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The map label for this gene is pdxH

Identifier: 88607508

GI number: 88607508

Start: 1066132

End: 1066752

Strand: Reverse

Name: pdxH

Synonym: APH_1008

Alternate gene names: 88607508

Gene position: 1066752-1066132 (Counterclockwise)

Preceding gene: 88606983

Following gene: 88607367

Centisome position: 72.5

GC content: 45.57

Gene sequence:

>621_bases
GTGACTATAAATAAGGAGGGCCTGCGTGTGGATGCGTGCAGTGGTGATCCCATGAGCATATTTGGCTTGTGGTATGAAGA
AGTACTAAGGGTGAAGAGCGTGAGGGAACCCTCTGCTATGGTTCTTGCCACCTGTGATTCTGAAAATAGGCCTTCTGCCA
GAGTGGTGTTGCTGAAGAGGTACAGTGACGCTGGGTTTGAGTTTTACACAAATCTTGAAAGCAGAAAGGCAAGAGAAATA
GCTTTGAACCCATGTGTTTCCCTGGTTTTTGATTGGAGGCCCATCTATAAACAGGTGCGTGTAGAGGGGATTGCTGAGTT
TATGGATGCCAGTGAGTCAGATGCATACTTTGCATCTAGATCGAGAGAGAGTCAGATAGGAGCTTGGTGTTCTAGACAGT
CTATGATCCTCGAAGATAGGGATGTGCTGTTGTCTAAAATAGAACTTATGGAACGAGAGTATGAAGGGCGAGAGATTCCG
AGGCCGAAATTCTGGGGAGGTATTAGGGTAGTACCAAACGTGATCGAATTTTGGATGGATGGTAAGCATAGGTTGCATGA
TAGGAGGCAGTATAGCAAAAATATCGATGGTACATGGACGTCGGTTTATCTGTATCCTTAG

Upstream 100 bases:

>100_bases
ACTTAGTATGTTTTGCCAGAGTTTTGAGATGAGCAGTTGCTTGGAGTATTGCGATCACGCTTGTAAAAAGTGGTAGCATA
TTTTGTAGTGTGCCTGTGAG

Downstream 100 bases:

>100_bases
TGGGTAACTACCCCTTTCTTAAGTCCGTTAGGATGCTAAAAGTTTTGGCATGTTATGAGTAGGTTACGATAAGCATTGTT
GCGCAAAGGTCCACAGTGCT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTINKEGLRVDACSGDPMSIFGLWYEEVLRVKSVREPSAMVLATCDSENRPSARVVLLKRYSDAGFEFYTNLESRKAREI
ALNPCVSLVFDWRPIYKQVRVEGIAEFMDASESDAYFASRSRESQIGAWCSRQSMILEDRDVLLSKIELMEREYEGREIP
RPKFWGGIRVVPNVIEFWMDGKHRLHDRRQYSKNIDGTWTSVYLYP

Sequences:

>Translated_206_residues
MTINKEGLRVDACSGDPMSIFGLWYEEVLRVKSVREPSAMVLATCDSENRPSARVVLLKRYSDAGFEFYTNLESRKAREI
ALNPCVSLVFDWRPIYKQVRVEGIAEFMDASESDAYFASRSRESQIGAWCSRQSMILEDRDVLLSKIELMEREYEGREIP
RPKFWGGIRVVPNVIEFWMDGKHRLHDRRQYSKNIDGTWTSVYLYP
>Mature_205_residues
TINKEGLRVDACSGDPMSIFGLWYEEVLRVKSVREPSAMVLATCDSENRPSARVVLLKRYSDAGFEFYTNLESRKAREIA
LNPCVSLVFDWRPIYKQVRVEGIAEFMDASESDAYFASRSRESQIGAWCSRQSMILEDRDVLLSKIELMEREYEGREIPR
PKFWGGIRVVPNVIEFWMDGKHRLHDRRQYSKNIDGTWTSVYLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=180, Percent_Identity=45, Blast_Score=174, Evalue=6e-44,
Organism=Escherichia coli, GI1787926, Length=203, Percent_Identity=44.8275862068966, Blast_Score=171, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17553712, Length=189, Percent_Identity=37.037037037037, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319509, Length=210, Percent_Identity=37.6190476190476, Blast_Score=139, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24644901, Length=181, Percent_Identity=41.4364640883978, Blast_Score=133, Evalue=7e-32,
Organism=Drosophila melanogaster, GI45551845, Length=181, Percent_Identity=41.4364640883978, Blast_Score=133, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24644903, Length=184, Percent_Identity=28.804347826087, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_ANAPZ (Q2GJ82)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505569.1
- ProteinModelPortal:   Q2GJ82
- SMR:   Q2GJ82
- STRING:   Q2GJ82
- GeneID:   3930979
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_1008
- NMPDR:   fig|212042.5.peg.953
- TIGR:   APH_1008
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- PhylomeDB:   Q2GJ82
- ProtClustDB:   CLSK747290
- BioCyc:   APHA212042:APH_1008-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24008; Mature: 23876

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 54-54 BINDING 57-57 BINDING 59-59 BINDING 76-76 BINDING 116-116 BINDING 120-120 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTINKEGLRVDACSGDPMSIFGLWYEEVLRVKSVREPSAMVLATCDSENRPSARVVLLKR
CCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEE
YSDAGFEFYTNLESRKAREIALNPCVSLVFDWRPIYKQVRVEGIAEFMDASESDAYFASR
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHC
SRESQIGAWCSRQSMILEDRDVLLSKIELMEREYEGREIPRPKFWGGIRVVPNVIEFWMD
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC
GKHRLHDRRQYSKNIDGTWTSVYLYP
CHHHHHHHHHHHCCCCCCEEEEEEEC
>Mature Secondary Structure 
TINKEGLRVDACSGDPMSIFGLWYEEVLRVKSVREPSAMVLATCDSENRPSARVVLLKR
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEE
YSDAGFEFYTNLESRKAREIALNPCVSLVFDWRPIYKQVRVEGIAEFMDASESDAYFASR
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHC
SRESQIGAWCSRQSMILEDRDVLLSKIELMEREYEGREIPRPKFWGGIRVVPNVIEFWMD
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC
GKHRLHDRRQYSKNIDGTWTSVYLYP
CHHHHHHHHHHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA