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The map label for this gene is parE [H]

Identifier: 89054416

GI number: 89054416

Start: 1912371

End: 1914332

Strand: Reverse

Name: parE [H]

Synonym: Jann_1925

Alternate gene names: 89054416

Gene position: 1914332-1912371 (Counterclockwise)

Preceding gene: 89054417

Following gene: 89054415

Centisome position: 44.33

GC content: 63.4

Gene sequence:

>1962_bases
ATGGCAGATGACCTCCTCTCCGGCGCGCCTGATGACCAGTCCTATGACGCCTCCTCCATCGAGGTGCTGGAAGGGCTGGA
GCCGGTCCGCAAACGCCCCGGCATGTATATCGGCGGCACCGATGAACGCGCGCTCCATCACCTGGTCGCGGAAGTCCTCG
ACAATTCCATGGACGAGGCGGTCGCAGGCTACGCCACCCGCATCGAAGTCGAACTCCACGCCGACCACGCCGTCACCATC
CGTGACAACGGGCGCGGCATGCCATTTGACCCGCACCCCAAGTTTCCCGGCAAATCCGCCCTCGAAGTGATCCTCTGCAC
CCTGCATGCGGGCGGCAAATTCTCCGGCAAGGCCTACCAGACCTCGGGCGGCCTGCACGGCGTCGGCGCGTCGGTCGTCA
ACGCGCTCTCGGACTCCATGGTCGTGCAGGTGGCCCGTGACCGCAAAGTGGTGGAACAACGCTTCTCCCGTGGCCTGCCC
CTTGGCCCCGTCACCGAAATCGGCGCCGCTCCCAACCGCCGTGGCACCACGACCACCTTCCACGCCGACGAACAGATTTT
TGGGTCCCACCGCTTCAAGCCCGCCCGCCTGATGAAGATGGTGCAGTCCAAGGCCTACCTCTTCTCCGGCGTCGAAATCC
GTTGGAAATCGGCCATCGATGACGGTGAGACGCCCACGGAGGCCACCTTCCACTTCCCCGGTGGCCTGTCCGATTACCTC
ACGGAAACCCTCGGTAAAACAGCCACTTACACAGAAATCCCCTTCGCGGGCAAAGTCGAATTCCAGCAACGCTTCAACGT
CCCCGGATCGGTCGAATGGGCGATCTCCTGGACGCCCGCGCGCGACGGCTTCATCCAGTCGTTCTGCAACACCGTCCCCA
CCCCCGAAGGCGGCACCCATGAGGCCGGGTTCTGGGCCGCGATCCTCAAAGGCATCCGCGCTTACGGAGAGCTGGCGGGC
AACAAGAAGGCCGCCAACATCACCCGTGATGACATCGCCACCGGGGCGGGCGCGCTGGTGTCGTGTTTCATCGCCGAGCC
GGAATTTGTCGGCCAGACCAAGGACCGTCTCGCCACGACGGAGGCGCAGCGGCTGGTCGAACAGGCCGTTCGCGATCATT
TCGACAACTGGCTGGGGCAGAACACGAAGGAGGCCGGGGCGATCCTCGATTTCCTCGTGCTCCGCGCCGAAGAACGTCTG
CGCCGCCGGGCCGAGAAGGAAACGGCGCGCAAATCCGCCACCAAAAAGCTGCGCCTGCCCGGCAAGCTGGTCGATTGCTC
CCAATCCGCGCGCGACGGCACGGAATTGTTCATTGTGGAGGGCGACTCGGCCGGCGGCTCCGCCAAGATGGCGCGTAACC
GCAAGAACCAGGCCCTCCTGCCCCTGCGCGGAAAAATCCTCAACGTGCTGGGGGCCGCCTCGGGCAAGCTGACCTCCAAC
GCCGAGATTTCCGATCTCTGCCAAGCCCTTGGCGTGGGCATGGGCACCAAGTTCAATATCGAGGATCTGCGCTACGACAA
GATCATCATCATGACCGACGCCGACGTCGACGGCGCCCATATCGCGGCGCTGCTGATGACGTTCTTCTTCAGCCAGATGC
GCCCGATGATAGACGGCGGACACCTCTACCTGGCCTGCCCGCCGCTGTTTAGGCTGACCCAAGGCGCGCGCCGCGTCTAC
TGCCTGGATGAGCAGGAGCGGGATGAGATGATGGAGAAGGGCTTGGGCGGCAAAGGCAAAATCGACGTCTCCCGGTTCAA
GGGCCTGGGCGAGATGGACGCGAAGGACCTGAAAGAAACCACCATGGACCCGGAAAGCCGGAAGCTGATCCGGGTGTCCG
TGGATGATGACGTGCCGGGTGAGACGGGCGATCTGGTCGAACGATTAATGGGCAAGAAACCAGAGTTGCGGTTCCAGTAT
ATCCAGGAGAACGCGCGGTTCGTGGAGGAGTTGGATGTTTAA

Upstream 100 bases:

>100_bases
GCACTCGCCGCCCGTCGGCACGAAACGACACCCTAGCGCTTTCCCCGGACCCCCAAACCTGCCATTATTGAGAAAATCGA
CCACAAGATAGAGCAGACCC

Downstream 100 bases:

>100_bases
TGTCAAAGAAAATCTGTGTTTCATTGCACACCATAAAACTACACGAACTCCACACTACACTTAGACACCTTCAGAAGCAT
GATGAGAAATGGAGTGACCT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MADDLLSGAPDDQSYDASSIEVLEGLEPVRKRPGMYIGGTDERALHHLVAEVLDNSMDEAVAGYATRIEVELHADHAVTI
RDNGRGMPFDPHPKFPGKSALEVILCTLHAGGKFSGKAYQTSGGLHGVGASVVNALSDSMVVQVARDRKVVEQRFSRGLP
LGPVTEIGAAPNRRGTTTTFHADEQIFGSHRFKPARLMKMVQSKAYLFSGVEIRWKSAIDDGETPTEATFHFPGGLSDYL
TETLGKTATYTEIPFAGKVEFQQRFNVPGSVEWAISWTPARDGFIQSFCNTVPTPEGGTHEAGFWAAILKGIRAYGELAG
NKKAANITRDDIATGAGALVSCFIAEPEFVGQTKDRLATTEAQRLVEQAVRDHFDNWLGQNTKEAGAILDFLVLRAEERL
RRRAEKETARKSATKKLRLPGKLVDCSQSARDGTELFIVEGDSAGGSAKMARNRKNQALLPLRGKILNVLGAASGKLTSN
AEISDLCQALGVGMGTKFNIEDLRYDKIIIMTDADVDGAHIAALLMTFFFSQMRPMIDGGHLYLACPPLFRLTQGARRVY
CLDEQERDEMMEKGLGGKGKIDVSRFKGLGEMDAKDLKETTMDPESRKLIRVSVDDDVPGETGDLVERLMGKKPELRFQY
IQENARFVEELDV

Sequences:

>Translated_653_residues
MADDLLSGAPDDQSYDASSIEVLEGLEPVRKRPGMYIGGTDERALHHLVAEVLDNSMDEAVAGYATRIEVELHADHAVTI
RDNGRGMPFDPHPKFPGKSALEVILCTLHAGGKFSGKAYQTSGGLHGVGASVVNALSDSMVVQVARDRKVVEQRFSRGLP
LGPVTEIGAAPNRRGTTTTFHADEQIFGSHRFKPARLMKMVQSKAYLFSGVEIRWKSAIDDGETPTEATFHFPGGLSDYL
TETLGKTATYTEIPFAGKVEFQQRFNVPGSVEWAISWTPARDGFIQSFCNTVPTPEGGTHEAGFWAAILKGIRAYGELAG
NKKAANITRDDIATGAGALVSCFIAEPEFVGQTKDRLATTEAQRLVEQAVRDHFDNWLGQNTKEAGAILDFLVLRAEERL
RRRAEKETARKSATKKLRLPGKLVDCSQSARDGTELFIVEGDSAGGSAKMARNRKNQALLPLRGKILNVLGAASGKLTSN
AEISDLCQALGVGMGTKFNIEDLRYDKIIIMTDADVDGAHIAALLMTFFFSQMRPMIDGGHLYLACPPLFRLTQGARRVY
CLDEQERDEMMEKGLGGKGKIDVSRFKGLGEMDAKDLKETTMDPESRKLIRVSVDDDVPGETGDLVERLMGKKPELRFQY
IQENARFVEELDV
>Mature_652_residues
ADDLLSGAPDDQSYDASSIEVLEGLEPVRKRPGMYIGGTDERALHHLVAEVLDNSMDEAVAGYATRIEVELHADHAVTIR
DNGRGMPFDPHPKFPGKSALEVILCTLHAGGKFSGKAYQTSGGLHGVGASVVNALSDSMVVQVARDRKVVEQRFSRGLPL
GPVTEIGAAPNRRGTTTTFHADEQIFGSHRFKPARLMKMVQSKAYLFSGVEIRWKSAIDDGETPTEATFHFPGGLSDYLT
ETLGKTATYTEIPFAGKVEFQQRFNVPGSVEWAISWTPARDGFIQSFCNTVPTPEGGTHEAGFWAAILKGIRAYGELAGN
KKAANITRDDIATGAGALVSCFIAEPEFVGQTKDRLATTEAQRLVEQAVRDHFDNWLGQNTKEAGAILDFLVLRAEERLR
RRAEKETARKSATKKLRLPGKLVDCSQSARDGTELFIVEGDSAGGSAKMARNRKNQALLPLRGKILNVLGAASGKLTSNA
EISDLCQALGVGMGTKFNIEDLRYDKIIIMTDADVDGAHIAALLMTFFFSQMRPMIDGGHLYLACPPLFRLTQGARRVYC
LDEQERDEMMEKGLGGKGKIDVSRFKGLGEMDAKDLKETTMDPESRKLIRVSVDDDVPGETGDLVERLMGKKPELRFQYI
QENARFVEELDV

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=585, Percent_Identity=22.9059829059829, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI19913406, Length=596, Percent_Identity=24.496644295302, Blast_Score=126, Evalue=6e-29,
Organism=Escherichia coli, GI1789408, Length=644, Percent_Identity=42.0807453416149, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI48994957, Length=566, Percent_Identity=42.756183745583, Blast_Score=412, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17535065, Length=578, Percent_Identity=22.6643598615917, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI212645845, Length=370, Percent_Identity=25.6756756756757, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI212645657, Length=205, Percent_Identity=26.8292682926829, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=632, Percent_Identity=24.0506329113924, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI17136538, Length=593, Percent_Identity=24.6205733558179, Blast_Score=129, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: 5.99.1.3

Molecular weight: Translated: 71505; Mature: 71374

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDLLSGAPDDQSYDASSIEVLEGLEPVRKRPGMYIGGTDERALHHLVAEVLDNSMDEA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCHHHHH
VAGYATRIEVELHADHAVTIRDNGRGMPFDPHPKFPGKSALEVILCTLHAGGKFSGKAYQ
HHCCEEEEEEEEECCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCEEE
TSGGLHGVGASVVNALSDSMVVQVARDRKVVEQRFSRGLPLGPVTEIGAAPNRRGTTTTF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEE
HADEQIFGSHRFKPARLMKMVQSKAYLFSGVEIRWKSAIDDGETPTEATFHFPGGLSDYL
ECCHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCCHHHHH
TETLGKTATYTEIPFAGKVEFQQRFNVPGSVEWAISWTPARDGFIQSFCNTVPTPEGGTH
HHHHCCCCEEEECCCCCCCHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCC
EAGFWAAILKGIRAYGELAGNKKAANITRDDIATGAGALVSCFIAEPEFVGQTKDRLATT
CHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHCCCHHHCCCHHHHHHH
EAQRLVEQAVRDHFDNWLGQNTKEAGAILDFLVLRAEERLRRRAEKETARKSATKKLRLP
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GKLVDCSQSARDGTELFIVEGDSAGGSAKMARNRKNQALLPLRGKILNVLGAASGKLTSN
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCC
AEISDLCQALGVGMGTKFNIEDLRYDKIIIMTDADVDGAHIAALLMTFFFSQMRPMIDGG
CCHHHHHHHHCCCCCCEECHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
HLYLACPPLFRLTQGARRVYCLDEQERDEMMEKGLGGKGKIDVSRFKGLGEMDAKDLKET
EEEEECCHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCCEEHHHHCCCCCCCHHHHHHH
TMDPESRKLIRVSVDDDVPGETGDLVERLMGKKPELRFQYIQENARFVEELDV
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADDLLSGAPDDQSYDASSIEVLEGLEPVRKRPGMYIGGTDERALHHLVAEVLDNSMDEA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCHHHHH
VAGYATRIEVELHADHAVTIRDNGRGMPFDPHPKFPGKSALEVILCTLHAGGKFSGKAYQ
HHCCEEEEEEEEECCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCEEE
TSGGLHGVGASVVNALSDSMVVQVARDRKVVEQRFSRGLPLGPVTEIGAAPNRRGTTTTF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEE
HADEQIFGSHRFKPARLMKMVQSKAYLFSGVEIRWKSAIDDGETPTEATFHFPGGLSDYL
ECCHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCCHHHHH
TETLGKTATYTEIPFAGKVEFQQRFNVPGSVEWAISWTPARDGFIQSFCNTVPTPEGGTH
HHHHCCCCEEEECCCCCCCHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCC
EAGFWAAILKGIRAYGELAGNKKAANITRDDIATGAGALVSCFIAEPEFVGQTKDRLATT
CHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHCCCHHHCCCHHHHHHH
EAQRLVEQAVRDHFDNWLGQNTKEAGAILDFLVLRAEERLRRRAEKETARKSATKKLRLP
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GKLVDCSQSARDGTELFIVEGDSAGGSAKMARNRKNQALLPLRGKILNVLGAASGKLTSN
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCC
AEISDLCQALGVGMGTKFNIEDLRYDKIIIMTDADVDGAHIAALLMTFFFSQMRPMIDGG
CCHHHHHHHHCCCCCCEECHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
HLYLACPPLFRLTQGARRVYCLDEQERDEMMEKGLGGKGKIDVSRFKGLGEMDAKDLKET
EEEEECCHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCCEEHHHHCCCCCCCHHHHHHH
TMDPESRKLIRVSVDDDVPGETGDLVERLMGKKPELRFQYIQENARFVEELDV
CCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647; 9426128 [H]