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The map label for this gene is fhs

Identifier: 89053472

GI number: 89053472

Start: 937552

End: 939228

Strand: Direct

Name: fhs

Synonym: Jann_0981

Alternate gene names: 89053472

Gene position: 937552-939228 (Clockwise)

Preceding gene: 89053470

Following gene: 89053473

Centisome position: 21.71

GC content: 62.67

Gene sequence:

>1677_bases
ATGGGCTACAAATCAGACATCGAGATCGCGCGTGAGGCGGTGAAGCGGCCGATCCAGGAGATCGGGGCGAAGATCGGGAT
CGAGAGCGCGGACTTGCTGCCCTACGGTCACGACAAGGCGAAGGTGAGCCAATCGTTCATCAATTCGGTGCAGAATCGGG
ATAACGGCCACCTGATTCTGGTGACCGCGATCAATCCGACGCCTGCGGGCGAAGGTAAGACGACGACCACGGTGGGTCTG
GGCGACGGCCTGAACCGCATCGGCAAGAACGCGATGGTTTGTATCCGGGAGGCCTCCTTGGGGCCGAACTTCGGGATGAA
AGGTGGCGCGGCGGGCGGCGGTTACGCGCAGGTTGTGCCGATGGAGGAGATGAACCTCCACTTCACCGGTGATTTCCACG
CCATCACCTCGGCCCACTCGCTCCTGTCGGCGATGATCGACAACCACATCTACTGGGGTAATGAGCTGGAGATCGACGTG
CGCCGGGTTGTCTGGCGGCGCGTGGTGGACATGAACGACCGCGCTTTGCGGCAGATCACGGCGTCGCTCGGCGGCGTGGC
CAACGGCTTCCCGCGGGAGGCGGGATTTGACATCACCGTGGCCTCCGAGGTCATGGCGATCCTGTGCCTCGCGAAGGACC
TCAAGGACCTGCAAGAGCGTCTTGGCGCGATGATCGTCGCCTACCGTCGCGACCGGTCGCCCGTTTTCGCGCGGGATATC
AAGGCCGATGGCGCGATGACGGTACTGTTGAAGGACGCGATGCAGCCCAACATCGTGCAGACGCTGGAGAACAACCCGGC
GTTCGTGCACGGCGGCCCGTTTGCCAACATCGCCCACGGCTGTAACTCTGTCATCGCCACGACCACAGCGTTGAAGCTGT
GCGACTATGTGGTGACGGAAGCGGGCTTTGGCGCGGATCTGGGGGCGGAGAAGTTCCTCAACATCAAGTGCCGCAAGGCG
GGTCTTGCGCCCTCGGTCGTGGTTGTTGTGGCCACAGTGCGGGCGATGAAGATGAACGGCGGGGTCGCGAAAGCGGATTT
GGGCGCGGAAAATGTGGATGCGGTCCAGAACGGTTGCGCCAACCTCGGTCGTCACATCGAGAACGTCAAATCCTTCGGCG
TGCCGGTCGTCGTGGCCATTAACCACTTTGTGACGGATACCGACGCAGAAGTGCAGGCGGTGAAGGATTATGTGGCGTCG
CAAGGGGCCGAGGCTGTCCTCAGCCGTCACTGGGAGTTGGGCAGCGAGGGCTCTGCGCCGCTGGCCGAGAAGGTCGTGGA
GGTGATCGAAAAGGGCGAGGCCAACTTCCAGACGCTCTACCCCGACGACATGCCGCTGGCCGAGAAAATCCAGGCGGTCT
GCAAGGGCATCTACCGCGCGGATGAGGCGGTGATGGACAAGAAGATCCTCGATCAACTGAAGCTGTGGGAGGATCAGGGA
TACGGTAAACTACCGGTTTGCATGGCAAAAACCCAGTACTCCTTCACCACGGACCCCAATGAGCGCGGCGCGCCCACCGG
CTTCACCATCCCCGTGCGCGAAGTGCGGCTGAGCGCGGGCGCGGGCTTCATCGTGGCCGTCTGCGGCGAGATCATGACCA
TGCCCGGCCTGCCCCGCAAACCGTCGGCAGAGGCCATCCACCTCAACGACGACGGCCAGATCGAAGGCTTGTTCTGA

Upstream 100 bases:

>100_bases
GGATGCCCTGCGAAAATGTCGGAATTGGCACTATCTCCCGCTGGGATGCCCGGTAAGGCTGCGTATACAAACGTATTCAC
GCGACCGGGGAGAGCGCGCC

Downstream 100 bases:

>100_bases
CCCATGCATGAGGCCCGCGTGATCTGGCAATCCAGCGGTGACTTCGCCGCAAACCGCTACACGCGCGGGCATGTGTGGCG
GTTCGATGGGGGGGCAGAGG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MGYKSDIEIAREAVKRPIQEIGAKIGIESADLLPYGHDKAKVSQSFINSVQNRDNGHLILVTAINPTPAGEGKTTTTVGL
GDGLNRIGKNAMVCIREASLGPNFGMKGGAAGGGYAQVVPMEEMNLHFTGDFHAITSAHSLLSAMIDNHIYWGNELEIDV
RRVVWRRVVDMNDRALRQITASLGGVANGFPREAGFDITVASEVMAILCLAKDLKDLQERLGAMIVAYRRDRSPVFARDI
KADGAMTVLLKDAMQPNIVQTLENNPAFVHGGPFANIAHGCNSVIATTTALKLCDYVVTEAGFGADLGAEKFLNIKCRKA
GLAPSVVVVVATVRAMKMNGGVAKADLGAENVDAVQNGCANLGRHIENVKSFGVPVVVAINHFVTDTDAEVQAVKDYVAS
QGAEAVLSRHWELGSEGSAPLAEKVVEVIEKGEANFQTLYPDDMPLAEKIQAVCKGIYRADEAVMDKKILDQLKLWEDQG
YGKLPVCMAKTQYSFTTDPNERGAPTGFTIPVREVRLSAGAGFIVAVCGEIMTMPGLPRKPSAEAIHLNDDGQIEGLF

Sequences:

>Translated_558_residues
MGYKSDIEIAREAVKRPIQEIGAKIGIESADLLPYGHDKAKVSQSFINSVQNRDNGHLILVTAINPTPAGEGKTTTTVGL
GDGLNRIGKNAMVCIREASLGPNFGMKGGAAGGGYAQVVPMEEMNLHFTGDFHAITSAHSLLSAMIDNHIYWGNELEIDV
RRVVWRRVVDMNDRALRQITASLGGVANGFPREAGFDITVASEVMAILCLAKDLKDLQERLGAMIVAYRRDRSPVFARDI
KADGAMTVLLKDAMQPNIVQTLENNPAFVHGGPFANIAHGCNSVIATTTALKLCDYVVTEAGFGADLGAEKFLNIKCRKA
GLAPSVVVVVATVRAMKMNGGVAKADLGAENVDAVQNGCANLGRHIENVKSFGVPVVVAINHFVTDTDAEVQAVKDYVAS
QGAEAVLSRHWELGSEGSAPLAEKVVEVIEKGEANFQTLYPDDMPLAEKIQAVCKGIYRADEAVMDKKILDQLKLWEDQG
YGKLPVCMAKTQYSFTTDPNERGAPTGFTIPVREVRLSAGAGFIVAVCGEIMTMPGLPRKPSAEAIHLNDDGQIEGLF
>Mature_557_residues
GYKSDIEIAREAVKRPIQEIGAKIGIESADLLPYGHDKAKVSQSFINSVQNRDNGHLILVTAINPTPAGEGKTTTTVGLG
DGLNRIGKNAMVCIREASLGPNFGMKGGAAGGGYAQVVPMEEMNLHFTGDFHAITSAHSLLSAMIDNHIYWGNELEIDVR
RVVWRRVVDMNDRALRQITASLGGVANGFPREAGFDITVASEVMAILCLAKDLKDLQERLGAMIVAYRRDRSPVFARDIK
ADGAMTVLLKDAMQPNIVQTLENNPAFVHGGPFANIAHGCNSVIATTTALKLCDYVVTEAGFGADLGAEKFLNIKCRKAG
LAPSVVVVVATVRAMKMNGGVAKADLGAENVDAVQNGCANLGRHIENVKSFGVPVVVAINHFVTDTDAEVQAVKDYVASQ
GAEAVLSRHWELGSEGSAPLAEKVVEVIEKGEANFQTLYPDDMPLAEKIQAVCKGIYRADEAVMDKKILDQLKLWEDQGY
GKLPVCMAKTQYSFTTDPNERGAPTGFTIPVREVRLSAGAGFIVAVCGEIMTMPGLPRKPSAEAIHLNDDGQIEGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=43.1340872374798, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=43.4571890145396, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI310124614, Length=105, Percent_Identity=31.4285714285714, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=43.0868167202572, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=43.0868167202572, Blast_Score=462, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=41.5213946117274, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=41.6932907348243, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=43.6187399030695, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=43.6187399030695, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=43.6187399030695, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=43.6187399030695, Blast_Score=481, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_JANSC (Q28TR4)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508923.1
- ProteinModelPortal:   Q28TR4
- SMR:   Q28TR4
- STRING:   Q28TR4
- GeneID:   3933425
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0981
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- PhylomeDB:   Q28TR4
- ProtClustDB:   PRK13505
- BioCyc:   JSP290400:JANN_0981-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59829; Mature: 59698

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYKSDIEIAREAVKRPIQEIGAKIGIESADLLPYGHDKAKVSQSFINSVQNRDNGHLIL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
VTAINPTPAGEGKTTTTVGLGDGLNRIGKNAMVCIREASLGPNFGMKGGAAGGGYAQVVP
EEEECCCCCCCCCCEEEEECCCCHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEE
MEEMNLHFTGDFHAITSAHSLLSAMIDNHIYWGNELEIDVRRVVWRRVVDMNDRALRQIT
HHHCCEEECCCHHHHHHHHHHHHHHHHCCEECCCEEEHHHHHHHHHHHHCCCHHHHHHHH
ASLGGVANGFPREAGFDITVASEVMAILCLAKDLKDLQERLGAMIVAYRRDRSPVFARDI
HHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHC
KADGAMTVLLKDAMQPNIVQTLENNPAFVHGGPFANIAHGCNSVIATTTALKLCDYVVTE
CCCCCEEEEEHHCCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
AGFGADLGAEKFLNIKCRKAGLAPSVVVVVATVRAMKMNGGVAKADLGAENVDAVQNGCA
CCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHH
NLGRHIENVKSFGVPVVVAINHFVTDTDAEVQAVKDYVASQGAEAVLSRHWELGSEGSAP
HHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCH
LAEKVVEVIEKGEANFQTLYPDDMPLAEKIQAVCKGIYRADEAVMDKKILDQLKLWEDQG
HHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YGKLPVCMAKTQYSFTTDPNERGAPTGFTIPVREVRLSAGAGFIVAVCGEIMTMPGLPRK
CCCCCEEEEECCCEECCCCCCCCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHCCCCCCC
PSAEAIHLNDDGQIEGLF
CCCCEEEECCCCCEECCC
>Mature Secondary Structure 
GYKSDIEIAREAVKRPIQEIGAKIGIESADLLPYGHDKAKVSQSFINSVQNRDNGHLIL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
VTAINPTPAGEGKTTTTVGLGDGLNRIGKNAMVCIREASLGPNFGMKGGAAGGGYAQVVP
EEEECCCCCCCCCCEEEEECCCCHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEE
MEEMNLHFTGDFHAITSAHSLLSAMIDNHIYWGNELEIDVRRVVWRRVVDMNDRALRQIT
HHHCCEEECCCHHHHHHHHHHHHHHHHCCEECCCEEEHHHHHHHHHHHHCCCHHHHHHHH
ASLGGVANGFPREAGFDITVASEVMAILCLAKDLKDLQERLGAMIVAYRRDRSPVFARDI
HHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHC
KADGAMTVLLKDAMQPNIVQTLENNPAFVHGGPFANIAHGCNSVIATTTALKLCDYVVTE
CCCCCEEEEEHHCCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
AGFGADLGAEKFLNIKCRKAGLAPSVVVVVATVRAMKMNGGVAKADLGAENVDAVQNGCA
CCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHH
NLGRHIENVKSFGVPVVVAINHFVTDTDAEVQAVKDYVASQGAEAVLSRHWELGSEGSAP
HHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCH
LAEKVVEVIEKGEANFQTLYPDDMPLAEKIQAVCKGIYRADEAVMDKKILDQLKLWEDQG
HHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YGKLPVCMAKTQYSFTTDPNERGAPTGFTIPVREVRLSAGAGFIVAVCGEIMTMPGLPRK
CCCCCEEEEECCCEECCCCCCCCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHCCCCCCC
PSAEAIHLNDDGQIEGLF
CCCCEEEECCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA