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The map label for this gene is cyaB [H]

Identifier: 91790298

GI number: 91790298

Start: 4720041

End: 4721726

Strand: Reverse

Name: cyaB [H]

Synonym: Bpro_4465

Alternate gene names: 91790298

Gene position: 4721726-4720041 (Counterclockwise)

Preceding gene: 91790299

Following gene: 91790297

Centisome position: 90.8

GC content: 63.46

Gene sequence:

>1686_bases
ATGGATGACGTAGCGAGGCCGGGAGCGGGCGAGCCGCTCCATTCCAGCGCCGGTGCCATGCGTGCACCCGTGCAGCGCCG
TTCCCGCGTCCTTATCGTTGAAGACACGGCTGATATCCGCTACTTCCTCGAAACCCTGCTGAAGGATCAATACGAGGTCG
CCGCAGCTTCTGCTGGCGAGACCGGCCTGCAGATGGCGACGGGCGAACCCCGCCCCGAGATCATCCTGCTGGACGTCATG
ATGCCGGACATGGACGGCTATGAAGTCATGCGCCAGCTGGCCAAGGACCCGCGCACGGCGGAGATTCCGGTCATTTTCCT
CACGGCCCTTGGCAGCGTGGCGGATGAGCAAAAAGGGCTGGATCTGGGTGCCACCGACTACATCACCAAGCCGATCAGTC
CGCCCATTCTGCTGGCCCGCGTTAGGCTTCATCTGGAGCGCAGCGCCAATGCCAGGCGCCTGAAGGATTTGTCAGAGCAG
CTGTCGCGCTACCTGGCGCCGCAGGTCTACCAGTCGCTGTTCGATGGTTCCCGCCAGGCTGAAATTCAGACGCAGCGCAA
GCGGCTGACGGTGTTTTTTTCCGATATCAAGAACTTCACCGCCTCGACGGCGCAATGGCAGCCCGAAGAAGTCACGCTGC
TGCTGAACAGCTATTTCGCCGAGATGTCGCAGATCGCTGCGGAATACGGCGCAACGCTGGACAAATTCATCGGCGACGCC
ATCGTCATATTTTTTGGCGACCCGCACAGCCTGGGGCCGCGCCGGGATGCCTTGCAGTGCGTGAGGATGGCGGTGGCGAT
GCAAAGGCGCATGCAGGATTTGCAGCGGCGCTGGCGCAGCATGGACATCAGCAAGACGTTCGAGATACGTATCGGTATCA
ATTCCGGCTTCTGCGACGTGGGCAATTTCGGCAGTGCGCTGCGCATGGAATACACCATCATCGGGCGTGAGGTGAATCTC
GCGGCCAGGCTTGAGCAGGCCGCCGAGCCCGGCGAGATACTGATCTCCAGTGAAACCTATGCCCTGGTGCGGGGCGAAAT
CCTGGCTGATGCGCGGGAGCCCTTGCTGGCCAAGGGTTTTGCCGAGCCCATTGCCATCTATGCCGTTGATAAAGCCGCGA
TGGAAGGGGACGGCGACGCCAGCATCATCCGGTGTGACAGGCCGGGACTGCGCATGGACATCGACCTGGGCCGGCTGACA
GGCGCAGAGCGGACGCAAGCAGCCGTCCAGATTCGCAAGGCGCTTGTGAGCCTGGAAGCGTTGCCCGATGCCGCCGCTGT
GCCCGAACCCGCGGCAGCGGATGCGGCCGATGTTTCATTGCCCGAACACATGGCGGGGTTGGACCTGGCGTTGGGACTGT
CTCGCGCGATGGGGCTCAACCCGCTGTACGTCTCGATGCTCCGCCGCTTCCAGCAAAGCCACCAGGAAACGATCGCGCGC
ATCCGCCAGGCGCTGGAAGACGGCGAGCTGAAAACGGCAGAGCTGCTGAGCCACTCGTTGCGCGGGGTGGCAGGGCAGAT
TGGTGCAACGCGCGTGCCGCATGATGCCGAAGCGCTTGAGCAGGCCCTGGGGGGCAGCCAGCCGCGTGAAGCCATTGATG
GGCGGCTGGCAGCGCTGGAGGTGTCTCTTGGGGAATTGATTGCCGCACTGCATGCCGGGCTGCCGCCCGAAGCCGCCGCG
CCCTGA

Upstream 100 bases:

>100_bases
CGGTGATTGACGCGATGCGGACTGCGCTGGCGAGCTGAAGCCGCGTGCCGGGCCGCCATCGCGAAGCCGAGGCGCCTGGT
TTTAATGGAAGAGCCGGACC

Downstream 100 bases:

>100_bases
TCATTCCGACGCCGGGGTCGGGGTAATATGCAGACGCTGGTACGCCAGAACCTGCGGGCGTGCTTTGGGGAGTCGCTTGC
GAATGGGCGGGCCCTCAAGC

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MDDVARPGAGEPLHSSAGAMRAPVQRRSRVLIVEDTADIRYFLETLLKDQYEVAAASAGETGLQMATGEPRPEIILLDVM
MPDMDGYEVMRQLAKDPRTAEIPVIFLTALGSVADEQKGLDLGATDYITKPISPPILLARVRLHLERSANARRLKDLSEQ
LSRYLAPQVYQSLFDGSRQAEIQTQRKRLTVFFSDIKNFTASTAQWQPEEVTLLLNSYFAEMSQIAAEYGATLDKFIGDA
IVIFFGDPHSLGPRRDALQCVRMAVAMQRRMQDLQRRWRSMDISKTFEIRIGINSGFCDVGNFGSALRMEYTIIGREVNL
AARLEQAAEPGEILISSETYALVRGEILADAREPLLAKGFAEPIAIYAVDKAAMEGDGDASIIRCDRPGLRMDIDLGRLT
GAERTQAAVQIRKALVSLEALPDAAAVPEPAAADAADVSLPEHMAGLDLALGLSRAMGLNPLYVSMLRRFQQSHQETIAR
IRQALEDGELKTAELLSHSLRGVAGQIGATRVPHDAEALEQALGGSQPREAIDGRLAALEVSLGELIAALHAGLPPEAAA
P

Sequences:

>Translated_561_residues
MDDVARPGAGEPLHSSAGAMRAPVQRRSRVLIVEDTADIRYFLETLLKDQYEVAAASAGETGLQMATGEPRPEIILLDVM
MPDMDGYEVMRQLAKDPRTAEIPVIFLTALGSVADEQKGLDLGATDYITKPISPPILLARVRLHLERSANARRLKDLSEQ
LSRYLAPQVYQSLFDGSRQAEIQTQRKRLTVFFSDIKNFTASTAQWQPEEVTLLLNSYFAEMSQIAAEYGATLDKFIGDA
IVIFFGDPHSLGPRRDALQCVRMAVAMQRRMQDLQRRWRSMDISKTFEIRIGINSGFCDVGNFGSALRMEYTIIGREVNL
AARLEQAAEPGEILISSETYALVRGEILADAREPLLAKGFAEPIAIYAVDKAAMEGDGDASIIRCDRPGLRMDIDLGRLT
GAERTQAAVQIRKALVSLEALPDAAAVPEPAAADAADVSLPEHMAGLDLALGLSRAMGLNPLYVSMLRRFQQSHQETIAR
IRQALEDGELKTAELLSHSLRGVAGQIGATRVPHDAEALEQALGGSQPREAIDGRLAALEVSLGELIAALHAGLPPEAAA
P
>Mature_561_residues
MDDVARPGAGEPLHSSAGAMRAPVQRRSRVLIVEDTADIRYFLETLLKDQYEVAAASAGETGLQMATGEPRPEIILLDVM
MPDMDGYEVMRQLAKDPRTAEIPVIFLTALGSVADEQKGLDLGATDYITKPISPPILLARVRLHLERSANARRLKDLSEQ
LSRYLAPQVYQSLFDGSRQAEIQTQRKRLTVFFSDIKNFTASTAQWQPEEVTLLLNSYFAEMSQIAAEYGATLDKFIGDA
IVIFFGDPHSLGPRRDALQCVRMAVAMQRRMQDLQRRWRSMDISKTFEIRIGINSGFCDVGNFGSALRMEYTIIGREVNL
AARLEQAAEPGEILISSETYALVRGEILADAREPLLAKGFAEPIAIYAVDKAAMEGDGDASIIRCDRPGLRMDIDLGRLT
GAERTQAAVQIRKALVSLEALPDAAAVPEPAAADAADVSLPEHMAGLDLALGLSRAMGLNPLYVSMLRRFQQSHQETIAR
IRQALEDGELKTAELLSHSLRGVAGQIGATRVPHDAEALEQALGGSQPREAIDGRLAALEVSLGELIAALHAGLPPEAAA
P

Specific function: This Protein Is A Positive Regulator For The Phosphate Regulon. Transcription Of This Operon Is Positively Regulated By Phob And Phor When Phosphate Is Limited. [C]

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI24497587, Length=211, Percent_Identity=31.7535545023697, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI167830411, Length=156, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4580422, Length=152, Percent_Identity=32.8947368421053, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786599, Length=120, Percent_Identity=38.3333333333333, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1786784, Length=125, Percent_Identity=40, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87082012, Length=121, Percent_Identity=40.495867768595, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789809, Length=128, Percent_Identity=35.9375, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786911, Length=123, Percent_Identity=39.0243902439024, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=27.6018099547511, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788550, Length=137, Percent_Identity=31.3868613138686, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1790860, Length=125, Percent_Identity=40, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17534653, Length=184, Percent_Identity=29.8913043478261, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71989805, Length=195, Percent_Identity=29.2307692307692, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534655, Length=204, Percent_Identity=28.921568627451, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71989822, Length=195, Percent_Identity=29.2307692307692, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17534657, Length=184, Percent_Identity=29.8913043478261, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534651, Length=231, Percent_Identity=26.8398268398268, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193207841, Length=240, Percent_Identity=28.3333333333333, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17534649, Length=205, Percent_Identity=26.3414634146341, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17534659, Length=210, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI212645052, Length=175, Percent_Identity=30.8571428571429, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24585694, Length=242, Percent_Identity=26.4462809917355, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161076872, Length=156, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574512, Length=156, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221330470, Length=155, Percent_Identity=30.9677419354839, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330468, Length=155, Percent_Identity=30.9677419354839, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161084260, Length=170, Percent_Identity=30, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366320, Length=170, Percent_Identity=30, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 61101; Mature: 61101

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDVARPGAGEPLHSSAGAMRAPVQRRSRVLIVEDTADIRYFLETLLKDQYEVAAASAGE
CCCCCCCCCCCCCCCCCCHHHCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
TGLQMATGEPRPEIILLDVMMPDMDGYEVMRQLAKDPRTAEIPVIFLTALGSVADEQKGL
CCCEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHCCC
DLGATDYITKPISPPILLARVRLHLERSANARRLKDLSEQLSRYLAPQVYQSLFDGSRQA
CCCCHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
EIQTQRKRLTVFFSDIKNFTASTAQWQPEEVTLLLNSYFAEMSQIAAEYGATLDKFIGDA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCE
IVIFFGDPHSLGPRRDALQCVRMAVAMQRRMQDLQRRWRSMDISKTFEIRIGINSGFCDV
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCC
GNFGSALRMEYTIIGREVNLAARLEQAAEPGEILISSETYALVRGEILADAREPLLAKGF
CCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEECCCEEHHHHHHHHHHHCHHHHHCC
AEPIAIYAVDKAAMEGDGDASIIRCDRPGLRMDIDLGRLTGAERTQAAVQIRKALVSLEA
CCCEEEEEEHHHHHCCCCCCEEEEECCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHH
LPDAAAVPEPAAADAADVSLPEHMAGLDLALGLSRAMGLNPLYVSMLRRFQQSHQETIAR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IRQALEDGELKTAELLSHSLRGVAGQIGATRVPHDAEALEQALGGSQPREAIDGRLAALE
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHCCCHHEEH
VSLGELIAALHAGLPPEAAAP
HHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDDVARPGAGEPLHSSAGAMRAPVQRRSRVLIVEDTADIRYFLETLLKDQYEVAAASAGE
CCCCCCCCCCCCCCCCCCHHHCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
TGLQMATGEPRPEIILLDVMMPDMDGYEVMRQLAKDPRTAEIPVIFLTALGSVADEQKGL
CCCEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHCCC
DLGATDYITKPISPPILLARVRLHLERSANARRLKDLSEQLSRYLAPQVYQSLFDGSRQA
CCCCHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
EIQTQRKRLTVFFSDIKNFTASTAQWQPEEVTLLLNSYFAEMSQIAAEYGATLDKFIGDA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCE
IVIFFGDPHSLGPRRDALQCVRMAVAMQRRMQDLQRRWRSMDISKTFEIRIGINSGFCDV
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCC
GNFGSALRMEYTIIGREVNLAARLEQAAEPGEILISSETYALVRGEILADAREPLLAKGF
CCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEECCCEEHHHHHHHHHHHCHHHHHCC
AEPIAIYAVDKAAMEGDGDASIIRCDRPGLRMDIDLGRLTGAERTQAAVQIRKALVSLEA
CCCEEEEEEHHHHHCCCCCCEEEEECCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHH
LPDAAAVPEPAAADAADVSLPEHMAGLDLALGLSRAMGLNPLYVSMLRRFQQSHQETIAR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IRQALEDGELKTAELLSHSLRGVAGQIGATRVPHDAEALEQALGGSQPREAIDGRLAALE
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHCCCHHEEH
VSLGELIAALHAGLPPEAAAP
HHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]