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The map label for this gene is uvrC

Identifier: 91788931

GI number: 91788931

Start: 3236664

End: 3238664

Strand: Reverse

Name: uvrC

Synonym: Bpro_3071

Alternate gene names: 91788931

Gene position: 3238664-3236664 (Counterclockwise)

Preceding gene: 91788932

Following gene: 91788930

Centisome position: 62.28

GC content: 64.52

Gene sequence:

>2001_bases
ATGCCCCAAAACATGACCGCCAGCCATACCCCCGAGTTGCTCGCCGAGGTGGCCGCATTGCCGGCGATGCCCGGCGTGTA
CCGCTACTTCGATGCCGAGGGCGGGGTGCTCTATGTGGGCAAGGCGCGCAACCTGAAGAAGCGGGTGTCCAGCTATTTCC
AGAAAAACCATGGCGCCACGCGTATTGGCCACATGGTGACCAAGATCGTCCGCATGGAGACCACGGTGGTGCGGTCGGAG
GCCGAGGCGCTGCTGCTGGAAAACAACCTGATCAAGACGCTCAACCCGAAATACAACATCCTGTTCCGGGACGACAAAAG
CTACCCCTACCTCAAGCTGACCGCCGTGCAGCCGAGCGAGGCGGGCAGCGCCCCCGTGGCAACGGCTTTTCCGCGCATCG
CCTACTACCGCGGCGCGGTCGAGAAGAAGCACCGCTACTTCGGTCCGTACCCCAGTGCCTGGGCGGTCAAGGACACCATG
CTGCTGCTGCAGAAAGTGTTCAGGCTGCGCACCTGCGAAGACACGGTGTTCAACAACCGGACGCGCCCTTGCCTGCTGTA
CCAGATCAAGCGCTGCTCGGCGCCCTGTGTGGGCCATGTGTCGCCCGAGCAGTACGCACTGGACACGGCCAATGCCGAGC
GGTTTTTGCAGGGCCAGACGCAGGAAATCCTGACTGAACTGGAAAGGAAAATGCTGGCGCATGCCGACCGGCTGGAGTTC
GAACAGGCAGCCGAGTTGCGCAACCAGATGTCGGCGCTGTCCAAGGTGCTGCATCAGCAATCCATGGAGATCGGCGGCGA
CAAGGACGTGGACATCCTGGCGGTGAAAGTGCAGGGCGGCAAGGCTTGCGTCAACCTGGCCATGGTGCGTGGTGGCCGCC
ATCTGGGCGACCGGCCTTACTTTCCGACGCATGTCGAAAACGCCACCGATGTGGCCGCGCTCGACGCACAGGCCGATGAG
GGCGCGGGCGGCGGGGGCCCTGAAAGCGATGATAGAGCCGGCAAAACCGTTGTCCCCCTGCCGGCGCGGCCCGCCAAATC
GCTGGAAGCACTCGTGCTGGAGGCTTTCATTGCCCAGCACTACATCGACGTACCCGTGCCGCCCACGCTGGTGTGCAGCG
AGCCGGTGGACAAGGACCTGATCAGTGCGCTCGCCGCGCAGACCGGCAGCAAGATCACGGCCATACACCAGCCGCGCGAG
CAGCGCCGCATCTGGCTCGACATGGCCCAGAAAAATGCCGCCCTGCAACTGGCGCGCCTGCTGGCCGAGCAGGGCTCGCA
ACAGGCGCGCACACGTGCCCTGGCCGAAGCGCTGGACCTGTCGCTGGACAACCTGGATGCCCTGCGCATCGAGTGCTTTG
ACATCTCGCATACCGCGGGAGAGTCGACGCAGGCTTCGTGCGTGGTGTTTCAGGGGCACAAGATGCAGAACAGCGAGTAC
CGCCGCTACAACATCGAAGGCATCACCCCCGGTGACGACTACGCGGCCATGCGGCAGGTGCTGACGCGCCGCTACACCAA
ACTGGCCGAAGCCGCGCGCAATGGCAACGCCAGGCTGCCCGACCTGGTGCTGGTCGATGGCGGCAAGGGGCAGGTGTCGA
TGGCGCGCGAGGTGTTTGTGGAGCTGGGCCTGGACCTGGGGCTGATCGCGGGCGTTGAAAAAGGCGAGGGTCGCAAGGTC
GGGCTGGAAGAGCTGGTCTTTGCCGACGGGCGTGAGAAGGTCTACCTGGGCCGTGATTCCGCCGCGCTGATGCTGATTGC
GCAAATCAGGGACGAGGCCCACCGCTTTGCCATCACCGGCATGCGCGCGAGGCGGGCCAAGGTCCGCGTGGGCGGCAGCA
AGCTTGAGGACATTGCGGGCATTGGTCCCAAGCGGCGCGCCAGCCTGCTGCAGCGTTTTGGCGGTATTCGCGGCATTGCG
TCGGCCAGCGCCGAAGACATTGCCACGGTGGACGGCATTTCGAAAGACCTGGCCGAGGAGATTTACCGCGCGCTGCATTG
A

Upstream 100 bases:

>100_bases
GCCGTCCCGCCCCCGCCCCCGCCTGAGTCCGCGCACCTGCGGCTTGCCGTCCTTCTTCGGCTCGCAGTGAGGGTTTGTCG
CAGGCGGCAAAATACAGCTT

Downstream 100 bases:

>100_bases
CTGCGTCGCCCGGGGCTGTGCAGACCTGTGCAGACGTTTTTTGCGCAACGAAGTGCACCGATTTGGCGAGCCCGGAGCAC
CACTTTGGCAGGGGTTCGCG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MPQNMTASHTPELLAEVAALPAMPGVYRYFDAEGGVLYVGKARNLKKRVSSYFQKNHGATRIGHMVTKIVRMETTVVRSE
AEALLLENNLIKTLNPKYNILFRDDKSYPYLKLTAVQPSEAGSAPVATAFPRIAYYRGAVEKKHRYFGPYPSAWAVKDTM
LLLQKVFRLRTCEDTVFNNRTRPCLLYQIKRCSAPCVGHVSPEQYALDTANAERFLQGQTQEILTELERKMLAHADRLEF
EQAAELRNQMSALSKVLHQQSMEIGGDKDVDILAVKVQGGKACVNLAMVRGGRHLGDRPYFPTHVENATDVAALDAQADE
GAGGGGPESDDRAGKTVVPLPARPAKSLEALVLEAFIAQHYIDVPVPPTLVCSEPVDKDLISALAAQTGSKITAIHQPRE
QRRIWLDMAQKNAALQLARLLAEQGSQQARTRALAEALDLSLDNLDALRIECFDISHTAGESTQASCVVFQGHKMQNSEY
RRYNIEGITPGDDYAAMRQVLTRRYTKLAEAARNGNARLPDLVLVDGGKGQVSMAREVFVELGLDLGLIAGVEKGEGRKV
GLEELVFADGREKVYLGRDSAALMLIAQIRDEAHRFAITGMRARRAKVRVGGSKLEDIAGIGPKRRASLLQRFGGIRGIA
SASAEDIATVDGISKDLAEEIYRALH

Sequences:

>Translated_666_residues
MPQNMTASHTPELLAEVAALPAMPGVYRYFDAEGGVLYVGKARNLKKRVSSYFQKNHGATRIGHMVTKIVRMETTVVRSE
AEALLLENNLIKTLNPKYNILFRDDKSYPYLKLTAVQPSEAGSAPVATAFPRIAYYRGAVEKKHRYFGPYPSAWAVKDTM
LLLQKVFRLRTCEDTVFNNRTRPCLLYQIKRCSAPCVGHVSPEQYALDTANAERFLQGQTQEILTELERKMLAHADRLEF
EQAAELRNQMSALSKVLHQQSMEIGGDKDVDILAVKVQGGKACVNLAMVRGGRHLGDRPYFPTHVENATDVAALDAQADE
GAGGGGPESDDRAGKTVVPLPARPAKSLEALVLEAFIAQHYIDVPVPPTLVCSEPVDKDLISALAAQTGSKITAIHQPRE
QRRIWLDMAQKNAALQLARLLAEQGSQQARTRALAEALDLSLDNLDALRIECFDISHTAGESTQASCVVFQGHKMQNSEY
RRYNIEGITPGDDYAAMRQVLTRRYTKLAEAARNGNARLPDLVLVDGGKGQVSMAREVFVELGLDLGLIAGVEKGEGRKV
GLEELVFADGREKVYLGRDSAALMLIAQIRDEAHRFAITGMRARRAKVRVGGSKLEDIAGIGPKRRASLLQRFGGIRGIA
SASAEDIATVDGISKDLAEEIYRALH
>Mature_665_residues
PQNMTASHTPELLAEVAALPAMPGVYRYFDAEGGVLYVGKARNLKKRVSSYFQKNHGATRIGHMVTKIVRMETTVVRSEA
EALLLENNLIKTLNPKYNILFRDDKSYPYLKLTAVQPSEAGSAPVATAFPRIAYYRGAVEKKHRYFGPYPSAWAVKDTML
LLQKVFRLRTCEDTVFNNRTRPCLLYQIKRCSAPCVGHVSPEQYALDTANAERFLQGQTQEILTELERKMLAHADRLEFE
QAAELRNQMSALSKVLHQQSMEIGGDKDVDILAVKVQGGKACVNLAMVRGGRHLGDRPYFPTHVENATDVAALDAQADEG
AGGGGPESDDRAGKTVVPLPARPAKSLEALVLEAFIAQHYIDVPVPPTLVCSEPVDKDLISALAAQTGSKITAIHQPREQ
RRIWLDMAQKNAALQLARLLAEQGSQQARTRALAEALDLSLDNLDALRIECFDISHTAGESTQASCVVFQGHKMQNSEYR
RYNIEGITPGDDYAAMRQVLTRRYTKLAEAARNGNARLPDLVLVDGGKGQVSMAREVFVELGLDLGLIAGVEKGEGRKVG
LEELVFADGREKVYLGRDSAALMLIAQIRDEAHRFAITGMRARRAKVRVGGSKLEDIAGIGPKRRASLLQRFGGIRGIAS
ASAEDIATVDGISKDLAEEIYRALH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=662, Percent_Identity=42.1450151057402, Blast_Score=488, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_POLSJ (Q128Q7)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_549883.1
- ProteinModelPortal:   Q128Q7
- STRING:   Q128Q7
- GeneID:   4014266
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_3071
- NMPDR:   fig|296591.1.peg.2053
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q128Q7
- ProtClustDB:   PRK00558
- BioCyc:   PSP296591:BPRO_3071-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 73154; Mature: 73023

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQNMTASHTPELLAEVAALPAMPGVYRYFDAEGGVLYVGKARNLKKRVSSYFQKNHGAT
CCCCCCCCCCHHHHHHHHHCCCCCCHHEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCH
RIGHMVTKIVRMETTVVRSEAEALLLENNLIKTLNPKYNILFRDDKSYPYLKLTAVQPSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCCCEEEEEEECCCC
AGSAPVATAFPRIAYYRGAVEKKHRYFGPYPSAWAVKDTMLLLQKVFRLRTCEDTVFNNR
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
TRPCLLYQIKRCSAPCVGHVSPEQYALDTANAERFLQGQTQEILTELERKMLAHADRLEF
CCCHHHHHHHHCCCCCCCCCCCHHHEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
EQAAELRNQMSALSKVLHQQSMEIGGDKDVDILAVKVQGGKACVNLAMVRGGRHLGDRPY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCC
FPTHVENATDVAALDAQADEGAGGGGPESDDRAGKTVVPLPARPAKSLEALVLEAFIAQH
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHH
YIDVPVPPTLVCSEPVDKDLISALAAQTGSKITAIHQPREQRRIWLDMAQKNAALQLARL
HCCCCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LAEQGSQQARTRALAEALDLSLDNLDALRIECFDISHTAGESTQASCVVFQGHKMQNSEY
HHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCC
RRYNIEGITPGDDYAAMRQVLTRRYTKLAEAARNGNARLPDLVLVDGGKGQVSMAREVFV
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHH
ELGLDLGLIAGVEKGEGRKVGLEELVFADGREKVYLGRDSAALMLIAQIRDEAHRFAITG
HHCCCHHEEECCCCCCCCCCCHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHEEHCC
MRARRAKVRVGGSKLEDIAGIGPKRRASLLQRFGGIRGIASASAEDIATVDGISKDLAEE
CHHHHHEEEECCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
IYRALH
HHHHCC
>Mature Secondary Structure 
PQNMTASHTPELLAEVAALPAMPGVYRYFDAEGGVLYVGKARNLKKRVSSYFQKNHGAT
CCCCCCCCCHHHHHHHHHCCCCCCHHEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCH
RIGHMVTKIVRMETTVVRSEAEALLLENNLIKTLNPKYNILFRDDKSYPYLKLTAVQPSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCCCEEEEEEECCCC
AGSAPVATAFPRIAYYRGAVEKKHRYFGPYPSAWAVKDTMLLLQKVFRLRTCEDTVFNNR
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
TRPCLLYQIKRCSAPCVGHVSPEQYALDTANAERFLQGQTQEILTELERKMLAHADRLEF
CCCHHHHHHHHCCCCCCCCCCCHHHEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
EQAAELRNQMSALSKVLHQQSMEIGGDKDVDILAVKVQGGKACVNLAMVRGGRHLGDRPY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCC
FPTHVENATDVAALDAQADEGAGGGGPESDDRAGKTVVPLPARPAKSLEALVLEAFIAQH
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHH
YIDVPVPPTLVCSEPVDKDLISALAAQTGSKITAIHQPREQRRIWLDMAQKNAALQLARL
HCCCCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LAEQGSQQARTRALAEALDLSLDNLDALRIECFDISHTAGESTQASCVVFQGHKMQNSEY
HHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCC
RRYNIEGITPGDDYAAMRQVLTRRYTKLAEAARNGNARLPDLVLVDGGKGQVSMAREVFV
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHH
ELGLDLGLIAGVEKGEGRKVGLEELVFADGREKVYLGRDSAALMLIAQIRDEAHRFAITG
HHCCCHHEEECCCCCCCCCCCHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHEEHCC
MRARRAKVRVGGSKLEDIAGIGPKRRASLLQRFGGIRGIASASAEDIATVDGISKDLAEE
CHHHHHEEEECCCHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
IYRALH
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA