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The map label for this gene is folP [H]

Identifier: 91788712

GI number: 91788712

Start: 3004979

End: 3005860

Strand: Reverse

Name: folP [H]

Synonym: Bpro_2851

Alternate gene names: 91788712

Gene position: 3005860-3004979 (Counterclockwise)

Preceding gene: 91788713

Following gene: 91788711

Centisome position: 57.8

GC content: 63.49

Gene sequence:

>882_bases
ATGGACCATTTTCAGGAAAGCTGCTTCGTGATTTGGCAAACCTCCCGCTTTCAAATTGATGTGTCGCAGCCGCGCGTGAT
GGGCATCGTCAATGTCACGCCCGACTCGTTTTCCGATGGCGGCAAGTACTTCACGCCAAGCGGCGGTTTTTCGGGGGTGT
TCGCGCATTGCGAGCAGTTGATCCGCGACGGTGCCGACTTGCTCGACATTGGTGGCGAATCAACTCGCCCGGGCGCGCCG
CCGGTGCCGCTGCAGGAAGAGCTAGCGCGCGTGTTGCCGGTGGTTCGCCACGCGGCTACCCTCGGCGTACCGCTTTCGGT
AGATACCTACAAGCCCGAAGTCATGCAGGCGGTGCTGGATTTGGGTGCCGACATCATCAACGACATCTGGGCCCTGCGCC
AGCCGGGCGCCAGGCAGATCGTGGCCGGTCACCCGAGTTGCGGAGTCTGCCTGATGCACATGCATCGCGAGCCGCAAACC
ATGCAGATGGCCCCCATGGAAGGGGATGTGGTGCCTCAGGTGCTGTCGTTTCTGGTGGGTGCCGCAGGTGATCTGCAAGC
TGCCGGCGTTGACAGGGCCCGTATCGTGCTCGACGCGGGAGTCGGGTTTGGTAAAACCGTGGCACAGAATTTCTCGCTGC
TGGCGCACCAGCGTGAGTTCCTTGCGGCTGGCTATCCGCTGCTGGCTGCGTGGTCGCGCAAATCGTCACTGGCGGCTGTG
AGCGGCACCTCGCCAGCCGACGCCCCCCTGGCCATTGAAGACCGCCTGGTGCCTAGCGTGGCGGCGGCCTTGCTGGCCGT
GGAGCGTGGTGCCCGGGTGGTACGCGTTCACGACGTGCGCGAAACCGTTCAGGCCCTCAAAGTCTGGGCGGCTGCAAGTT
AA

Upstream 100 bases:

>100_bases
GTGGCCTGATGGTCTGCTGAAGACAGTCCGTAAAAATTATGACAACCGGGGCTAGTCCCCGGTTTTTTCTTTGTTGCGGG
CATTGCGCCGCAACAGCCTC

Downstream 100 bases:

>100_bases
AAGCCTGGGGCAATAAATTCCTCCTGCGCTGCTGTCGCGATCGGGAGCTTTTCCGCTGGGGAGGGTTTCAAAACACTCTC
GTATTTCGACGAGGCAAGCC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MDHFQESCFVIWQTSRFQIDVSQPRVMGIVNVTPDSFSDGGKYFTPSGGFSGVFAHCEQLIRDGADLLDIGGESTRPGAP
PVPLQEELARVLPVVRHAATLGVPLSVDTYKPEVMQAVLDLGADIINDIWALRQPGARQIVAGHPSCGVCLMHMHREPQT
MQMAPMEGDVVPQVLSFLVGAAGDLQAAGVDRARIVLDAGVGFGKTVAQNFSLLAHQREFLAAGYPLLAAWSRKSSLAAV
SGTSPADAPLAIEDRLVPSVAAALLAVERGARVVRVHDVRETVQALKVWAAAS

Sequences:

>Translated_293_residues
MDHFQESCFVIWQTSRFQIDVSQPRVMGIVNVTPDSFSDGGKYFTPSGGFSGVFAHCEQLIRDGADLLDIGGESTRPGAP
PVPLQEELARVLPVVRHAATLGVPLSVDTYKPEVMQAVLDLGADIINDIWALRQPGARQIVAGHPSCGVCLMHMHREPQT
MQMAPMEGDVVPQVLSFLVGAAGDLQAAGVDRARIVLDAGVGFGKTVAQNFSLLAHQREFLAAGYPLLAAWSRKSSLAAV
SGTSPADAPLAIEDRLVPSVAAALLAVERGARVVRVHDVRETVQALKVWAAAS
>Mature_293_residues
MDHFQESCFVIWQTSRFQIDVSQPRVMGIVNVTPDSFSDGGKYFTPSGGFSGVFAHCEQLIRDGADLLDIGGESTRPGAP
PVPLQEELARVLPVVRHAATLGVPLSVDTYKPEVMQAVLDLGADIINDIWALRQPGARQIVAGHPSCGVCLMHMHREPQT
MQMAPMEGDVVPQVLSFLVGAAGDLQAAGVDRARIVLDAGVGFGKTVAQNFSLLAHQREFLAAGYPLLAAWSRKSSLAAV
SGTSPADAPLAIEDRLVPSVAAALLAVERGARVVRVHDVRETVQALKVWAAAS

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=274, Percent_Identity=44.1605839416058, Blast_Score=219, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6324073, Length=329, Percent_Identity=28.2674772036474, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31205; Mature: 31205

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFQESCFVIWQTSRFQIDVSQPRVMGIVNVTPDSFSDGGKYFTPSGGFSGVFAHCEQL
CCCCCCCEEEEEECCEEEEECCCCEEEEEEEECCCCCCCCCCEECCCCCCHHHHHHHHHH
IRDGADLLDIGGESTRPGAPPVPLQEELARVLPVVRHAATLGVPLSVDTYKPEVMQAVLD
HHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHH
LGADIINDIWALRQPGARQIVAGHPSCGVCLMHMHREPQTMQMAPMEGDVVPQVLSFLVG
HCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHC
AAGDLQAAGVDRARIVLDAGVGFGKTVAQNFSLLAHQREFLAAGYPLLAAWSRKSSLAAV
CCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEE
SGTSPADAPLAIEDRLVPSVAAALLAVERGARVVRVHDVRETVQALKVWAAAS
CCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDHFQESCFVIWQTSRFQIDVSQPRVMGIVNVTPDSFSDGGKYFTPSGGFSGVFAHCEQL
CCCCCCCEEEEEECCEEEEECCCCEEEEEEEECCCCCCCCCCEECCCCCCHHHHHHHHHH
IRDGADLLDIGGESTRPGAPPVPLQEELARVLPVVRHAATLGVPLSVDTYKPEVMQAVLD
HHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHH
LGADIINDIWALRQPGARQIVAGHPSCGVCLMHMHREPQTMQMAPMEGDVVPQVLSFLVG
HCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHC
AAGDLQAAGVDRARIVLDAGVGFGKTVAQNFSLLAHQREFLAAGYPLLAAWSRKSSLAAV
CCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEE
SGTSPADAPLAIEDRLVPSVAAALLAVERGARVVRVHDVRETVQALKVWAAAS
CCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400191; 7642493; 10710307 [H]