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The map label for this gene is nadC [H]

Identifier: 91786804

GI number: 91786804

Start: 920045

End: 920908

Strand: Direct

Name: nadC [H]

Synonym: Bpro_0902

Alternate gene names: 91786804

Gene position: 920045-920908 (Clockwise)

Preceding gene: 91786796

Following gene: 91786805

Centisome position: 17.69

GC content: 65.05

Gene sequence:

>864_bases
ATGAAAAAGTCATTTGATTTCTCGGCTGAGGCCATCGTTGAGGTAGCCAAGGCCGACGCAATTCTTGCGCTGGCCGAAGA
TGTGGGCGCGGGCGATTTGACGGCGGGGCTGATTGATCCGGCCCGCAGCGCCCGGGCGCAGGTGCTGGCACGCGAAAGCG
CCGTGATTTGCGGCAGCGCCTGGGTGGAAGCCACGATTTTGCAGCTCGACCCCCAGGCCCGCCTGACCTGGCATGTGCGG
GACGGCGAGCGCTGCGCCGCCAACCAGGTGGTGCTGGAGATACAGGGTCGGGCGCAGGCCCTGCTGACGGCCGAGCGCAC
GGCGCTCAATTTTCTGCAGCTGCTGAGCGCGGTGGCCAGCAAAACGGCTGGCTATGTCGCTGCGGTGCAAGGCACGCGGG
CGCAGATTGTGGACACCCGCAAAACATTGCCCGGCCTGCGCCTGGCGCAGAAATACGCGGTGCGTACCGGCGGCGGCACC
AACCACCGGATTGGCCTCTACGACGCGGTGCTGATCAAGGAAAACCATATTGCCGCTGCCGGCGGCATTGCGCAGGTGCT
GGCGCGTGCGGCCGCGGTGGCGGCCCAGGCAGATTTTGTGCAAATCGAGGTTGAAGACCTGGCCGAGTTGCAGCAGGCCC
TGAATGCCGGCGCCCGCATGGTGCTGCTCGACAACATGACGCTGGACCAGTTGCGCGAGGCGGTGCGCATCAACGAGGGG
CGCGCCAGCCTGGAGATCTCCGGTGGCGTGACGCAGGAAAGCCTGCGCAGCCTGGCCGAAACTGGCGTGGACCGGATTTC
CATTGGCGGCCTGACCAAGGACGTCAAGGCCATCGATTTCTCGATGCGTTTTCACGAGCTGTAA

Upstream 100 bases:

>100_bases
GTAACATTTAGTCTGTTGAACCGTAGTCTAGGGGAGTCTTTATTCCCGTAGTCTAGGGGAGTCTTTATTCCATCTGGGCG
AGTCTTTATTCCAACTGGTT

Downstream 100 bases:

>100_bases
GGAACTGCGATGGGCGCCGTGACTGACGTGATTGATGTTGAATACGACTCGCCGCACCCGGCGGCGGTTCCGGGCGCCTC
GGCGTGCGACACCAGGCACG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKKSFDFSAEAIVEVAKADAILALAEDVGAGDLTAGLIDPARSARAQVLARESAVICGSAWVEATILQLDPQARLTWHVR
DGERCAANQVVLEIQGRAQALLTAERTALNFLQLLSAVASKTAGYVAAVQGTRAQIVDTRKTLPGLRLAQKYAVRTGGGT
NHRIGLYDAVLIKENHIAAAGGIAQVLARAAAVAAQADFVQIEVEDLAELQQALNAGARMVLLDNMTLDQLREAVRINEG
RASLEISGGVTQESLRSLAETGVDRISIGGLTKDVKAIDFSMRFHEL

Sequences:

>Translated_287_residues
MKKSFDFSAEAIVEVAKADAILALAEDVGAGDLTAGLIDPARSARAQVLARESAVICGSAWVEATILQLDPQARLTWHVR
DGERCAANQVVLEIQGRAQALLTAERTALNFLQLLSAVASKTAGYVAAVQGTRAQIVDTRKTLPGLRLAQKYAVRTGGGT
NHRIGLYDAVLIKENHIAAAGGIAQVLARAAAVAAQADFVQIEVEDLAELQQALNAGARMVLLDNMTLDQLREAVRINEG
RASLEISGGVTQESLRSLAETGVDRISIGGLTKDVKAIDFSMRFHEL
>Mature_287_residues
MKKSFDFSAEAIVEVAKADAILALAEDVGAGDLTAGLIDPARSARAQVLARESAVICGSAWVEATILQLDPQARLTWHVR
DGERCAANQVVLEIQGRAQALLTAERTALNFLQLLSAVASKTAGYVAAVQGTRAQIVDTRKTLPGLRLAQKYAVRTGGGT
NHRIGLYDAVLIKENHIAAAGGIAQVLARAAAVAAQADFVQIEVEDLAELQQALNAGARMVLLDNMTLDQLREAVRINEG
RASLEISGGVTQESLRSLAETGVDRISIGGLTKDVKAIDFSMRFHEL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=258, Percent_Identity=36.046511627907, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1786299, Length=268, Percent_Identity=50.3731343283582, Blast_Score=249, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6321162, Length=284, Percent_Identity=30.6338028169014, Blast_Score=123, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30476; Mature: 30476

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSFDFSAEAIVEVAKADAILALAEDVGAGDLTAGLIDPARSARAQVLARESAVICGSA
CCCCCCCCHHHHHHHHHHHHHEEEHHCCCCCCHHHHHCCCHHHHHHHHHHHCCEEEECCH
WVEATILQLDPQARLTWHVRDGERCAANQVVLEIQGRAQALLTAERTALNFLQLLSAVAS
HHEEEEEEECCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
KTAGYVAAVQGTRAQIVDTRKTLPGLRLAQKYAVRTGGGTNHRIGLYDAVLIKENHIAAA
HCCCEEEEECCCHHHEEHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCEEHH
GGIAQVLARAAAVAAQADFVQIEVEDLAELQQALNAGARMVLLDNMTLDQLREAVRINEG
CHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCC
RASLEISGGVTQESLRSLAETGVDRISIGGLTKDVKAIDFSMRFHEL
CEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCHHHHEEEEHCCCC
>Mature Secondary Structure
MKKSFDFSAEAIVEVAKADAILALAEDVGAGDLTAGLIDPARSARAQVLARESAVICGSA
CCCCCCCCHHHHHHHHHHHHHEEEHHCCCCCCHHHHHCCCHHHHHHHHHHHCCEEEECCH
WVEATILQLDPQARLTWHVRDGERCAANQVVLEIQGRAQALLTAERTALNFLQLLSAVAS
HHEEEEEEECCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
KTAGYVAAVQGTRAQIVDTRKTLPGLRLAQKYAVRTGGGTNHRIGLYDAVLIKENHIAAA
HCCCEEEEECCCHHHEEHHHHCCCCHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCEEHH
GGIAQVLARAAAVAAQADFVQIEVEDLAELQQALNAGARMVLLDNMTLDQLREAVRINEG
CHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCC
RASLEISGGVTQESLRSLAETGVDRISIGGLTKDVKAIDFSMRFHEL
CEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCHHHHEEEEHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]