Click here to switch to the map view.

The map label for this gene is pqqL [C]

Identifier: 88607349

GI number: 88607349

Start: 104398

End: 105669

Strand: Reverse

Name: pqqL [C]

Synonym: APH_0101

Alternate gene names: 88607349

Gene position: 105669-104398 (Counterclockwise)

Preceding gene: 88607011

Following gene: 88607695

Centisome position: 7.18

GC content: 42.77

Gene sequence:

>1272_bases
ATGGTTACACTGCCTGTAGTTACGAAGCTGAAAAATAATCTTTCTGTTATTACTGAACACATTGGCGGGGTAAATTCGGT
AGGAATCAATCTTTGGGTCAAGGTGGGAAGTAGACATGAAGTGCATGAGAAGATCGGGCTTGCACACTTCCTTGAACATA
TGGCTTTCAAGGGTACGACCACAAGATCTGCCTTAGACATAGCAAAAACTTTCGATGCGATCGGCGGAAACTTTAATGCT
TACACAGATAAAGAACATACTGTGTATCACCTAAAAGTGATGAAAAAAGATGCACGTCTCGCCCTTGAGGTTCTCACTGA
TATAGTGCTAAGATCGTCATTTCCCGAAGAAGAAATGGAGAGGGAAAAAGACGTAGTACTGCAGGAGATTTACCAAACAA
ATGATTCTCCTAGCAGTATAATATTTGATAAGTACCTAGAAGCTGCATACGAAGGACAGATCTTCGGTAAATCTATTTTG
GGCTCTGTGCATACGGTGCAAAACTTTTCTAAGGAAGACTTGGTCTCTCACATGGACAAGCATTATTACGGAAGTAATAT
GGTGCTCTCCTTGGCCGGAGATATAGTACATGATGAGGTTTTGGAAATGGCGCAAGGCTTGGAGCAGCTTAAAGATCGGC
AACACTGCTCCCCTGTCCAAGTGCCACAGTATACAGGTGGGGAATATCTAGAAGAACGCAACCACCTAGAGCAGGTAAAC
ATAATAATAGGTTTTCCCGGTGTACCTTACGGAGATGAACGTTTTCACGCAATGCAAGTGTTGGATACTATACTTGGCAG
CGGGCTTTCTTCGCGGTTGTTTCAAGAAGTGCGCGAGAAGCTAGGTTTAGTGTACAGTATCTGCTCTTTCAATTATAGCT
ACTCTGATAGCGGCCTTTTCTCAGTGCATGCAGCGACTGACAGCACAAAGCTACCTATTCTGCTTCAAACCGTCACCACG
GAGTTAAAGAAGCTTCCTGATACCATAGAAGATGAAGAGCTCCAACGCGCAAAGAGTAAATTGGAAGCTGAAATTTTAAT
GTCTCGAGAAAGTCCAGTAGCGAAGTCTGAAGCACTGGGCTATTACTACTCTCACTATGGCAGATACATACAAAAGCAAG
AACTTATAGAAAAAATTCGCTCTATAGACGCACGCAATGTTCAAGACGTAGCGAACTTTTTACTGCAAAGCAGTTCTAAT
ATAACACTAGCTGCAATAGGCAAACTTGACTCTTCTATAAGTCGGGTTGAAGTTGCTTCAATGCTTGCGTGA

Upstream 100 bases:

>100_bases
TAAGGTAACTAGTCAAATCAGCCGATGAAATTAATTTCTACTTTCACGGCACAGCATAATGCGGTACCATCGACTGCTTA
TAATCTGTCTGTAGATCGCG

Downstream 100 bases:

>100_bases
AGTACGTTGTCGTAATAGCCTACACGCTATCGTTGATACGCCAGTACGGGGAGCACAACATACTAGAAATAGAACTGCTG
AAATAGCTCACCCTGTTGGG

Product: M16 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MVTLPVVTKLKNNLSVITEHIGGVNSVGINLWVKVGSRHEVHEKIGLAHFLEHMAFKGTTTRSALDIAKTFDAIGGNFNA
YTDKEHTVYHLKVMKKDARLALEVLTDIVLRSSFPEEEMEREKDVVLQEIYQTNDSPSSIIFDKYLEAAYEGQIFGKSIL
GSVHTVQNFSKEDLVSHMDKHYYGSNMVLSLAGDIVHDEVLEMAQGLEQLKDRQHCSPVQVPQYTGGEYLEERNHLEQVN
IIIGFPGVPYGDERFHAMQVLDTILGSGLSSRLFQEVREKLGLVYSICSFNYSYSDSGLFSVHAATDSTKLPILLQTVTT
ELKKLPDTIEDEELQRAKSKLEAEILMSRESPVAKSEALGYYYSHYGRYIQKQELIEKIRSIDARNVQDVANFLLQSSSN
ITLAAIGKLDSSISRVEVASMLA

Sequences:

