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The map label for this gene is edd [H]

Identifier: 89054444

GI number: 89054444

Start: 1945899

End: 1947704

Strand: Direct

Name: edd [H]

Synonym: Jann_1953

Alternate gene names: 89054444

Gene position: 1945899-1947704 (Clockwise)

Preceding gene: 89054442

Following gene: 89054445

Centisome position: 45.07

GC content: 64.17

Gene sequence:

>1806_bases
ATGCCACTCGACCCGCGCATCGCCGATATCACGGACCGTATCATCGAGCGGTCCCGCCCCACGCGGGAGCCGTATCTTGA
GCGGATGCGCAAGCTGGCCGAAGATGGCCCCCGTCGCGCGCATCTGACCTGTGGCAATCAGGCTCACGCCTATGCGGCCA
TGGGGGGTGACAAGGACGCGCTGGTGGCCGCGCATGCGCCCAATATCGGGATCGTGACGGCCTATAACGATATGCTGTCG
GCCCACCAACCCTTTGAAACCTATCCGCAAAAAATCAAGGATGCCGCGCGGGGGATTGGGGCCACGGCCCAGGTCGCGGG
CGGTGTGCCTGCGATGTGTGATGGCGTCACGCAGGGGCAGGTGGGCATGGAACTGTCGCTCTTCTCCCGCGACGTTATCG
CCATGGCGGCAGGGGTGGCGCTGTCGCACAACACGTTTGACGCGGCCCTCTATCTGGGGGTGTGCGACAAGATCGTGCCG
GGCCTTGTCATCGCGGCGGCGACATTCGGCTATATCCCCGCGCTGTTCGTGCCCGCAGGTCCCATGGTCTCCGGCCTGCC
CAACGACGAGAAGGCGCGCGTGCGTCAGCAATTCGCCGCCGGTGAGGTGGGCCGTGACAAGTTAATGGAGGCGGAAATGG
CCTCCTATCACGGGCCGGGCACCTGCACCTTCTACGGCACCGCCAATTCCAACCAGATGTTGATGGAATTCATGGGGTTG
CACCTGCCCGGGGCCTCCTTCGTCAACCCCGGCACGCCGCTGCGTGATGCCCTCACCATAGCGGCAACGGAACGCGCCGC
CTCCATCACCGCGCTTGGCAACGCCTATACGCCCGTCTGCGATATCCTCGATGAGAAGGCCTTTGTAAACGGCCTCGTGG
GCCTCATGGCCACGGGCGGCTCCACCAACCTGGTCATCCACCTCATCGCCATGGCGCGCGCGGCCGGCATCATCCTGCAA
TGCAATGATTTCAACGACATCTCGGAAGCCACGCCGCTGATGGCGCGCGTCTACCCCAATGGCTTGGCAGATGTGAACCA
CTTCCACGCCGCCGGGGGCCTTGGCTATATGATCGGCCAATTGCTGGATGCGGGCCTGATGCATGACGACGTCAAAACCG
CCGCTGGCGACGGCCTGTCGCTCTACACGCAGGAACCCGCGCTGAATGACGGCGCGTTCCACTATCGGGACGGCCCGAAA
GAGACGCTGAATGACAAGATCCTCCGCCCCCCGTCCGATCCTTTCGCCGCCACGGGTGGTCTGGCGGAGCTGAAAGGCAA
CCTTGGCATCGGCGTCATGAAGGTCTCTGCCGTTGATCCCGAGCGGCATTGTATCGAGGCGCCCGCCGCCATTTTCCACT
CCCAGGACGCGGTCAAGGAAGCGTTCAAGAACAATGAGTTGGAGCGCGACGTTGTTGTGGTCGTCCGCTTCCAGGGCCCC
AAGGCCAATGGCATGCCGGAACTCCATTCCCTCACGCCGCTGCTGTCGATCTTGCAGGGCCGTGGCCACCGCGTGGCGCT
GGTGACCGATGGCCGCATGTCCGGCGCGTCCGGCAAGGTCCCCTCTGCCATCCATGTCGCGCCAGAGGCCTTGGACGGCG
GCCTTATCGGCAAACTTCAGGACGGGGATCTCATCCGGGTCGATGCCAAAAACGGAACGCTCGACGTGCTGACCAACGGC
GTTGCGGCTCGGGCACCGGTCACCGCAGATCTCTCGGGCAACAGCCACGGTGTGGGTCGCGAGCTGTTTGAAATCTTCCG
CCAATCCGCGGGCCCCGCTACCACCGGCGCGGGTGTTGTGGTCTAA

Upstream 100 bases:

>100_bases
CTGGCACTCCTAACACCCCCGCGCTTGATCGCATGTGACCTCTGGACATGTTAGCGCTAACATGATACCAGCGTACCAAC
AGGTTTCACGGAGCAGCCCC

Downstream 100 bases:

>100_bases
GGCTATCGCATCCGCCCCGGGTCCGCCGCTGGCCCATCCCGGTCCCATCCCGGGGACGCGCTCCGCTCCCTCTTTCATCT
GGGTAAATACAACTCAATCC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MPLDPRIADITDRIIERSRPTREPYLERMRKLAEDGPRRAHLTCGNQAHAYAAMGGDKDALVAAHAPNIGIVTAYNDMLS
AHQPFETYPQKIKDAARGIGATAQVAGGVPAMCDGVTQGQVGMELSLFSRDVIAMAAGVALSHNTFDAALYLGVCDKIVP
GLVIAAATFGYIPALFVPAGPMVSGLPNDEKARVRQQFAAGEVGRDKLMEAEMASYHGPGTCTFYGTANSNQMLMEFMGL
HLPGASFVNPGTPLRDALTIAATERAASITALGNAYTPVCDILDEKAFVNGLVGLMATGGSTNLVIHLIAMARAAGIILQ
CNDFNDISEATPLMARVYPNGLADVNHFHAAGGLGYMIGQLLDAGLMHDDVKTAAGDGLSLYTQEPALNDGAFHYRDGPK
ETLNDKILRPPSDPFAATGGLAELKGNLGIGVMKVSAVDPERHCIEAPAAIFHSQDAVKEAFKNNELERDVVVVVRFQGP
KANGMPELHSLTPLLSILQGRGHRVALVTDGRMSGASGKVPSAIHVAPEALDGGLIGKLQDGDLIRVDAKNGTLDVLTNG
VAARAPVTADLSGNSHGVGRELFEIFRQSAGPATTGAGVVV

Sequences:

>Translated_601_residues
MPLDPRIADITDRIIERSRPTREPYLERMRKLAEDGPRRAHLTCGNQAHAYAAMGGDKDALVAAHAPNIGIVTAYNDMLS
AHQPFETYPQKIKDAARGIGATAQVAGGVPAMCDGVTQGQVGMELSLFSRDVIAMAAGVALSHNTFDAALYLGVCDKIVP
GLVIAAATFGYIPALFVPAGPMVSGLPNDEKARVRQQFAAGEVGRDKLMEAEMASYHGPGTCTFYGTANSNQMLMEFMGL
HLPGASFVNPGTPLRDALTIAATERAASITALGNAYTPVCDILDEKAFVNGLVGLMATGGSTNLVIHLIAMARAAGIILQ
CNDFNDISEATPLMARVYPNGLADVNHFHAAGGLGYMIGQLLDAGLMHDDVKTAAGDGLSLYTQEPALNDGAFHYRDGPK
ETLNDKILRPPSDPFAATGGLAELKGNLGIGVMKVSAVDPERHCIEAPAAIFHSQDAVKEAFKNNELERDVVVVVRFQGP
KANGMPELHSLTPLLSILQGRGHRVALVTDGRMSGASGKVPSAIHVAPEALDGGLIGKLQDGDLIRVDAKNGTLDVLTNG
VAARAPVTADLSGNSHGVGRELFEIFRQSAGPATTGAGVVV
>Mature_600_residues
PLDPRIADITDRIIERSRPTREPYLERMRKLAEDGPRRAHLTCGNQAHAYAAMGGDKDALVAAHAPNIGIVTAYNDMLSA
HQPFETYPQKIKDAARGIGATAQVAGGVPAMCDGVTQGQVGMELSLFSRDVIAMAAGVALSHNTFDAALYLGVCDKIVPG
LVIAAATFGYIPALFVPAGPMVSGLPNDEKARVRQQFAAGEVGRDKLMEAEMASYHGPGTCTFYGTANSNQMLMEFMGLH
LPGASFVNPGTPLRDALTIAATERAASITALGNAYTPVCDILDEKAFVNGLVGLMATGGSTNLVIHLIAMARAAGIILQC
NDFNDISEATPLMARVYPNGLADVNHFHAAGGLGYMIGQLLDAGLMHDDVKTAAGDGLSLYTQEPALNDGAFHYRDGPKE
TLNDKILRPPSDPFAATGGLAELKGNLGIGVMKVSAVDPERHCIEAPAAIFHSQDAVKEAFKNNELERDVVVVVRFQGPK
ANGMPELHSLTPLLSILQGRGHRVALVTDGRMSGASGKVPSAIHVAPEALDGGLIGKLQDGDLIRVDAKNGTLDVLTNGV
AARAPVTADLSGNSHGVGRELFEIFRQSAGPATTGAGVVV

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=601, Percent_Identity=57.2379367720466, Blast_Score=695, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=535, Percent_Identity=30.6542056074766, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI2367371, Length=494, Percent_Identity=31.3765182186235, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1786464, Length=467, Percent_Identity=29.9785867237687, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322476, Length=470, Percent_Identity=30.8510638297872, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 63032; Mature: 62901

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00380 RHODANESE_1 ; PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDPRIADITDRIIERSRPTREPYLERMRKLAEDGPRRAHLTCGNQAHAYAAMGGDKDA
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCE
LVAAHAPNIGIVTAYNDMLSAHQPFETYPQKIKDAARGIGATAQVAGGVPAMCDGVTQGQ
EEEECCCCCEEEEECHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCCCC
VGMELSLFSRDVIAMAAGVALSHNTFDAALYLGVCDKIVPGLVIAAATFGYIPALFVPAG
CCCEEHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PMVSGLPNDEKARVRQQFAAGEVGRDKLMEAEMASYHGPGTCTFYGTANSNQMLMEFMGL
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCC
HLPGASFVNPGTPLRDALTIAATERAASITALGNAYTPVCDILDEKAFVNGLVGLMATGG
CCCCCCCCCCCCCHHHHEEEEEHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
STNLVIHLIAMARAAGIILQCNDFNDISEATPLMARVYPNGLADVNHFHAAGGLGYMIGQ
CCHHHHHHHHHHHHCCEEEEECCCCCHHHHCCHHEECCCCCCCCCCHHHHCCCHHHHHHH
LLDAGLMHDDVKTAAGDGLSLYTQEPALNDGAFHYRDGPKETLNDKILRPPSDPFAATGG
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCHHHHCCCCCCCCCCCCCCCCC
LAELKGNLGIGVMKVSAVDPERHCIEAPAAIFHSQDAVKEAFKNNELERDVVVVVRFQGP
HHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEEEECCC
KANGMPELHSLTPLLSILQGRGHRVALVTDGRMSGASGKVPSAIHVAPEALDGGLIGKLQ
CCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECHHHHCCCCEEEEC
DGDLIRVDAKNGTLDVLTNGVAARAPVTADLSGNSHGVGRELFEIFRQSAGPATTGAGVV
CCCEEEEECCCCEEHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
V
C
>Mature Secondary Structure 
PLDPRIADITDRIIERSRPTREPYLERMRKLAEDGPRRAHLTCGNQAHAYAAMGGDKDA
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCE
LVAAHAPNIGIVTAYNDMLSAHQPFETYPQKIKDAARGIGATAQVAGGVPAMCDGVTQGQ
EEEECCCCCEEEEECHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCCCC
VGMELSLFSRDVIAMAAGVALSHNTFDAALYLGVCDKIVPGLVIAAATFGYIPALFVPAG
CCCEEHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PMVSGLPNDEKARVRQQFAAGEVGRDKLMEAEMASYHGPGTCTFYGTANSNQMLMEFMGL
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCC
HLPGASFVNPGTPLRDALTIAATERAASITALGNAYTPVCDILDEKAFVNGLVGLMATGG
CCCCCCCCCCCCCHHHHEEEEEHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
STNLVIHLIAMARAAGIILQCNDFNDISEATPLMARVYPNGLADVNHFHAAGGLGYMIGQ
CCHHHHHHHHHHHHCCEEEEECCCCCHHHHCCHHEECCCCCCCCCCHHHHCCCHHHHHHH
LLDAGLMHDDVKTAAGDGLSLYTQEPALNDGAFHYRDGPKETLNDKILRPPSDPFAATGG
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCHHHHCCCCCCCCCCCCCCCCC
LAELKGNLGIGVMKVSAVDPERHCIEAPAAIFHSQDAVKEAFKNNELERDVVVVVRFQGP
HHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEEEECCC
KANGMPELHSLTPLLSILQGRGHRVALVTDGRMSGASGKVPSAIHVAPEALDGGLIGKLQ
CCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECHHHHCCCCEEEEC
DGDLIRVDAKNGTLDVLTNGVAARAPVTADLSGNSHGVGRELFEIFRQSAGPATTGAGVV
CCCEEEEECCCCEEHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]