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The map label for this gene is hemH [H]

Identifier: 88607381

GI number: 88607381

Start: 263637

End: 264599

Strand: Reverse

Name: hemH [H]

Synonym: APH_0263

Alternate gene names: 88607381

Gene position: 264599-263637 (Counterclockwise)

Preceding gene: 88606740

Following gene: 88607848

Centisome position: 17.98

GC content: 39.77

Gene sequence:

>963_bases
ATGTCTAGAAAAATTGCTGTTGTTTTGTTTAATCTTGGTGGTCCTGCTTCCTTGCGAGAGGTAGAATCTTTTCTATTTAA
CATGTTCAATGATAGTCATATTGTTAGCGCGCCAAGGCCTTTCAGGTACTTTTTAGCAAAGGCAATTTCCAAGCTAAGAG
CGCGATCTTCTCGCGAGATTTACACGCTAATGGGTGGCAAGTCTATTGTAGAGCAGGAAACTGCAAAACAAGCTATCGCG
TTAGAAGAACTATTGAATAAAAATGCTGAGACTGGATGCTCATATAAAGTGTTTACCTGCATGCGCTACTCCGCACCAAA
CGCACTTACGGTGTTAGGTGACATTGATGAATATAAACCATGCAAAGTAGTTCTATTACCTATGTATCCGCAATATTCAT
CAGCTACCACACAATCGTCCATAGAAGATTGGTTTAGTACATCTCACAAAGCGGGATACAGTTTTTGGACTGATATTATT
TGGGATTATCATAGTGATGAGCATTTCATTGCGGCACATTGTAAACTAATATCAGAGGCCTATGAAAAGGCACTAGCTTT
GAATGCACGAGCAAGGATTCTTTTCTCAGCACACAGTTTACCAGTATCATTTATTGAAAAGGGTGATCCTTACAAACAGC
AACTGCGGCAAACCGTGCTGTCTATATTGCAAAACATGGGTTTACAGTCTATAGATAACACTCTTTGTTATCAGAGTAAA
CTTGGACCAGTGCGCTGGTTAGAGCCCAGCACAAAGTCTGAACTTCTCAGAGCCTGCAATGATAATGTATCTGTAGTTCT
TGTCCCTATAGCATTCGTTTCTGAAAACTCTGAAACGCTTGTTGAACTTGATATAGAATACAAAGCCTTGGTGGGAGAAA
AGAAGTTCATTAGAGTCCCTACTCTGGGAACAGATCCAAAATTTATAGAGTGTTTGTGCAATCTCGTATTAGCTAAACAG
TAA

Upstream 100 bases:

>100_bases
GTGTTTTCAGGCGCACTGCTTCTTTTTAAAAGGTGATATTGCTGGCATTAAGCGAGCGCTGTAGCTACAATAATTATGCT
CATGTGTAAGGTGTCACCTG

Downstream 100 bases:

>100_bases
GGCTCTATTTTTGATGGGGCTTATGTCTTTTAACTGGATTTATGAGTTACCATGCTGCAGACCCCATTTCTGATAATCTT
GACATCGCGCGTTTTATATC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSRKIAVVLFNLGGPASLREVESFLFNMFNDSHIVSAPRPFRYFLAKAISKLRARSSREIYTLMGGKSIVEQETAKQAIA
LEELLNKNAETGCSYKVFTCMRYSAPNALTVLGDIDEYKPCKVVLLPMYPQYSSATTQSSIEDWFSTSHKAGYSFWTDII
WDYHSDEHFIAAHCKLISEAYEKALALNARARILFSAHSLPVSFIEKGDPYKQQLRQTVLSILQNMGLQSIDNTLCYQSK
LGPVRWLEPSTKSELLRACNDNVSVVLVPIAFVSENSETLVELDIEYKALVGEKKFIRVPTLGTDPKFIECLCNLVLAKQ

Sequences:

>Translated_320_residues
MSRKIAVVLFNLGGPASLREVESFLFNMFNDSHIVSAPRPFRYFLAKAISKLRARSSREIYTLMGGKSIVEQETAKQAIA
LEELLNKNAETGCSYKVFTCMRYSAPNALTVLGDIDEYKPCKVVLLPMYPQYSSATTQSSIEDWFSTSHKAGYSFWTDII
WDYHSDEHFIAAHCKLISEAYEKALALNARARILFSAHSLPVSFIEKGDPYKQQLRQTVLSILQNMGLQSIDNTLCYQSK
LGPVRWLEPSTKSELLRACNDNVSVVLVPIAFVSENSETLVELDIEYKALVGEKKFIRVPTLGTDPKFIECLCNLVLAKQ
>Mature_319_residues
SRKIAVVLFNLGGPASLREVESFLFNMFNDSHIVSAPRPFRYFLAKAISKLRARSSREIYTLMGGKSIVEQETAKQAIAL
EELLNKNAETGCSYKVFTCMRYSAPNALTVLGDIDEYKPCKVVLLPMYPQYSSATTQSSIEDWFSTSHKAGYSFWTDIIW
DYHSDEHFIAAHCKLISEAYEKALALNARARILFSAHSLPVSFIEKGDPYKQQLRQTVLSILQNMGLQSIDNTLCYQSKL
GPVRWLEPSTKSELLRACNDNVSVVLVPIAFVSENSETLVELDIEYKALVGEKKFIRVPTLGTDPKFIECLCNLVLAKQ

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=325, Percent_Identity=31.0769230769231, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI60499025, Length=325, Percent_Identity=31.0769230769231, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1786681, Length=330, Percent_Identity=24.2424242424242, Blast_Score=78, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324750, Length=320, Percent_Identity=28.4375, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17864156, Length=323, Percent_Identity=31.5789473684211, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24651774, Length=253, Percent_Identity=29.6442687747036, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45552018, Length=129, Percent_Identity=40.3100775193798, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36047; Mature: 35916

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKIAVVLFNLGGPASLREVESFLFNMFNDSHIVSAPRPFRYFLAKAISKLRARSSREI
CCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCE
YTLMGGKSIVEQETAKQAIALEELLNKNAETGCSYKVFTCMRYSAPNALTVLGDIDEYKP
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCC
CKVVLLPMYPQYSSATTQSSIEDWFSTSHKAGYSFWTDIIWDYHSDEHFIAAHCKLISEA
CEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
YEKALALNARARILFSAHSLPVSFIEKGDPYKQQLRQTVLSILQNMGLQSIDNTLCYQSK
HHHHHHHCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
LGPVRWLEPSTKSELLRACNDNVSVVLVPIAFVSENSETLVELDIEYKALVGEKKFIRVP
CCCEEECCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCEEEEEECHHHHHCCCCEEEECC
TLGTDPKFIECLCNLVLAKQ
CCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRKIAVVLFNLGGPASLREVESFLFNMFNDSHIVSAPRPFRYFLAKAISKLRARSSREI
CCEEEEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCE
YTLMGGKSIVEQETAKQAIALEELLNKNAETGCSYKVFTCMRYSAPNALTVLGDIDEYKP
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCC
CKVVLLPMYPQYSSATTQSSIEDWFSTSHKAGYSFWTDIIWDYHSDEHFIAAHCKLISEA
CEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
YEKALALNARARILFSAHSLPVSFIEKGDPYKQQLRQTVLSILQNMGLQSIDNTLCYQSK
HHHHHHHCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
LGPVRWLEPSTKSELLRACNDNVSVVLVPIAFVSENSETLVELDIEYKALVGEKKFIRVP
CCCEEECCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCEEEEEECHHHHHCCCCEEEECC
TLGTDPKFIECLCNLVLAKQ
CCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA