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The map label for this gene is lpd [H]

Identifier: 89053328

GI number: 89053328

Start: 792435

End: 793823

Strand: Direct

Name: lpd [H]

Synonym: Jann_0837

Alternate gene names: 89053328

Gene position: 792435-793823 (Clockwise)

Preceding gene: 89053327

Following gene: 89053331

Centisome position: 18.35

GC content: 61.34

Gene sequence:

>1389_bases
ATGTCCAGCTATGACGTTATCGTAATCGGCTCCGGCCCCGGCGGCTATGTCTGCGCCATCCGCTGCGCGCAACTGGGCCT
GAAAACGGCCTGTGTGGAGGGGCGCGAGACCCTTGGCGGGACCTGCCTCAACATCGGCTGCATTCCGTCCAAGGCGCTGC
TCCATGCCTCGCATATGTTGCACGAGGCCGAACACAATTTTGCGACGATGGGCCTGAAGGGGAAATCCCCCTCTGTCGAT
TGGCCGCAGATGCAGACCTACAAGACCGACGTGATTGGCCAGAACACCAAGGGCATCGAGTTTCTGTTCAAGAAAAACAA
GATTGATTGGCTCAAAGGCTGGGGCAGCATCCCGGAGGCGGGCAAGGTCAAGGTGGGCGATGACGTTCACGAGGCCAAAA
CCATCATCATCGCCTCCGGGTCTGAGCCGTCCAGCCTGCCGGGGATCGAGATCGACCAGAAGGTTGTCGTGGACAGCGAA
GGCGCGCTGAGCCTGCCGAAAGTGCCCAAGAAGATGATCGTGATCGGTGCGGGCGTGATCGGGTTGGAACTGGGATCCGT
CTATGCGCGGCTTGGGTCCGAGGTCGAGGTGATCGAATTCCTCGATCACATCACCCCGGGGATGGATGCGGAAGTGTCAA
AGGTGTTCCAGCGGACCCTGAAAAAGCAGGGGATCGGGTTCACGTTGGGGGCCGCCGTGCAGAGCGTCGCGGCCACAAAG
ACGAAAGCCAAGGTCACCTACAAGCTGCGCAAGGACGACAGCGAAGTGACGGTTGACGCCGATGTCGTGTTGGTTGCCGC
GGGACGGAAGCCGTATACCGATGGTCTGGGGCTCGACGCGCTTGGCGTGAAAATGTCTGATCGCGGCCAGATCGAAGTGG
ATGTGCAATATCGGACCAACGTGCCCGGTATCATGGCCATTGGTGACGCCATTGCGGGCCCCATGCTGGCCCATAAGGCT
GAGGATGAAGGGATGGCCGCGGCAGAGGTCGCGGCGGGCAAGCATGGCCACGTGAACTACGGCGTGATCCCCGGTGTAAT
CTACACGCACCCGGAAGTCGCCAATGTCGGCGCATCCGAGGAGGATCTGAAAGAGGCGGGCCGCGCCTACAAAGTCGGCA
AGTTTTCGTTCATGGGCAATGGCCGCGCGAAGGCGAACTTTGCGGGGGAAGGCTTCGTGAAAATCCTCGCGGATGCAGAG
ACGGACAGGATCCTTGGCGCGCATATCATCGGGCCGATGGCGGGGGATCTGATCCATGAGGTCTGCGTGGCGATGGAGTT
TGGCGCGTCCGCCCAGGATCTGGCGATGACGTGCCACGCCCACCCAACGTATTCGGAGGCCGTGCGCGAAGCAGCACTTG
CCTGCGGCGACGGCGCGATCCACGCCTGA

Upstream 100 bases:

>100_bases
CCGGGCCGCGTGATCGCGGCAAAGCAGTGCAGGCTGTGGTTGTCTGCCCGGGGCGGCGGGCGTAACGTGCGCTTAACCGA
ATGACCCCGATGGAGTTCCC

Downstream 100 bases:

>100_bases
CGGCGCGCGGCGCAATCCTAGTTCGCCAAAAGTCGCAGGCCCTGTGTGACGTCAGCCCGCAGGGCCAGCCGCAGTCCCGG
CTCATCTCCCGCGCGCAGCG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSSYDVIVIGSGPGGYVCAIRCAQLGLKTACVEGRETLGGTCLNIGCIPSKALLHASHMLHEAEHNFATMGLKGKSPSVD
WPQMQTYKTDVIGQNTKGIEFLFKKNKIDWLKGWGSIPEAGKVKVGDDVHEAKTIIIASGSEPSSLPGIEIDQKVVVDSE
GALSLPKVPKKMIVIGAGVIGLELGSVYARLGSEVEVIEFLDHITPGMDAEVSKVFQRTLKKQGIGFTLGAAVQSVAATK
TKAKVTYKLRKDDSEVTVDADVVLVAAGRKPYTDGLGLDALGVKMSDRGQIEVDVQYRTNVPGIMAIGDAIAGPMLAHKA
EDEGMAAAEVAAGKHGHVNYGVIPGVIYTHPEVANVGASEEDLKEAGRAYKVGKFSFMGNGRAKANFAGEGFVKILADAE
TDRILGAHIIGPMAGDLIHEVCVAMEFGASAQDLAMTCHAHPTYSEAVREAALACGDGAIHA

Sequences:

>Translated_462_residues
MSSYDVIVIGSGPGGYVCAIRCAQLGLKTACVEGRETLGGTCLNIGCIPSKALLHASHMLHEAEHNFATMGLKGKSPSVD
WPQMQTYKTDVIGQNTKGIEFLFKKNKIDWLKGWGSIPEAGKVKVGDDVHEAKTIIIASGSEPSSLPGIEIDQKVVVDSE
GALSLPKVPKKMIVIGAGVIGLELGSVYARLGSEVEVIEFLDHITPGMDAEVSKVFQRTLKKQGIGFTLGAAVQSVAATK
TKAKVTYKLRKDDSEVTVDADVVLVAAGRKPYTDGLGLDALGVKMSDRGQIEVDVQYRTNVPGIMAIGDAIAGPMLAHKA
EDEGMAAAEVAAGKHGHVNYGVIPGVIYTHPEVANVGASEEDLKEAGRAYKVGKFSFMGNGRAKANFAGEGFVKILADAE
TDRILGAHIIGPMAGDLIHEVCVAMEFGASAQDLAMTCHAHPTYSEAVREAALACGDGAIHA
>Mature_461_residues
SSYDVIVIGSGPGGYVCAIRCAQLGLKTACVEGRETLGGTCLNIGCIPSKALLHASHMLHEAEHNFATMGLKGKSPSVDW
PQMQTYKTDVIGQNTKGIEFLFKKNKIDWLKGWGSIPEAGKVKVGDDVHEAKTIIIASGSEPSSLPGIEIDQKVVVDSEG
ALSLPKVPKKMIVIGAGVIGLELGSVYARLGSEVEVIEFLDHITPGMDAEVSKVFQRTLKKQGIGFTLGAAVQSVAATKT
KAKVTYKLRKDDSEVTVDADVVLVAAGRKPYTDGLGLDALGVKMSDRGQIEVDVQYRTNVPGIMAIGDAIAGPMLAHKAE
DEGMAAAEVAAGKHGHVNYGVIPGVIYTHPEVANVGASEEDLKEAGRAYKVGKFSFMGNGRAKANFAGEGFVKILADAET
DRILGAHIIGPMAGDLIHEVCVAMEFGASAQDLAMTCHAHPTYSEAVREAALACGDGAIHA

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=52.1551724137931, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=27.3318872017354, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI33519430, Length=444, Percent_Identity=26.3513513513513, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI33519428, Length=444, Percent_Identity=26.3513513513513, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI33519426, Length=444, Percent_Identity=26.3513513513513, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI148277065, Length=444, Percent_Identity=26.3513513513513, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI148277071, Length=444, Percent_Identity=26.3513513513513, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI291045266, Length=428, Percent_Identity=27.5700934579439, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI22035672, Length=473, Percent_Identity=29.3868921775898, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI291045268, Length=421, Percent_Identity=26.603325415677, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=42.5720620842572, Blast_Score=335, Evalue=5e-93,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=30.5194805194805, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=30.1149425287356, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=26.304347826087, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=54.1304347826087, Blast_Score=486, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=27.4261603375527, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=25.4988913525499, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71983429, Length=454, Percent_Identity=25.3303964757709, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71982272, Length=490, Percent_Identity=24.2857142857143, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17559934, Length=174, Percent_Identity=25.2873563218391, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=50.5285412262156, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=32.2784810126582, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=29.4871794871795, Blast_Score=179, Evalue=6e-46,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=54.0130151843818, Blast_Score=477, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=30.188679245283, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=30.188679245283, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24640551, Length=481, Percent_Identity=30.3534303534304, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI17737741, Length=469, Percent_Identity=27.5053304904051, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48547; Mature: 48416

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSYDVIVIGSGPGGYVCAIRCAQLGLKTACVEGRETLGGTCLNIGCIPSKALLHASHML
CCCCEEEEEECCCCCEEEEEEHHHHCHHHHHHCCCHHCCCEEEEECCCCHHHHHHHHHHH
HEAEHNFATMGLKGKSPSVDWPQMQTYKTDVIGQNTKGIEFLFKKNKIDWLKGWGSIPEA
HHHCCCEEEEEECCCCCCCCCCCCHHEEHHHCCCCCCCEEEEEECCCCHHHHCCCCCCCC
GKVKVGDDVHEAKTIIIASGSEPSSLPGIEIDQKVVVDSEGALSLPKVPKKMIVIGAGVI
CCEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCHH
GLELGSVYARLGSEVEVIEFLDHITPGMDAEVSKVFQRTLKKQGIGFTLGAAVQSVAATK
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCC
TKAKVTYKLRKDDSEVTVDADVVLVAAGRKPYTDGLGLDALGVKMSDRGQIEVDVQYRTN
CCEEEEEEEECCCCCEEEECCEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEEECC
VPGIMAIGDAIAGPMLAHKAEDEGMAAAEVAAGKHGHVNYGVIPGVIYTHPEVANVGASE
CCCEEEECHHHHCCHHHHCCCCCCCCHHHHHCCCCCCEECCCCCCEEEECCCHHCCCCCH
EDLKEAGRAYKVGKFSFMGNGRAKANFAGEGFVKILADAETDRILGAHIIGPMAGDLIHE
HHHHHCCCEEEEEEEEEECCCCCEEEECCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHH
VCVAMEFGASAQDLAMTCHAHPTYSEAVREAALACGDGAIHA
HHHHHHCCCCHHHHEEEECCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSYDVIVIGSGPGGYVCAIRCAQLGLKTACVEGRETLGGTCLNIGCIPSKALLHASHML
CCCEEEEEECCCCCEEEEEEHHHHCHHHHHHCCCHHCCCEEEEECCCCHHHHHHHHHHH
HEAEHNFATMGLKGKSPSVDWPQMQTYKTDVIGQNTKGIEFLFKKNKIDWLKGWGSIPEA
HHHCCCEEEEEECCCCCCCCCCCCHHEEHHHCCCCCCCEEEEEECCCCHHHHCCCCCCCC
GKVKVGDDVHEAKTIIIASGSEPSSLPGIEIDQKVVVDSEGALSLPKVPKKMIVIGAGVI
CCEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCHH
GLELGSVYARLGSEVEVIEFLDHITPGMDAEVSKVFQRTLKKQGIGFTLGAAVQSVAATK
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCC
TKAKVTYKLRKDDSEVTVDADVVLVAAGRKPYTDGLGLDALGVKMSDRGQIEVDVQYRTN
CCEEEEEEEECCCCCEEEECCEEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEEECC
VPGIMAIGDAIAGPMLAHKAEDEGMAAAEVAAGKHGHVNYGVIPGVIYTHPEVANVGASE
CCCEEEECHHHHCCHHHHCCCCCCCCHHHHHCCCCCCEECCCCCCEEEECCCHHCCCCCH
EDLKEAGRAYKVGKFSFMGNGRAKANFAGEGFVKILADAETDRILGAHIIGPMAGDLIHE
HHHHHCCCEEEEEEEEEECCCCCEEEECCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHH
VCVAMEFGASAQDLAMTCHAHPTYSEAVREAALACGDGAIHA
HHHHHHCCCCHHHHEEEECCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9226266 [H]