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The map label for this gene is sucD [H]

Identifier: 88657940

GI number: 88657940

Start: 1002513

End: 1003394

Strand: Direct

Name: sucD [H]

Synonym: ECH_0980

Alternate gene names: 88657940

Gene position: 1002513-1003394 (Clockwise)

Preceding gene: 88658279

Following gene: 88658445

Centisome position: 85.23

GC content: 38.66

Gene sequence:

>882_bases
ATGTCCGTTTTAGTAAATAGCAACACAAAAGTTATATGCCAGGGATTTACTGGTGCTCATGGTACATTTCATTCAGAACA
AGCTATTGCTTATGGAACAAACATGGTAGGTGGAGTAACTCCTGGAAAAGGTGGAACATATCATCTAAACCTACCAGTGT
TTAATACTGTAAAGCAAGCCAAACTAGAGGCAAAAGCTAATGCTACTGTTATTTATGTTCCAGCTCCTTACGCAGCAGAT
GCAATACTAGAAGCAATTGAAGCTGAGATAGAACTTATTGTTTGCATTACAGAAGGTATACCTACCCTAGATATGGTACA
GGTAAAACATGCTTTACTCAACTCATCAAGTACATTAATAGGACCAAACTGTCCTGGAATTATCACCCCAGAAGAATGCA
AAATTGGTATTATGCCTGGATATATACATAAACGTGGTCACATAGGTATTGTTTCACGTTCTGGAACACTCACATATGAA
GCAGTAGCACAAACCACAGAAGTGGGGTTAGGACAATCAACATGTATTGGTATAGGTGGAGATCCTATCCATGGAATGTC
TTTTACAGATTGCATTAGACTATTTATAAATGATCCAGATACACATGGTATTATCATGATTGGAGAGATTGGAGGATCAG
AAGAAGAAGAAGCTGCAGAATTTATCAAATTATCAGGAACTAACAAACCTGTAGTTGGCTTCATCGCTGGCAAGACTGCA
CCCCCAGGAAAACGTATGGGACACGCTGGAGCGATTTCTTCAGGTACCTCAGGTAGTGCTGAAAGCAAAATAGAAGCTAT
GAAAAATGCAGGTATTATTATTGCTGAAACTCCAGCAGTCATAGGCAAAACAATGTTAGAAGCTATGAATAATAAACGCT
AA

Upstream 100 bases:

>100_bases
AAAAAGTTACTAGATGATTCAAATCTAAATATTATTACAGCAAACGATTTAAGTGAAGCAGCATACAATATAGTTAATAT
AGTAAGAAAATAGAGGCGAT

Downstream 100 bases:

>100_bases
ACACTTTAACTAATGATTGATTAGTTCATATTTTTTAGGGGCTACTTTCACATTAATGTTGTTTGTGTTCTACATTTTAG
CACTTTAATATCAACACATT

Product: succinyl-CoA synthetase, alpha subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSVLVNSNTKVICQGFTGAHGTFHSEQAIAYGTNMVGGVTPGKGGTYHLNLPVFNTVKQAKLEAKANATVIYVPAPYAAD
AILEAIEAEIELIVCITEGIPTLDMVQVKHALLNSSSTLIGPNCPGIITPEECKIGIMPGYIHKRGHIGIVSRSGTLTYE
AVAQTTEVGLGQSTCIGIGGDPIHGMSFTDCIRLFINDPDTHGIIMIGEIGGSEEEEAAEFIKLSGTNKPVVGFIAGKTA
PPGKRMGHAGAISSGTSGSAESKIEAMKNAGIIIAETPAVIGKTMLEAMNNKR

Sequences:

>Translated_293_residues
MSVLVNSNTKVICQGFTGAHGTFHSEQAIAYGTNMVGGVTPGKGGTYHLNLPVFNTVKQAKLEAKANATVIYVPAPYAAD
AILEAIEAEIELIVCITEGIPTLDMVQVKHALLNSSSTLIGPNCPGIITPEECKIGIMPGYIHKRGHIGIVSRSGTLTYE
AVAQTTEVGLGQSTCIGIGGDPIHGMSFTDCIRLFINDPDTHGIIMIGEIGGSEEEEAAEFIKLSGTNKPVVGFIAGKTA
PPGKRMGHAGAISSGTSGSAESKIEAMKNAGIIIAETPAVIGKTMLEAMNNKR
>Mature_292_residues
SVLVNSNTKVICQGFTGAHGTFHSEQAIAYGTNMVGGVTPGKGGTYHLNLPVFNTVKQAKLEAKANATVIYVPAPYAADA
ILEAIEAEIELIVCITEGIPTLDMVQVKHALLNSSSTLIGPNCPGIITPEECKIGIMPGYIHKRGHIGIVSRSGTLTYEA
VAQTTEVGLGQSTCIGIGGDPIHGMSFTDCIRLFINDPDTHGIIMIGEIGGSEEEEAAEFIKLSGTNKPVVGFIAGKTAP
PGKRMGHAGAISSGTSGSAESKIEAMKNAGIIIAETPAVIGKTMLEAMNNKR

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=295, Percent_Identity=65.4237288135593, Blast_Score=335, Evalue=3e-92,
Organism=Homo sapiens, GI38569423, Length=249, Percent_Identity=28.9156626506024, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI38569421, Length=249, Percent_Identity=28.9156626506024, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786949, Length=285, Percent_Identity=65.6140350877193, Blast_Score=373, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17553126, Length=292, Percent_Identity=62.6712328767123, Blast_Score=340, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI17550194, Length=289, Percent_Identity=61.5916955017301, Blast_Score=337, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI17551266, Length=262, Percent_Identity=26.7175572519084, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17557344, Length=257, Percent_Identity=27.2373540856031, Blast_Score=88, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6324716, Length=296, Percent_Identity=51.3513513513513, Blast_Score=282, Evalue=6e-77,
Organism=Drosophila melanogaster, GI21356559, Length=289, Percent_Identity=60.5536332179931, Blast_Score=356, Evalue=1e-98,
Organism=Drosophila melanogaster, GI28574296, Length=291, Percent_Identity=62.5429553264605, Blast_Score=333, Evalue=7e-92,
Organism=Drosophila melanogaster, GI281363477, Length=246, Percent_Identity=26.8292682926829, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281363475, Length=246, Percent_Identity=26.8292682926829, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281363473, Length=246, Percent_Identity=26.8292682926829, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30472; Mature: 30341

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLVNSNTKVICQGFTGAHGTFHSEQAIAYGTNMVGGVTPGKGGTYHLNLPVFNTVKQA
CEEEEECCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHH
KLEAKANATVIYVPAPYAADAILEAIEAEIELIVCITEGIPTLDMVQVKHALLNSSSTLI
HHHHCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEE
GPNCPGIITPEECKIGIMPGYIHKRGHIGIVSRSGTLTYEAVAQTTEVGLGQSTCIGIGG
CCCCCCCCCCCCCEEEECCCCEECCCCEEEEECCCCEEEHHHHHHHHCCCCCCEEEECCC
DPIHGMSFTDCIRLFINDPDTHGIIMIGEIGGSEEEEAAEFIKLSGTNKPVVGFIAGKTA
CCCCCCCHHHHHEEEECCCCCCCEEEEECCCCCCHHHHHHEEEECCCCCCEEEEEECCCC
PPGKRMGHAGAISSGTSGSAESKIEAMKNAGIIIAETPAVIGKTMLEAMNNKR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVLVNSNTKVICQGFTGAHGTFHSEQAIAYGTNMVGGVTPGKGGTYHLNLPVFNTVKQA
EEEEECCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHH
KLEAKANATVIYVPAPYAADAILEAIEAEIELIVCITEGIPTLDMVQVKHALLNSSSTLI
HHHHCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEE
GPNCPGIITPEECKIGIMPGYIHKRGHIGIVSRSGTLTYEAVAQTTEVGLGQSTCIGIGG
CCCCCCCCCCCCCEEEECCCCEECCCCEEEEECCCCEEEHHHHHHHHCCCCCCEEEECCC
DPIHGMSFTDCIRLFINDPDTHGIIMIGEIGGSEEEEAAEFIKLSGTNKPVVGFIAGKTA
CCCCCCCHHHHHEEEECCCCCCCEEEEECCCCCCHHHHHHEEEECCCCCCEEEEEECCCC
PPGKRMGHAGAISSGTSGSAESKIEAMKNAGIIIAETPAVIGKTMLEAMNNKR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]