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The map label for this gene is gor [H]

Identifier: 89256566

GI number: 89256566

Start: 1192573

End: 1193934

Strand: Direct

Name: gor [H]

Synonym: FTL_1248

Alternate gene names: 89256566

Gene position: 1192573-1193934 (Clockwise)

Preceding gene: 89256565

Following gene: 89256567

Centisome position: 62.9

GC content: 36.05

Gene sequence:

>1362_bases
ATGAGTAATAATCATTTTGATGTAATAAGTTTAGGTGGTGGTTCTGGTGGTATAGCATCTGCTGTACAGGCTGCGAAGTT
CGGTAAAAAAGTAGCAATTATTGAAAAGCGTGAGCTTGGTGGTACATGTGTAAATAGAGGTTGTGTACCTAAAAAAGCTA
TGTGGTATGGCGCTAATCTAGCTGAAATACTAAAGCATGATGTCGCAGGATATGGTTTTGACGTTGAAGTTAAAGGATTT
AACTGGGCAAAGCTTAAAGAAAAAAGAGCTACATATATAGGTAATATCCATGGTTTCTATGACAGATTATTAGATAAATG
GAATATTACTCATTTTAATAACTGGGGTAAATTTAAAGATAATAAAACTATAGTCCTAGATGATGGTACAGAGCTGACAG
CAGATCATATCTTTATATCACCAGGTGCATATCCTATCGTGCCTAAAAATATCGAAGGTGCTGAACTTGGTATCACATCT
GATGAGTTTTTCGAATTAGAAGAAACTCCAAAAAAAGCTGTAATCGTTGGTGGTGGCTATATAGGTGTTGAGATCGCTGG
AGTACTAAATGCTCATGGTACAGATACAACTATTATGGTGCGTAGAGATAAACCATTAATGGAGTTTGATAATTGTATTA
GTGATGCTCTGGTTGAATGTATGCAAATGACAGATCTAAATATCATGAACCATACAAATATCACAAAAGTTGAAAAAACT
GGAAGTACTCTAAAAATTACTACTGATACAGATAAGGTTTTAGAAGATGTTGATACTCTAATATGGGCAACTGGTCGCGC
GCCAAATACTCATAACCTAGGTATAGAAAATACTGATATAAGAATTACTGATAAAGGCGTAATACCTGCTAATGAATGGT
CTGAAACAAATGTTGCTGGAGTGTACTCTTTAGGTGATGCCTCAGGTGTGCCACAACTTACACCTGTAGCTATCAAGACA
GGTAGATATCTAGCTCGTAGATTATTTAATGGCGAAACTAATCTAAAAGCTAATTTGGAATATATCCCTACAGTGATCTT
CTCGCACCCTGCTATTGGTACAGTTGGCTTGACTGAAAAAGAAGCTAGAGATAAATATGGTGATGAAAATGTAAAAGTAT
ACAAATCTCGCTTTACAGCACTATATTGTGCTATTTCAGGACATAGAATGCCTACTGTTATGAAACTAGTAGTAACAGGT
GATAATGAAAAAATTGTCGGATGTCATATGATTGGTCTAAATGTTGATGAGATGCTACAAGGGTTTGCAGTCGCTATCAA
TATGGGTGCTACTAAGCGTGACTTTGATGATACCATAGCTATCCACCCTACTAGTTCTGAAGAGCTTGTGACTTTAGTTT
AA

Upstream 100 bases:

>100_bases
GGTGAAGTTGATGAAAATGGGCAAGTAACTAAAACTCTACATATTTATAAACTAAATAAGTAAAATTGTAGACATAAAAT
AAATATAGTAAGGAAATATA

Downstream 100 bases:

>100_bases
GGAATATCCTATGATATTAACTACAGCAGATACTCTTGGTAAAAGAGAAATTATAGAATACAAAGGTCTAGTTACAGGAA
TAATTGTAAGAACACCAACT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSNNHFDVISLGGGSGGIASAVQAAKFGKKVAIIEKRELGGTCVNRGCVPKKAMWYGANLAEILKHDVAGYGFDVEVKGF
NWAKLKEKRATYIGNIHGFYDRLLDKWNITHFNNWGKFKDNKTIVLDDGTELTADHIFISPGAYPIVPKNIEGAELGITS
DEFFELEETPKKAVIVGGGYIGVEIAGVLNAHGTDTTIMVRRDKPLMEFDNCISDALVECMQMTDLNIMNHTNITKVEKT
GSTLKITTDTDKVLEDVDTLIWATGRAPNTHNLGIENTDIRITDKGVIPANEWSETNVAGVYSLGDASGVPQLTPVAIKT
GRYLARRLFNGETNLKANLEYIPTVIFSHPAIGTVGLTEKEARDKYGDENVKVYKSRFTALYCAISGHRMPTVMKLVVTG
DNEKIVGCHMIGLNVDEMLQGFAVAINMGATKRDFDDTIAIHPTSSEELVTLV

Sequences:

>Translated_453_residues
MSNNHFDVISLGGGSGGIASAVQAAKFGKKVAIIEKRELGGTCVNRGCVPKKAMWYGANLAEILKHDVAGYGFDVEVKGF
NWAKLKEKRATYIGNIHGFYDRLLDKWNITHFNNWGKFKDNKTIVLDDGTELTADHIFISPGAYPIVPKNIEGAELGITS
DEFFELEETPKKAVIVGGGYIGVEIAGVLNAHGTDTTIMVRRDKPLMEFDNCISDALVECMQMTDLNIMNHTNITKVEKT
GSTLKITTDTDKVLEDVDTLIWATGRAPNTHNLGIENTDIRITDKGVIPANEWSETNVAGVYSLGDASGVPQLTPVAIKT
GRYLARRLFNGETNLKANLEYIPTVIFSHPAIGTVGLTEKEARDKYGDENVKVYKSRFTALYCAISGHRMPTVMKLVVTG
DNEKIVGCHMIGLNVDEMLQGFAVAINMGATKRDFDDTIAIHPTSSEELVTLV
>Mature_452_residues
SNNHFDVISLGGGSGGIASAVQAAKFGKKVAIIEKRELGGTCVNRGCVPKKAMWYGANLAEILKHDVAGYGFDVEVKGFN
WAKLKEKRATYIGNIHGFYDRLLDKWNITHFNNWGKFKDNKTIVLDDGTELTADHIFISPGAYPIVPKNIEGAELGITSD
EFFELEETPKKAVIVGGGYIGVEIAGVLNAHGTDTTIMVRRDKPLMEFDNCISDALVECMQMTDLNIMNHTNITKVEKTG
STLKITTDTDKVLEDVDTLIWATGRAPNTHNLGIENTDIRITDKGVIPANEWSETNVAGVYSLGDASGVPQLTPVAIKTG
RYLARRLFNGETNLKANLEYIPTVIFSHPAIGTVGLTEKEARDKYGDENVKVYKSRFTALYCAISGHRMPTVMKLVVTGD
NEKIVGCHMIGLNVDEMLQGFAVAINMGATKRDFDDTIAIHPTSSEELVTLV

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=48.471615720524, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI22035672, Length=458, Percent_Identity=36.0262008733624, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI148277071, Length=457, Percent_Identity=34.3544857768052, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI148277065, Length=457, Percent_Identity=34.3544857768052, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI33519430, Length=457, Percent_Identity=34.3544857768052, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI33519428, Length=457, Percent_Identity=34.3544857768052, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI33519426, Length=457, Percent_Identity=34.3544857768052, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI291045266, Length=459, Percent_Identity=32.8976034858388, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI291045268, Length=459, Percent_Identity=30.9368191721133, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI91199540, Length=460, Percent_Identity=28.2608695652174, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=48.2678983833718, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=26.8292682926829, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=27.5711159737418, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=25.9340659340659, Blast_Score=123, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=432, Percent_Identity=46.5277777777778, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71983429, Length=432, Percent_Identity=46.5277777777778, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17557007, Length=476, Percent_Identity=37.8151260504202, Blast_Score=287, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI71982272, Length=487, Percent_Identity=33.6755646817248, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI32565766, Length=453, Percent_Identity=26.7108167770419, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=46.1538461538462, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6321091, Length=465, Percent_Identity=27.3118279569892, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6325240, Length=462, Percent_Identity=24.6753246753247, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=33.8297872340426, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=33.2622601279318, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=33.8297872340426, Blast_Score=228, Evalue=9e-60,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=32.7004219409283, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=26.5217391304348, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49548; Mature: 49417

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNHFDVISLGGGSGGIASAVQAAKFGKKVAIIEKRELGGTCVNRGCVPKKAMWYGANL
CCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEECCCH
AEILKHDVAGYGFDVEVKGFNWAKLKEKRATYIGNIHGFYDRLLDKWNITHFNNWGKFKD
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCCCC
NKTIVLDDGTELTADHIFISPGAYPIVPKNIEGAELGITSDEFFELEETPKKAVIVGGGY
CCEEEEECCCEEEEEEEEECCCCCEECCCCCCCCEECCCCHHHEECCCCCCEEEEEECCE
IGVEIAGVLNAHGTDTTIMVRRDKPLMEFDNCISDALVECMQMTDLNIMNHTNITKVEKT
EEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEECC
GSTLKITTDTDKVLEDVDTLIWATGRAPNTHNLGIENTDIRITDKGVIPANEWSETNVAG
CCEEEEECCHHHHHHHHHHHEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEE
VYSLGDASGVPQLTPVAIKTGRYLARRLFNGETNLKANLEYIPTVIFSHPAIGTVGLTEK
EEEECCCCCCCCCCEEEEEHHHHHHHHHHCCCCCEEECHHEECEEEECCCCCCCCCCCCH
EARDKYGDENVKVYKSRFTALYCAISGHRMPTVMKLVVTGDNEKIVGCHMIGLNVDEMLQ
HHHHHCCCCCEEEEEEEEEEEEEEECCCCCCEEEEEEEECCCCEEEEEEEECCCHHHHHC
GFAVAINMGATKRDFDDTIAIHPTSSEELVTLV
CEEEEEECCCCCCCCCCEEEECCCCCCCEEEEC
>Mature Secondary Structure 
SNNHFDVISLGGGSGGIASAVQAAKFGKKVAIIEKRELGGTCVNRGCVPKKAMWYGANL
CCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEECCCH
AEILKHDVAGYGFDVEVKGFNWAKLKEKRATYIGNIHGFYDRLLDKWNITHFNNWGKFKD
HHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCCCC
NKTIVLDDGTELTADHIFISPGAYPIVPKNIEGAELGITSDEFFELEETPKKAVIVGGGY
CCEEEEECCCEEEEEEEEECCCCCEECCCCCCCCEECCCCHHHEECCCCCCEEEEEECCE
IGVEIAGVLNAHGTDTTIMVRRDKPLMEFDNCISDALVECMQMTDLNIMNHTNITKVEKT
EEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEECC
GSTLKITTDTDKVLEDVDTLIWATGRAPNTHNLGIENTDIRITDKGVIPANEWSETNVAG
CCEEEEECCHHHHHHHHHHHEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEE
VYSLGDASGVPQLTPVAIKTGRYLARRLFNGETNLKANLEYIPTVIFSHPAIGTVGLTEK
EEEECCCCCCCCCCEEEEEHHHHHHHHHHCCCCCEEECHHEECEEEECCCCCCCCCCCCH
EARDKYGDENVKVYKSRFTALYCAISGHRMPTVMKLVVTGDNEKIVGCHMIGLNVDEMLQ
HHHHHCCCCCEEEEEEEEEEEEEEECCCCCCEEEEEEEECCCCEEEEEEEECCCHHHHHC
GFAVAINMGATKRDFDDTIAIHPTSSEELVTLV
CEEEEEECCCCCCCCCCEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8525054 [H]