| Definition | Polaromonas sp. JS666 chromosome, complete genome. |
|---|---|
| Accession | NC_007948 |
| Length | 5,200,264 |
Click here to switch to the map view.
The map label for this gene is purH [H]
Identifier: 91787030
GI number: 91787030
Start: 1169744
End: 1171327
Strand: Direct
Name: purH [H]
Synonym: Bpro_1132
Alternate gene names: 91787030
Gene position: 1169744-1171327 (Clockwise)
Preceding gene: 91787029
Following gene: 91787033
Centisome position: 22.49
GC content: 62.31
Gene sequence:
>1584_bases ATGAACGCATTGATTTCCGTCTCCGACAAGACCGGTATCCTCGAATTTGCCCAGGCGCTGCATGCGTTGGGCATCAAGCT GATTTCCACCGGCGGCACGGCCAAGTTGCTGGCCGAGGCCGGCCTGCCGGTGACCGAGGTGGCGGAGCTCACGGGCTTTC CGGAAATGCTCGACGGTCGCGTCAAGACGCTGCACCCCAAGGTGCATGGCGGACTGCTGGCGCGGCGTGATGTGCCCGAG CATATGGCCGCCCTGAAAGCGCACCAGATAGACACGATTGACCTGCTGGTCGTCAACCTCTATCCGTTTGAGGCGACGGT GGCCAAGGCCGGCTGCACGCTGGAAGACGCGATCGAAAACATCGACATCGGTGGCCCGGCCATGGTGCGCTCGGCCGCCA AAAACTGGAAGGACGTGGGCGTGTTGACCGATGCCTCGCAGTACGCCGGGGTGCTGGACGAACTCAAGGCCGGCGGCAAG CTGACGGACCAGACCAAATTCGCCCTGTCGGTGGCGGCATTCAACCGCATCAGCCAGTACGACGGTGCCATCAGCGACTA TCTCTCGGGCATTCAGGCTGATGGCACGCACAGCCTGTTTCCGGGCCAGGCCAATGGCCGTTTCATCAAGGTGCAGGATT TGCGTTATGGCGAAAATTCGCACCAGCAGGCCGCGCTGTACCGGGATTTGTACCCCGCGCCGGGTTCGCTCGTGACCGCC AAACAGCTGCAGGGCAAGGAACTCTCCTACAACAACATTGCCGATGCCGACGCCGCCTGGGAATGCGTCAAGAGCTTTGA TTTCCTCAAGGATGGTGCCGCCTGCGTGATCGTCAAGCATGCCAACCCCTGCGGTGTGGCCGTGGGCAAGGATGGGCTGG AGGCCTACAGCAAGGCCTTCAAGACCGATCCCACATCCGCGTTCGGCGGCATCATCGCGTTGAACTGTCCTCTCGACGAG CACGCCGCGCTGCAAATTTCGAAGCAGTTCGTTGAAGTGCTGATGGCGCCGGCCTTTTCGCCCGAAGCGCTGGAAGTGTT CAAGGCCAAGGTCAACGTGCGGATTCTGCAAATTGACCTGCCGCCCGGCGGCGATACGGCGTGGAAGCAGGGCCGCAATT TGATCGACGTCAAGCGTGTGGGTTCGGGCCTTCTGATGCAGACCGCGGATAACCACGAGCTGGCCATCGGCGAGCTGAAG GTCGTCAGCAAGCTGCAACCGACGCAGGAGCAGCTGCACGACATGCTGTTTGCCTGGAAGGTCGCGAAATACGTGAAATC CAATGCCATCGTGTTTTGCTCGGGCGGCATGACGCTGGGTGTGGGTGCGGGCCAGATGAGCCGCATCGACTCGGCACGCA TCGCCTCGATCAAAGCTGCAAATGCCGGCCTGACGCTGCAGGGATCGGCCGTTGCCAGCGACGCGTTCTTTCCGTTCCGC GACGGGCTTGACGTGGTGGTGGACGCGGGAGCGACCTGCGTCATCCAGCCAGGTGGCAGCATGCGCGATGACGAGGTGAT CGCCGCGGCCAACGACCGCGAGGTGGTGATGGTGCTGACCGGCGTGCGGCACTTCAGGCACTGA
Upstream 100 bases:
>100_bases CTTCGCAAGAAGCTGGTTGAGCACAAGCTCATCAAATAAGAACAAGCCCTGTACATATCACCGTCCGGTTTGCCGGCACG GCATTTTTTCAAAGACAAAA
Downstream 100 bases:
>100_bases GAGGCGTTTGCCTGGTCAGGAAAAGTGCTGGCACCGATTAAATGGGCGCCGTCAGCTATTGAATTGATAGCGGGTGGCGC GGGCCATTTTGATATTGGGG
Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
Products: NA
Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]
Number of amino acids: Translated: 527; Mature: 527
Protein sequence:
>527_residues MNALISVSDKTGILEFAQALHALGIKLISTGGTAKLLAEAGLPVTEVAELTGFPEMLDGRVKTLHPKVHGGLLARRDVPE HMAALKAHQIDTIDLLVVNLYPFEATVAKAGCTLEDAIENIDIGGPAMVRSAAKNWKDVGVLTDASQYAGVLDELKAGGK LTDQTKFALSVAAFNRISQYDGAISDYLSGIQADGTHSLFPGQANGRFIKVQDLRYGENSHQQAALYRDLYPAPGSLVTA KQLQGKELSYNNIADADAAWECVKSFDFLKDGAACVIVKHANPCGVAVGKDGLEAYSKAFKTDPTSAFGGIIALNCPLDE HAALQISKQFVEVLMAPAFSPEALEVFKAKVNVRILQIDLPPGGDTAWKQGRNLIDVKRVGSGLLMQTADNHELAIGELK VVSKLQPTQEQLHDMLFAWKVAKYVKSNAIVFCSGGMTLGVGAGQMSRIDSARIASIKAANAGLTLQGSAVASDAFFPFR DGLDVVVDAGATCVIQPGGSMRDDEVIAAANDREVVMVLTGVRHFRH
Sequences:
>Translated_527_residues MNALISVSDKTGILEFAQALHALGIKLISTGGTAKLLAEAGLPVTEVAELTGFPEMLDGRVKTLHPKVHGGLLARRDVPE HMAALKAHQIDTIDLLVVNLYPFEATVAKAGCTLEDAIENIDIGGPAMVRSAAKNWKDVGVLTDASQYAGVLDELKAGGK LTDQTKFALSVAAFNRISQYDGAISDYLSGIQADGTHSLFPGQANGRFIKVQDLRYGENSHQQAALYRDLYPAPGSLVTA KQLQGKELSYNNIADADAAWECVKSFDFLKDGAACVIVKHANPCGVAVGKDGLEAYSKAFKTDPTSAFGGIIALNCPLDE HAALQISKQFVEVLMAPAFSPEALEVFKAKVNVRILQIDLPPGGDTAWKQGRNLIDVKRVGSGLLMQTADNHELAIGELK VVSKLQPTQEQLHDMLFAWKVAKYVKSNAIVFCSGGMTLGVGAGQMSRIDSARIASIKAANAGLTLQGSAVASDAFFPFR DGLDVVVDAGATCVIQPGGSMRDDEVIAAANDREVVMVLTGVRHFRH >Mature_527_residues MNALISVSDKTGILEFAQALHALGIKLISTGGTAKLLAEAGLPVTEVAELTGFPEMLDGRVKTLHPKVHGGLLARRDVPE HMAALKAHQIDTIDLLVVNLYPFEATVAKAGCTLEDAIENIDIGGPAMVRSAAKNWKDVGVLTDASQYAGVLDELKAGGK LTDQTKFALSVAAFNRISQYDGAISDYLSGIQADGTHSLFPGQANGRFIKVQDLRYGENSHQQAALYRDLYPAPGSLVTA KQLQGKELSYNNIADADAAWECVKSFDFLKDGAACVIVKHANPCGVAVGKDGLEAYSKAFKTDPTSAFGGIIALNCPLDE HAALQISKQFVEVLMAPAFSPEALEVFKAKVNVRILQIDLPPGGDTAWKQGRNLIDVKRVGSGLLMQTADNHELAIGELK VVSKLQPTQEQLHDMLFAWKVAKYVKSNAIVFCSGGMTLGVGAGQMSRIDSARIASIKAANAGLTLQGSAVASDAFFPFR DGLDVVVDAGATCVIQPGGSMRDDEVIAAANDREVVMVLTGVRHFRH
Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]
COG id: COG0138
COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the purH family [H]
Homologues:
Organism=Homo sapiens, GI20127454, Length=482, Percent_Identity=37.1369294605809, Blast_Score=254, Evalue=2e-67, Organism=Escherichia coli, GI1790439, Length=533, Percent_Identity=57.4108818011257, Blast_Score=593, Evalue=1e-170, Organism=Caenorhabditis elegans, GI71985564, Length=510, Percent_Identity=33.921568627451, Blast_Score=240, Evalue=1e-63, Organism=Caenorhabditis elegans, GI71985574, Length=356, Percent_Identity=26.123595505618, Blast_Score=82, Evalue=5e-16, Organism=Saccharomyces cerevisiae, GI6323056, Length=489, Percent_Identity=35.5828220858896, Blast_Score=256, Evalue=6e-69, Organism=Saccharomyces cerevisiae, GI6323768, Length=482, Percent_Identity=35.2697095435685, Blast_Score=250, Evalue=5e-67, Organism=Drosophila melanogaster, GI24649832, Length=485, Percent_Identity=38.3505154639175, Blast_Score=271, Evalue=8e-73,
Paralogues:
None
Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002695 - InterPro: IPR013982 - InterPro: IPR016193 - InterPro: IPR011607 [H]
Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]
EC number: =2.1.2.3; =3.5.4.10 [H]
Molecular weight: Translated: 56050; Mature: 56050
Theoretical pI: Translated: 6.20; Mature: 6.20
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNALISVSDKTGILEFAQALHALGIKLISTGGTAKLLAEAGLPVTEVAELTGFPEMLDGR CCCEEEECCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCHHHHHHHCCCHHHHCCC VKTLHPKVHGGLLARRDVPEHMAALKAHQIDTIDLLVVNLYPFEATVAKAGCTLEDAIEN CEEECCHHHCCEEECCCCHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHCCCCHHHHHHH IDIGGPAMVRSAAKNWKDVGVLTDASQYAGVLDELKAGGKLTDQTKFALSVAAFNRISQY CCCCCHHHHHHHHCCCHHCCEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH DGAISDYLSGIQADGTHSLFPGQANGRFIKVQDLRYGENSHQQAALYRDLYPAPGSLVTA CCHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEH KQLQGKELSYNNIADADAAWECVKSFDFLKDGAACVIVKHANPCGVAVGKDGLEAYSKAF HHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEECCHHHHHHHHHH KTDPTSAFGGIIALNCPLDEHAALQISKQFVEVLMAPAFSPEALEVFKAKVNVRILQIDL CCCCCCHHCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEEEEEEC PPGGDTAWKQGRNLIDVKRVGSGLLMQTADNHELAIGELKVVSKLQPTQEQLHDMLFAWK CCCCCHHHHCCCCEEEHHHCCCCEEEEECCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHH VAKYVKSNAIVFCSGGMTLGVGAGQMSRIDSARIASIKAANAGLTLQGSAVASDAFFPFR HHHHHHCCEEEEEECCCEEEECCCHHHHCCCHHHEEEEECCCCEEEECCCCCCCCCCCCC DGLDVVVDAGATCVIQPGGSMRDDEVIAAANDREVVMVLTGVRHFRH CCCEEEEECCCEEEECCCCCCCCCCEEEECCCCEEEEEEECHHHHCC >Mature Secondary Structure MNALISVSDKTGILEFAQALHALGIKLISTGGTAKLLAEAGLPVTEVAELTGFPEMLDGR CCCEEEECCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCHHHHHHHCCCHHHHCCC VKTLHPKVHGGLLARRDVPEHMAALKAHQIDTIDLLVVNLYPFEATVAKAGCTLEDAIEN CEEECCHHHCCEEECCCCHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHCCCCHHHHHHH IDIGGPAMVRSAAKNWKDVGVLTDASQYAGVLDELKAGGKLTDQTKFALSVAAFNRISQY CCCCCHHHHHHHHCCCHHCCEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH DGAISDYLSGIQADGTHSLFPGQANGRFIKVQDLRYGENSHQQAALYRDLYPAPGSLVTA CCHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEH KQLQGKELSYNNIADADAAWECVKSFDFLKDGAACVIVKHANPCGVAVGKDGLEAYSKAF HHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEECCHHHHHHHHHH KTDPTSAFGGIIALNCPLDEHAALQISKQFVEVLMAPAFSPEALEVFKAKVNVRILQIDL CCCCCCHHCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEEEEEEC PPGGDTAWKQGRNLIDVKRVGSGLLMQTADNHELAIGELKVVSKLQPTQEQLHDMLFAWK CCCCCHHHHCCCCEEEHHHCCCCEEEEECCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHH VAKYVKSNAIVFCSGGMTLGVGAGQMSRIDSARIASIKAANAGLTLQGSAVASDAFFPFR HHHHHHCCEEEEEECCCEEEECCCHHHHCCCHHHEEEEECCCCEEEECCCCCCCCCCCCC DGLDVVVDAGATCVIQPGGSMRDDEVIAAANDREVVMVLTGVRHFRH CCCEEEEECCCEEEECCCCCCCCCCEEEECCCCEEEEEEECHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA