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The map label for this gene is hslU [H]

Identifier: 89256313

GI number: 89256313

Start: 931784

End: 933151

Strand: Reverse

Name: hslU [H]

Synonym: FTL_0964

Alternate gene names: 89256313

Gene position: 933151-931784 (Counterclockwise)

Preceding gene: 89256314

Following gene: 89256312

Centisome position: 49.22

GC content: 35.38

Gene sequence:

>1368_bases
ATGACACAAATAATGACTCCAAAAACAATCGTACATGAATTAGAAAGACACATAATTGGTCAAAACGATGCTAAAAAAGC
AGTTGCTATTGCTTTGCGTAATAGATGGCGCAGAATGCAACTTGACAATGAAATGCGTCAAGAAGTAACTCCTAAGAACA
TTCTTATGATTGGTCCAACAGGTGTGGGTAAAACAGAAATTGCGCGTAGATTAGCAAAATTAGCAGATGCTCCATTTATC
AAAGTAGAAGCAACTAAATTTACAGAAGTTGGTTATGTAGGCAAGGATGTTGAATCTATTATCCGTGATTTAGTTGAAAC
AGCTGTCAAAATGAAGCGTGAGGAAGCTAAAGAAAAAGTCACAGAAAAGGCTGCTAGATTAGCCGAAGATAGAATTTTAG
ATGTGCTAATTCCACCTGCAAGAACTTCAGAATCAAAGGTTGGTTTTGCAAATGAACCTGCAGAAGATGCTGCTAGTAAA
AAGGAAAAAGAAAATAAAACTCGTGAAATATTTAGAAAGAAAATCCAAAACGGCGAACTTGATGATAAAGAAATCGAGAT
TGAAGTAGCTGTGGCTCCAAAAACTATAGGCGTAATGGGCCCTCCAGGAATGGAAGATATGACAAGTCAGTTGCAAGATC
TTTTCTCTAGCTTAAGCACTGATAAGAAAAAAAACAAAAAAATGCGTATTAAAGATGCAATCAAGTTAGCCCAAGATGAA
GAAGCTGCAAAACTAGTTAATGAAGAAGACATAAAGGCTCGTGCTCTAGAAGCTGTTGAGCAAAATGGTATCGTATTCTT
AGATGAGATTGATAAAGTATGTAGAAAATCAAGCAACTCAGGGGCTGATGTGTCACGCGAAGGTGTACAGCGTGATTTAT
TACCATTAGTTGAAGGTTCTACAGTATCCACAAAATATGGCGTGATCAAAACTGATCATATACTATTTATTGCATCTGGT
GCATTTCATGTTGCTAAACCTTCTGACCTTATACCAGAGCTACAAGGTAGATTACCAATTAGGGTTGAGCTGAAATCTCT
AGAAATAGAAGATTTTGTAAGAATTTTAAGAGAACCTGACTGCTCTATTCTTAAGCAGTACATTGCTTTGATGAAAACTG
AAGGTATTGATTTAAGCTTTGAAGAAGATGCAATTAGAAAAATTGCTGAAATTGCCTATAAAGTCAATGAAGAAGTTGAA
AATATCGGTGCTAGAAGACTTCATACTGTTATGGAAAGACTTCTTGAGAAAATCTCTTTCGATGCTCCAGAACTAGTAGA
GAAAAATATCAACATAACTACAGACTATGTCAATGAAAAACTAGGAAACCTAGTTAAGAATAAAGATCTAAGTCAATATA
TTCTATAA

Upstream 100 bases:

>100_bases
ATTGTTAGAAAAAGTCTTACAATAGCTGCTGATACTTGTATTTATACAAACCATAACTTCACGATAGAAAGTTTAGAAAA
TAAAAAAGGATAGTTATACT

Downstream 100 bases:

>100_bases
TAACTAAGCTGATTTTATATTTTTTTTACGCGTAATATATATATATTTCCTTGTGTTATGACGATAAAATCTTGTTTACT
ATTTTATCAACTTAAAAATG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MTQIMTPKTIVHELERHIIGQNDAKKAVAIALRNRWRRMQLDNEMRQEVTPKNILMIGPTGVGKTEIARRLAKLADAPFI
KVEATKFTEVGYVGKDVESIIRDLVETAVKMKREEAKEKVTEKAARLAEDRILDVLIPPARTSESKVGFANEPAEDAASK
KEKENKTREIFRKKIQNGELDDKEIEIEVAVAPKTIGVMGPPGMEDMTSQLQDLFSSLSTDKKKNKKMRIKDAIKLAQDE
EAAKLVNEEDIKARALEAVEQNGIVFLDEIDKVCRKSSNSGADVSREGVQRDLLPLVEGSTVSTKYGVIKTDHILFIASG
AFHVAKPSDLIPELQGRLPIRVELKSLEIEDFVRILREPDCSILKQYIALMKTEGIDLSFEEDAIRKIAEIAYKVNEEVE
NIGARRLHTVMERLLEKISFDAPELVEKNINITTDYVNEKLGNLVKNKDLSQYIL

Sequences:

>Translated_455_residues
MTQIMTPKTIVHELERHIIGQNDAKKAVAIALRNRWRRMQLDNEMRQEVTPKNILMIGPTGVGKTEIARRLAKLADAPFI
KVEATKFTEVGYVGKDVESIIRDLVETAVKMKREEAKEKVTEKAARLAEDRILDVLIPPARTSESKVGFANEPAEDAASK
KEKENKTREIFRKKIQNGELDDKEIEIEVAVAPKTIGVMGPPGMEDMTSQLQDLFSSLSTDKKKNKKMRIKDAIKLAQDE
EAAKLVNEEDIKARALEAVEQNGIVFLDEIDKVCRKSSNSGADVSREGVQRDLLPLVEGSTVSTKYGVIKTDHILFIASG
AFHVAKPSDLIPELQGRLPIRVELKSLEIEDFVRILREPDCSILKQYIALMKTEGIDLSFEEDAIRKIAEIAYKVNEEVE
NIGARRLHTVMERLLEKISFDAPELVEKNINITTDYVNEKLGNLVKNKDLSQYIL
>Mature_454_residues
TQIMTPKTIVHELERHIIGQNDAKKAVAIALRNRWRRMQLDNEMRQEVTPKNILMIGPTGVGKTEIARRLAKLADAPFIK
VEATKFTEVGYVGKDVESIIRDLVETAVKMKREEAKEKVTEKAARLAEDRILDVLIPPARTSESKVGFANEPAEDAASKK
EKENKTREIFRKKIQNGELDDKEIEIEVAVAPKTIGVMGPPGMEDMTSQLQDLFSSLSTDKKKNKKMRIKDAIKLAQDEE
AAKLVNEEDIKARALEAVEQNGIVFLDEIDKVCRKSSNSGADVSREGVQRDLLPLVEGSTVSTKYGVIKTDHILFIASGA
FHVAKPSDLIPELQGRLPIRVELKSLEIEDFVRILREPDCSILKQYIALMKTEGIDLSFEEDAIRKIAEIAYKVNEEVEN
IGARRLHTVMERLLEKISFDAPELVEKNINITTDYVNEKLGNLVKNKDLSQYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=94, Percent_Identity=39.3617021276596, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790366, Length=451, Percent_Identity=64.7450110864745, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1786642, Length=219, Percent_Identity=32.8767123287671, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982905, Length=56, Percent_Identity=48.2142857142857, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71982908, Length=56, Percent_Identity=48.2142857142857, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319704, Length=108, Percent_Identity=38.8888888888889, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24648289, Length=243, Percent_Identity=30.4526748971193, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24648291, Length=250, Percent_Identity=30.4, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 51238; Mature: 51107

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIMTPKTIVHELERHIIGQNDAKKAVAIALRNRWRRMQLDNEMRQEVTPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GVGKTEIARRLAKLADAPFIKVEATKFTEVGYVGKDVESIIRDLVETAVKMKREEAKEKV
CCCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TEKAARLAEDRILDVLIPPARTSESKVGFANEPAEDAASKKEKENKTREIFRKKIQNGEL
HHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
DDKEIEIEVAVAPKTIGVMGPPGMEDMTSQLQDLFSSLSTDKKKNKKMRIKDAIKLAQDE
CCCEEEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCH
EAAKLVNEEDIKARALEAVEQNGIVFLDEIDKVCRKSSNSGADVSREGVQRDLLPLVEGS
HHHHHCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
TVSTKYGVIKTDHILFIASGAFHVAKPSDLIPELQGRLPIRVELKSLEIEDFVRILREPD
CCCCCCCEEEECCEEEEECCCEECCCCHHHHHHHHCCCCEEEEHHHCCHHHHHHHHCCCC
CSILKQYIALMKTEGIDLSFEEDAIRKIAEIAYKVNEEVENIGARRLHTVMERLLEKISF
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DAPELVEKNINITTDYVNEKLGNLVKNKDLSQYIL
CCHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TQIMTPKTIVHELERHIIGQNDAKKAVAIALRNRWRRMQLDNEMRQEVTPKNILMIGPT
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
GVGKTEIARRLAKLADAPFIKVEATKFTEVGYVGKDVESIIRDLVETAVKMKREEAKEKV
CCCHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TEKAARLAEDRILDVLIPPARTSESKVGFANEPAEDAASKKEKENKTREIFRKKIQNGEL
HHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
DDKEIEIEVAVAPKTIGVMGPPGMEDMTSQLQDLFSSLSTDKKKNKKMRIKDAIKLAQDE
CCCEEEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCH
EAAKLVNEEDIKARALEAVEQNGIVFLDEIDKVCRKSSNSGADVSREGVQRDLLPLVEGS
HHHHHCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
TVSTKYGVIKTDHILFIASGAFHVAKPSDLIPELQGRLPIRVELKSLEIEDFVRILREPD
CCCCCCCEEEECCEEEEECCCEECCCCHHHHHHHHCCCCEEEEHHHCCHHHHHHHHCCCC
CSILKQYIALMKTEGIDLSFEEDAIRKIAEIAYKVNEEVENIGARRLHTVMERLLEKISF
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DAPELVEKNINITTDYVNEKLGNLVKNKDLSQYIL
CCHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA