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The map label for this gene is coaBC [H]

Identifier: 89256178

GI number: 89256178

Start: 796228

End: 797403

Strand: Direct

Name: coaBC [H]

Synonym: FTL_0808

Alternate gene names: 89256178

Gene position: 796228-797403 (Clockwise)

Preceding gene: 89256177

Following gene: 89256183

Centisome position: 42.0

GC content: 28.91

Gene sequence:

>1176_bases
ATGAGTAATAAGATTTTATTTGGGATCACTGGCAGTATATCAGCTTTTAAAACTATAAATTTGATAAGACTTTTTATTAA
AAGTGGTGTTGAATGTAGAGCTATAGTTACTAAAGGTGCACAGCAGTTTATAAAGCCTGAACTTTTAGTAGCTTTAGGCT
GTGATGTTTATACTGATGAAAAACTAGATATGTTATCTTATCAGCAAAGTATGGCACATATAAATTTATCACGTTGGGCT
GATAAGATATTTATAGTTCCTGCTTCAGCAAATACTATTGCAAAATTAGCTTATGGTTTAGCAGATGATTTATTAAGTCA
AACAATATTAGCTAATGATGATAATTCTAAGGTATATATAGCTCCTGCTATGAATGTAAATATGTGGCAAAACCAACTTA
CTCAAGATAATATTAATAAACTTCAAACTTTAGGATTTAATTTGATATTACCTGATAAAGGTCTTCAAGCTTGTGGAGAT
ATTGGTAGTGGTAGATTACATGAGCCGGAAGTCTTGTTTGATTTATTGAGTGTTTCTCAAGATTTCAAAGCTAAAAAAGT
AGTGATAACAGTAGGAGCAACTGTAGAAGATATTGATGGTGTTAGATATTTATCAAATTATAGCTCTGGTAAAATGGGCT
TTGCTTTGGTAAGAGAGTTACTTGCAAGAGGAGCTAGTGTTGTAGTATTAAAAGCAAAAACTACAATAAGCTTTGATATT
AAACATCCTAATTTAGAAATTATTAATACCAAAAGTGCTGATGATATGAACCAAGCAATGCTTAAAAAAGCTAAAGATAG
TGATATTTTTATAGGCTGTGCTGCAGTTGCTGATTATAAGATCAAAAATAAATTTACTAATAAAATTAAAAAAACTGATG
ATACATTAACTTTAGAGTTTATAAAAAATCCTGATGTTTTAGCTAATTGTAAAAAAACATACCCAAATATCTTTGCTATA
GGTTTTGCAGCAGAATCACAAAATATAGTAGATTATGCTCAGGCTAAACTTGTCAAAAAGAATCTAAATATGGTAGTTGC
AAATTCAACTGAAGTATTTGGTAATGATAACTCAAGTGTAACAATATTATCTAAGCATCAAACTAAACAATATAACAATA
AATCAAAGTCAGAAATAGCTAAGTTAATATTAGATTTTGCTAAGGAAATAATATGA

Upstream 100 bases:

>100_bases
GAATGTGAATATCTTAGCTGTAGTAGTTGCTATTATGGTCTTACTAATAATCATGTTTTATAAAAGAGAGAAGATATTAA
ATAAATAGAGATTAATATTT

Downstream 100 bases:

>100_bases
GTGTTAGAGAAGTTTGTATAGCTGGTAAATGTAATAAGCTGATAACTTTAAAAAATGATAATATTGAATTGATACTTTTG
AATCAAGGAGCAACTGTTTT

Product: bifunctional 4'-phosphopantothenoylcysteine decarboxylase,phosphopantothenoylcysteine synthetase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSNKILFGITGSISAFKTINLIRLFIKSGVECRAIVTKGAQQFIKPELLVALGCDVYTDEKLDMLSYQQSMAHINLSRWA
DKIFIVPASANTIAKLAYGLADDLLSQTILANDDNSKVYIAPAMNVNMWQNQLTQDNINKLQTLGFNLILPDKGLQACGD
IGSGRLHEPEVLFDLLSVSQDFKAKKVVITVGATVEDIDGVRYLSNYSSGKMGFALVRELLARGASVVVLKAKTTISFDI
KHPNLEIINTKSADDMNQAMLKKAKDSDIFIGCAAVADYKIKNKFTNKIKKTDDTLTLEFIKNPDVLANCKKTYPNIFAI
GFAAESQNIVDYAQAKLVKKNLNMVVANSTEVFGNDNSSVTILSKHQTKQYNNKSKSEIAKLILDFAKEII

Sequences:

>Translated_391_residues
MSNKILFGITGSISAFKTINLIRLFIKSGVECRAIVTKGAQQFIKPELLVALGCDVYTDEKLDMLSYQQSMAHINLSRWA
DKIFIVPASANTIAKLAYGLADDLLSQTILANDDNSKVYIAPAMNVNMWQNQLTQDNINKLQTLGFNLILPDKGLQACGD
IGSGRLHEPEVLFDLLSVSQDFKAKKVVITVGATVEDIDGVRYLSNYSSGKMGFALVRELLARGASVVVLKAKTTISFDI
KHPNLEIINTKSADDMNQAMLKKAKDSDIFIGCAAVADYKIKNKFTNKIKKTDDTLTLEFIKNPDVLANCKKTYPNIFAI
GFAAESQNIVDYAQAKLVKKNLNMVVANSTEVFGNDNSSVTILSKHQTKQYNNKSKSEIAKLILDFAKEII
>Mature_390_residues
SNKILFGITGSISAFKTINLIRLFIKSGVECRAIVTKGAQQFIKPELLVALGCDVYTDEKLDMLSYQQSMAHINLSRWAD
KIFIVPASANTIAKLAYGLADDLLSQTILANDDNSKVYIAPAMNVNMWQNQLTQDNINKLQTLGFNLILPDKGLQACGDI
GSGRLHEPEVLFDLLSVSQDFKAKKVVITVGATVEDIDGVRYLSNYSSGKMGFALVRELLARGASVVVLKAKTTISFDIK
HPNLEIINTKSADDMNQAMLKKAKDSDIFIGCAAVADYKIKNKFTNKIKKTDDTLTLEFIKNPDVLANCKKTYPNIFAIG
FAAESQNIVDYAQAKLVKKNLNMVVANSTEVFGNDNSSVTILSKHQTKQYNNKSKSEIAKLILDFAKEII

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=179, Percent_Identity=32.9608938547486, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI87082301, Length=396, Percent_Identity=36.6161616161616, Blast_Score=244, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17560194, Length=171, Percent_Identity=35.0877192982456, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322762, Length=179, Percent_Identity=32.4022346368715, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=29.0322580645161, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43093; Mature: 42962

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKILFGITGSISAFKTINLIRLFIKSGVECRAIVTKGAQQFIKPELLVALGCDVYTDE
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCEEEEECCCCCCCC
KLDMLSYQQSMAHINLSRWADKIFIVPASANTIAKLAYGLADDLLSQTILANDDNSKVYI
CHHHHHHHHHHHHEEHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEE
APAMNVNMWQNQLTQDNINKLQTLGFNLILPDKGLQACGDIGSGRLHEPEVLFDLLSVSQ
EECCCCHHHHHHCCHHHHHHHHHCCCEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHCCC
DFKAKKVVITVGATVEDIDGVRYLSNYSSGKMGFALVRELLARGASVVVLKAKTTISFDI
CCCCEEEEEEECCCHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEEEE
KHPNLEIINTKSADDMNQAMLKKAKDSDIFIGCAAVADYKIKNKFTNKIKKTDDTLTLEF
ECCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEHHHCHHHHHHHHHHHHCCCCEEEEEE
IKNPDVLANCKKTYPNIFAIGFAAESQNIVDYAQAKLVKKNLNMVVANSTEVFGNDNSSV
ECCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCEEEECCCCCEE
TILSKHQTKQYNNKSKSEIAKLILDFAKEII
EEEECCCHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNKILFGITGSISAFKTINLIRLFIKSGVECRAIVTKGAQQFIKPELLVALGCDVYTDE
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCEEEEECCCCCCCC
KLDMLSYQQSMAHINLSRWADKIFIVPASANTIAKLAYGLADDLLSQTILANDDNSKVYI
CHHHHHHHHHHHHEEHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEE
APAMNVNMWQNQLTQDNINKLQTLGFNLILPDKGLQACGDIGSGRLHEPEVLFDLLSVSQ
EECCCCHHHHHHCCHHHHHHHHHCCCEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHCCC
DFKAKKVVITVGATVEDIDGVRYLSNYSSGKMGFALVRELLARGASVVVLKAKTTISFDI
CCCCEEEEEEECCCHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEEEE
KHPNLEIINTKSADDMNQAMLKKAKDSDIFIGCAAVADYKIKNKFTNKIKKTDDTLTLEF
ECCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEHHHCHHHHHHHHHHHHCCCCEEEEEE
IKNPDVLANCKKTYPNIFAIGFAAESQNIVDYAQAKLVKKNLNMVVANSTEVFGNDNSSV
ECCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCEEEECCCCCEE
TILSKHQTKQYNNKSKSEIAKLILDFAKEII
EEEECCCHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]