Click here to switch to the map view.

The map label for this gene is ggt [H]

Identifier: 89256149

GI number: 89256149

Start: 755198

End: 757003

Strand: Direct

Name: ggt [H]

Synonym: FTL_0766

Alternate gene names: 89256149

Gene position: 755198-757003 (Clockwise)

Preceding gene: 89256148

Following gene: 89256152

Centisome position: 39.83

GC content: 34.94

Gene sequence:

>1806_bases
ATGCGTCGTTTTTTGTTATCTTATACTTATTCTGTTTTTAAAAATACACTGAGGTTATTAGTGAAAAAATTATTTGTAAA
CTTAATGTCATTGTTAATACTGCTACCAAGTTTAACTCTAATTGCTGCACCAGTCCCTACAGGTTATGGTTTTATTCCTA
TTCAAGAAGAGATGCAAATTGCTCAACCTTTTACTGCAACACATGGTATGGTTTCTTCTCAAGAAGCTCTGGCAAGTAAA
GTAGGCTTAGATATCCTAAAGCAAGGTGGTAATGCTGTAGATGCAGCTGTAGCTGTTGGTTTTGCTTTAGCTGTCACGCT
ACCAAGAGCTGGTAATCTCGCTGGTGGTGGATTTATGATTATACATCTACAAGATGGCAATAAGAATATAGCTATAAACT
ATCGTGAAAAAGCTCCAGCGAAAGCATCTCGTGATATGTTTCTAAATGATAAAGGTGATATTGATTATGCTAAAGTTTCT
GGTTCATATAGCGCATCTGGTGTTCCTGGTACTGTTGCATGCTTAATCGATGCACAACAAAAATATGGCAAATTAAAACT
ATCACAAGTTATTGAACCTGCTATCAAACTTGCTGAAGATGGTATTCCTGTAAGCTATGATCTTCACCAGTCACTTGTAA
CTGCAAAACCATGGCTACAAAAATCTCCAGATGCGATGAAAATCTTTTATAAAAAAGATGGATCAGCCTATGAGGTAGGA
GAAATCCTAAAACAGCCTGAACTTGCTAATAGTTTAAAGCTAATTGCAAAACAAGGCAAAAAAGCTTTCTATGAAGGAGA
AATAGCTCATAAGATAGCCGATAGTATGGCTAAAAATGGTGGTTTAATAACATTGCAAGATTTGAAAAATTATAATATTG
AGGAGATGAAGCCAGTTAAGGGAACTTATAGAGGTTATACTATATATTCTATGCCGCCGCCAAGTTCTGGTGGTGTGATT
CTAATAGAATTATTAAATATTCTGGAGAATTTTCCATTGTCTGACTATGGTAACAATAGTGCTAAGACTATTAATCTTAT
GAGTAATGCGATGAGCTATGCTTATAATGATAGGAATTCTGACTTAGGAGATCCAGATTTTGTCAAAATGGATTTAGCTA
AGTTTTTATCTAAGAAGTATGCAAAACAGATTGCTCAAAAGATAACTACAGATAAGCATATCCCTAGTAAAGATATTAGT
ACTATAGATCCGGATGATCATGAAAAATTACAAACTACACATTTTAGTATTATTGATAAAGATGGTAATATGGTATCAAA
TACTTATACCTTAAATTATTCTTATGGAAGTGGTATTGTAGTACCAGGAACGGGAATTTTTTTAAATAACGAAATGGATG
ATTTCGCTGCTAAAGTTGGCGAGGCAAATGTCTTTGGTTTGGTTCAAGGTGAAGTAAATACTGTCGCACCGAATAAACGA
CCATTAAGTTCAATGACTCCAACGATAGTATTAGATAATGATGGTAAACCATTTTTAGCTACAGGTTCTCCTGGAGGAAG
TCGTATTATTACAACAACGTTACAAGTGATTCTAAATATCATTGATTTTAATATGAATCTTCAAGCAGCAGTTAATAATC
CTCGTATACATAGTCAATTATGGCCAGAAGAGATTGGTGTAGAGCAGGGTATATCTGTAGATACAATTAATCTACTTAAG
AAGATGGGTAACACTGTCACACCTTATGCTGCTATGGGAGCTGCTGAATCTGTAATGTCAGATGGACAATATGTCTATGG
AGCTGCAGATCCACGCAGAGCTAGCGCATTAGCTATAGGTTATTAA

Upstream 100 bases:

>100_bases
GCTTAAAAGCAGTCTTTCAAGTGTAAACCAGGTTGCTGAAGTTTAATTAAATATTATGATGTAATTTTTAAATATTTTTT
GGTTTATTTTTGTTTCTTTA

Downstream 100 bases:

>100_bases
ACACTTTAATAGATTTTATTTGTTGATATAACATTTAAATATAATTGGCCAAACGACAGTATATACTTTTTTACTGTCTC
CCCATGATTCTCTGAATTTA

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MRRFLLSYTYSVFKNTLRLLVKKLFVNLMSLLILLPSLTLIAAPVPTGYGFIPIQEEMQIAQPFTATHGMVSSQEALASK
VGLDILKQGGNAVDAAVAVGFALAVTLPRAGNLAGGGFMIIHLQDGNKNIAINYREKAPAKASRDMFLNDKGDIDYAKVS
GSYSASGVPGTVACLIDAQQKYGKLKLSQVIEPAIKLAEDGIPVSYDLHQSLVTAKPWLQKSPDAMKIFYKKDGSAYEVG
EILKQPELANSLKLIAKQGKKAFYEGEIAHKIADSMAKNGGLITLQDLKNYNIEEMKPVKGTYRGYTIYSMPPPSSGGVI
LIELLNILENFPLSDYGNNSAKTINLMSNAMSYAYNDRNSDLGDPDFVKMDLAKFLSKKYAKQIAQKITTDKHIPSKDIS
TIDPDDHEKLQTTHFSIIDKDGNMVSNTYTLNYSYGSGIVVPGTGIFLNNEMDDFAAKVGEANVFGLVQGEVNTVAPNKR
PLSSMTPTIVLDNDGKPFLATGSPGGSRIITTTLQVILNIIDFNMNLQAAVNNPRIHSQLWPEEIGVEQGISVDTINLLK
KMGNTVTPYAAMGAAESVMSDGQYVYGAADPRRASALAIGY

Sequences:

>Translated_601_residues
MRRFLLSYTYSVFKNTLRLLVKKLFVNLMSLLILLPSLTLIAAPVPTGYGFIPIQEEMQIAQPFTATHGMVSSQEALASK
VGLDILKQGGNAVDAAVAVGFALAVTLPRAGNLAGGGFMIIHLQDGNKNIAINYREKAPAKASRDMFLNDKGDIDYAKVS
GSYSASGVPGTVACLIDAQQKYGKLKLSQVIEPAIKLAEDGIPVSYDLHQSLVTAKPWLQKSPDAMKIFYKKDGSAYEVG
EILKQPELANSLKLIAKQGKKAFYEGEIAHKIADSMAKNGGLITLQDLKNYNIEEMKPVKGTYRGYTIYSMPPPSSGGVI
LIELLNILENFPLSDYGNNSAKTINLMSNAMSYAYNDRNSDLGDPDFVKMDLAKFLSKKYAKQIAQKITTDKHIPSKDIS
TIDPDDHEKLQTTHFSIIDKDGNMVSNTYTLNYSYGSGIVVPGTGIFLNNEMDDFAAKVGEANVFGLVQGEVNTVAPNKR
PLSSMTPTIVLDNDGKPFLATGSPGGSRIITTTLQVILNIIDFNMNLQAAVNNPRIHSQLWPEEIGVEQGISVDTINLLK
KMGNTVTPYAAMGAAESVMSDGQYVYGAADPRRASALAIGY
>Mature_601_residues
MRRFLLSYTYSVFKNTLRLLVKKLFVNLMSLLILLPSLTLIAAPVPTGYGFIPIQEEMQIAQPFTATHGMVSSQEALASK
VGLDILKQGGNAVDAAVAVGFALAVTLPRAGNLAGGGFMIIHLQDGNKNIAINYREKAPAKASRDMFLNDKGDIDYAKVS
GSYSASGVPGTVACLIDAQQKYGKLKLSQVIEPAIKLAEDGIPVSYDLHQSLVTAKPWLQKSPDAMKIFYKKDGSAYEVG
EILKQPELANSLKLIAKQGKKAFYEGEIAHKIADSMAKNGGLITLQDLKNYNIEEMKPVKGTYRGYTIYSMPPPSSGGVI
LIELLNILENFPLSDYGNNSAKTINLMSNAMSYAYNDRNSDLGDPDFVKMDLAKFLSKKYAKQIAQKITTDKHIPSKDIS
TIDPDDHEKLQTTHFSIIDKDGNMVSNTYTLNYSYGSGIVVPGTGIFLNNEMDDFAAKVGEANVFGLVQGEVNTVAPNKR
PLSSMTPTIVLDNDGKPFLATGSPGGSRIITTTLQVILNIIDFNMNLQAAVNNPRIHSQLWPEEIGVEQGISVDTINLLK
KMGNTVTPYAAMGAAESVMSDGQYVYGAADPRRASALAIGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=497, Percent_Identity=32.1931589537223, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI73915090, Length=497, Percent_Identity=32.1931589537223, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI73915096, Length=497, Percent_Identity=32.1931589537223, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI73915094, Length=497, Percent_Identity=32.1931589537223, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI113429324, Length=484, Percent_Identity=30.5785123966942, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI113429326, Length=488, Percent_Identity=29.9180327868852, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI109148539, Length=550, Percent_Identity=30, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI153266885, Length=548, Percent_Identity=28.1021897810219, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI153266901, Length=549, Percent_Identity=28.0510018214936, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI153266907, Length=549, Percent_Identity=26.9581056466302, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI30581157, Length=186, Percent_Identity=35.4838709677419, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI30581155, Length=186, Percent_Identity=35.4838709677419, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI218505805, Length=177, Percent_Identity=34.4632768361582, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310124095, Length=179, Percent_Identity=31.8435754189944, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1789856, Length=547, Percent_Identity=51.9195612431444, Blast_Score=539, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI212646519, Length=545, Percent_Identity=33.394495412844, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI72000294, Length=545, Percent_Identity=33.394495412844, Blast_Score=262, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17542894, Length=603, Percent_Identity=31.6749585406302, Blast_Score=235, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17506189, Length=550, Percent_Identity=32.1818181818182, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI193208247, Length=561, Percent_Identity=31.0160427807487, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI193208245, Length=562, Percent_Identity=31.3167259786477, Blast_Score=219, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17564448, Length=437, Percent_Identity=27.0022883295195, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI72001495, Length=226, Percent_Identity=28.3185840707965, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI72001497, Length=226, Percent_Identity=28.3185840707965, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323330, Length=575, Percent_Identity=29.9130434782609, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI18859893, Length=511, Percent_Identity=32.4853228962818, Blast_Score=243, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24642670, Length=542, Percent_Identity=30.4428044280443, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24642666, Length=542, Percent_Identity=30.4428044280443, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI45551474, Length=542, Percent_Identity=30.4428044280443, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI161077880, Length=542, Percent_Identity=30.4428044280443, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI161077878, Length=542, Percent_Identity=30.4428044280443, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI161077496, Length=505, Percent_Identity=31.0891089108911, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI18859741, Length=520, Percent_Identity=26.7307692307692, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 65150; Mature: 65150

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRFLLSYTYSVFKNTLRLLVKKLFVNLMSLLILLPSLTLIAAPVPTGYGFIPIQEEMQI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECCCCCCCEEECHHHHHH
AQPFTATHGMVSSQEALASKVGLDILKQGGNAVDAAVAVGFALAVTLPRAGNLAGGGFMI
HCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCCEEE
IHLQDGNKNIAINYREKAPAKASRDMFLNDKGDIDYAKVSGSYSASGVPGTVACLIDAQQ
EEEECCCCEEEEEECCCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCCEEEEEEECHH
KYGKLKLSQVIEPAIKLAEDGIPVSYDLHQSLVTAKPWLQKSPDAMKIFYKKDGSAYEVG
HHCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCHHCCCCCCEEEEEECCCCEEHHH
EILKQPELANSLKLIAKQGKKAFYEGEIAHKIADSMAKNGGLITLQDLKNYNIEEMKPVK
HHHCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCC
GTYRGYTIYSMPPPSSGGVILIELLNILENFPLSDYGNNSAKTINLMSNAMSYAYNDRNS
CCCCCEEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCC
DLGDPDFVKMDLAKFLSKKYAKQIAQKITTDKHIPSKDISTIDPDDHEKLQTTHFSIIDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHEEEEEEEEEC
DGNMVSNTYTLNYSYGSGIVVPGTGIFLNNEMDDFAAKVGEANVFGLVQGEVNTVAPNKR
CCCEEEEEEEEEEECCCCEEECCCEEEECCCHHHHHHHCCCCCEEEEEECCEEECCCCCC
PLSSMTPTIVLDNDGKPFLATGSPGGSRIITTTLQVILNIIDFNMNLQAAVNNPRIHSQL
CCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHC
WPEEIGVEQGISVDTINLLKKMGNTVTPYAAMGAAESVMSDGQYVYGAADPRRASALAIG
CHHHHCHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEC
Y
C
>Mature Secondary Structure
MRRFLLSYTYSVFKNTLRLLVKKLFVNLMSLLILLPSLTLIAAPVPTGYGFIPIQEEMQI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECCCCCCCEEECHHHHHH
AQPFTATHGMVSSQEALASKVGLDILKQGGNAVDAAVAVGFALAVTLPRAGNLAGGGFMI
HCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCCEEE
IHLQDGNKNIAINYREKAPAKASRDMFLNDKGDIDYAKVSGSYSASGVPGTVACLIDAQQ
EEEECCCCEEEEEECCCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCCEEEEEEECHH
KYGKLKLSQVIEPAIKLAEDGIPVSYDLHQSLVTAKPWLQKSPDAMKIFYKKDGSAYEVG
HHCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCHHCCCCCCEEEEEECCCCEEHHH
EILKQPELANSLKLIAKQGKKAFYEGEIAHKIADSMAKNGGLITLQDLKNYNIEEMKPVK
HHHCCCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCC
GTYRGYTIYSMPPPSSGGVILIELLNILENFPLSDYGNNSAKTINLMSNAMSYAYNDRNS
CCCCCEEEEECCCCCCCCEEHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCC
DLGDPDFVKMDLAKFLSKKYAKQIAQKITTDKHIPSKDISTIDPDDHEKLQTTHFSIIDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHEEEEEEEEEC
DGNMVSNTYTLNYSYGSGIVVPGTGIFLNNEMDDFAAKVGEANVFGLVQGEVNTVAPNKR
CCCEEEEEEEEEEECCCCEEECCCEEEECCCHHHHHHHCCCCCEEEEEECCEEECCCCCC
PLSSMTPTIVLDNDGKPFLATGSPGGSRIITTTLQVILNIIDFNMNLQAAVNNPRIHSQL
CCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHC
WPEEIGVEQGISVDTINLLKKMGNTVTPYAAMGAAESVMSDGQYVYGAADPRRASALAIG
CHHHHCHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]