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The map label for this gene is coaBC [H]

Identifier: 91789040

GI number: 91789040

Start: 3363403

End: 3364638

Strand: Reverse

Name: coaBC [H]

Synonym: Bpro_3180

Alternate gene names: 91789040

Gene position: 3364638-3363403 (Counterclockwise)

Preceding gene: 91789047

Following gene: 91789039

Centisome position: 64.7

GC content: 64.24

Gene sequence:

>1236_bases
TTGGACCTGGCCGGCAGGCATCTGGTGCTGGGCCTGTCGGGCGGCATTGCCTGCTACAAGTCGGCCGAGCTGTGCCGCGC
GCTGATCAAGGCTGGCGCCACCGTGCAGGTGGTCATGACGGAAGCGGCCGAGCAGTTCATCACACCTGTCACCATGCAGG
CGCTGAGCGGCCGGCCGGTTTACACCAGCCAGTGGGACAGTCGCGAAGCCAACAACATGGCGCATATCAACCTGTCGCGC
GAGGCCGATGCGATTTTGATCGCACCCATGAGCGCTGACTTCATGGCGAAGCTCCTCCATGGCCGCGCCGATGATTTGCT
GAGCCTGATGTGCCTGGCCCGGCCCATCGACAAGGTGTCGCTGCTGGTGGCGCCGGCGATGAACCGCGAGATGTATGCGC
ACCCGGCGACGCAGCGCAACTTTGTTCAGCTTGAAGCAGACGGCGCCAGGGTGCTGGGCGTGGGCAACGGCTTTCAGGCG
TGCGGGGAAACGGGTGATGGGCGCATGCTGGAACCCGAGCAACTGCTGGAAGACATCATTGCCTTCTTTGCGCCCAAGGT
GCTGGCCGGTCAGCGCGTGCTGGTCACGGCTGGCCCCACATATGAGGCCATTGACCCGGTGCGCGGCATTACCAACCTGT
CCAGCGGGAAGATGGGTTTTGCCATTGCACGCGCTGCGCGTGAAGCGGGTGCCGAGGTCACGCTGGTCGCCGGCCCGGTG
GGCCTGCCCACACCACGGGGTGTCACGCGCATTGACGTGAGATCTGCACAGAATATGCTCGATACCGTGATGGACCGGGT
GCAGGGCGCTGCTGTTTTCATCGCTACCGCGGCTGTGGCCGACTGGCGTCCTGCGACACCATCAACCCAAAAGATCAAGA
AAGACGGCTCGGGCCACGCGCCGCAACTGGGATTCACGGAAAACGCGGATATCCTCGCCACCGTTGCCAAGTCTGCCGCC
GCCCGGGCGGGCAAGCTGTTTTGCGTGGGCTTTGCCGCAGAAAGCCATGACCTGGCCGAGAACGCCCAAGCCAAGCGCCT
GCGCAAAAACGTCCCACTGCTGGTAGGTAACATCGGGCCCGATACTTTTGGACAGGACCATAACGCGTTGCTGCTGGTTG
ACGAGCAAGGCAGCACCGAGGTGGCCCGGGCGTCCAAGCTGTCGCTGGCACGCCGGCTGGTTCAGGAAATCGCTGCCAGG
CTGGCGGCGCCGGCCGCTTCGACCCGGAAAGGGTGA

Upstream 100 bases:

>100_bases
ACACGCAGTGAAAAGCGTGGGGGCCCATCTAGCTGCTACATTGCGAAACATGACAAATCAAGCCAATCCCCTGGAAAACA
GCGCGGCCGGCGGCGAAGCC

Downstream 100 bases:

>100_bases
GCTGCTTGATACACCCCTCCGACACCCCTCCTGATGGCGATTTCGCGCGGTACGTCGAACGCTTGACCAGCGGAAATATT
TCAGCCGGCGCGCGCCCGGA

Product: phosphopantothenate-cysteine ligase/phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MDLAGRHLVLGLSGGIACYKSAELCRALIKAGATVQVVMTEAAEQFITPVTMQALSGRPVYTSQWDSREANNMAHINLSR
EADAILIAPMSADFMAKLLHGRADDLLSLMCLARPIDKVSLLVAPAMNREMYAHPATQRNFVQLEADGARVLGVGNGFQA
CGETGDGRMLEPEQLLEDIIAFFAPKVLAGQRVLVTAGPTYEAIDPVRGITNLSSGKMGFAIARAAREAGAEVTLVAGPV
GLPTPRGVTRIDVRSAQNMLDTVMDRVQGAAVFIATAAVADWRPATPSTQKIKKDGSGHAPQLGFTENADILATVAKSAA
ARAGKLFCVGFAAESHDLAENAQAKRLRKNVPLLVGNIGPDTFGQDHNALLLVDEQGSTEVARASKLSLARRLVQEIAAR
LAAPAASTRKG

Sequences:

>Translated_411_residues
MDLAGRHLVLGLSGGIACYKSAELCRALIKAGATVQVVMTEAAEQFITPVTMQALSGRPVYTSQWDSREANNMAHINLSR
EADAILIAPMSADFMAKLLHGRADDLLSLMCLARPIDKVSLLVAPAMNREMYAHPATQRNFVQLEADGARVLGVGNGFQA
CGETGDGRMLEPEQLLEDIIAFFAPKVLAGQRVLVTAGPTYEAIDPVRGITNLSSGKMGFAIARAAREAGAEVTLVAGPV
GLPTPRGVTRIDVRSAQNMLDTVMDRVQGAAVFIATAAVADWRPATPSTQKIKKDGSGHAPQLGFTENADILATVAKSAA
ARAGKLFCVGFAAESHDLAENAQAKRLRKNVPLLVGNIGPDTFGQDHNALLLVDEQGSTEVARASKLSLARRLVQEIAAR
LAAPAASTRKG
>Mature_411_residues
MDLAGRHLVLGLSGGIACYKSAELCRALIKAGATVQVVMTEAAEQFITPVTMQALSGRPVYTSQWDSREANNMAHINLSR
EADAILIAPMSADFMAKLLHGRADDLLSLMCLARPIDKVSLLVAPAMNREMYAHPATQRNFVQLEADGARVLGVGNGFQA
CGETGDGRMLEPEQLLEDIIAFFAPKVLAGQRVLVTAGPTYEAIDPVRGITNLSSGKMGFAIARAAREAGAEVTLVAGPV
GLPTPRGVTRIDVRSAQNMLDTVMDRVQGAAVFIATAAVADWRPATPSTQKIKKDGSGHAPQLGFTENADILATVAKSAA
ARAGKLFCVGFAAESHDLAENAQAKRLRKNVPLLVGNIGPDTFGQDHNALLLVDEQGSTEVARASKLSLARRLVQEIAAR
LAAPAASTRKG

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=171, Percent_Identity=34.5029239766082, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI87082301, Length=405, Percent_Identity=45.679012345679, Blast_Score=297, Evalue=8e-82,
Organism=Saccharomyces cerevisiae, GI6322762, Length=193, Percent_Identity=29.5336787564767, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24657262, Length=190, Percent_Identity=31.5789473684211, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43394; Mature: 43394

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLAGRHLVLGLSGGIACYKSAELCRALIKAGATVQVVMTEAAEQFITPVTMQALSGRPV
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCHHHHHHHCCCCC
YTSQWDSREANNMAHINLSREADAILIAPMSADFMAKLLHGRADDLLSLMCLARPIDKVS
CCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHH
LLVAPAMNREMYAHPATQRNFVQLEADGARVLGVGNGFQACGETGDGRMLEPEQLLEDII
EEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHCCCCCCCEECHHHHHHHHH
AFFAPKVLAGQRVLVTAGPTYEAIDPVRGITNLSSGKMGFAIARAAREAGAEVTLVAGPV
HHHCHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCC
GLPTPRGVTRIDVRSAQNMLDTVMDRVQGAAVFIATAAVADWRPATPSTQKIKKDGSGHA
CCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCHHHHHCCCCCCC
PQLGFTENADILATVAKSAAARAGKLFCVGFAAESHDLAENAQAKRLRKNVPLLVGNIGP
CCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCC
DTFGQDHNALLLVDEQGSTEVARASKLSLARRLVQEIAARLAAPAASTRKG
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDLAGRHLVLGLSGGIACYKSAELCRALIKAGATVQVVMTEAAEQFITPVTMQALSGRPV
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCHHHHHHHCCCCC
YTSQWDSREANNMAHINLSREADAILIAPMSADFMAKLLHGRADDLLSLMCLARPIDKVS
CCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHH
LLVAPAMNREMYAHPATQRNFVQLEADGARVLGVGNGFQACGETGDGRMLEPEQLLEDII
EEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHCCCCCCCEECHHHHHHHHH
AFFAPKVLAGQRVLVTAGPTYEAIDPVRGITNLSSGKMGFAIARAAREAGAEVTLVAGPV
HHHCHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCC
GLPTPRGVTRIDVRSAQNMLDTVMDRVQGAAVFIATAAVADWRPATPSTQKIKKDGSGHA
CCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCHHHHHCCCCCCC
PQLGFTENADILATVAKSAAARAGKLFCVGFAAESHDLAENAQAKRLRKNVPLLVGNIGP
CCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCC
DTFGQDHNALLLVDEQGSTEVARASKLSLARRLVQEIAARLAAPAASTRKG
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]