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The map label for this gene is ilvC [H]

Identifier: 89256267

GI number: 89256267

Start: 888462

End: 889505

Strand: Direct

Name: ilvC [H]

Synonym: FTL_0916

Alternate gene names: 89256267

Gene position: 888462-889505 (Clockwise)

Preceding gene: 89256266

Following gene: 89256275

Centisome position: 46.86

GC content: 36.88

Gene sequence:

>1044_bases
ATGGCAAAAATGAAATTTGGTAGTGTAGAAGAAACAGTAATAACACAACAAGAATTTACTTTAGAAAAAGCTTTAGAAAC
TCTAAAAGATGAGACTATAGCAATTATTGGCTATGGAGTACAAGGACCAGCACAAGCTCTTAACCTAAGAGATAATGGTT
TTAATGTAATAATTGGACAAAGAGAGAACTCAAAATCATGGGATAAAGCAATCGAAGATGGTTGGGTTGCTGGTAAGTCT
CTATTTAACATCGCTGAAGCTACTGCTAAAGGTACTATCGTAGTTAACCTATTATCAGATGCAGGTCAGATTGCTTCTTG
GAGTACTATCAAAGAGAATCTTAAGTCAGGTGATTTATTAATGTTCTCTCATGGTTTTGGTGTGACATATAGTGAAAAAA
CTAGCATCATTCCACCAGCAGATGTTGATGTTGCTTTAGTAGCACCAAAAGGTTCTGGGACTAGTGTTAGAAGATTATTC
TTAGCTAAGAAAGGTATTAACTCAAGCTATGCAATCTATCAGGACGCTACTGGTAAGGCTGAGAAAAGAACTTTAGCTTA
TGGTATAGGCGTAGGTTCTGGTTACTTATTTGAAACTACTTTTGAAAAAGAAGTATACAGTGATCTTACAGGTGAGAGAG
GTGTTCTTATGGGTGCTCTTGCTGGTATCATTGAAGCTCAGTATGAAGTATTACGTGCAAACGGACATTCTCCAAGTGAA
GCTTTCAATGAGACAGTTGAAGAGTTGACACAAAGTTTAGTGCCATTAGTTGCTGAAAATGGTATGGACTGGATGTTTGC
AAACTGTTCTACTACTGCTCAAAGAGGCGCTTTAGATTGGGCTCCTAAGTTTAGAGATGCTACAAAAGGTGTATTTGCTG
AGTTATATAATGAAGTAAAAAATGGTAATGAAGCACAACGTACTATTGATAAGAACAGTCATGCTGATTCTCGTAAAGAT
CTTGAGAAAGAGCTTGAAGAACTTAGCCAAAAAGAAGTATGGCAAGCTGGTAAGACTGTTAGATCTCTTCGTCCTAACAA
ATAG

Upstream 100 bases:

>100_bases
GCCAATGCAAGGAACTGTTGTAAGTGAAGTTCCTCAAAATGTCAAAACGGCAAGTCAAAGAAAAGCAGCTTAATATTTAA
AATTTAGGAGAATATAATAA

Downstream 100 bases:

>100_bases
CTAAATTATAAACTTAGTATCTTTTTAATATTTATATTTATTTCCAAAGCTATATCAATTTTAATTAAGTAATTCTAATA
AAGATTATAATCAGTATATT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MAKMKFGSVEETVITQQEFTLEKALETLKDETIAIIGYGVQGPAQALNLRDNGFNVIIGQRENSKSWDKAIEDGWVAGKS
LFNIAEATAKGTIVVNLLSDAGQIASWSTIKENLKSGDLLMFSHGFGVTYSEKTSIIPPADVDVALVAPKGSGTSVRRLF
LAKKGINSSYAIYQDATGKAEKRTLAYGIGVGSGYLFETTFEKEVYSDLTGERGVLMGALAGIIEAQYEVLRANGHSPSE
AFNETVEELTQSLVPLVAENGMDWMFANCSTTAQRGALDWAPKFRDATKGVFAELYNEVKNGNEAQRTIDKNSHADSRKD
LEKELEELSQKEVWQAGKTVRSLRPNK

Sequences:

>Translated_347_residues
MAKMKFGSVEETVITQQEFTLEKALETLKDETIAIIGYGVQGPAQALNLRDNGFNVIIGQRENSKSWDKAIEDGWVAGKS
LFNIAEATAKGTIVVNLLSDAGQIASWSTIKENLKSGDLLMFSHGFGVTYSEKTSIIPPADVDVALVAPKGSGTSVRRLF
LAKKGINSSYAIYQDATGKAEKRTLAYGIGVGSGYLFETTFEKEVYSDLTGERGVLMGALAGIIEAQYEVLRANGHSPSE
AFNETVEELTQSLVPLVAENGMDWMFANCSTTAQRGALDWAPKFRDATKGVFAELYNEVKNGNEAQRTIDKNSHADSRKD
LEKELEELSQKEVWQAGKTVRSLRPNK
>Mature_346_residues
AKMKFGSVEETVITQQEFTLEKALETLKDETIAIIGYGVQGPAQALNLRDNGFNVIIGQRENSKSWDKAIEDGWVAGKSL
FNIAEATAKGTIVVNLLSDAGQIASWSTIKENLKSGDLLMFSHGFGVTYSEKTSIIPPADVDVALVAPKGSGTSVRRLFL
AKKGINSSYAIYQDATGKAEKRTLAYGIGVGSGYLFETTFEKEVYSDLTGERGVLMGALAGIIEAQYEVLRANGHSPSEA
FNETVEELTQSLVPLVAENGMDWMFANCSTTAQRGALDWAPKFRDATKGVFAELYNEVKNGNEAQRTIDKNSHADSRKDL
EKELEELSQKEVWQAGKTVRSLRPNK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=289, Percent_Identity=26.643598615917, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323387, Length=345, Percent_Identity=55.0724637681159, Blast_Score=388, Evalue=1e-109,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 37879; Mature: 37748

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKMKFGSVEETVITQQEFTLEKALETLKDETIAIIGYGVQGPAQALNLRDNGFNVIIGQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHEEECCCCEEEEEEC
RENSKSWDKAIEDGWVAGKSLFNIAEATAKGTIVVNLLSDAGQIASWSTIKENLKSGDLL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEE
MFSHGFGVTYSEKTSIIPPADVDVALVAPKGSGTSVRRLFLAKKGINSSYAIYQDATGKA
EEECCCCCEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCH
EKRTLAYGIGVGSGYLFETTFEKEVYSDLTGERGVLMGALAGIIEAQYEVLRANGHSPSE
HHCEEEEEEECCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
AFNETVEELTQSLVPLVAENGMDWMFANCSTTAQRGALDWAPKFRDATKGVFAELYNEVK
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
NGNEAQRTIDKNSHADSRKDLEKELEELSQKEVWQAGKTVRSLRPNK
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AKMKFGSVEETVITQQEFTLEKALETLKDETIAIIGYGVQGPAQALNLRDNGFNVIIGQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHEEECCCCEEEEEEC
RENSKSWDKAIEDGWVAGKSLFNIAEATAKGTIVVNLLSDAGQIASWSTIKENLKSGDLL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEE
MFSHGFGVTYSEKTSIIPPADVDVALVAPKGSGTSVRRLFLAKKGINSSYAIYQDATGKA
EEECCCCCEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCH
EKRTLAYGIGVGSGYLFETTFEKEVYSDLTGERGVLMGALAGIIEAQYEVLRANGHSPSE
HHCEEEEEEECCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
AFNETVEELTQSLVPLVAENGMDWMFANCSTTAQRGALDWAPKFRDATKGVFAELYNEVK
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
NGNEAQRTIDKNSHADSRKDLEKELEELSQKEVWQAGKTVRSLRPNK
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA