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The map label for this gene is fkpB [H]

Identifier: 91786852

GI number: 91786852

Start: 973284

End: 973757

Strand: Direct

Name: fkpB [H]

Synonym: Bpro_0950

Alternate gene names: 91786852

Gene position: 973284-973757 (Clockwise)

Preceding gene: 91786848

Following gene: 91786853

Centisome position: 18.72

GC content: 66.67

Gene sequence:

>474_bases
ATGCCCCCCGTGGAAACCACCGCTCCCGCACTTGTCCAGCCCGGCTCTTTTTTGACGCTGCATTACCGCATGGCCGGCCC
GGACGGCGCCGACATCATCAACACCTTTGGCGGCAAGCCGGCCACGCTGAGCCTGGGCACCGGTGAGTTGTCACCCGCGA
TCGAGCAGCGCCTGCTGGGCCTGCCCGAGGGCACGCGCACCACGTTCGAGCTGGCCGCCGGTGCGGCCTTTGGCGAGCGC
AACCCCACCCTGGTGCAATGGGTGGCGCGCAAGCTGCTCAATGAGCTGGGCGACCCCGACGAGCAGTACAAGGTCGGCGA
TGTGGTGCAGTTCCCCACGCCTGACGGCATGGGGCAGTACGCCGGCGCCGTTCAGCAGGTCAAGGAGGGCGGCGATGCCG
TGCAGTTCGACTTCAACCACCCGCTGGCCGGCCAGCCGGTGGTGTTTGAAGTGCAAGTGATTGGCGTTTTATGA

Upstream 100 bases:

>100_bases
ATATAGTCGGTCGATTGACCGAAATGAGGCGACGCGAGTCGCACCAATAGAGGCAGTTTACAAACAGTTGTTGGCCGCCC
CCGCCGGCCCAGAGAGTTTT

Downstream 100 bases:

>100_bases
ATACCGCAGACAAACGGCTTGACGAAATCCTGCTCGCGGAGCCGCGCGGCTTTTGCGCCGGTGTCGACCGGGCCATTGAA
ATCGTCGAGCGGGCGCTCAC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MPPVETTAPALVQPGSFLTLHYRMAGPDGADIINTFGGKPATLSLGTGELSPAIEQRLLGLPEGTRTTFELAAGAAFGER
NPTLVQWVARKLLNELGDPDEQYKVGDVVQFPTPDGMGQYAGAVQQVKEGGDAVQFDFNHPLAGQPVVFEVQVIGVL

Sequences:

>Translated_157_residues
MPPVETTAPALVQPGSFLTLHYRMAGPDGADIINTFGGKPATLSLGTGELSPAIEQRLLGLPEGTRTTFELAAGAAFGER
NPTLVQWVARKLLNELGDPDEQYKVGDVVQFPTPDGMGQYAGAVQQVKEGGDAVQFDFNHPLAGQPVVFEVQVIGVL
>Mature_156_residues
PPVETTAPALVQPGSFLTLHYRMAGPDGADIINTFGGKPATLSLGTGELSPAIEQRLLGLPEGTRTTFELAAGAAFGERN
PTLVQWVARKLLNELGDPDEQYKVGDVVQFPTPDGMGQYAGAVQQVKEGGDAVQFDFNHPLAGQPVVFEVQVIGVL

Specific function: PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide', where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786211, Length=146, Percent_Identity=37.6712328767123, Blast_Score=97, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16601; Mature: 16470

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPVETTAPALVQPGSFLTLHYRMAGPDGADIINTFGGKPATLSLGTGELSPAIEQRLLG
CCCCCCCCCCEECCCCEEEEEEEECCCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHC
LPEGTRTTFELAAGAAFGERNPTLVQWVARKLLNELGDPDEQYKVGDVVQFPTPDGMGQY
CCCCCCEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHEECCCEEECCCCCCCHHH
AGAVQQVKEGGDAVQFDFNHPLAGQPVVFEVQVIGVL
HHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
PPVETTAPALVQPGSFLTLHYRMAGPDGADIINTFGGKPATLSLGTGELSPAIEQRLLG
CCCCCCCCCEECCCCEEEEEEEECCCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHC
LPEGTRTTFELAAGAAFGERNPTLVQWVARKLLNELGDPDEQYKVGDVVQFPTPDGMGQY
CCCCCCEEEEHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHEECCCEEECCCCCCCHHH
AGAVQQVKEGGDAVQFDFNHPLAGQPVVFEVQVIGVL
HHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]