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The map label for this gene is lktA [H]

Identifier: 89053858

GI number: 89053858

Start: 1332803

End: 1335076

Strand: Direct

Name: lktA [H]

Synonym: Jann_1367

Alternate gene names: 89053858

Gene position: 1332803-1335076 (Clockwise)

Preceding gene: 89053857

Following gene: 89053859

Centisome position: 30.87

GC content: 58.53

Gene sequence:

>2274_bases
ATGCAGAACCTGACCATCACCAACGTGACCTACACGGGTGGCACGTTGAATGCAGAGCATTTCAATGTGAACGTCCTTGT
TGCAGCCAATACGGGCGAGACGCCCTTTGGTGGCAATGCGGGCAACGAGCTTGGTATCCCAACGGTCGAGTCCCTCGCGG
CGATGGAGAAGTTCGGGGTTACGTCGGTTCGCTTTCCTGCTGGTCAGGCCAATGAAATCTTCTCTGCGACCGGATTGATT
GTGAATGGGGACCTTCCGTCCTTCCTGCGGAACTTCCTTGTGCATGCGCAAGAAAACAACCTGTCGGTGAACCTCGTGCT
GCCGGTCGAGTCGCTGGAACAGTTTGGCGGGCCGTCGCAAGCGGAAATTCTGGAAGGCCTGCGGGACATCGCAGCGATCG
TGGCCGAAGAGTTCCCGAACGTTGTGACGGGCTATGAACTTGGGAACGAGTATTGGGGTGGGCGAGAGCGCGGAGATGAC
ACGCGAGAGGCGGCCTATGGCGAAGCCGCAGGGCTTGCAGCGGTTGCCCTGAGTGAAGGGGCCGCCGACTTCGGCATGGA
TCCCAACATCATCTTGCAGGCCAGCGGCAACCTGGGCGGGGCGTGGGACACGCTGACTGAAGCCAATGTCGCGATCCAAG
ATGCGTTTGAGGCGGTTGAAGGTGCCATGGAGACTGTGGATTCAGTGCTTCGGAACTTCTACTGGCGCGACGGGGGAACA
GGAGCCTTCGACAACAGCACCGGTACCTTCCAGGAGGATCGGGGCCTGGACGAAAACCTGAACGGGTGGGGCGCGGCCAA
TTGGGACCTATGGGCCGGACGGGATCTCACGACATATGTCGGGGAGTACAACATCACCAACCGGCTTTCATTCGGCGAGG
ATGCCATCGATCTGGGCATTCACGGCGCGTCGATGCTGTTGGAGCATTATACCAACATGGTTGAGGCGAACGTGGATGTC
GCCTACGCGTGGCCATTTCTGCACGCCACGCGCAACTCATTCCTCTGGCAGCATGAGGACATTGAAGTCGCAGACATTCA
TGGCATGGAGATTGTCACCAACACCACTCGCGGCGCGATGTATGATTTGCTGCGTCAGACGGTTGCTGACGGTGAGTTGG
TTGATCTGAATTGGGACACGAACAGCGCGGTTGAAGTGACGGCATTCCGGGATGTGCTGGGGGCCGGCAACGGCGATACA
ATGACGTCTTACACGAAAACTGTGTTTCTCAGCTCTCGCAGCGATCAGTTCGAGACCCTGAATGTGGATCTGTCCCCGTT
CGTCAACGACTACGCAAGCATGAGCGGGCTGAGCATCTTTTACGAAGATACGGGCGGCCATCACCGGGATGCCGTCATCA
CCGAGATCTCCGCCCTCGACCCGAACGGCGATGGTGTCTTTTCGATTGATCTGAACCCCTACGAGGTTGTGCAACTCACG
TTCCAATACGGATATATGCACTCAACCGGGGGCACCCTCACCTCCAATACGGGAACCACGGTTGATGGCGGCGGTGCCCC
GGGCGAGACTTTCATCCGGGGTGACGGCGCGGACACGGTCTATGGAACTGACGGCGCCGACTGGATCGATGGTGGTAACG
GGAATGACCTTCTGGCCGGTGAAGGCGGCAACGACACCCTGATCGGTGGCGGCTCTGCAGACACACTCAATGGCGGTGCG
GGGGATGACATGCTTCACGGCAACTGGGGGCGCGACTTGATCAACGGTGATGACGGCGATGATACGGCCTATGCGGGCAC
CATGGACGACACCGTGAACGGTGGGCTCGGCGACGATTCCCTTTTCGGCGGGACCGGCAATGACGTGCTCCATGGGGATA
GTGGACGGGATGTCCTCAATGGCCAGGACGGCGATGATGCCCTCTATGGTGACATGGATAATGACGCCCTCAACGGGGGG
CTCGGGAACGACACCCTGAGCGGCGGGACCGGGAACGACGCCCTTGATGGTGGCGCGGGATCTGATTTCCTTGACGGAGG
AGCCGGAGACGACACGTTGTTCGGAAACGCCGATGCGGATGTGTTCGGTTTTGACGCGGGCCACGGCCACGATACGATTG
GTGACTTTGATGCGCAGAACGATCTTGAGGTGATCGATCTTTCTGGAGTTGGGCGGTTCAACTCTTTTGACGATGTTGCG
TCGAACATGGTTGAAGATGGGACCGGTGTCACAATCGTGACATCCAGCTTCAGCAGCATCTTTTTGACGGGGGTTGAGGC
CGCTGATCTCGATGCCAACGACTTCATTTTCTGA

Upstream 100 bases:

>100_bases
CGCAGTTTTGCCACCCCGTATTCCCGGGTCGCCGAAATCGTGCCGAACCTCGGCCCCGCCCAGATGGTCAATGGGTGCAT
CTACGCCGAAAGAGGAACCG

Downstream 100 bases:

>100_bases
AAGCCGCACAGGAGCGTCGCAACCCACGAAGTGACGTCGACCTCTTCGGTGGTGAGATGCCGGTCGCTGTTCCCGGTCCG
GTTGCTGCACCGATCCCCCG

Product: hemolysin-type calcium-binding protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 757; Mature: 757

Protein sequence:

>757_residues
MQNLTITNVTYTGGTLNAEHFNVNVLVAANTGETPFGGNAGNELGIPTVESLAAMEKFGVTSVRFPAGQANEIFSATGLI
VNGDLPSFLRNFLVHAQENNLSVNLVLPVESLEQFGGPSQAEILEGLRDIAAIVAEEFPNVVTGYELGNEYWGGRERGDD
TREAAYGEAAGLAAVALSEGAADFGMDPNIILQASGNLGGAWDTLTEANVAIQDAFEAVEGAMETVDSVLRNFYWRDGGT
GAFDNSTGTFQEDRGLDENLNGWGAANWDLWAGRDLTTYVGEYNITNRLSFGEDAIDLGIHGASMLLEHYTNMVEANVDV
AYAWPFLHATRNSFLWQHEDIEVADIHGMEIVTNTTRGAMYDLLRQTVADGELVDLNWDTNSAVEVTAFRDVLGAGNGDT
MTSYTKTVFLSSRSDQFETLNVDLSPFVNDYASMSGLSIFYEDTGGHHRDAVITEISALDPNGDGVFSIDLNPYEVVQLT
FQYGYMHSTGGTLTSNTGTTVDGGGAPGETFIRGDGADTVYGTDGADWIDGGNGNDLLAGEGGNDTLIGGGSADTLNGGA
GDDMLHGNWGRDLINGDDGDDTAYAGTMDDTVNGGLGDDSLFGGTGNDVLHGDSGRDVLNGQDGDDALYGDMDNDALNGG
LGNDTLSGGTGNDALDGGAGSDFLDGGAGDDTLFGNADADVFGFDAGHGHDTIGDFDAQNDLEVIDLSGVGRFNSFDDVA
SNMVEDGTGVTIVTSSFSSIFLTGVEAADLDANDFIF

Sequences:

>Translated_757_residues
MQNLTITNVTYTGGTLNAEHFNVNVLVAANTGETPFGGNAGNELGIPTVESLAAMEKFGVTSVRFPAGQANEIFSATGLI
VNGDLPSFLRNFLVHAQENNLSVNLVLPVESLEQFGGPSQAEILEGLRDIAAIVAEEFPNVVTGYELGNEYWGGRERGDD
TREAAYGEAAGLAAVALSEGAADFGMDPNIILQASGNLGGAWDTLTEANVAIQDAFEAVEGAMETVDSVLRNFYWRDGGT
GAFDNSTGTFQEDRGLDENLNGWGAANWDLWAGRDLTTYVGEYNITNRLSFGEDAIDLGIHGASMLLEHYTNMVEANVDV
AYAWPFLHATRNSFLWQHEDIEVADIHGMEIVTNTTRGAMYDLLRQTVADGELVDLNWDTNSAVEVTAFRDVLGAGNGDT
MTSYTKTVFLSSRSDQFETLNVDLSPFVNDYASMSGLSIFYEDTGGHHRDAVITEISALDPNGDGVFSIDLNPYEVVQLT
FQYGYMHSTGGTLTSNTGTTVDGGGAPGETFIRGDGADTVYGTDGADWIDGGNGNDLLAGEGGNDTLIGGGSADTLNGGA
GDDMLHGNWGRDLINGDDGDDTAYAGTMDDTVNGGLGDDSLFGGTGNDVLHGDSGRDVLNGQDGDDALYGDMDNDALNGG
LGNDTLSGGTGNDALDGGAGSDFLDGGAGDDTLFGNADADVFGFDAGHGHDTIGDFDAQNDLEVIDLSGVGRFNSFDDVA
SNMVEDGTGVTIVTSSFSSIFLTGVEAADLDANDFIF
>Mature_757_residues
MQNLTITNVTYTGGTLNAEHFNVNVLVAANTGETPFGGNAGNELGIPTVESLAAMEKFGVTSVRFPAGQANEIFSATGLI
VNGDLPSFLRNFLVHAQENNLSVNLVLPVESLEQFGGPSQAEILEGLRDIAAIVAEEFPNVVTGYELGNEYWGGRERGDD
TREAAYGEAAGLAAVALSEGAADFGMDPNIILQASGNLGGAWDTLTEANVAIQDAFEAVEGAMETVDSVLRNFYWRDGGT
GAFDNSTGTFQEDRGLDENLNGWGAANWDLWAGRDLTTYVGEYNITNRLSFGEDAIDLGIHGASMLLEHYTNMVEANVDV
AYAWPFLHATRNSFLWQHEDIEVADIHGMEIVTNTTRGAMYDLLRQTVADGELVDLNWDTNSAVEVTAFRDVLGAGNGDT
MTSYTKTVFLSSRSDQFETLNVDLSPFVNDYASMSGLSIFYEDTGGHHRDAVITEISALDPNGDGVFSIDLNPYEVVQLT
FQYGYMHSTGGTLTSNTGTTVDGGGAPGETFIRGDGADTVYGTDGADWIDGGNGNDLLAGEGGNDTLIGGGSADTLNGGA
GDDMLHGNWGRDLINGDDGDDTAYAGTMDDTVNGGLGDDSLFGGTGNDVLHGDSGRDVLNGQDGDDALYGDMDNDALNGG
LGNDTLSGGTGNDALDGGAGSDFLDGGAGDDTLFGNADADVFGFDAGHGHDTIGDFDAQNDLEVIDLSGVGRFNSFDDVA
SNMVEDGTGVTIVTSSFSSIFLTGVEAADLDANDFIF

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 79464; Mature: 79464

Theoretical pI: Translated: 3.59; Mature: 3.59

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNLTITNVTYTGGTLNAEHFNVNVLVAANTGETPFGGNAGNELGIPTVESLAAMEKFGV
CCCEEEEEEEECCCEEECCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
TSVRFPAGQANEIFSATGLIVNGDLPSFLRNFLVHAQENNLSVNLVLPVESLEQFGGPSQ
CEEECCCCCCCCEEEECCEEEECCHHHHHHHHHEEEECCCEEEEEEEEHHHHHHCCCCCH
AEILEGLRDIAAIVAEEFPNVVTGYELGNEYWGGRERGDDTREAAYGEAAGLAAVALSEG
HHHHHHHHHHHHHHHHHCCCCEECHHCCCHHCCCCCCCCCHHHHHCCCHHCEEEEEECCC
AADFGMDPNIILQASGNLGGAWDTLTEANVAIQDAFEAVEGAMETVDSVLRNFYWRDGGT
CHHCCCCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
GAFDNSTGTFQEDRGLDENLNGWGAANWDLWAGRDLTTYVGEYNITNRLSFGEDAIDLGI
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCEECCCCCEEHCCCCCCCCCCCCCCCHHEECC
HGASMLLEHYTNMVEANVDVAYAWPFLHATRNSFLWQHEDIEVADIHGMEIVTNTTRGAM
CHHHHHHHHHHHHHHCCCCEEEECHHHHHHHCCCEEECCCCEEEEECCEEEEECCCHHHH
YDLLRQTVADGELVDLNWDTNSAVEVTAFRDVLGAGNGDTMTSYTKTVFLSSRSDQFETL
HHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHHCCCCCCCEEEEEEEEEEECCCCCEEEE
NVDLSPFVNDYASMSGLSIFYEDTGGHHRDAVITEISALDPNGDGVFSIDLNPYEVVQLT
EEEHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEEE
FQYGYMHSTGGTLTSNTGTTVDGGGAPGETFIRGDGADTVYGTDGADWIDGGNGNDLLAG
EEECEEECCCCEEECCCCCEECCCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCEEEEC
EGGNDTLIGGGSADTLNGGAGDDMLHGNWGRDLINGDDGDDTAYAGTMDDTVNGGLGDDS
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
LFGGTGNDVLHGDSGRDVLNGQDGDDALYGDMDNDALNGGLGNDTLSGGTGNDALDGGAG
CCCCCCCCCEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SDFLDGGAGDDTLFGNADADVFGFDAGHGHDTIGDFDAQNDLEVIDLSGVGRFNSFDDVA
CCCCCCCCCCCCEECCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHH
SNMVEDGTGVTIVTSSFSSIFLTGVEAADLDANDFIF
HHHHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MQNLTITNVTYTGGTLNAEHFNVNVLVAANTGETPFGGNAGNELGIPTVESLAAMEKFGV
CCCEEEEEEEECCCEEECCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
TSVRFPAGQANEIFSATGLIVNGDLPSFLRNFLVHAQENNLSVNLVLPVESLEQFGGPSQ
CEEECCCCCCCCEEEECCEEEECCHHHHHHHHHEEEECCCEEEEEEEEHHHHHHCCCCCH
AEILEGLRDIAAIVAEEFPNVVTGYELGNEYWGGRERGDDTREAAYGEAAGLAAVALSEG
HHHHHHHHHHHHHHHHHCCCCEECHHCCCHHCCCCCCCCCHHHHHCCCHHCEEEEEECCC
AADFGMDPNIILQASGNLGGAWDTLTEANVAIQDAFEAVEGAMETVDSVLRNFYWRDGGT
CHHCCCCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
GAFDNSTGTFQEDRGLDENLNGWGAANWDLWAGRDLTTYVGEYNITNRLSFGEDAIDLGI
CCCCCCCCCCHHHCCCCCCCCCCCCCCCCEECCCCCEEHCCCCCCCCCCCCCCCHHEECC
HGASMLLEHYTNMVEANVDVAYAWPFLHATRNSFLWQHEDIEVADIHGMEIVTNTTRGAM
CHHHHHHHHHHHHHHCCCCEEEECHHHHHHHCCCEEECCCCEEEEECCEEEEECCCHHHH
YDLLRQTVADGELVDLNWDTNSAVEVTAFRDVLGAGNGDTMTSYTKTVFLSSRSDQFETL
HHHHHHHHCCCEEEEEECCCCCEEEEEEHHHHHCCCCCCCEEEEEEEEEEECCCCCEEEE
NVDLSPFVNDYASMSGLSIFYEDTGGHHRDAVITEISALDPNGDGVFSIDLNPYEVVQLT
EEEHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEEE
FQYGYMHSTGGTLTSNTGTTVDGGGAPGETFIRGDGADTVYGTDGADWIDGGNGNDLLAG
EEECEEECCCCEEECCCCCEECCCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCEEEEC
EGGNDTLIGGGSADTLNGGAGDDMLHGNWGRDLINGDDGDDTAYAGTMDDTVNGGLGDDS
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
LFGGTGNDVLHGDSGRDVLNGQDGDDALYGDMDNDALNGGLGNDTLSGGTGNDALDGGAG
CCCCCCCCCEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SDFLDGGAGDDTLFGNADADVFGFDAGHGHDTIGDFDAQNDLEVIDLSGVGRFNSFDDVA
CCCCCCCCCCCCEECCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHH
SNMVEDGTGVTIVTSSFSSIFLTGVEAADLDANDFIF
HHHHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]