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The map label for this gene is hemL [H]

Identifier: 89256592

GI number: 89256592

Start: 1222952

End: 1224247

Strand: Reverse

Name: hemL [H]

Synonym: FTL_1283

Alternate gene names: 89256592

Gene position: 1224247-1222952 (Counterclockwise)

Preceding gene: 89256593

Following gene: 89256587

Centisome position: 64.57

GC content: 35.26

Gene sequence:

>1296_bases
ATGGAGAATAAATCAAACTCTCAAATTTTATTTGCAGAAGCACAGCAATATATACCAGGTGGAGTAAACTCTCCAGTTAG
GGCATTTAAGAGTGTTGGACAAGAATTTCCAAGATTTATAAAGTTTGCAAAAGGCGCTTATCTATATGATGTTGATTGGA
ACAAATACATAGACTATATTGGATCATGGGGACCGATGATTTTAGGTCATTGTGATGACGATGTTTTAGAAGCAATACAA
TGTCAGGTCAAAAATGGACTAAGCTATGGAGCACCATGTAAGCAAGAGGTTGATCTAGCTAAAAAAATAATTGAGCTAAT
GCCAAATATTGAGCAAGTAAGATTTGTAAACTCAGGTACTGAAGCTACTATTAGTGCAATCAGATTAGCAAGAGCATATA
CATGTAGAAATAAAATTATTAAATTTGAAGGCTGTTATCATGGTCATGCTGATGAGTTTCTTGTTGCAGCTGGTTCTGGT
GCGTTATCTCTAGGACAACCAAACTCTCCTGGAGTGCCGGAAGATGTTGTCAAAGATACTTTAGTAGCTAGTTTTAATGA
TATGGAGTCTATTCAAGCACTTTTTGAAAAATATAAAGATGAAATTGCTTGTATTATCGTTGAGCCAATTGCTGGTAATA
TGAATATGATTTTCCCACAAGATGGCTTCTTAGCCAAACTTAGAGCTATTTGTGATCAAAATAGTAGTTTATTGATATTT
GATGAAGTGATGACTGGTTTTAGAGTTGCTTTGGGTGGTGCGCAAAGTATCTATAATGTTAAGCCAGATTTGACAACTTT
GGGTAAAGTTATTGGTGGTGGTATGCCAGTTGGGGCTTTTGGCGGACGTAAAGAGATTATGCAAAAAGTTTCTCCAGCTG
GACCAGTTTACCAAGCAGGGACACTATCTGGAAATCCTATTGCGATGACAGCAGGTATCAAAACTTTAGAAAAAATCTCA
CAACCAGGGTTCTTTGATGAGCTTGGAGTTAAAGCACAAAAGCTAGTAGATGGTTTAAATGAGGCTGCTAAAGCCTATGA
TTTTAATTTTCATGCAAAATGTCTGGGCGGAATGTTTGGTTTATTTTTCTGTAGTGACAAAATTGCAGTAAATACATTTG
TAGATTTAGGCAAAACAAACCTTAAGATGTTTAATCAATTCTTTGCATATATGCTTGATAATGGTGTATATTTAGCGCCA
TCAGCTTATGAAGCAGGTTTTATTTCAATAGCTCATAGTGATGAAGATATTGAAAAAACCATTTGTCTTGCTAAAAAATT
TTTTCAAGAGAATTAG

Upstream 100 bases:

>100_bases
GGTATCCAAGAGATATACAAAGCTACAAAAATAAACGCTGCTAGTTTACTAATGCAAGCAGTTGAGAAAAAAATAAATAA
GATGAGACAGGAACACGAAA

Downstream 100 bases:

>100_bases
ATTAAAGTTGATAAATTAATTTATAAACTGACTGGTAGTACTCCTTTAATCTCTTTATTACCAAAAATATTTTCTAATGT
TGTTTGAATATTAATCTTTA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYIGSWGPMILGHCDDDVLEAIQ
CQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGTEATISAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSG
ALSLGQPNSPGVPEDVVKDTLVASFNDMESIQALFEKYKDEIACIIVEPIAGNMNMIFPQDGFLAKLRAICDQNSSLLIF
DEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAGTLSGNPIAMTAGIKTLEKIS
QPGFFDELGVKAQKLVDGLNEAAKAYDFNFHAKCLGGMFGLFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAP
SAYEAGFISIAHSDEDIEKTICLAKKFFQEN

Sequences:

>Translated_431_residues
MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYIGSWGPMILGHCDDDVLEAIQ
CQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGTEATISAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSG
ALSLGQPNSPGVPEDVVKDTLVASFNDMESIQALFEKYKDEIACIIVEPIAGNMNMIFPQDGFLAKLRAICDQNSSLLIF
DEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAGTLSGNPIAMTAGIKTLEKIS
QPGFFDELGVKAQKLVDGLNEAAKAYDFNFHAKCLGGMFGLFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAP
SAYEAGFISIAHSDEDIEKTICLAKKFFQEN
>Mature_431_residues
MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYIGSWGPMILGHCDDDVLEAIQ
CQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGTEATISAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSG
ALSLGQPNSPGVPEDVVKDTLVASFNDMESIQALFEKYKDEIACIIVEPIAGNMNMIFPQDGFLAKLRAICDQNSSLLIF
DEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAGTLSGNPIAMTAGIKTLEKIS
QPGFFDELGVKAQKLVDGLNEAAKAYDFNFHAKCLGGMFGLFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAP
SAYEAGFISIAHSDEDIEKTICLAKKFFQEN

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=311, Percent_Identity=28.9389067524116, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI13994255, Length=321, Percent_Identity=27.4143302180685, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI284507298, Length=228, Percent_Identity=29.3859649122807, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI37574042, Length=328, Percent_Identity=26.219512195122, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI226442709, Length=302, Percent_Identity=26.4900662251656, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI226442705, Length=266, Percent_Identity=26.6917293233083, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=58.4507042253521, Blast_Score=506, Evalue=1e-145,
Organism=Escherichia coli, GI1789016, Length=384, Percent_Identity=29.4270833333333, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789759, Length=330, Percent_Identity=31.2121212121212, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788044, Length=332, Percent_Identity=31.9277108433735, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI145693181, Length=336, Percent_Identity=29.7619047619048, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787560, Length=340, Percent_Identity=29.7058823529412, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786991, Length=310, Percent_Identity=27.741935483871, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=378, Percent_Identity=26.7195767195767, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=355, Percent_Identity=25.3521126760563, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=197, Percent_Identity=28.9340101522843, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324432, Length=332, Percent_Identity=29.5180722891566, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=309, Percent_Identity=27.1844660194175, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357415, Length=330, Percent_Identity=25.7575757575758, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356575, Length=347, Percent_Identity=26.5129682997118, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 47065; Mature: 47065

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYI
CCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHH
GSWGPMILGHCDDDVLEAIQCQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGT
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEECCCC
EATISAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSGALSLGQPNSPGVPEDVVKDT
HHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCCCEECCCCCCCCCCHHHHHHH
LVASFNDMESIQALFEKYKDEIACIIVEPIAGNMNMIFPQDGFLAKLRAICDQNSSLLIF
HHHHHCHHHHHHHHHHHHCCCEEEEEEEECCCCCEEECCCCCHHHHHHHHHCCCCCEEEE
DEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAG
HHHHHHHHHHHCCCHHHEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEECC
TLSGNPIAMTAGIKTLEKISQPGFFDELGVKAQKLVDGLNEAAKAYDFNFHAKCLGGMFG
CCCCCCEEEEHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAPSAYEAGFISIAHSDEDIEKT
HHHHCCCCEEHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCHHHHHH
ICLAKKFFQEN
HHHHHHHHHCC
>Mature Secondary Structure
MENKSNSQILFAEAQQYIPGGVNSPVRAFKSVGQEFPRFIKFAKGAYLYDVDWNKYIDYI
CCCCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHH
GSWGPMILGHCDDDVLEAIQCQVKNGLSYGAPCKQEVDLAKKIIELMPNIEQVRFVNSGT
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEECCCC
EATISAIRLARAYTCRNKIIKFEGCYHGHADEFLVAAGSGALSLGQPNSPGVPEDVVKDT
HHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEECCCCEECCCCCCCCCCHHHHHHH
LVASFNDMESIQALFEKYKDEIACIIVEPIAGNMNMIFPQDGFLAKLRAICDQNSSLLIF
HHHHHCHHHHHHHHHHHHCCCEEEEEEEECCCCCEEECCCCCHHHHHHHHHCCCCCEEEE
DEVMTGFRVALGGAQSIYNVKPDLTTLGKVIGGGMPVGAFGGRKEIMQKVSPAGPVYQAG
HHHHHHHHHHHCCCHHHEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEECC
TLSGNPIAMTAGIKTLEKISQPGFFDELGVKAQKLVDGLNEAAKAYDFNFHAKCLGGMFG
CCCCCCEEEEHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LFFCSDKIAVNTFVDLGKTNLKMFNQFFAYMLDNGVYLAPSAYEAGFISIAHSDEDIEKT
HHHHCCCCEEHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCHHHHHH
ICLAKKFFQEN
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA