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The map label for this gene is mdmC [H]

Identifier: 88607321

GI number: 88607321

Start: 612385

End: 613041

Strand: Reverse

Name: mdmC [H]

Synonym: APH_0584

Alternate gene names: 88607321

Gene position: 613041-612385 (Counterclockwise)

Preceding gene: 88606989

Following gene: 88607412

Centisome position: 41.67

GC content: 40.18

Gene sequence:

>657_bases
GTGCGCAATGTCTCTTTAAGCAAACAAGATGAGTACCTTAATAAGCTTTTTGCTGTAGATACTGAGGGTGCATTGAAGGC
GCATAAAACTGCACCTTCTGAGTTGCGTATGGCACAATTAGGGACTGTTGAAGGACAAATGCTACAGCTTTTAATAAGAA
TGGCTGGTATACATTCAATAGTCGAAGTGGGTACTTGTGTGGGATTTTCCGCAATATGTATGGCGCATGCCCTGCCTTCT
AAGGGACATATATACACAATAGAGAAAGATTACGAAAACGTAGTGACCGCAAATCAGAACATAGTCAACTGTAAACTGGA
AGATAAAATAACGGTATTGCATGGTGAGGCTTTGGCGCAGCTAAACACTTTAAAGGAAATGGCTCCATTTGATATGATAT
TTATAGATGCAAACAAATCCTCATACCTTGCTTACTTAAACTGGGCTAAAATGTATATAAGGAAGGGTGGCCTCATAGTT
GCTGATAACACCTTCCTCTTTGGCAGCGTATTTGATGAGCACCCAACTGAAAAAGTTTCTAGTAATGCTCATGCCAGTAT
GCGAGCGTTTAATGACGAACTCGCTAATAAAGAAAAATACCTCTCTACCATTATACCTACTAGCGAAGGCATGATGGTAT
CGATAAAGCTCACATGA

Upstream 100 bases:

>100_bases
AATTATCACGCTGCATATACTTATAAAGTTAACGATATGTTGAAGGAATTTATAAAAAAATATAAGATCTTCCTACAAAT
TAGAAACGTATAGGTAATAA

Downstream 100 bases:

>100_bases
TTTCACGCCACAGACATTTGATCTCTAGACATCTTGTAATGACTCAAGATTTTAGAATACGCAAGAACATGTAGCGTGTG
TTTATAAGCGGATCTATTCT

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRNVSLSKQDEYLNKLFAVDTEGALKAHKTAPSELRMAQLGTVEGQMLQLLIRMAGIHSIVEVGTCVGFSAICMAHALPS
KGHIYTIEKDYENVVTANQNIVNCKLEDKITVLHGEALAQLNTLKEMAPFDMIFIDANKSSYLAYLNWAKMYIRKGGLIV
ADNTFLFGSVFDEHPTEKVSSNAHASMRAFNDELANKEKYLSTIIPTSEGMMVSIKLT

Sequences:

>Translated_218_residues
MRNVSLSKQDEYLNKLFAVDTEGALKAHKTAPSELRMAQLGTVEGQMLQLLIRMAGIHSIVEVGTCVGFSAICMAHALPS
KGHIYTIEKDYENVVTANQNIVNCKLEDKITVLHGEALAQLNTLKEMAPFDMIFIDANKSSYLAYLNWAKMYIRKGGLIV
ADNTFLFGSVFDEHPTEKVSSNAHASMRAFNDELANKEKYLSTIIPTSEGMMVSIKLT
>Mature_218_residues
MRNVSLSKQDEYLNKLFAVDTEGALKAHKTAPSELRMAQLGTVEGQMLQLLIRMAGIHSIVEVGTCVGFSAICMAHALPS
KGHIYTIEKDYENVVTANQNIVNCKLEDKITVLHGEALAQLNTLKEMAPFDMIFIDANKSSYLAYLNWAKMYIRKGGLIV
ADNTFLFGSVFDEHPTEKVSSNAHASMRAFNDELANKEKYLSTIIPTSEGMMVSIKLT

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Caenorhabditis elegans, GI72001127, Length=173, Percent_Identity=32.9479768786127, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25148771, Length=173, Percent_Identity=32.9479768786127, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17565612, Length=171, Percent_Identity=28.6549707602339, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72001028, Length=200, Percent_Identity=29.5, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24151; Mature: 24151

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNVSLSKQDEYLNKLFAVDTEGALKAHKTAPSELRMAQLGTVEGQMLQLLIRMAGIHSI
CCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VEVGTCVGFSAICMAHALPSKGHIYTIEKDYENVVTANQNIVNCKLEDKITVLHGEALAQ
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHEECCCCEEEEEECCCEEEEEHHHHHH
LNTLKEMAPFDMIFIDANKSSYLAYLNWAKMYIRKGGLIVADNTFLFGSVFDEHPTEKVS
HHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHCCCEEEECCCEEEECHHCCCCHHHHC
SNAHASMRAFNDELANKEKYLSTIIPTSEGMMVSIKLT
CCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEEC
>Mature Secondary Structure
MRNVSLSKQDEYLNKLFAVDTEGALKAHKTAPSELRMAQLGTVEGQMLQLLIRMAGIHSI
CCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VEVGTCVGFSAICMAHALPSKGHIYTIEKDYENVVTANQNIVNCKLEDKITVLHGEALAQ
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHEECCCCEEEEEECCCEEEEEHHHHHH
LNTLKEMAPFDMIFIDANKSSYLAYLNWAKMYIRKGGLIVADNTFLFGSVFDEHPTEKVS
HHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHCCCEEEECCCEEEECHHCCCCHHHHC
SNAHASMRAFNDELANKEKYLSTIIPTSEGMMVSIKLT
CCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]