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The map label for this gene is mdmC [H]

Identifier: 88657893

GI number: 88657893

Start: 759154

End: 759813

Strand: Direct

Name: mdmC [H]

Synonym: ECH_0754

Alternate gene names: 88657893

Gene position: 759154-759813 (Clockwise)

Preceding gene: 88657631

Following gene: 88657797

Centisome position: 64.54

GC content: 27.42

Gene sequence:

>660_bases
ATGCGTAACAAAATATTAAGCAAAAAATCACAATATATTCATGATTTGTTTTCAATTACAGATACAGACGTTGTAGCAAC
ACATCAACTTATCGAGGATGATATATCCTTAATGCAACTTAGTCTTATGGAAGGCCAGATATTACAATTATTAATAAAGA
TGAACAATATAAAATCTATAATTGAAATTGGAACCTTTGTTGGATCATCTGCTATATGTATGGTTAAAGCATTACCAAAA
GATGGGCACATATATACCATAGAAAAAAACACTACAAATGCTAAATTAGCAGAAGACAACTTCAAAAAATACAACTTATC
TAATAACATAACAGTAATAAATGACACAGGAATATCAGCATTAAACAAATTAACTAACATGTCACCATTTGACATGATAT
TTATAGATGCCAATAAATCAGGATATTGTGATTACTTAGATTGGGCAGAATTAAATATAAAAAAAAGTGGTTTAATAGTT
GCCGATAATACACTATTATTTGGCACTGTATACTCTAATGATAATGTAAATAAAAAAGTATCTAAAGCTACAATTAACAA
AATGCTCTCCTTTAATAAAAGGCTATCTGATAAAAACAAATATCTTACAACTTTATTACCTACAGAAGAAGGTATGACAA
TTGCATTAAAATTGTTCTAA

Upstream 100 bases:

>100_bases
GTTAATTTACCACGTAATAATATATTAATAATTGAATAAAAACTCAAATTAAATTACAATCTAGATTATACTATTAATTC
TTATCATATAAAATGGTTTC

Downstream 100 bases:

>100_bases
GGATTTTCTCAACTTGAATATTAATAGAAAATTAAATTATGTGATCACCCTCTACCCAACAGTATAATATTCATATAGCA
ATCTTAGGCATTTATATTAT

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MRNKILSKKSQYIHDLFSITDTDVVATHQLIEDDISLMQLSLMEGQILQLLIKMNNIKSIIEIGTFVGSSAICMVKALPK
DGHIYTIEKNTTNAKLAEDNFKKYNLSNNITVINDTGISALNKLTNMSPFDMIFIDANKSGYCDYLDWAELNIKKSGLIV
ADNTLLFGTVYSNDNVNKKVSKATINKMLSFNKRLSDKNKYLTTLLPTEEGMTIALKLF

Sequences:

>Translated_219_residues
MRNKILSKKSQYIHDLFSITDTDVVATHQLIEDDISLMQLSLMEGQILQLLIKMNNIKSIIEIGTFVGSSAICMVKALPK
DGHIYTIEKNTTNAKLAEDNFKKYNLSNNITVINDTGISALNKLTNMSPFDMIFIDANKSGYCDYLDWAELNIKKSGLIV
ADNTLLFGTVYSNDNVNKKVSKATINKMLSFNKRLSDKNKYLTTLLPTEEGMTIALKLF
>Mature_219_residues
MRNKILSKKSQYIHDLFSITDTDVVATHQLIEDDISLMQLSLMEGQILQLLIKMNNIKSIIEIGTFVGSSAICMVKALPK
DGHIYTIEKNTTNAKLAEDNFKKYNLSNNITVINDTGISALNKLTNMSPFDMIFIDANKSGYCDYLDWAELNIKKSGLIV
ADNTLLFGTVYSNDNVNKKVSKATINKMLSFNKRLSDKNKYLTTLLPTEEGMTIALKLF

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Caenorhabditis elegans, GI72001127, Length=205, Percent_Identity=28.780487804878, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25148771, Length=180, Percent_Identity=28.3333333333333, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565612, Length=178, Percent_Identity=28.0898876404494, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24602; Mature: 24602

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNKILSKKSQYIHDLFSITDTDVVATHQLIEDDISLMQLSLMEGQILQLLIKMNNIKSI
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEIGTFVGSSAICMVKALPKDGHIYTIEKNTTNAKLAEDNFKKYNLSNNITVINDTGISA
HHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCEECCCCCEEEECCCCEEEEECCCHHH
LNKLTNMSPFDMIFIDANKSGYCDYLDWAELNIKKSGLIVADNTLLFGTVYSNDNVNKKV
HHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCEEEECCEEEEEEEECCCCCCHHH
SKATINKMLSFNKRLSDKNKYLTTLLPTEEGMTIALKLF
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEC
>Mature Secondary Structure
MRNKILSKKSQYIHDLFSITDTDVVATHQLIEDDISLMQLSLMEGQILQLLIKMNNIKSI
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEIGTFVGSSAICMVKALPKDGHIYTIEKNTTNAKLAEDNFKKYNLSNNITVINDTGISA
HHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCCEECCCCCEEEECCCCEEEEECCCHHH
LNKLTNMSPFDMIFIDANKSGYCDYLDWAELNIKKSGLIVADNTLLFGTVYSNDNVNKKV
HHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCEEEECCEEEEEEEECCCCCCHHH
SKATINKMLSFNKRLSDKNKYLTTLLPTEEGMTIALKLF
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]