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The map label for this gene is lysC [H]

Identifier: 91788721

GI number: 91788721

Start: 3015272

End: 3016540

Strand: Reverse

Name: lysC [H]

Synonym: Bpro_2860

Alternate gene names: 91788721

Gene position: 3016540-3015272 (Counterclockwise)

Preceding gene: 91788722

Following gene: 91788718

Centisome position: 58.01

GC content: 61.07

Gene sequence:

>1269_bases
ATGGCTTTGATCGTTCATAAATACGGCGGCACATCGATGGGCTCAACCGAGCGCATCCGCAATGTGGCCAAGCGCGTCGC
CAAGTGGGCGCGGGCCGGCCACCAGATGGTCGTGGTTCCCAGCGCTATGAGTGGCGAAACCAATCGTTTGCTGGGCCTGG
CCAAAGAGCTGGCCCCCGCACGGCCCGGTGACGACTATCATCGTGAACTCGACGCGCTGGCCGCGACCGGCGAGCAGGCC
TCCAGCGCGCTGCTGGCCATTGCCCTGCAGTCCGAAGGCATGCAGGCCGTGAGCTACGCCGGCTGGCAGGTCACCATCAA
GACCAACAACGCCTACACCAAGGCCCGCATCGAGTCGATTGACGACGAGCGCGTGCGCGCCGACCTGGACGCCGGCAAGG
TCGTCATCATCACCGGCTTCCAGGGTGTGGACGAGGGCGGCAACGTCACCACGCTGGGCCGCGGCGGCTCCGACACCTCT
GCCGTGGCGATCGCGGCAGCCCTGAAAGCCCACGAGTGCCTGATTTACACCGACGTGGACGGCGTGTACACGACCGACCC
GCGCGTGGTGCCCGAGGCACGCCGCCTGCATACCGTGAGTTTCGAGGAAATGCTGGAGATGGCCTCCATGGGCTCCAAGG
TGCTGCAGATCCGCTCGGTGGAATTTGCCGGCAAGTACAAGGTGCCGCTGCGCGTGCTGTCCAGCTTCACCGACTGGGAC
ATCGACATCAACGAAGAAGCCAGATCAGGCACTTTGATCAGTTTTGAGGAAGACGAAAACATGGAACAAGCCATCGTATC
GGGCATCGCTTTCAACCGCGATGAAGCCAAAATCTCCGTCCTCGGCGTGCCAGACACTCCGGGCATTGCCTACCAGATCC
TCGGCGCCGTGGCTGACGCCAACATCGAAGTCGATGTGATCATCCAGAATATCAGCAAGGACGGCAAGACCGACTTCAGC
TTTACCGTGCACCGCAACGACTATTCCAAAGCCGTTGACCTGCTGAAAACCCAGGTGCTGCCCAAACTCGGCGCGCAGGA
AGTCACCGGCGACGCCAAGATCTGCAAGGTCAGCATCGTAGGCATCGGCATGCGCAGCCATGTGGGTGTTGCCAGCAAGA
TGTTCCGCGTGCTCAGCGAAGAGGGCATCAACATCCAGATGATTTCCACCAGCGAAATCAAGACCTCCGTGGTCATTGAT
GAAAAATACATGGAGCTGGCCGTTCGTGCCTTGCACAAGGCTTTTGACCTGGACCAGCCCGCCGCCTGA

Upstream 100 bases:

>100_bases
GGCAGCCAAAGCCTTCCCTGCAGAATGCAGAAAGGGCATGAGAGGCCTGCAAAAAGCAGCACGCAATGTTCGCAACCAAC
TCCTGAATTGACATCCTGCA

Downstream 100 bases:

>100_bases
AAACCGGCTTTAAGTCGTGAGATAATCGCTTTATTGGAAACGTGACCGAGTGGCCGAAGGTGCTCCCCTGCTAAGGGAGT
ATGGGGTGTAGAGCCTCATC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MALIVHKYGGTSMGSTERIRNVAKRVAKWARAGHQMVVVPSAMSGETNRLLGLAKELAPARPGDDYHRELDALAATGEQA
SSALLAIALQSEGMQAVSYAGWQVTIKTNNAYTKARIESIDDERVRADLDAGKVVIITGFQGVDEGGNVTTLGRGGSDTS
AVAIAAALKAHECLIYTDVDGVYTTDPRVVPEARRLHTVSFEEMLEMASMGSKVLQIRSVEFAGKYKVPLRVLSSFTDWD
IDINEEARSGTLISFEEDENMEQAIVSGIAFNRDEAKISVLGVPDTPGIAYQILGAVADANIEVDVIIQNISKDGKTDFS
FTVHRNDYSKAVDLLKTQVLPKLGAQEVTGDAKICKVSIVGIGMRSHVGVASKMFRVLSEEGINIQMISTSEIKTSVVID
EKYMELAVRALHKAFDLDQPAA

Sequences:

>Translated_422_residues
MALIVHKYGGTSMGSTERIRNVAKRVAKWARAGHQMVVVPSAMSGETNRLLGLAKELAPARPGDDYHRELDALAATGEQA
SSALLAIALQSEGMQAVSYAGWQVTIKTNNAYTKARIESIDDERVRADLDAGKVVIITGFQGVDEGGNVTTLGRGGSDTS
AVAIAAALKAHECLIYTDVDGVYTTDPRVVPEARRLHTVSFEEMLEMASMGSKVLQIRSVEFAGKYKVPLRVLSSFTDWD
IDINEEARSGTLISFEEDENMEQAIVSGIAFNRDEAKISVLGVPDTPGIAYQILGAVADANIEVDVIIQNISKDGKTDFS
FTVHRNDYSKAVDLLKTQVLPKLGAQEVTGDAKICKVSIVGIGMRSHVGVASKMFRVLSEEGINIQMISTSEIKTSVVID
EKYMELAVRALHKAFDLDQPAA
>Mature_421_residues
ALIVHKYGGTSMGSTERIRNVAKRVAKWARAGHQMVVVPSAMSGETNRLLGLAKELAPARPGDDYHRELDALAATGEQAS
SALLAIALQSEGMQAVSYAGWQVTIKTNNAYTKARIESIDDERVRADLDAGKVVIITGFQGVDEGGNVTTLGRGGSDTSA
VAIAAALKAHECLIYTDVDGVYTTDPRVVPEARRLHTVSFEEMLEMASMGSKVLQIRSVEFAGKYKVPLRVLSSFTDWDI
DINEEARSGTLISFEEDENMEQAIVSGIAFNRDEAKISVLGVPDTPGIAYQILGAVADANIEVDVIIQNISKDGKTDFSF
TVHRNDYSKAVDLLKTQVLPKLGAQEVTGDAKICKVSIVGIGMRSHVGVASKMFRVLSEEGINIQMISTSEIKTSVVIDE
KYMELAVRALHKAFDLDQPAA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=477, Percent_Identity=28.7211740041929, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790455, Length=439, Percent_Identity=28.246013667426, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790376, Length=280, Percent_Identity=25.7142857142857, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=393, Percent_Identity=27.2264631043257, Blast_Score=110, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 45562; Mature: 45431

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVHKYGGTSMGSTERIRNVAKRVAKWARAGHQMVVVPSAMSGETNRLLGLAKELAPA
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCC
RPGDDYHRELDALAATGEQASSALLAIALQSEGMQAVSYAGWQVTIKTNNAYTKARIESI
CCCCHHHHHHHHHHHCCCHHCCEEEEEEECCCCCCEEEECCEEEEEEECCCEEEHHHHCC
DDERVRADLDAGKVVIITGFQGVDEGGNVTTLGRGGSDTSAVAIAAALKAHECLIYTDVD
CCHHHEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCEEEEEEECC
GVYTTDPRVVPEARRLHTVSFEEMLEMASMGSKVLQIRSVEFAGKYKVPLRVLSSFTDWD
CEEECCCCCCCCHHHEEEECHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHCCCCCCC
IDINEEARSGTLISFEEDENMEQAIVSGIAFNRDEAKISVLGVPDTPGIAYQILGAVADA
EEECCCCCCCCEEEECCCCCHHHHHHHHHEECCCCCEEEEEECCCCCCHHHHHHHHHHCC
NIEVDVIIQNISKDGKTDFSFTVHRNDYSKAVDLLKTQVLPKLGAQEVTGDAKICKVSIV
CCEEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHCCCCCEEEEEEEE
GIGMRSHVGVASKMFRVLSEEGINIQMISTSEIKTSVVIDEKYMELAVRALHKAFDLDQP
EECHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCC
AA
CC
>Mature Secondary Structure 
ALIVHKYGGTSMGSTERIRNVAKRVAKWARAGHQMVVVPSAMSGETNRLLGLAKELAPA
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCC
RPGDDYHRELDALAATGEQASSALLAIALQSEGMQAVSYAGWQVTIKTNNAYTKARIESI
CCCCHHHHHHHHHHHCCCHHCCEEEEEEECCCCCCEEEECCEEEEEEECCCEEEHHHHCC
DDERVRADLDAGKVVIITGFQGVDEGGNVTTLGRGGSDTSAVAIAAALKAHECLIYTDVD
CCHHHEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCEEEEEEECC
GVYTTDPRVVPEARRLHTVSFEEMLEMASMGSKVLQIRSVEFAGKYKVPLRVLSSFTDWD
CEEECCCCCCCCHHHEEEECHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHCCCCCCC
IDINEEARSGTLISFEEDENMEQAIVSGIAFNRDEAKISVLGVPDTPGIAYQILGAVADA
EEECCCCCCCCEEEECCCCCHHHHHHHHHEECCCCCEEEEEECCCCCCHHHHHHHHHHCC
NIEVDVIIQNISKDGKTDFSFTVHRNDYSKAVDLLKTQVLPKLGAQEVTGDAKICKVSIV
CCEEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHCCCCCEEEEEEEE
GIGMRSHVGVASKMFRVLSEEGINIQMISTSEIKTSVVIDEKYMELAVRALHKAFDLDQP
EECHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]