>Translated_423_residues
MVTLPVVTKLKNNLSVITEHIGGVNSVGINLWVKVGSRHEVHEKIGLAHFLEHMAFKGTTTRSALDIAKTFDAIGGNFNA
YTDKEHTVYHLKVMKKDARLALEVLTDIVLRSSFPEEEMEREKDVVLQEIYQTNDSPSSIIFDKYLEAAYEGQIFGKSIL
GSVHTVQNFSKEDLVSHMDKHYYGSNMVLSLAGDIVHDEVLEMAQGLEQLKDRQHCSPVQVPQYTGGEYLEERNHLEQVN
IIIGFPGVPYGDERFHAMQVLDTILGSGLSSRLFQEVREKLGLVYSICSFNYSYSDSGLFSVHAATDSTKLPILLQTVTT
ELKKLPDTIEDEELQRAKSKLEAEILMSRESPVAKSEALGYYYSHYGRYIQKQELIEKIRSIDARNVQDVANFLLQSSSN
ITLAAIGKLDSSISRVEVASMLA
>Mature_423_residues
MVTLPVVTKLKNNLSVITEHIGGVNSVGINLWVKVGSRHEVHEKIGLAHFLEHMAFKGTTTRSALDIAKTFDAIGGNFNA
YTDKEHTVYHLKVMKKDARLALEVLTDIVLRSSFPEEEMEREKDVVLQEIYQTNDSPSSIIFDKYLEAAYEGQIFGKSIL
GSVHTVQNFSKEDLVSHMDKHYYGSNMVLSLAGDIVHDEVLEMAQGLEQLKDRQHCSPVQVPQYTGGEYLEERNHLEQVN
IIIGFPGVPYGDERFHAMQVLDTILGSGLSSRLFQEVREKLGLVYSICSFNYSYSDSGLFSVHAATDSTKLPILLQTVTT
ELKKLPDTIEDEELQRAKSKLEAEILMSRESPVAKSEALGYYYSHYGRYIQKQELIEKIRSIDARNVQDVANFLLQSSSN
ITLAAIGKLDSSISRVEVASMLA

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=415, Percent_Identity=30.8433734939759, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI46593007, Length=400, Percent_Identity=28.25, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI24308013, Length=434, Percent_Identity=26.9585253456221, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI50592988, Length=419, Percent_Identity=23.3890214797136, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1787770, Length=186, Percent_Identity=26.8817204301075, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71999683, Length=414, Percent_Identity=28.0193236714976, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17553678, Length=401, Percent_Identity=26.4339152119701, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17510601, Length=436, Percent_Identity=24.0825688073394, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17555260, Length=391, Percent_Identity=24.2966751918159, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17569737, Length=336, Percent_Identity=23.5119047619048, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=419, Percent_Identity=30.5489260143198, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6321813, Length=432, Percent_Identity=27.3148148148148, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6319426, Length=445, Percent_Identity=21.7977528089888, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357875, Length=406, Percent_Identity=32.0197044334975, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24646943, Length=406, Percent_Identity=32.0197044334975, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI19921772, Length=430, Percent_Identity=25.8139534883721, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24665395, Length=389, Percent_Identity=23.1362467866324, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47426; Mature: 47426

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLPVVTKLKNNLSVITEHIGGVNSVGINLWVKVGSRHEVHEKIGLAHFLEHMAFKGTT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
TRSALDIAKTFDAIGGNFNAYTDKEHTVYHLKVMKKDARLALEVLTDIVLRSSFPEEEME
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHH
REKDVVLQEIYQTNDSPSSIIFDKYLEAAYEGQIFGKSILGSVHTVQNFSKEDLVSHMDK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
HYYGSNMVLSLAGDIVHDEVLEMAQGLEQLKDRQHCSPVQVPQYTGGEYLEERNHLEQVN
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCEEEE
IIIGFPGVPYGDERFHAMQVLDTILGSGLSSRLFQEVREKLGLVYSICSFNYSYSDSGLF
EEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
SVHAATDSTKLPILLQTVTTELKKLPDTIEDEELQRAKSKLEAEILMSRESPVAKSEALG
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YYYSHYGRYIQKQELIEKIRSIDARNVQDVANFLLQSSSNITLAAIGKLDSSISRVEVAS
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHH
MLA
HCC
>Mature Secondary Structure
MVTLPVVTKLKNNLSVITEHIGGVNSVGINLWVKVGSRHEVHEKIGLAHFLEHMAFKGTT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
TRSALDIAKTFDAIGGNFNAYTDKEHTVYHLKVMKKDARLALEVLTDIVLRSSFPEEEME
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHH
REKDVVLQEIYQTNDSPSSIIFDKYLEAAYEGQIFGKSILGSVHTVQNFSKEDLVSHMDK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
HYYGSNMVLSLAGDIVHDEVLEMAQGLEQLKDRQHCSPVQVPQYTGGEYLEERNHLEQVN
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCEEEE
IIIGFPGVPYGDERFHAMQVLDTILGSGLSSRLFQEVREKLGLVYSICSFNYSYSDSGLF
EEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
SVHAATDSTKLPILLQTVTTELKKLPDTIEDEELQRAKSKLEAEILMSRESPVAKSEALG
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
YYYSHYGRYIQKQELIEKIRSIDARNVQDVANFLLQSSSNITLAAIGKLDSSISRVEVAS
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHH
MLA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA