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The map label for this gene is ilvD [H]

Identifier: 89053478

GI number: 89053478

Start: 944460

End: 946313

Strand: Direct

Name: ilvD [H]

Synonym: Jann_0987

Alternate gene names: 89053478

Gene position: 944460-946313 (Clockwise)

Preceding gene: 89053474

Following gene: 89053493

Centisome position: 21.87

GC content: 61.76

Gene sequence:

>1854_bases
ATGACCGGTCGTCGCGATAGGCTTGTCTCAATATATGGCCTTCAGTTCCACATAGTGGGACTCAATCTTGCACAGGAACC
GCCCATGTCCGACACGCGCGCAAATCGCCGTTACCGCAGCCAGGAGTGGTTCGACAATCCCAACAATCCGGGCATGACCG
CGCTTTACCTGGAACGCTATCAAAATCAGGCGTTCACCAGAGCCGAGTTGCAGGCCGAAAAGCCCATCGTCGGCATCGCG
CAGACGGGCAGCGATCTGGTGCCGTGCAACAAGATCCACGTTTTCCTGATGGACCGGATCAAAGCTGGCATTCGCGATGC
GGGCGGCATCCCGTTGGAATTCCCGGTGCACCCTATCCAGGAAACGGGCAAACGGCCCACGGCCGCCCTGGACAGAAACC
TGCAATATCTATCGTTGGTCGAAGTGTTGCACGGCTATCCGCTGGACGGCGTGGTGCTGACGACCGGCTGCGACAAGACC
ACGCCTGCGATGCTGATGGGGGCTGCGACCGTCGATTTGCCCGCGATTGCGCTGAATGGCGGGCCGATGCTGGACGGGTG
GTTTCGCGGCAAACGCGCGGGGTCCGGTACGTCGATCTGGGAGGGACGGCGGCTGCTGGCGAAAGGCGAGATCGACTATG
AAGAGTTCATGGAATTGGCCTGCGCGTCCTCGCCAAGCCTGGGGCATTGCAACACGATGGGCACGGCGTCGACGATGAAC
GCCTTGGCCGAAGCGCTTGGCATGACACTGCCCGGCGCGGCGGCGATCCCTGCTCCTTTTCGGGAGCGGATGGAGATGGC
CTACCTGACAGGAAAACGCGCCGTGGAGATGGTGGAGGACGATCTGAAACCGTCCGACATCCTGACACGGGCGGCGTTCG
AGAATGCGATAAAGGTGAACACCGCGATTGGCGGCTCAACCAATGCGCCCCCGCATTTGCAGGCATTGGCGCGCCATGCG
GGCGTCGAATTGCATGTGACGGACTGGGAAAAGATCGGTCTTGCGCTGCCGTTGTTGGTGAACATGCAGCCAGCAGGCGA
GTATCTGGGCGAGTCGTTTTTCCGCGCGGGCGGGGTCCCGGCGGTGATGGGAGAGTTGCACGCGGCAGGTCTGTTGGACG
GGTCGGTGATGACCGCGTCCGGAAAGGTTCTGGACGAGGCCCTGGGCGGCGCGCGCAGCCGGGACCGCCTGGTCATTCGC
CCGGTGGACGACCCAATGCGGGAAGAGGCGGGGTTTGCGGTGCTGTCAGGCAACCTTTTTGACAGCGCATTGATGAAAAC
CTCGGTGATATCGGAGGATTTCCGTGAGCGATTTCTGAAAGATAATCAGTATGAAGGCCGGGCTATCGTGTTTGAAGGCC
CCGAGGACTACCATGATCGAGTCAATGATCCGGATCTGGCCATCGATGATGAGTGCATCCTGTTCATCCGCGGCGTGGGC
TGCGTTGGGTATCCGGGCTCGGCTGAGGTTGTGAACATGCAACCGCCCGACGCGCTGATCAAAGGCGGCATCAAACACCT
GCCGACGGTGGGCGACGGGCGGCAATCGGGCACGTCTGAGTCGCCGTCGATCCTGAACGCCTCGCCTGAATCGGTCGTTG
GCGGCGGGCTGGCGTATCTGGAAACCGGTGACCGGGTGCGGCTGGATCTGAATGCCGGGACGTTGAACGCCTTGGTGCCA
GAGCAGGATTGGGAGGCGCGGAAGGCCAACTGGACCGCATCGGAGATCCACCACCAGACCCCTTGGCAGGAATTGTACCG
CCAGCATGTGGGCCAATTGGCCGATGGGGGGTGCCTCGAACTGGCGACCGCCTATCAGCGGATCGCCAAGCACCTGCCGC
GCGACAACCATTGA

Upstream 100 bases:

>100_bases
GATAGGGCGCGGATCGGGGCGCGTCACGGGGCTCGGGGTATATCAATAGTATATCAATTCAGAAAACACCGGGCTTGATG
GCAAAGCTATGGGTTGAGGG

Downstream 100 bases:

>100_bases
CTTTGGCCTATAAAAAGACGCGGTTTCAGGAGCTTAGTGGACGATCTTCTCTTCGCGAACGTAGAGGTTTTCCCACGCGC
GGTCGATGTAGTCGGGCGTC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MTGRRDRLVSIYGLQFHIVGLNLAQEPPMSDTRANRRYRSQEWFDNPNNPGMTALYLERYQNQAFTRAELQAEKPIVGIA
QTGSDLVPCNKIHVFLMDRIKAGIRDAGGIPLEFPVHPIQETGKRPTAALDRNLQYLSLVEVLHGYPLDGVVLTTGCDKT
TPAMLMGAATVDLPAIALNGGPMLDGWFRGKRAGSGTSIWEGRRLLAKGEIDYEEFMELACASSPSLGHCNTMGTASTMN
ALAEALGMTLPGAAAIPAPFRERMEMAYLTGKRAVEMVEDDLKPSDILTRAAFENAIKVNTAIGGSTNAPPHLQALARHA
GVELHVTDWEKIGLALPLLVNMQPAGEYLGESFFRAGGVPAVMGELHAAGLLDGSVMTASGKVLDEALGGARSRDRLVIR
PVDDPMREEAGFAVLSGNLFDSALMKTSVISEDFRERFLKDNQYEGRAIVFEGPEDYHDRVNDPDLAIDDECILFIRGVG
CVGYPGSAEVVNMQPPDALIKGGIKHLPTVGDGRQSGTSESPSILNASPESVVGGGLAYLETGDRVRLDLNAGTLNALVP
EQDWEARKANWTASEIHHQTPWQELYRQHVGQLADGGCLELATAYQRIAKHLPRDNH

Sequences:

>Translated_617_residues
MTGRRDRLVSIYGLQFHIVGLNLAQEPPMSDTRANRRYRSQEWFDNPNNPGMTALYLERYQNQAFTRAELQAEKPIVGIA
QTGSDLVPCNKIHVFLMDRIKAGIRDAGGIPLEFPVHPIQETGKRPTAALDRNLQYLSLVEVLHGYPLDGVVLTTGCDKT
TPAMLMGAATVDLPAIALNGGPMLDGWFRGKRAGSGTSIWEGRRLLAKGEIDYEEFMELACASSPSLGHCNTMGTASTMN
ALAEALGMTLPGAAAIPAPFRERMEMAYLTGKRAVEMVEDDLKPSDILTRAAFENAIKVNTAIGGSTNAPPHLQALARHA
GVELHVTDWEKIGLALPLLVNMQPAGEYLGESFFRAGGVPAVMGELHAAGLLDGSVMTASGKVLDEALGGARSRDRLVIR
PVDDPMREEAGFAVLSGNLFDSALMKTSVISEDFRERFLKDNQYEGRAIVFEGPEDYHDRVNDPDLAIDDECILFIRGVG
CVGYPGSAEVVNMQPPDALIKGGIKHLPTVGDGRQSGTSESPSILNASPESVVGGGLAYLETGDRVRLDLNAGTLNALVP
EQDWEARKANWTASEIHHQTPWQELYRQHVGQLADGGCLELATAYQRIAKHLPRDNH
>Mature_616_residues
TGRRDRLVSIYGLQFHIVGLNLAQEPPMSDTRANRRYRSQEWFDNPNNPGMTALYLERYQNQAFTRAELQAEKPIVGIAQ
TGSDLVPCNKIHVFLMDRIKAGIRDAGGIPLEFPVHPIQETGKRPTAALDRNLQYLSLVEVLHGYPLDGVVLTTGCDKTT
PAMLMGAATVDLPAIALNGGPMLDGWFRGKRAGSGTSIWEGRRLLAKGEIDYEEFMELACASSPSLGHCNTMGTASTMNA
LAEALGMTLPGAAAIPAPFRERMEMAYLTGKRAVEMVEDDLKPSDILTRAAFENAIKVNTAIGGSTNAPPHLQALARHAG
VELHVTDWEKIGLALPLLVNMQPAGEYLGESFFRAGGVPAVMGELHAAGLLDGSVMTASGKVLDEALGGARSRDRLVIRP
VDDPMREEAGFAVLSGNLFDSALMKTSVISEDFRERFLKDNQYEGRAIVFEGPEDYHDRVNDPDLAIDDECILFIRGVGC
VGYPGSAEVVNMQPPDALIKGGIKHLPTVGDGRQSGTSESPSILNASPESVVGGGLAYLETGDRVRLDLNAGTLNALVPE
QDWEARKANWTASEIHHQTPWQELYRQHVGQLADGGCLELATAYQRIAKHLPRDNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=587, Percent_Identity=27.0868824531516, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1788157, Length=460, Percent_Identity=30, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI2367371, Length=470, Percent_Identity=29.1489361702128, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1786464, Length=440, Percent_Identity=30, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322476, Length=559, Percent_Identity=26.8336314847943, Blast_Score=191, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 66951; Mature: 66820

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRRDRLVSIYGLQFHIVGLNLAQEPPMSDTRANRRYRSQEWFDNPNNPGMTALYLERY
CCCCCCCEEEEEEEEEEEEEEECCCCCCCCCHHHHHHHCCHHHCCCCCCCCCCHHHHHHH
QNQAFTRAELQAEKPIVGIAQTGSDLVPCNKIHVFLMDRIKAGIRDAGGIPLEFPVHPIQ
HCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCHH
ETGKRPTAALDRNLQYLSLVEVLHGYPLDGVVLTTGCDKTTPAMLMGAATVDLPAIALNG
HCCCCCCHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHEECHHCCCCEEEECC
GPMLDGWFRGKRAGSGTSIWEGRRLLAKGEIDYEEFMELACASSPSLGHCNTMGTASTMN
CCCCCHHHCCCCCCCCCCHHCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHH
ALAEALGMTLPGAAAIPAPFRERMEMAYLTGKRAVEMVEDDLKPSDILTRAAFENAIKVN
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEE
TAIGGSTNAPPHLQALARHAGVELHVTDWEKIGLALPLLVNMQPAGEYLGESFFRAGGVP
EECCCCCCCCHHHHHHHHHCCCEEEECCHHHHCEEEHHEEECCCHHHHHHHHHHHCCCCH
AVMGELHAAGLLDGSVMTASGKVLDEALGGARSRDRLVIRPVDDPMREEAGFAVLSGNLF
HHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCCCCEEEEECCCCHHHHHCCEEEEECCHH
DSALMKTSVISEDFRERFLKDNQYEGRAIVFEGPEDYHDRVNDPDLAIDDECILFIRGVG
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHCCCCCCCEECCCEEEEEECCC
CVGYPGSAEVVNMQPPDALIKGGIKHLPTVGDGRQSGTSESPSILNASPESVVGGGLAYL
CCCCCCCCCEEECCCCHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEE
ETGDRVRLDLNAGTLNALVPEQDWEARKANWTASEIHHQTPWQELYRQHVGQLADGGCLE
ECCCEEEEEECCCCEECCCCCCCCCHHHCCCCHHHHHCCCCHHHHHHHHHHHCCCCCHHH
LATAYQRIAKHLPRDNH
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TGRRDRLVSIYGLQFHIVGLNLAQEPPMSDTRANRRYRSQEWFDNPNNPGMTALYLERY
CCCCCCEEEEEEEEEEEEEEECCCCCCCCCHHHHHHHCCHHHCCCCCCCCCCHHHHHHH
QNQAFTRAELQAEKPIVGIAQTGSDLVPCNKIHVFLMDRIKAGIRDAGGIPLEFPVHPIQ
HCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCHH
ETGKRPTAALDRNLQYLSLVEVLHGYPLDGVVLTTGCDKTTPAMLMGAATVDLPAIALNG
HCCCCCCHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHEECHHCCCCEEEECC
GPMLDGWFRGKRAGSGTSIWEGRRLLAKGEIDYEEFMELACASSPSLGHCNTMGTASTMN
CCCCCHHHCCCCCCCCCCHHCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHH
ALAEALGMTLPGAAAIPAPFRERMEMAYLTGKRAVEMVEDDLKPSDILTRAAFENAIKVN
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEE
TAIGGSTNAPPHLQALARHAGVELHVTDWEKIGLALPLLVNMQPAGEYLGESFFRAGGVP
EECCCCCCCCHHHHHHHHHCCCEEEECCHHHHCEEEHHEEECCCHHHHHHHHHHHCCCCH
AVMGELHAAGLLDGSVMTASGKVLDEALGGARSRDRLVIRPVDDPMREEAGFAVLSGNLF
HHHHHHHHHHCCCCCEEECCCHHHHHHHCCCCCCCEEEEECCCCHHHHHCCEEEEECCHH
DSALMKTSVISEDFRERFLKDNQYEGRAIVFEGPEDYHDRVNDPDLAIDDECILFIRGVG
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHCCCCCCCEECCCEEEEEECCC
CVGYPGSAEVVNMQPPDALIKGGIKHLPTVGDGRQSGTSESPSILNASPESVVGGGLAYL
CCCCCCCCCEEECCCCHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEE
ETGDRVRLDLNAGTLNALVPEQDWEARKANWTASEIHHQTPWQELYRQHVGQLADGGCLE
ECCCEEEEEECCCCEECCCCCCCCCHHHCCCCHHHHHCCCCHHHHHHHHHHHCCCCCHHH
LATAYQRIAKHLPRDNH
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA