGCATTGAACGAATAC
CTGCGGCAAATGGCCCTTCATTCGCGGATGCAGAAGCAGATCGACTACGTCGACTCCCCCGAGGTGGTGTCGTCGGACTT
CGTGGGCAATCGCCATGCCGGCATCGTCGATGCCCAGGCGACCATCGCCGACGACCGCCAGGTCGTGCTCTACGTCTGGT
ACGACAACGAGTTCGGCTACAGCTGCCAGGTGGTGCGCATCCTGCAGCACATGTCCAACGTGAGCTTCGTTTACCTCCCC
CGCGAACAGCACTGA

Upstream 100 bases:

>100_bases
GAATTACACCGCATGCGACCAAGCTGGCATTGCCAAGTCCGTGAAAGCCTACCGATAATGCGCGGGTTTTCGATCCCCCG
CTGCCGTGACGAGGCCCGCC

Downstream 100 bases:

>100_bases
AGCGCAGGCCGTTTCTCTCTCGTGGCGCCCCGGGTCTTCCCGGGGCGCTCGTCGTCGTCGGTATCATGCCGCGTAAGCCC
TATGCTTCCTATGGTTATGT

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSQQKLETYFQDWQENEALAEEMIPLLGRLYRKYNIVPSLYGRSLINRSVIRILKNHRYVKKVEGTELSVRDTLPMVKAM
TELDLGPAHVDIGKLGVAFKRSGQDDVKAFLETELADIVGRHADTGMGGEPKDVVLYGFGRIGRLLARIMIEKAGGGNLL
RLRAIVVRGGGDDLEKRASLLRRDSVHGPFAGTIRVDHDNQAIIANGNYIQVIHADAPQDIDYTAYGIDNALVVDNTGKW
RDEEGLSQHLASKGVAKVLLTAPGKGGVKNIVHGINHDEITDEDRVISAASCTTNAIVPVLKAVNDEFGIVHGHVETVHA
YTNDQNLIDNYHKGDRRGRSAALNMVLTETGAAKAVAKALPELSGKLSGNAIRVPTPDVSMAILNLTLDKAADRQALNEY
LRQMALHSRMQKQIDYVDSPEVVSSDFVGNRHAGIVDAQATIADDRQVVLYVWYDNEFGYSCQVVRILQHMSNVSFVYLP
REQH

Sequences:

>Translated_484_residues
MSQQKLETYFQDWQENEALAEEMIPLLGRLYRKYNIVPSLYGRSLINRSVIRILKNHRYVKKVEGTELSVRDTLPMVKAM
TELDLGPAHVDIGKLGVAFKRSGQDDVKAFLETELADIVGRHADTGMGGEPKDVVLYGFGRIGRLLARIMIEKAGGGNLL
RLRAIVVRGGGDDLEKRASLLRRDSVHGPFAGTIRVDHDNQAIIANGNYIQVIHADAPQDIDYTAYGIDNALVVDNTGKW
RDEEGLSQHLASKGVAKVLLTAPGKGGVKNIVHGINHDEITDEDRVISAASCTTNAIVPVLKAVNDEFGIVHGHVETVHA
YTNDQNLIDNYHKGDRRGRSAALNMVLTETGAAKAVAKALPELSGKLSGNAIRVPTPDVSMAILNLTLDKAADRQALNEY
LRQMALHSRMQKQIDYVDSPEVVSSDFVGNRHAGIVDAQATIADDRQVVLYVWYDNEFGYSCQVVRILQHMSNVSFVYLP
REQH
>Mature_483_residues
SQQKLETYFQDWQENEALAEEMIPLLGRLYRKYNIVPSLYGRSLINRSVIRILKNHRYVKKVEGTELSVRDTLPMVKAMT
ELDLGPAHVDIGKLGVAFKRSGQDDVKAFLETELADIVGRHADTGMGGEPKDVVLYGFGRIGRLLARIMIEKAGGGNLLR
LRAIVVRGGGDDLEKRASLLRRDSVHGPFAGTIRVDHDNQAIIANGNYIQVIHADAPQDIDYTAYGIDNALVVDNTGKWR
DEEGLSQHLASKGVAKVLLTAPGKGGVKNIVHGINHDEITDEDRVISAASCTTNAIVPVLKAVNDEFGIVHGHVETVHAY
TNDQNLIDNYHKGDRRGRSAALNMVLTETGAAKAVAKALPELSGKLSGNAIRVPTPDVSMAILNLTLDKAADRQALNEYL
RQMALHSRMQKQIDYVDSPEVVSSDFVGNRHAGIVDAQATIADDRQVVLYVWYDNEFGYSCQVVRILQHMSNVSFVYLPR
EQH

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7657116, Length=337, Percent_Identity=38.2789317507418, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI7669492, Length=338, Percent_Identity=37.8698224852071, Blast_Score=201, Evalue=2e-51,
Organism=Escherichia coli, GI1788079, Length=346, Percent_Identity=38.728323699422, Blast_Score=208, Evalue=8e-55,
Organism=Escherichia coli, GI1789295, Length=345, Percent_Identity=32.463768115942, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17534677, Length=347, Percent_Identity=37.7521613832853, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17534679, Length=347, Percent_Identity=37.7521613832853, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI17568413, Length=350, Percent_Identity=38, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI32566163, Length=342, Percent_Identity=38.0116959064327, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322409, Length=342, Percent_Identity=37.719298245614, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6322468, Length=341, Percent_Identity=36.3636363636364, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321631, Length=341, Percent_Identity=36.3636363636364, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17933600, Length=336, Percent_Identity=38.0952380952381, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI18110149, Length=336, Percent_Identity=38.0952380952381, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI85725000, Length=336, Percent_Identity=38.0952380952381, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI22023983, Length=336, Percent_Identity=38.0952380952381, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI19922412, Length=335, Percent_Identity=37.6119402985075, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 53401; Mature: 53270

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQKLETYFQDWQENEALAEEMIPLLGRLYRKYNIVPSLYGRSLINRSVIRILKNHRYV
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCE
KKVEGTELSVRDTLPMVKAMTELDLGPAHVDIGKLGVAFKRSGQDDVKAFLETELADIVG
EECCCCEEEHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
RHADTGMGGEPKDVVLYGFGRIGRLLARIMIEKAGGGNLLRLRAIVVRGGGDDLEKRASL
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCHHHHHHH
LRRDSVHGPFAGTIRVDHDNQAIIANGNYIQVIHADAPQDIDYTAYGIDNALVVDNTGKW
HHHCCCCCCEEEEEEEECCCCEEEECCCEEEEEECCCCCCCCEEEECCCCEEEECCCCCC
RDEEGLSQHLASKGVAKVLLTAPGKGGVKNIVHGINHDEITDEDRVISAASCTTNAIVPV
CCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHH
LKAVNDEFGIVHGHVETVHAYTNDQNLIDNYHKGDRRGRSAALNMVLTETGAAKAVAKAL
HHHCCCCCCEEECCEEEEEEECCCCHHHHHHHCCCCCCHHHHEEEEEECCCHHHHHHHHH
PELSGKLSGNAIRVPTPDVSMAILNLTLDKAADRQALNEYLRQMALHSRMQKQIDYVDSP
HHHCCCCCCCEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EVVSSDFVGNRHAGIVDAQATIADDRQVVLYVWYDNEFGYSCQVVRILQHMSNVSFVYLP
CHHHHCCCCCCCCCEEECCEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEC
REQH
CCCC
>Mature Secondary Structure 
SQQKLETYFQDWQENEALAEEMIPLLGRLYRKYNIVPSLYGRSLINRSVIRILKNHRYV
CHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCE
KKVEGTELSVRDTLPMVKAMTELDLGPAHVDIGKLGVAFKRSGQDDVKAFLETELADIVG
EECCCCEEEHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
RHADTGMGGEPKDVVLYGFGRIGRLLARIMIEKAGGGNLLRLRAIVVRGGGDDLEKRASL
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCHHHHHHH
LRRDSVHGPFAGTIRVDHDNQAIIANGNYIQVIHADAPQDIDYTAYGIDNALVVDNTGKW
HHHCCCCCCEEEEEEEECCCCEEEECCCEEEEEECCCCCCCCEEEECCCCEEEECCCCCC
RDEEGLSQHLASKGVAKVLLTAPGKGGVKNIVHGINHDEITDEDRVISAASCTTNAIVPV
CCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHH
LKAVNDEFGIVHGHVETVHAYTNDQNLIDNYHKGDRRGRSAALNMVLTETGAAKAVAKAL
HHHCCCCCCEEECCEEEEEEECCCCHHHHHHHCCCCCCHHHHEEEEEECCCHHHHHHHHH
PELSGKLSGNAIRVPTPDVSMAILNLTLDKAADRQALNEYLRQMALHSRMQKQIDYVDSP
HHHCCCCCCCEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EVVSSDFVGNRHAGIVDAQATIADDRQVVLYVWYDNEFGYSCQVVRILQHMSNVSFVYLP
CHHHHCCCCCCCCCEEECCEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEC
REQH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8508805; 10360571; 2401296; 7877172 [H]