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The map label for this gene is nrdA [H]

Identifier: 89256332

GI number: 89256332

Start: 955358

End: 957130

Strand: Reverse

Name: nrdA [H]

Synonym: FTL_0986

Alternate gene names: 89256332

Gene position: 957130-955358 (Counterclockwise)

Preceding gene: 89256333

Following gene: 89256331

Centisome position: 50.48

GC content: 35.98

Gene sequence:

>1773_bases
ATGTCTAATCAAAGCTATCTTGGCATTAATATTGATTTATCTAGAGATCGTGAGCTTTCAGAACAAGCTCAACAACTACT
GACAAACTATTATTGCTTACAAAATGAACCCTCTCCTCAATATGCTTTTGCACGAGCTGCTGTTGCTTATTCTTTTGGGG
ATATGAACCTAGCTCAGCGCATTTATGATGCTGCTGCTAAAGGTTGGTTTATGTTTGCTTCACCTGTGCTTTCTAATGCA
CCACTTCCAGGTGCAAAAGTAAAATCTTTACCTATTAGTTGTTTTTTATCTTATGTGCCAGATTCATTAGAAGGTCTTAT
CGAGCATTCATCAGAACTTAGATGGTTATCAGTAAAAGGTGGAGGTGTTGGAGGACACTGGTCTAGTGTTCGCGCGGTAT
CTGATAAAGCTCCAGGACCTATCCCATTTATGCATACAGTTGATGCTGATATGGTTGCCTATAGACAAGGTAAAACTCGT
AAAGGTTCATATGCTGCATATATGGACATATCACACCCTGATATAATTGAATTTTTAGGTATCCGTGTGCCAACAGGTGA
TGTAAATAGAAAATGTCTAAACCTACATCATGCTGTAAATCTGACTGATGATTTTATGCAAGCAGTTGCAAATGACCAAG
ACTGGAAACTTATTGATCCAGATGACAAAACAGTAAGAGATGTTATCAAGGCTCGCAAAATTTGGGAAACCATATTAGAA
ACTCGTTACCGTACAGGTGAACCATACTTAAACTTTATTGACACAGCTAATAGAGCTTTACCAAAATCTCAAAAAGACCT
GGGCTTGACAATCAAAGGTTCAAATCTATGCAATGAGATTCATTTAGTTACAGATGAAAAACGTACAGCAGTATGCTGTT
TATCTTCTGTAAATTTAGAAAGATACGATGAATGGAAAGATACCTCACTTATCAAAGATTTAATTAGATTTTTAGATAAC
GTATTACAGTTTTTCATAGATCATGCTGGTGATGAAATCTCTAAGGCTAGATATAGTGCTTCACGTGAAAGAAGTCTAGG
TCTAGGAGCTATGGGGTTTCATTCTTATTTACAGCTTCATCGTGTACCTTTTGAGTCTCAAAGAGCAAAAGAAATTAATG
AAGAGATATTTAAGCGTATCAAAGAACAAGCGCTAGAAGAAACTCTAATACTTGGTGCTGAAAAAGGCGAAGCGCCAGAC
ATGGCAGGAACAGGACGTAGAAATGCTCACTTACTTGCTATAGCTCCTAATGCCAATAGTTCGCTTATCTTGAATACTTC
TCCAAGTATTGAACCTTGGAAAGCAAATGCTTTTACCTCTAGAACAAGAGTTGGTTCACATCTTAATAAGAACAAATATC
TAGAACAAGAACTAGAAAAAATTGGTAAAAATACTGAAGAAGTTTGGTCAGATATTATTACTAATGGTGGATCAGTTCAA
AAACTAGATTTTCTCAGTAAAGAATTAAAAGAAGTATTTAAAACTGCTATTGAAATGGATCAAGATTGGTTAGTCTATCT
AGGTGGTGAACGCCAAAAATATCTATGCCAAGGACAATCATTAAATGTATTTTTCCCAGCGGGAGCATCGCGTGGATATC
TTCACAAAGTACACTTTAATGCTTGGAAATATGGTTGTAAAGGTTTATATTATCTAAGAACAGAGACTTCAAATAGAGCT
GAGAATATTTCTAAAAAAGTCGAGAAGAAAAGACTTGTAGAGTTCTCAGAAATTAAGCAGTCTGAAAATGAGTGTATCGC
TTGTGAAGGATAA

Upstream 100 bases:

>100_bases
AAAAAATTGATAAAATTTTACTAAGAAATAAATAATTATACTAATCTAGTATAGTATTACTATCAAGTTAGTATATAAGC
ATTTTAAATAGGGTTTTATC

Downstream 100 bases:

>100_bases
AATATGAAAGTAAAAATATATATTAGAAATGGTTGTCCATATTGTGTTTGGGCAAAACAATGGTTCGAAGAAAATAATAT
AGCTTTTGATGAAACTATAA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 590; Mature: 589

Protein sequence:

>590_residues
MSNQSYLGINIDLSRDRELSEQAQQLLTNYYCLQNEPSPQYAFARAAVAYSFGDMNLAQRIYDAAAKGWFMFASPVLSNA
PLPGAKVKSLPISCFLSYVPDSLEGLIEHSSELRWLSVKGGGVGGHWSSVRAVSDKAPGPIPFMHTVDADMVAYRQGKTR
KGSYAAYMDISHPDIIEFLGIRVPTGDVNRKCLNLHHAVNLTDDFMQAVANDQDWKLIDPDDKTVRDVIKARKIWETILE
TRYRTGEPYLNFIDTANRALPKSQKDLGLTIKGSNLCNEIHLVTDEKRTAVCCLSSVNLERYDEWKDTSLIKDLIRFLDN
VLQFFIDHAGDEISKARYSASRERSLGLGAMGFHSYLQLHRVPFESQRAKEINEEIFKRIKEQALEETLILGAEKGEAPD
MAGTGRRNAHLLAIAPNANSSLILNTSPSIEPWKANAFTSRTRVGSHLNKNKYLEQELEKIGKNTEEVWSDIITNGGSVQ
KLDFLSKELKEVFKTAIEMDQDWLVYLGGERQKYLCQGQSLNVFFPAGASRGYLHKVHFNAWKYGCKGLYYLRTETSNRA
ENISKKVEKKRLVEFSEIKQSENECIACEG

Sequences:

>Translated_590_residues
MSNQSYLGINIDLSRDRELSEQAQQLLTNYYCLQNEPSPQYAFARAAVAYSFGDMNLAQRIYDAAAKGWFMFASPVLSNA
PLPGAKVKSLPISCFLSYVPDSLEGLIEHSSELRWLSVKGGGVGGHWSSVRAVSDKAPGPIPFMHTVDADMVAYRQGKTR
KGSYAAYMDISHPDIIEFLGIRVPTGDVNRKCLNLHHAVNLTDDFMQAVANDQDWKLIDPDDKTVRDVIKARKIWETILE
TRYRTGEPYLNFIDTANRALPKSQKDLGLTIKGSNLCNEIHLVTDEKRTAVCCLSSVNLERYDEWKDTSLIKDLIRFLDN
VLQFFIDHAGDEISKARYSASRERSLGLGAMGFHSYLQLHRVPFESQRAKEINEEIFKRIKEQALEETLILGAEKGEAPD
MAGTGRRNAHLLAIAPNANSSLILNTSPSIEPWKANAFTSRTRVGSHLNKNKYLEQELEKIGKNTEEVWSDIITNGGSVQ
KLDFLSKELKEVFKTAIEMDQDWLVYLGGERQKYLCQGQSLNVFFPAGASRGYLHKVHFNAWKYGCKGLYYLRTETSNRA
ENISKKVEKKRLVEFSEIKQSENECIACEG
>Mature_589_residues
SNQSYLGINIDLSRDRELSEQAQQLLTNYYCLQNEPSPQYAFARAAVAYSFGDMNLAQRIYDAAAKGWFMFASPVLSNAP
LPGAKVKSLPISCFLSYVPDSLEGLIEHSSELRWLSVKGGGVGGHWSSVRAVSDKAPGPIPFMHTVDADMVAYRQGKTRK
GSYAAYMDISHPDIIEFLGIRVPTGDVNRKCLNLHHAVNLTDDFMQAVANDQDWKLIDPDDKTVRDVIKARKIWETILET
RYRTGEPYLNFIDTANRALPKSQKDLGLTIKGSNLCNEIHLVTDEKRTAVCCLSSVNLERYDEWKDTSLIKDLIRFLDNV
LQFFIDHAGDEISKARYSASRERSLGLGAMGFHSYLQLHRVPFESQRAKEINEEIFKRIKEQALEETLILGAEKGEAPDM
AGTGRRNAHLLAIAPNANSSLILNTSPSIEPWKANAFTSRTRVGSHLNKNKYLEQELEKIGKNTEEVWSDIITNGGSVQK
LDFLSKELKEVFKTAIEMDQDWLVYLGGERQKYLCQGQSLNVFFPAGASRGYLHKVHFNAWKYGCKGLYYLRTETSNRAE
NISKKVEKKRLVEFSEIKQSENECIACEG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=605, Percent_Identity=30.9090909090909, Blast_Score=246, Evalue=3e-65,
Organism=Escherichia coli, GI1789030, Length=609, Percent_Identity=22.9885057471264, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI2367133, Length=648, Percent_Identity=22.6851851851852, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17555242, Length=624, Percent_Identity=29.3269230769231, Blast_Score=239, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6322123, Length=640, Percent_Identity=28.28125, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6320914, Length=635, Percent_Identity=29.2913385826772, Blast_Score=229, Evalue=7e-61,
Organism=Drosophila melanogaster, GI17352481, Length=601, Percent_Identity=27.6206322795341, Blast_Score=220, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 66565; Mature: 66434

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQSYLGINIDLSRDRELSEQAQQLLTNYYCLQNEPSPQYAFARAAVAYSFGDMNLAQR
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHH
IYDAAAKGWFMFASPVLSNAPLPGAKVKSLPISCFLSYVPDSLEGLIEHSSELRWLSVKG
HHHHHHCCCEEEECHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCEEEEEEEC
GGVGGHWSSVRAVSDKAPGPIPFMHTVDADMVAYRQGKTRKGSYAAYMDISHPDIIEFLG
CCCCCCHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHC
IRVPTGDVNRKCLNLHHAVNLTDDFMQAVANDQDWKLIDPDDKTVRDVIKARKIWETILE
CCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
TRYRTGEPYLNFIDTANRALPKSQKDLGLTIKGSNLCNEIHLVTDEKRTAVCCLSSVNLE
HHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEECCCCEEEEEEHHCCHH
RYDEWKDTSLIKDLIRFLDNVLQFFIDHAGDEISKARYSASRERSLGLGAMGFHSYLQLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RVPFESQRAKEINEEIFKRIKEQALEETLILGAEKGEAPDMAGTGRRNAHLLAIAPNANS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEECCCCCC
SLILNTSPSIEPWKANAFTSRTRVGSHLNKNKYLEQELEKIGKNTEEVWSDIITNGGSVQ
EEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCH
KLDFLSKELKEVFKTAIEMDQDWLVYLGGERQKYLCQGQSLNVFFPAGASRGYLHKVHFN
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEEECCCCCCCCEEEEEEC
AWKYGCKGLYYLRTETSNRAENISKKVEKKRLVEFSEIKQSENECIACEG
HHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure 
SNQSYLGINIDLSRDRELSEQAQQLLTNYYCLQNEPSPQYAFARAAVAYSFGDMNLAQR
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHH
IYDAAAKGWFMFASPVLSNAPLPGAKVKSLPISCFLSYVPDSLEGLIEHSSELRWLSVKG
HHHHHHCCCEEEECHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCEEEEEEEC
GGVGGHWSSVRAVSDKAPGPIPFMHTVDADMVAYRQGKTRKGSYAAYMDISHPDIIEFLG
CCCCCCHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHC
IRVPTGDVNRKCLNLHHAVNLTDDFMQAVANDQDWKLIDPDDKTVRDVIKARKIWETILE
CCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
TRYRTGEPYLNFIDTANRALPKSQKDLGLTIKGSNLCNEIHLVTDEKRTAVCCLSSVNLE
HHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEEECCCCEEEEEEHHCCHH
RYDEWKDTSLIKDLIRFLDNVLQFFIDHAGDEISKARYSASRERSLGLGAMGFHSYLQLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RVPFESQRAKEINEEIFKRIKEQALEETLILGAEKGEAPDMAGTGRRNAHLLAIAPNANS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEECCCCCC
SLILNTSPSIEPWKANAFTSRTRVGSHLNKNKYLEQELEKIGKNTEEVWSDIITNGGSVQ
EEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCH
KLDFLSKELKEVFKTAIEMDQDWLVYLGGERQKYLCQGQSLNVFFPAGASRGYLHKVHFN
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEEECCCCCCCCEEEEEEC
AWKYGCKGLYYLRTETSNRAENISKKVEKKRLVEFSEIKQSENECIACEG
HHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]