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The map label for this gene is dcp [H]

Identifier: 89053403

GI number: 89053403

Start: 867275

End: 869299

Strand: Direct

Name: dcp [H]

Synonym: Jann_0912

Alternate gene names: 89053403

Gene position: 867275-869299 (Clockwise)

Preceding gene: 89053402

Following gene: 89053404

Centisome position: 20.09

GC content: 62.17

Gene sequence:

>2025_bases
ATGACCATGACCAATGCGCTGCTCGACACCTGGGATACGCCGTTTGAGATGCCACCGTTCGCGCGGATCAGCGACGCGGA
TTTCGGCCCCGCGCTGGATGCGGCGTTGGACGAGGGCCGCGCAAGGGTGGCGGCGATTGCCGAGCAGTCCGAGGCGCCGA
CATTTGCCAATACCGTCGACGCGTTGGAATTGGCGGATGAGGTGCTGGACCGGGTCGCAGGCGTGTTTTTCAACCTCGCC
GGGGCCGATGCGACGCCTGAGCGCGAGGCATTGCAACGCGATTATGCGCCGAAGTTTGCGGCGTATTCGTCGGAAATCAC
CAACAATACCAAACTTTTCGCGCGGATAGACGCGCTTTGGGAAAACCGCGATGCGCTGTCATTGAGTGAGGAGCAGGCCC
GCGTCCTGCACCTGACGCATCGATCTTTCGTGCGCTCGGGCGCGGCGGTCAGAGGCGCGGACGGAGAGCGCCTGACCGAG
GTCAAATCGCGCCTCGCCGTGTTGGGCACGCAGTTCATGCAGAACCTTCTGGCCGATGAGCGGGCGTGGTTCATGGACCT
GTCTGAGGCGGACCTTGAAGGCCTTCCGGATTTCGTCATCGACGCCGCCCGTACGGCGGGCGAAGAGAAGGGCGCAGACG
GTCCGGTCCTGACGCTATCGCGGTCGTTGATCGTGCCGTTTTTGCAGTTCTCGCCCCGGCGGGATCTGCGCGAAAGGGCG
TATCGGGCCTGGGCCGCGCGTGGGGCAAACGGCGGTGAGACTGACAATCTGGGCATCGCGGCCGAGACGCTTGCGTTGCG
CGAAGAACGGGCCAAGCTGCTGGGGTACAAGGATTTCGCGGCCTTCAAGTTGGAAACTGAAATGGCCGGATCGGCTGATA
AAGTCCGCAATCTGTTGATGGCCGTGTGGGAGCCCGCGAAGGCGCAGGCAGAGGCGGATGCCGACAAGCTGACCGCGATG
ATGGCCAAGGACGGGGTGAACGGCCCGTTGGAGCCTTGGGACTGGCGCTATTATTCCGAAAAGCGCCGCAAGGCGGAGCA
TGATCTGGATGAGGCGGCGTTGAAGCCTTACCTGAGCCTTGAGGCAATGATCAACGCTGCCTTTGATTGCGCGACACGGC
TGTTCGGGTTGGAGTTCAAAGCGCTCGATATCCCCCTCTACCACGCCGATGCCCGCGCGTGGGAAGTCACGCGGGACGGA
AATCATGTCGCTGTTTTCATTGGTGATTACTTCGCGCGCGGATCAAAGCGGTCGGGCGCGTGGTGCTCGGCCATGCGGTC
GCAAAAGAAGCTGGGTGGCGACACGCGACCCATCGTTGTGAACGTCTGCAACTTCGCCAAGGGCGACCCGGCGCTGCTGT
CCTATGACGACGCGCGCACGCTGTTTCACGAGTTCGGCCACGCCCTGCACCAGATGCTGTCGGACGTGACCTATGGCTCC
ATCTCCGGCACGTCTGTGGCGCGGGATTTTGTGGAACTGCCAAGCCAGCTGTATGAACATTGGCTGGAAGTGCCTGAAGT
CCTTGAAACTTTCGCCACCCACGTGGAGACCGGCGAGCCGATGCCAAAGGCGTTGTTGGAGCGTCTTCTGGCGGCGCAGA
CCTATGATATGGGATTCTCGACGGTGGAATATGTCGCGTCGGCCCTTGTGGATCTGGACTTCCACGACGGGGCAGCACCC
GCTGATCCGATGGCCGCACAAAAGGCGACGCTGGAGCGTCTGGGAATGCCCCACGCGATCGAGATGCGCCACCGCACGCC
GCAATTTGCCCATGTGTTTGCGGGCGATGGCTATTCCAGCGGCTACTACAGCTACATGTGGTCGGAGGTGATGGATGCCG
ACGCGTTTGCAGCGTTTGAGGAGGCGGGCGGGCCGTTTGATCCGGCGTTGGCCAAGTCTCTGGAAGATAACATCCTGTCC
GCCGGTGGCAGCCAGGAGGCGGACATTCTTTACACCGCATTCCGGGGGCGGATGCCGGGAGTTGAAGCACTTCTGAAAGG
GCGCGGTTTGGACCGGGTTGCCTGA

Upstream 100 bases:

>100_bases
GCGAGAGGCGCTGCCTCTCGCGCTCTCCGGGATATTTGCCGAACGGGGAAGGAGGGGGTGTAGGCGCTGGCATTCGGGCC
TATGTAAGGGGCAAAGGAGA

Downstream 100 bases:

>100_bases
CCAAAATCGCGCATGGGGTATATCAATGGTGCATCAATTTGCGATTGCCCTGATCGTGGGCGCCGCATTGCCCGGGCCGG
TCGCTGCTCAAACTGATCCC

Product: peptidyl-dipeptidase Dcp

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 674; Mature: 673

Protein sequence:

>674_residues
MTMTNALLDTWDTPFEMPPFARISDADFGPALDAALDEGRARVAAIAEQSEAPTFANTVDALELADEVLDRVAGVFFNLA
GADATPEREALQRDYAPKFAAYSSEITNNTKLFARIDALWENRDALSLSEEQARVLHLTHRSFVRSGAAVRGADGERLTE
VKSRLAVLGTQFMQNLLADERAWFMDLSEADLEGLPDFVIDAARTAGEEKGADGPVLTLSRSLIVPFLQFSPRRDLRERA
YRAWAARGANGGETDNLGIAAETLALREERAKLLGYKDFAAFKLETEMAGSADKVRNLLMAVWEPAKAQAEADADKLTAM
MAKDGVNGPLEPWDWRYYSEKRRKAEHDLDEAALKPYLSLEAMINAAFDCATRLFGLEFKALDIPLYHADARAWEVTRDG
NHVAVFIGDYFARGSKRSGAWCSAMRSQKKLGGDTRPIVVNVCNFAKGDPALLSYDDARTLFHEFGHALHQMLSDVTYGS
ISGTSVARDFVELPSQLYEHWLEVPEVLETFATHVETGEPMPKALLERLLAAQTYDMGFSTVEYVASALVDLDFHDGAAP
ADPMAAQKATLERLGMPHAIEMRHRTPQFAHVFAGDGYSSGYYSYMWSEVMDADAFAAFEEAGGPFDPALAKSLEDNILS
AGGSQEADILYTAFRGRMPGVEALLKGRGLDRVA

Sequences:

>Translated_674_residues
MTMTNALLDTWDTPFEMPPFARISDADFGPALDAALDEGRARVAAIAEQSEAPTFANTVDALELADEVLDRVAGVFFNLA
GADATPEREALQRDYAPKFAAYSSEITNNTKLFARIDALWENRDALSLSEEQARVLHLTHRSFVRSGAAVRGADGERLTE
VKSRLAVLGTQFMQNLLADERAWFMDLSEADLEGLPDFVIDAARTAGEEKGADGPVLTLSRSLIVPFLQFSPRRDLRERA
YRAWAARGANGGETDNLGIAAETLALREERAKLLGYKDFAAFKLETEMAGSADKVRNLLMAVWEPAKAQAEADADKLTAM
MAKDGVNGPLEPWDWRYYSEKRRKAEHDLDEAALKPYLSLEAMINAAFDCATRLFGLEFKALDIPLYHADARAWEVTRDG
NHVAVFIGDYFARGSKRSGAWCSAMRSQKKLGGDTRPIVVNVCNFAKGDPALLSYDDARTLFHEFGHALHQMLSDVTYGS
ISGTSVARDFVELPSQLYEHWLEVPEVLETFATHVETGEPMPKALLERLLAAQTYDMGFSTVEYVASALVDLDFHDGAAP
ADPMAAQKATLERLGMPHAIEMRHRTPQFAHVFAGDGYSSGYYSYMWSEVMDADAFAAFEEAGGPFDPALAKSLEDNILS
AGGSQEADILYTAFRGRMPGVEALLKGRGLDRVA
>Mature_673_residues
TMTNALLDTWDTPFEMPPFARISDADFGPALDAALDEGRARVAAIAEQSEAPTFANTVDALELADEVLDRVAGVFFNLAG
ADATPEREALQRDYAPKFAAYSSEITNNTKLFARIDALWENRDALSLSEEQARVLHLTHRSFVRSGAAVRGADGERLTEV
KSRLAVLGTQFMQNLLADERAWFMDLSEADLEGLPDFVIDAARTAGEEKGADGPVLTLSRSLIVPFLQFSPRRDLRERAY
RAWAARGANGGETDNLGIAAETLALREERAKLLGYKDFAAFKLETEMAGSADKVRNLLMAVWEPAKAQAEADADKLTAMM
AKDGVNGPLEPWDWRYYSEKRRKAEHDLDEAALKPYLSLEAMINAAFDCATRLFGLEFKALDIPLYHADARAWEVTRDGN
HVAVFIGDYFARGSKRSGAWCSAMRSQKKLGGDTRPIVVNVCNFAKGDPALLSYDDARTLFHEFGHALHQMLSDVTYGSI
SGTSVARDFVELPSQLYEHWLEVPEVLETFATHVETGEPMPKALLERLLAAQTYDMGFSTVEYVASALVDLDFHDGAAPA
DPMAAQKATLERLGMPHAIEMRHRTPQFAHVFAGDGYSSGYYSYMWSEVMDADAFAAFEEAGGPFDPALAKSLEDNILSA
GGSQEADILYTAFRGRMPGVEALLKGRGLDRVA

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=591, Percent_Identity=28.7648054145516, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI14149738, Length=593, Percent_Identity=27.8246205733558, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI156105687, Length=575, Percent_Identity=25.7391304347826, Blast_Score=142, Evalue=1e-33,
Organism=Escherichia coli, GI1787819, Length=684, Percent_Identity=34.7953216374269, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1789913, Length=688, Percent_Identity=34.7383720930233, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI32565901, Length=600, Percent_Identity=21.8333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71999758, Length=336, Percent_Identity=23.8095238095238, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319793, Length=685, Percent_Identity=23.3576642335766, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6322715, Length=452, Percent_Identity=23.8938053097345, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21356111, Length=491, Percent_Identity=25.4582484725051, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI20129717, Length=410, Percent_Identity=25.3658536585366, Blast_Score=122, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 74108; Mature: 73977

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTNALLDTWDTPFEMPPFARISDADFGPALDAALDEGRARVAAIAEQSEAPTFANTVD
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHH
ALELADEVLDRVAGVFFNLAGADATPEREALQRDYAPKFAAYSSEITNNTKLFARIDALW
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHH
ENRDALSLSEEQARVLHLTHRSFVRSGAAVRGADGERLTEVKSRLAVLGTQFMQNLLADE
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
RAWFMDLSEADLEGLPDFVIDAARTAGEEKGADGPVLTLSRSLIVPFLQFSPRRDLRERA
HHHHHCCCHHCCCCCCHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHCCCCHHHHHHH
YRAWAARGANGGETDNLGIAAETLALREERAKLLGYKDFAAFKLETEMAGSADKVRNLLM
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHEEEEHHHCCCHHHHHHHHH
AVWEPAKAQAEADADKLTAMMAKDGVNGPLEPWDWRYYSEKRRKAEHDLDEAALKPYLSL
HHHCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
EAMINAAFDCATRLFGLEFKALDIPLYHADARAWEVTRDGNHVAVFIGDYFARGSKRSGA
HHHHHHHHHHHHHHHCCEEEEEECEEEECCCCEEEEECCCCEEEEEEEHHHHCCCCCCCH
WCSAMRSQKKLGGDTRPIVVNVCNFAKGDPALLSYDDARTLFHEFGHALHQMLSDVTYGS
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCC
ISGTSVARDFVELPSQLYEHWLEVPEVLETFATHVETGEPMPKALLERLLAAQTYDMGFS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHH
TVEYVASALVDLDFHDGAAPADPMAAQKATLERLGMPHAIEMRHRTPQFAHVFAGDGYSS
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHCCCCCEEEEEECCCCCC
GYYSYMWSEVMDADAFAAFEEAGGPFDPALAKSLEDNILSAGGSQEADILYTAFRGRMPG
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCC
VEALLKGRGLDRVA
HHHHHHCCCCCCCC
>Mature Secondary Structure 
TMTNALLDTWDTPFEMPPFARISDADFGPALDAALDEGRARVAAIAEQSEAPTFANTVD
CCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHH
ALELADEVLDRVAGVFFNLAGADATPEREALQRDYAPKFAAYSSEITNNTKLFARIDALW
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHH
ENRDALSLSEEQARVLHLTHRSFVRSGAAVRGADGERLTEVKSRLAVLGTQFMQNLLADE
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
RAWFMDLSEADLEGLPDFVIDAARTAGEEKGADGPVLTLSRSLIVPFLQFSPRRDLRERA
HHHHHCCCHHCCCCCCHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHCCCCHHHHHHH
YRAWAARGANGGETDNLGIAAETLALREERAKLLGYKDFAAFKLETEMAGSADKVRNLLM
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHEEEEHHHCCCHHHHHHHHH
AVWEPAKAQAEADADKLTAMMAKDGVNGPLEPWDWRYYSEKRRKAEHDLDEAALKPYLSL
HHHCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
EAMINAAFDCATRLFGLEFKALDIPLYHADARAWEVTRDGNHVAVFIGDYFARGSKRSGA
HHHHHHHHHHHHHHHCCEEEEEECEEEECCCCEEEEECCCCEEEEEEEHHHHCCCCCCCH
WCSAMRSQKKLGGDTRPIVVNVCNFAKGDPALLSYDDARTLFHEFGHALHQMLSDVTYGS
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCC
ISGTSVARDFVELPSQLYEHWLEVPEVLETFATHVETGEPMPKALLERLLAAQTYDMGFS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHH
TVEYVASALVDLDFHDGAAPADPMAAQKATLERLGMPHAIEMRHRTPQFAHVFAGDGYSS
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHCCCCCEEEEEECCCCCC
GYYSYMWSEVMDADAFAAFEEAGGPFDPALAKSLEDNILSAGGSQEADILYTAFRGRMPG
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCC
VEALLKGRGLDRVA
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537804; 11677609 [H]