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The map label for this gene is trpE [H]

Identifier: 89054373

GI number: 89054373

Start: 1871255

End: 1872763

Strand: Reverse

Name: trpE [H]

Synonym: Jann_1882

Alternate gene names: 89054373

Gene position: 1872763-1871255 (Counterclockwise)

Preceding gene: 89054374

Following gene: 89054371

Centisome position: 43.37

GC content: 63.62

Gene sequence:

>1509_bases
ATGGCACAGCTCTCTGATTTTGAGGCATTTCGCGCGGGCTGGGAGCGGGGGGAAAATCAACTTGTCCACGCGCGGCTGGC
CGCCGATCTGGATACACCTGTCTCGGTCATGCTGAAGCTCACGGATGCAGGTCGCGATGCGTTTATCCTGGAATCTGTGA
CGGGCGGAGAGGTGCGCGGGCGCTATTCGATCATCGGCATGAAGCCCGATCTGGTCTGGGAATGCCGGGGGGATGCCTCG
CGCCTGAACCGCGCCGCGCGCTATGACCGCGAAACGTTTGAGCCCTGCGAAGAGGCCCCGCTCGACGCCATCCGCGCGCT
TCTGGCGGAATCCGCCATTGATATGCCGGATGATCTCCCCGCCGCCGCTGCCGGCCTTTTTGGCTATCTCGGCTACGACA
TGATCCGTCTGGTGGAGCATCTGCCAAACGTGAACCCGGACCCATTGGGCCTGCCCGATGCGGTGCTCCTGCGTCCGTCT
GTCGTGGCGGTGCTGGATGGCGTGAAGGGCGAAGTCACCATCGTCTCGCCCGCCTGGCAATCGGGCGGTCTGTCGGCCCG
CGCGGCCTATGCCCAGGCGGCGGAACGGGTCTCGGATGCGTTGCGCGATCTGGAGCGCGCGCCAAGTGTTGCGGCCCGCG
AGATGGGCGATGCGCAGCCCCTTGGGGAGCCGGTGTCCAATTTCACCCACGCCGATTACCTGAAAGCCGTGGACACTGCC
AAGGATTACATCCGCAAGGGCGACATCTTTCAGGTCGTGCCTTCTCAACGCTGGACGGTTGATTTTCCCGCCCCACCCTT
CGCACTCTACCGCGCGCTGCGCCGGACCAACCCGTCACCCTTCATGTTCTACTTCAATTTCGGCGGCTTTCAGGTGGTGG
GGGCCTCGCCCGAGATCCTTGTGCGCGTCTTTGATGATGAGGTCACGATCCGTCCCATCGCGGGCACCCGGCCCCGCGGT
GCCACGCCCGACGAAGACCGCGCGCTGGAAGCCGACCTGATGGCCGACCAGAAAGAGCTGGCCGAACATCTCATGCTGCT
CGATCTGGGACGTAACGACACCGGCAAGGTCTCCAAGATCGGCACCGTGCGCCCGACCGAAGAATTCATCGTCGAACGCT
ACAGCCACGTCATGCACATCGTCTCCAACGTGGTGGGGGAGTTGGCCGAGGATCAGGACGCGCTCTCGGCCTTCATGGCC
GGAATGCCCGCAGGCACGGTCTCCGGCGCACCGAAGGTACGTGCGATGGAGATCATCGACGAGCTGGAGCCGGAGAAACG
CGGCGTTTACGGCGGTGGCGTGGGCTATTTCAGCGCGGGCGGTGACATGGACATGTGTATCGCGTTGCGCACGGCGGTTT
TGAAAGACGAGAAACTCTATATTCAGGCGGGCGGCGGCGTCGTCTACGACAGCGATCCGGAGGCCGAGTTCACCGAAACC
GTCAACAAATCCCGCGCCATTCGCAAAGCCGCAGAAGACGCCAGCCTGTTCACCCGCGGCAATGCCTGA

Upstream 100 bases:

>100_bases
CTTTGAGGCCTATGGTCAGGCGCTGCAGGCGAATGCGGGCATCACCACCAACCAAGGCGTGATCAACGCGGTTCACGCGT
CGTTTCCTTAGGGACCTCTG

Downstream 100 bases:

>100_bases
GTTCCACCGGCTCCAATCCCACCCCAACTTCCCCGTTCTTCAAATATCCTCCCGCGGAAGCGTGGGGGAACTTGCGCCAG
CAAGTGGGGGCAAAGCCCCA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MAQLSDFEAFRAGWERGENQLVHARLAADLDTPVSVMLKLTDAGRDAFILESVTGGEVRGRYSIIGMKPDLVWECRGDAS
RLNRAARYDRETFEPCEEAPLDAIRALLAESAIDMPDDLPAAAAGLFGYLGYDMIRLVEHLPNVNPDPLGLPDAVLLRPS
VVAVLDGVKGEVTIVSPAWQSGGLSARAAYAQAAERVSDALRDLERAPSVAAREMGDAQPLGEPVSNFTHADYLKAVDTA
KDYIRKGDIFQVVPSQRWTVDFPAPPFALYRALRRTNPSPFMFYFNFGGFQVVGASPEILVRVFDDEVTIRPIAGTRPRG
ATPDEDRALEADLMADQKELAEHLMLLDLGRNDTGKVSKIGTVRPTEEFIVERYSHVMHIVSNVVGELAEDQDALSAFMA
GMPAGTVSGAPKVRAMEIIDELEPEKRGVYGGGVGYFSAGGDMDMCIALRTAVLKDEKLYIQAGGGVVYDSDPEAEFTET
VNKSRAIRKAAEDASLFTRGNA

Sequences:

>Translated_502_residues
MAQLSDFEAFRAGWERGENQLVHARLAADLDTPVSVMLKLTDAGRDAFILESVTGGEVRGRYSIIGMKPDLVWECRGDAS
RLNRAARYDRETFEPCEEAPLDAIRALLAESAIDMPDDLPAAAAGLFGYLGYDMIRLVEHLPNVNPDPLGLPDAVLLRPS
VVAVLDGVKGEVTIVSPAWQSGGLSARAAYAQAAERVSDALRDLERAPSVAAREMGDAQPLGEPVSNFTHADYLKAVDTA
KDYIRKGDIFQVVPSQRWTVDFPAPPFALYRALRRTNPSPFMFYFNFGGFQVVGASPEILVRVFDDEVTIRPIAGTRPRG
ATPDEDRALEADLMADQKELAEHLMLLDLGRNDTGKVSKIGTVRPTEEFIVERYSHVMHIVSNVVGELAEDQDALSAFMA
GMPAGTVSGAPKVRAMEIIDELEPEKRGVYGGGVGYFSAGGDMDMCIALRTAVLKDEKLYIQAGGGVVYDSDPEAEFTET
VNKSRAIRKAAEDASLFTRGNA
>Mature_501_residues
AQLSDFEAFRAGWERGENQLVHARLAADLDTPVSVMLKLTDAGRDAFILESVTGGEVRGRYSIIGMKPDLVWECRGDASR
LNRAARYDRETFEPCEEAPLDAIRALLAESAIDMPDDLPAAAAGLFGYLGYDMIRLVEHLPNVNPDPLGLPDAVLLRPSV
VAVLDGVKGEVTIVSPAWQSGGLSARAAYAQAAERVSDALRDLERAPSVAAREMGDAQPLGEPVSNFTHADYLKAVDTAK
DYIRKGDIFQVVPSQRWTVDFPAPPFALYRALRRTNPSPFMFYFNFGGFQVVGASPEILVRVFDDEVTIRPIAGTRPRGA
TPDEDRALEADLMADQKELAEHLMLLDLGRNDTGKVSKIGTVRPTEEFIVERYSHVMHIVSNVVGELAEDQDALSAFMAG
MPAGTVSGAPKVRAMEIIDELEPEKRGVYGGGVGYFSAGGDMDMCIALRTAVLKDEKLYIQAGGGVVYDSDPEAEFTETV
NKSRAIRKAAEDASLFTRGNA

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=405, Percent_Identity=38.2716049382716, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788114, Length=448, Percent_Identity=30.8035714285714, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87082077, Length=260, Percent_Identity=27.6923076923077, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1786809, Length=215, Percent_Identity=28.8372093023256, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=491, Percent_Identity=37.6782077393075, Blast_Score=275, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6324361, Length=412, Percent_Identity=25, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54573; Mature: 54442

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLSDFEAFRAGWERGENQLVHARLAADLDTPVSVMLKLTDAGRDAFILESVTGGEVRG
CCCCHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCC
RYSIIGMKPDLVWECRGDASRLNRAARYDRETFEPCEEAPLDAIRALLAESAIDMPDDLP
EEEEEECCCCEEEEECCCHHHHHHHHHCCHHHCCHHHCCCHHHHHHHHHHHHCCCCCCCC
AAAAGLFGYLGYDMIRLVEHLPNVNPDPLGLPDAVLLRPSVVAVLDGVKGEVTIVSPAWQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHCCCCCCEEEEECCCC
SGGLSARAAYAQAAERVSDALRDLERAPSVAAREMGDAQPLGEPVSNFTHADYLKAVDTA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHCHHHHHHHHHHHH
KDYIRKGDIFQVVPSQRWTVDFPAPPFALYRALRRTNPSPFMFYFNFGGFQVVGASPEIL
HHHHHCCCEEEECCCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCEEE
VRVFDDEVTIRPIAGTRPRGATPDEDRALEADLMADQKELAEHLMLLDLGRNDTGKVSKI
EEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCC
GTVRPTEEFIVERYSHVMHIVSNVVGELAEDQDALSAFMAGMPAGTVSGAPKVRAMEIID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
ELEPEKRGVYGGGVGYFSAGGDMDMCIALRTAVLKDEKLYIQAGGGVVYDSDPEAEFTET
HCCHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCEEEECCCCCHHHHHH
VNKSRAIRKAAEDASLFTRGNA
HHHHHHHHHHHHHHHHEECCCC
>Mature Secondary Structure 
AQLSDFEAFRAGWERGENQLVHARLAADLDTPVSVMLKLTDAGRDAFILESVTGGEVRG
CCCHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCC
RYSIIGMKPDLVWECRGDASRLNRAARYDRETFEPCEEAPLDAIRALLAESAIDMPDDLP
EEEEEECCCCEEEEECCCHHHHHHHHHCCHHHCCHHHCCCHHHHHHHHHHHHCCCCCCCC
AAAAGLFGYLGYDMIRLVEHLPNVNPDPLGLPDAVLLRPSVVAVLDGVKGEVTIVSPAWQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHCCCCCCEEEEECCCC
SGGLSARAAYAQAAERVSDALRDLERAPSVAAREMGDAQPLGEPVSNFTHADYLKAVDTA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHCHHHHHHHHHHHH
KDYIRKGDIFQVVPSQRWTVDFPAPPFALYRALRRTNPSPFMFYFNFGGFQVVGASPEIL
HHHHHCCCEEEECCCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCEEE
VRVFDDEVTIRPIAGTRPRGATPDEDRALEADLMADQKELAEHLMLLDLGRNDTGKVSKI
EEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCC
GTVRPTEEFIVERYSHVMHIVSNVVGELAEDQDALSAFMAGMPAGTVSGAPKVRAMEIID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
ELEPEKRGVYGGGVGYFSAGGDMDMCIALRTAVLKDEKLYIQAGGGVVYDSDPEAEFTET
HCCHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCEEEECCCCCHHHHHH
VNKSRAIRKAAEDASLFTRGNA
HHHHHHHHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA